Santa Ana Holidays from £977

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Your Santa Ana Holiday

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana holiday package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're travelling with and whatever you want to spend, your dream Santa Ana holiday is just clicks away with Expedia.

Price found within the past 48 hours. Click for updated prices.
Hotel Panamonte

Hotel Panamonte

3.5 out of 5
Price was £1,330, price is now £977 per person
£977
per person
16 Oct - 23 Oct
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
9.4/10 Exceptional! (111 reviews)
The grounds where beautiful and the staff was so friendly.

Reviewed on 19 Jul 2025

Central Hotel Bocas del Toro

Central Hotel Bocas del Toro

3 out of 5
Save 100% on your flight
Price was £3,177, price is now £1,964 per person
£1,964
per person
16 Oct - 23 Oct
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
No reviews
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was £2,113, price is now £1,367 per person
£1,367
per person
15 Nov - 21 Nov
found 17 hours ago
Return direct flight included
Bristol (BRS) to Panama City (PTY)
9/10 Wonderful! (974 reviews)
clean and functional with excellent staff

Reviewed on 23 Aug 2025

La Coralina Island House

La Coralina Island House

3.5 out of 5
Price was £1,706, price is now £1,243 per person
£1,243
per person
16 Oct - 23 Oct
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
9.4/10 Exceptional! (84 reviews)
Wow! This resort is absolutely amazing! Bekar went above and beyond for us! He even brought in a TV to the lobby so we could watch the NHL playoff game! Food is 10/10 as well. We will definitely go back!

Reviewed on 18 May 2025

NAYARA Bocas del Toro

NAYARA Bocas del Toro

4 out of 5
Save 100% on your flight
Price was £4,153, price is now £3,052 per person
£3,052
per person
16 Oct - 23 Oct
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
10/10 Exceptional! (54 reviews)
Amazing time across the board staying at both the Treehouse and the Ocean Villa for the week. The attention to the details made this an experience like no other. The treehouse created a one-of-a-kind experience especially with the views and birds around the island. Highly recommend doing both. The service staff were extremely kind and attentive to all needs with a caring spirit of service. The housekeeping staff kept the places immaculate each day. The food quality was exceptional, especially at dinner each night in the Elephant House. The focus and creativity of each meal along with the unique presentation each night really made it special. The soups and main course served each night were absoutely the best we have ever experienced. Our conpliments to the chefs. A special thanks to the staff that made us feel very special and exhibited the gift of hospitality. Outstanding service really shined through Gilberto, Andrea, Mikeal, Franco, Ruby, Carlos, Victor, Liz, Williams, Sherill, and so many others! If you desire an intimate, unique resort experience that you will never forget, this is your place!

Reviewed on 2 Aug 2025

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
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Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Metropolitan Cathedral of Panama or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

3 out of 5
C. 16 Oeste, Panama City, Provincia de Panamá
9.2/10 Wonderful! (45 reviews)
"Excellent location and great food."

Reviewed on 25 Aug 2025

Get rates
Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella, Panama City, Panama
Fully refundableReserve now, pay when you stay
The price is £82 per night from 30 Aug to 31 Aug
£82
30 Aug - 31 Aug
includes taxes & fees
9/10 Wonderful! (4,193 reviews)
Great stay
"This hotel gave me one of the most luxurious hotel experiences I’ve ever had. It is centrally located with easy access to all your daily social and business needs. The room was brilliantly designed to ensure for the customer luxury feel, comfort, convenience, and ample space. The staff were very ..."

Reviewed on 23 Aug 2025

Hotel Riu Plaza Panama
Dreams Playa Bonita Panama - All Inclusive

Dreams Playa Bonita Panama - All Inclusive

4 out of 5
KM 7, Road to Veracruz, Veracruz, Panama
Fully refundableReserve now, pay when you stay
The price is £164 per night from 16 Sept to 17 Sept
£164
16 Sept - 17 Sept
includes taxes & fees
7.2/10 Good! (1,008 reviews)
"The resort was amazing!!"

Reviewed on 24 Aug 2025

Dreams Playa Bonita Panama - All Inclusive
See all 1,516 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Ana travel package cost?
Starting from as low as £977, a package is your passport to low-cost travel. Build your own Santa Ana escape by picking from our great range of hotels, flights and rental cars.
If I'm not able to travel, can I cancel my Santa Ana travel package?
It is possible to cancel your Santa Ana booking if your plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel free of charge if you booked in the last 24 hours. Head to our Customer Service Portal to find out more.
How do I get a cheap travel package to Santa Ana?
Bundle your hotels and flights, add extras such as activities or a rental car, and save with a Santa Ana travel package. You won't just score exciting discounts on your escape — you'll have lots of choice too. When you book with Expedia, you can choose from more than 550 airlines and 1,000,000 hotels across the globe. Your affordable holiday starts right here, right now!
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Yes. Expedia has partnered with online lender Klarna to help you easily pay for your holiday in instalments. Simply select the payment plan best suited to your needs during the checkout process and take the stress out of budgeting for your next trip. Be sure to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your holiday buck. Check out our flexible payment options below:

  • Pay monthly holidays: Realise your holiday dreams sