Title: The Best Hotels in Santa Ana, Panama City - 2026 Updated Prices | Expedia.co.uk [Santa Ana Travel Guide](https://expedia.co.uk/Panama-City-Santa-Ana.dx553248623199107606)[Holiday Rentals in Panama City](https://expedia.co.uk/Panama-City-Holiday-Rentals.d2897.Travel-Guide-HolidayRentals)[Flights to Panama City](https://expedia.co.uk/Cheap-Flights-To-Panama-City.d2897.Travel-Guide-Flights)[Things to do in Panama City](https://expedia.co.uk/Things-To-Do-In-Panama-City.d2897.Travel-Guide-Activities)[Santa Ana Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Ana.d553248623199107606.Car-Hire-Guide)[Santa Ana Holidays](https://expedia.co.uk/Santa-Ana.d553248623199107606.Holidays-City-Breaks) ![View from the fish market go there and eat fresh and yummy fish in all variations](https://images.trvl-media.com/place/2897/bac01da0-ec19-4429-ad25-62008eb40af6.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Isa # Search Hotels in Santa Ana, Panama City - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [10 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248623199107606&startDate=2026-01-10&endDate=2026-01-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [11 Jan - 12 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248623199107606&startDate=2026-01-11&endDate=2026-01-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248623199107606&startDate=2026-01-16&endDate=2026-01-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248623199107606&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Santa Ana hotels ![Living area](https://images.trvl-media.com/lodging/88000000/87400000/87396800/87396713/83a1ee2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/88000000/87400000/87396800/87396713/4a38aa01.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Double Bed | Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/88000000/87400000/87396800/87396713/c38aaf6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/88000000/87400000/87396800/87396713/3e5ecf32.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hostal La Cigarra [](https://www.expedia.co.uk/Panama-City-Hotels-Hostal-La-Cigarra.h87396713.Hotel-Information) Santa Ana 7.4/10 Good (56 reviews) "Excelente " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) David £19 includes taxes & fees 30 Jan - 31 Jan [](https://www.expedia.co.uk/Panama-City-Hotels-Hostal-La-Cigarra.h87396713.Hotel-Information) ![Outdoor pool, open 8:00 AM to 10:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/103000000/102810000/102803600/102803573/w846h1318x0y4-5df5c378.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Apartment | Balcony](https://images.trvl-media.com/lodging/103000000/102810000/102803600/102803573/ee1ac3ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Apartment | Living area | Smart TV](https://images.trvl-media.com/lodging/103000000/102810000/102803600/102803573/03e26607.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/103000000/102810000/102803600/102803573/762cceb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Casco View Apartments [](https://www.expedia.co.uk/Panama-City-Hotels-Casco-View-Apartments.h102803573.Hotel-Information) Santa Ana 9.0/10 Wonderful (61 reviews) "We live this property and stay here whenever we are in town." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) chris £68 includes taxes & fees 11 Jan - 12 Jan [](https://www.expedia.co.uk/Panama-City-Hotels-Casco-View-Apartments.h102803573.Hotel-Information) ![Double Room | View from room](https://images.trvl-media.com/lodging/4000000/3260000/3257600/3257592/77400971.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/4000000/3260000/3257600/3257592/92156b5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/4000000/3260000/3257600/3257592/9363bddf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hallway](https://images.trvl-media.com/lodging/4000000/3260000/3257600/3257592/ce5bf1ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel República [](https://www.expedia.co.uk/Panama-City-Hotels-Hotel-Republica.h3257592.Hotel-Information) Santa Ana 6.6/10 (182 reviews) "Fantastic customer service" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) OLGA [](https://www.expedia.co.uk/Panama-City-Hotels-Hotel-Republica.h3257592.Hotel-Information) ![Apartment (20) | Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/101000000/100580000/100572500/100572489/dacdb94e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment (05) | Living area | 40-inch Smart TV with cable channels](https://images.trvl-media.com/lodging/101000000/100580000/100572500/100572489/679f386c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Traditional Apartment | Dining room](https://images.trvl-media.com/lodging/101000000/100580000/100572500/100572489/ef205966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/101000000/100580000/100572500/100572489/6c701342.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Manzana by Wynwood House [](https://www.expedia.co.uk/Panama-City-Hotels-La-Manzana-By-Wynwood-House.h100572489.Hotel-Information) Santa Ana 7.2/10 Good (15 reviews) "Great hotel. Very close to Casco viejo" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LUCILA £70 includes taxes & fees 11 Jan - 12 Jan [](https://www.expedia.co.uk/Panama-City-Hotels-La-Manzana-By-Wynwood-House.h100572489.Hotel-Information) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse (In the heart of the City) | Minibar, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/c6c3b77c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Penthouse (In the heart of the City) | City view](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/81e63597.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/096c0ccc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Riu Plaza Panama [](https://www.expedia.co.uk/Panama-City-Hotels-Hotel-Riu-Plaza-Panama.h3900395.Hotel-Information) Campo Alegre, 2.2 mi from Santa Ana 9.0/10 Wonderful (4,811 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria Teresa £100 includes taxes & fees 22 Jan - 23 Jan [](https://www.expedia.co.uk/Panama-City-Hotels-Hotel-Riu-Plaza-Panama.h3900395.Hotel-Information) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/877d081d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/8103ef2b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/2f37bae5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, soundproofing](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/5f648ea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crowne Plaza Panama Airport by IHG [](https://www.expedia.co.uk/Tocumen-Hotels-Crowne-Plaza-Panama-Airport.h8836117.Hotel-Information) 12.8 mi from Santa Ana 8.6/10 Excellent (2,388 reviews) "Great staff and close to the airport " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) CARLOS ROBERTO £90 includes taxes & fees 12 Jan - 13 Jan [](https://www.expedia.co.uk/Tocumen-Hotels-Crowne-Plaza-Panama-Airport.h8836117.Hotel-Information) ![Garden](https://images.trvl-media.com/lodging/1000000/810000/809200/809149/fe3d7092.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/810000/809200/809149/ae564df0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/810000/809200/809149/dea447f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/810000/809200/809149/93c6a3dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Radisson Hotel Panama Canal [](https://www.expedia.co.uk/Amador-Hotels-Radisson-Hotel-Panama-Canal.h809149.Hotel-Information) Amador, 1.4 mi from Santa Ana 8.6/10 Excellent (1,002 reviews) "Unbeatable location if your visit is all about the Panama Canal. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vitaliy £61 includes taxes & fees 7 Feb - 8 Feb [](https://www.expedia.co.uk/Amador-Hotels-Radisson-Hotel-Panama-Canal.h809149.Hotel-Information) ![Outdoor pool, open 7:00 AM to 10:30 PM, free pool cabanas](https://images.trvl-media.com/lodging/1000000/30000/26300/26240/b7e843b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/1000000/30000/26300/26240/dc6a5657.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside views, serves lunch and dinner](https://images.trvl-media.com/lodging/1000000/30000/26300/26240/88cca748.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Poolside bar](https://images.trvl-media.com/lodging/1000000/30000/26300/26240/d73825f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Riande Aeropuerto Hotel & Casino [](https://www.expedia.co.uk/Tocumen-Hotels-Riande-Aeropuerto-Hotel-Casino.h26240.Hotel-Information) 12.3 mi from Santa Ana 8.6/10 Excellent (1,845 reviews) "Better than expected: Location, transportation to and from airport, pool area tropical and comfortable. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marty £102 includes taxes & fees 13 Jan - 14 Jan [](https://www.expedia.co.uk/Tocumen-Hotels-Riande-Aeropuerto-Hotel-Casino.h26240.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/120000000/119870000/119860600/119860522/19fc3193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/120000000/119870000/119860600/119860522/cc0414b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Double Room, Garden View | Free WiFi](https://images.trvl-media.com/lodging/120000000/119870000/119860600/119860522/d2c4357e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Living area](https://images.trvl-media.com/lodging/120000000/119870000/119860600/119860522/febf3b4c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### ORHO HOTEL BOUTIQUE PANAMA Airport [](https://www.expedia.co.uk/Tocumen-Hotels-ORHO-HOTEL-BOUTIQUE-PANAMA-Airport.h119860522.Hotel-Information) 12.7 mi from Santa Ana 9.0/10 Wonderful (47 reviews) "Great staff and nice boutique hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Margie £116 includes taxes & fees 12 Jan - 13 Jan [](https://www.expedia.co.uk/Tocumen-Hotels-ORHO-HOTEL-BOUTIQUE-PANAMA-Airport.h119860522.Hotel-Information) ![View from property](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/3972c3df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/166e4001.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch served; local and international cuisine ](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/ea9ff933.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch served; local and international cuisine ](https://images.trvl-media.com/lodging/21000000/20960000/20958600/20958573/c579d87e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City [](https://www.expedia.co.uk/Panama-City-Hotels-The-Santa-Maria.h20958573.Hotel-Information) Juan Diaz, 7.9 mi from Santa Ana 9.6/10 Exceptional (651 reviews) "As usual the stay was amazing in this hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose £214 includes taxes & fees 6 Feb - 7 Feb [](https://www.expedia.co.uk/Panama-City-Hotels-The-Santa-Maria.h20958573.Hotel-Information) ![Food and drink](https://images.trvl-media.com/lodging/5000000/4320000/4316400/4316336/c1dda5ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/5000000/4320000/4316400/4316336/afc6d0da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/5000000/4320000/4316400/4316336/f53158fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves breakfast, lunch and dinner](https://images.trvl-media.com/lodging/5000000/4320000/4316400/4316336/d12ac1da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Panama Metromall [](https://www.expedia.co.uk/San-Miguelito-Hotels-Courtyard-By-Marriott-Panama-Metromall.h4316336.Hotel-Information) 9.1 mi from Santa Ana 8.8/10 Excellent (1,004 reviews) "Very courteous staff - early check in - room clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Arthur £83 includes taxes & fees 6 Feb - 7 Feb [](https://www.expedia.co.uk/San-Miguelito-Hotels-Courtyard-By-Marriott-Panama-Metromall.h4316336.Hotel-Information) ![2 restaurants, local cuisine](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/5dc0b3d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/8f2104c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Urban Suite,1 King, Partial City view | In-room safe, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/0b373179.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/22000000/21320000/21314100/21314035/1175365b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### W Panama [](https://www.expedia.co.uk/Panama-City-Hotels-W-Panama.h21314035.Hotel-Information) Campo Alegre, 2 mi from Santa Ana 9.0/10 Wonderful (1,001 reviews) "Beautiful room, super clean, and friendly staff!!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kimberly £163 includes taxes & fees 30 Jan - 31 Jan [](https://www.expedia.co.uk/Panama-City-Hotels-W-Panama.h21314035.Hotel-Information) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/9000000/8220000/8217000/8216939/7d8fcf8b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/9000000/8220000/8217000/8216939/49d1f8ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/9000000/8220000/8217000/8216939/c826c327.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/9000000/8220000/8217000/8216939/094aef75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ramada Plaza by Wyndham Panama Punta Pacifica [](https://www.expedia.co.uk/Panama-City-Hotels-Ramada-Plaza-By-Wyndham-Panama-Punta-Pacifica.h8216939.Hotel-Information) San Francisco, 3.2 mi from Santa Ana 9.6/10 Exceptional (1,141 reviews) "The room was clean and the location was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Wendy £89 includes taxes & fees 13 Jan - 14 Jan [](https://www.expedia.co.uk/Panama-City-Hotels-Ramada-Plaza-By-Wyndham-Panama-Punta-Pacifica.h8216939.Hotel-Information) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/9000000/8790000/8785100/8785045/ab95ae6e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/9000000/8790000/8785100/8785045/f6840e58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/9000000/8790000/8785100/8785045/86e96c74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 2 Bedrooms, City View | View from room](https://images.trvl-media.com/lodging/9000000/8790000/8785100/8785045/d12ffdbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sortis Hotel, Spa & Casino, Autograph Collection by Marriott [](https://www.expedia.co.uk/Panama-City-Hotels-Sortis-Hotel.h8785045.Hotel-Information) Obarrio, 2.6 mi from Santa Ana 8.8/10 Excellent (1,014 reviews) "Great hotel. Great spa" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Robert £111 includes taxes & fees 13 Jan - 14 Jan [](https://www.expedia.co.uk/Panama-City-Hotels-Sortis-Hotel.h8785045.Hotel-Information) ![2 bars/lounges, gastropub](https://images.trvl-media.com/lodging/1000000/190000/185300/185277/f3b8e5d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/1000000/190000/185300/185277/96fd75ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch served; local and international cuisine ](https://images.trvl-media.com/lodging/1000000/190000/185300/185277/6db7ada6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/190000/185300/185277/d27e0b6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Riande Urban Hotel [](https://www.expedia.co.uk/Panama-City-Hotels-Riande-Urban-Hotel.h185277.Hotel-Information) El Cangrejo, 2.4 mi from Santa Ana 8.8/10 Excellent (1,049 reviews) "Good hotel and nice staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose £69 includes taxes & fees 13 Jan - 14 Jan [](https://www.expedia.co.uk/Panama-City-Hotels-Riande-Urban-Hotel.h185277.Hotel-Information) ![Front of property – evening/night](https://images.trvl-media.com/lodging/8000000/7460000/7451800/7451703/2baee2b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/8000000/7460000/7451800/7451703/aee77a8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Snack bar](https://images.trvl-media.com/lodging/8000000/7460000/7451800/7451703/fd44364f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room | Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/8000000/7460000/7451800/7451703/9e0f8c6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Principe Hotel and Suites [](https://www.expedia.co.uk/Panama-City-Hotels-Principe-Hotel-And-Suites.h7451703.Hotel-Information) El Cangrejo, 2.4 mi from Santa Ana 9.0/10 Wonderful (1,646 reviews) "A easy and convenient stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dave £48 includes taxes & fees 12 Jan - 13 Jan [](https://www.expedia.co.uk/Panama-City-Hotels-Principe-Hotel-And-Suites.h7451703.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/530000/522100/522086/493046b7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 8:00 AM to 6:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/530000/522100/522086/e3ee3bd7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/530000/522100/522086/af0ce5c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed | View from room](https://images.trvl-media.com/lodging/1000000/530000/522100/522086/243f1471.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Executive Hotel [](https://www.expedia.co.uk/Panama-City-Hotels-The-Executive-Hotel.h522086.Hotel-Information) Campo Alegre, 2 mi from Santa Ana 9.2/10 Wonderful (1,004 reviews) "A nice hotel to stay great location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) angela [](https://www.expedia.co.uk/Panama-City-Hotels-The-Executive-Hotel.h522086.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/530000/527000/526925/91ac7bea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/530000/527000/526925/3db8be94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/530000/527000/526925/5b3a3c75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/530000/527000/526925/4ac2734a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Plaza Paitilla Inn Hotel [](https://www.expedia.co.uk/Panama-City-Hotels-Plaza-Paitilla-Inn-Hotel.h526925.Hotel-Information) Punta Paitilla, 2.1 mi from Santa Ana 9.4/10 Exceptional (2,149 reviews) "Great location of the hotel with a lovely breakfast and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) fouad £88 includes taxes & fees 13 Jan - 14 Jan [](https://www.expedia.co.uk/Panama-City-Hotels-Plaza-Paitilla-Inn-Hotel.h526925.Hotel-Information) ![4 outdoor pools, free pool cabanas, pool umbrellas](https://images.trvl-media.com/lodging/5000000/4110000/4109200/4109123/fb42dbf6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![4 outdoor pools, free pool cabanas, pool umbrellas](https://images.trvl-media.com/lodging/5000000/4110000/4109200/4109123/0babe4e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Suite, 1 King Bed, Partial Ocean View | Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds](https://images.trvl-media.com/lodging/5000000/4110000/4109200/4109123/2c21fbc7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4110000/4109200/4109123/w3996h2667x4y0-a167c2ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### JW Marriott Panama [](https://www.expedia.co.uk/Panama-City-Hotels-JW-Marriott-Panama.h4109123.Hotel-Information) Punta Pacifica, 2.7 mi from Santa Ana 9.0/10 Wonderful (1,005 reviews) "Great Hotel and great staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rudolph £228 includes taxes & fees 7 Feb - 8 Feb [](https://www.expedia.co.uk/Panama-City-Hotels-JW-Marriott-Panama.h4109123.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/112000000/111850000/111843300/111843270/616200e0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/112000000/111850000/111843300/111843270/4edef1fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/112000000/111850000/111843300/111843270/6fa9ba2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/112000000/111850000/111843300/111843270/w5759h3838x0y0-d4c8ab5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency Panama City [](https://www.expedia.co.uk/Panama-City-Hotels-Hyatt-Regency-Panama-City.h111843270.Hotel-Information) Campo Alegre, 2 mi from Santa Ana 9.8/10 Exceptional (163 reviews) "Breakfast was so good , hotel was clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ankit £128 includes taxes & fees 7 Feb - 8 Feb [](https://www.expedia.co.uk/Panama-City-Hotels-Hyatt-Regency-Panama-City.h111843270.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-24&endDate=2026-01-25®ionId=553248623199107606&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Where to stay in Santa Ana Find the best Santa Ana areas for the activities you enjoy most. [Learn more about Santa Ana](https://www.expedia.co.uk/Panama-City-Santa-Ana.dx553248623199107606) - Casco Viejo - Bella Vista - El Cangrejo - San Felipe - San Francisco [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=6285189) ![Casco Viejo map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:w%7Csu%40z%7CmdNsAsJNa%40sCsD%60HKJ%7DFO_Ai%40A%3F%5B%5C%3FBmAXC%7D%40aBd%40yBj%40%3FB%7D%40b%40%40Nl%40t%40I%60%40uA%7C%40D%40r%40%7ECNNm%40%60AIaAAVoCbFdAjB%7B%40pEvAKn%40_J%7CB%3FzDt%40%3FHnDZCKl%40f%40bAq%40r%40GrApAFQrAlBp%40O%7EBgEY%5CrCr%40%5EVxAiSFmDpA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=uEe2tFISgoY2i6D1L7Cp-Szzr7E=) ### Casco Viejo Unique features of Casco Viejo include the historical sites and bars. Make a stop by Interoceanic Canal Museum or National Theater while you're exploring the area. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=6285189) ![](https://mediaim.expedia.com/destination/1/1916fc53ea2cb142bbaeb7b9e6efaf16.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/1/d5ab8e549e1cfa831dcb33b7e1b0352d.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/1/919b43d85bf36a400b3c07d30881f725.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/1/de251296a0096f0bf5fd9914c545600d.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/1/a8f0f1d663e33ab4f81206a124826dcd.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=3000663485) ![Bella Vista map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ksxu%40xrmdNeY_Ea%60Ach%40wd%40eZ%60AmN%60KeE%7EE%7DIvIw%40bC%7BFvJkEf%40cEx%5BaVbHnA%7CGrN%60HxCfGnFlD_AhLfHlHj%40%60EiErGh%40tIfx%40qFbFoH%7Cc%40aI_BsItR&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=kybUo6TOAHV5XfFCWEb1fcek5LQ=) ### Bella Vista Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina. You might spend time checking out top sights like Via Espana and Crown Casino. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=3000663485) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=6285972) ![El Cangrejo map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7Bpzu%40%60xldN%7D%5BcRdDeKmFiDvDaNbCgGxW%7D%40rIrDpFzGvJpGwFlIpFnGg%60%40zR&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=TyMwYMNUwH4f3VdmHvCgBWau0RI=) ### El Cangrejo The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Crown Casino or Luxor Towers might round out your trip. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=6285972) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=829297728598073344) ![San Felipe map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:w%7Csu%40z%7CmdNsAsJNa%40sCsD%60HKJ%7DFO_Ai%40A%3F%5B%5C%3FBmAXC%7D%40aBd%40yBj%40%3FB%7D%40b%40%40Nl%40t%40I%60%40uA%7C%40D%40r%40%7ECNNm%40%60AIaAAVoCbFdAjB%7B%40pEvAKn%40_J%7CB%3FzDt%40%3FHnDZCKl%40f%40bAq%40r%40GrApAFQrAlBp%40O%7EBgEY%5CrCr%40%5EVxAiSFmDpA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=uEe2tFISgoY2i6D1L7Cp-Szzr7E=) ### San Felipe While visiting San Felipe, you might make a stop by sights like Interoceanic Canal Museum and National Theater. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=829297728598073344) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248623199112076) ![San Francisco map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wr%7Bu%40hdjdNiV%7BDud%40_SiCcEAqJ%7B%40aEkW_Zh%5EeK%7E%40_CWkNbDFxD%7BAgA%7BEqBqDL%7DDwDoKIkCt%40sBsAgAo%40oBvCKhG%7EDhBFh%40i%40%7C%40CxAx%40zCZrEu%40lA%7D%40So%40b%40qChA%7D%40dCAtExD%60DrGvCxArDQMwDvBWl%40y%40rAJo%40w%40z%40_AxCrBtBn%40pEpD%7BBlCmAyAt%40dEb%40Nd%40e%40HaAzBkCnFfDFr%40%7B%40h%40Jr%40pIvFlFdL%7EJlJhM%60SlDPbe%40eBrBlAr%40xAA%60AsAtBaFnBO%60%40p%40bEQtF%60HxAi%40lAIoA%7DEQCXz%40VoATQdAn%40p%40lH%40xBrBh%40xBK%60ArAVh%40%7EAvAd%40jD%7ECXjAYhE%5E%5CdBKnAnA_EzD%7BDp%40kBkAyFy%40qAdAqC%5Ec%40b%40yBYuBXaEtDeFi%40qC%7B%40kHiFgAKgBn%40eAE_ByBuEaDcCk%40kAyA_GuMaDB_DiB_A%7CAsFrB%7D%40jEiGjCeDVQfC%7BBx%40HrB%5DhAsIfEgBbE&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=LnVVpfxBpjhgnoVjOyo-4O6-uto=) ### San Francisco San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50\. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248623199112076) ## Top Santa Ana Hotel Reviews ![JW Marriott Panama](https://images.trvl-media.com/lodging/5000000/4110000/4109200/4109123/fb42dbf6_y.jpg) ### JW Marriott Panama 10/10 Excellent "Clean room" [](https://expedia.co.uk/Panama-City-Hotels-JW-Marriott-Panama.h4109123.Hotel-Information) ![Hotel El Panama by Faranda Grand, a member of Radisson Individuals](https://images.trvl-media.com/lodging/1000000/10000/7200/7164/cfc3400a_y.jpg) ### Hotel El Panama by Faranda Grand, a member of Radisson Individuals 10/10 Excellent "The staff were very polite and helpful and the room was quite nice. Its my second trip to panama and my second time staying at the hotel. It will always be my place to stay" [](https://expedia.co.uk/Panama-City-Hotels-Hotel-El-Panama-By-Faranda-Grand.h7164.Hotel-Information) ![Plaza Paitilla Inn Hotel](https://images.trvl-media.com/lodging/1000000/530000/527000/526925/a63bd0ec_y.jpg) ### Plaza Paitilla Inn Hotel 10/10 Excellent "The room was very nice with wrap around windows to see the skyline. Beds comfortable, breakfast was very good." [](https://expedia.co.uk/Panama-City-Hotels-Plaza-Paitilla-Inn-Hotel.h526925.Hotel-Information) ![Hotel Riu Plaza Panama](https://images.trvl-media.com/lodging/4000000/3910000/3900400/3900395/1eaf88f5_y.jpg) ### Hotel Riu Plaza Panama 10/10 Excellent "5 🌟 " [](https://expedia.co.uk/Panama-City-Hotels-Hotel-Riu-Plaza-Panama.h3900395.Hotel-Information) ![The Executive Hotel](https://images.trvl-media.com/lodging/1000000/530000/522100/522086/493046b7_y.jpg) ### The Executive Hotel 10/10 Excellent "Clean room great staff" [](https://expedia.co.uk/Panama-City-Hotels-The-Executive-Hotel.h522086.Hotel-Information) ![Crowne Plaza Panama Airport by IHG](https://images.trvl-media.com/lodging/9000000/8840000/8836200/8836117/877d081d_y.jpg) ### Crowne Plaza Panama Airport by IHG 10/10 Excellent "Staff was very helpful. Shuttle was very convenient and on time Food was great and hotel was clean. Will stay again " [](https://expedia.co.uk/Tocumen-Hotels-Crowne-Plaza-Panama-Airport.h8836117.Hotel-Information) ![Hyatt Regency Panama City](https://images.trvl-media.com/lodging/112000000/111850000/111843300/111843270/w3837h2557x3y3-241f7e7d_y.jpg) ### Hyatt Regency Panama City 10/10 Excellent "We only stay for one night and our room was very clean and modern. Staff was very friendly as well." [](https://expedia.co.uk/Panama-City-Hotels-Hyatt-Regency-Panama-City.h111843270.Hotel-Information) ![Marriott Panama Hotel](https://images.trvl-media.com/lodging/7000000/6100000/6099300/6099287/b61be540_y.jpg) ### Marriott Panama Hotel 10/10 Excellent "Yes very good service. " [](https://expedia.co.uk/Panama-City-Hotels-Marriott-Panama-Hotel.h6099287.Hotel-Information) ![Waymore Hotel Spa & Casino](https://images.trvl-media.com/lodging/97000000/96830000/96825200/96825193/75048cd3_y.jpg) ### Waymore Hotel Spa & Casino 10/10 Excellent "Clean room and very luxurious" [](https://expedia.co.uk/Panama-City-Hotels-Waymore-Hotel-Spa-Casino.h96825193.Hotel-Information) ## Frequently asked questions ### What are the best budget hotels in Santa Ana? > For those seeking a luxurious experience without breaking the bank, [Hotel República](https://www.expedia.co.uk/Panama-City-Hotels-Hotel-Republica.h3257592.Hotel-Information) presents a charming option with its rooftop terrace providing partial ocean views, superb for relaxing after a day of adventures. This hotel also features free WiFi and air conditioning, ensuring comfort during your stay. Families can take advantage of the area shuttle service to explore Panama City's attractions conveniently. ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Santa Ana hotel booking with Expedia? ### How much is the nightly rate at a Santa Ana hotel? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - [Hotels near Albrook Shopping Mall ](https://www.expedia.co.uk/Albrook-Shopping-Mall-Hotels.0-l6159851-0.Travel-Guide-Filter-Hotels) - [Hotels near Amador Causeway ](https://www.expedia.co.uk/Amador-Causeway-Hotels.0-l6286127-0.Travel-Guide-Filter-Hotels) - [Amador Hotels ](https://www.expedia.co.uk/Amador-Panama-City-Hotels.0-n553248635933392377-0.Travel-Guide-Filter-Hotels) - [Hotels near Ancon Hill ](https://www.expedia.co.uk/Ancon-Hill-Hotels.0-l6286129-0.Travel-Guide-Filter-Hotels) - [Balboa Hotels ](https://www.expedia.co.uk/Balboa-Panama-City-Hotels.0-n6323179-0.Travel-Guide-Filter-Hotels) - [Barrio Chino Hotels ](https://www.expedia.co.uk/Barrio-Chino-Panama-City-Hotels.0-n714749931894550528-0.Travel-Guide-Filter-Hotels) - [Bella Vista Hotels ](https://www.expedia.co.uk/Bella-Vista-Panama-City-Hotels.0-n3000663485-0.Travel-Guide-Filter-Hotels) - [Calidonia Hotels ](https://www.expedia.co.uk/Calidonia-Panama-City-Hotels.0-n3000663488-0.Travel-Guide-Filter-Hotels) - [Campo Alegre Hotels ](https://www.expedia.co.uk/Campo-Alegre-Panama-City-Hotels.0-n553248635976397615-0.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Casco Viejo ](https://www.expedia.co.uk/Casco-Viejo-Panama-City-Hotels-Boutique-Hotel.0-n6285189-0-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - [Hilton Hotels in Casco Viejo ](https://www.expedia.co.uk/Casco-Viejo-Panama-City-Hotels-Hilton-Hotels.0-n6285189-0--bHiltonHotels.Travel-Guide-Filter-Hotels) - [Historic Hotels in Casco Viejo ](https://www.expedia.co.uk/Casco-Viejo-Panama-City-Hotels-Historic-Hotel.0-n6285189-0-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Wedding Hotels in Casco Viejo ](https://www.expedia.co.uk/Casco-Viejo-Panama-City-Hotels-Wedding-Hotel.0-n6285189-0-tWeddingHotel.Travel-Guide-Filter-Hotels) - [Casco Viejo Hotels ](https://www.expedia.co.uk/Casco-Viejo-Panama-City-Hotels.0-n6285189-0.Travel-Guide-Filter-Hotels) - [Causeway Islands Hotels ](https://www.expedia.co.uk/Causeway-Islands-Hotels.d6336377.Travel-Guide-Hotels) - [Hotels near Cinta Costera ](https://www.expedia.co.uk/Cinta-Costera-Hotels.0-l6245970-0.Travel-Guide-Filter-Hotels) - [Curundu Hotels ](https://www.expedia.co.uk/Curundu-Panama-City-Hotels.0-n553248623199107736-0.Travel-Guide-Filter-Hotels) - [All-Inclusive Hotels in Panamá Province ](https://www.expedia.co.uk/Destinations-In-Panama-Province-All-Inclusive-Hotel.0-0-d6246281-tAllInclusiveHotel.Hotel-Filter-Destinations) - [Gay-Friendly Hotels in Panamá Province ](https://www.expedia.co.uk/Destinations-In-Panama-Province-Gay-Friendly-Hotel.0-0-d6246281-tGayFriendlyHotel.Hotel-Filter-Destinations) - [Panamá Province Hotels ](https://www.expedia.co.uk/Destinations-In-Panama-Province.d6246281.Hotel-Destinations) - [El Cangrejo Hotels ](https://www.expedia.co.uk/El-Cangrejo-Panama-City-Hotels.0-n6285972-0.Travel-Guide-Filter-Hotels) - [El Chorrillo Hotels ](https://www.expedia.co.uk/El-Chorrillo-Panama-City-Hotels.0-n553248623199107689-0.Travel-Guide-Filter-Hotels) - [Hotels near Estación Lotería ](https://www.expedia.co.uk/Estacion-Loteria-Hotels.d553248635125946139.Travel-Guide-Hotels) - [Hotels near Fuerte Amador Resort & Marina ](https://www.expedia.co.uk/Fuerte-Amador-Resort-Marina-Hotels.0-l553248621532964846-0.Travel-Guide-Filter-Hotels) - [Hotels near Isla Flamenco Shopping Center ](https://www.expedia.co.uk/Isla-Flamenco-Shopping-Center-Hotels.0-l553248621532963847-0.Travel-Guide-Filter-Hotels) - [Marbella Hotels ](https://www.expedia.co.uk/Marbella-Panama-City-Hotels.0-n3000663483-0.Travel-Guide-Filter-Hotels) - [Hotels near Marcos A. 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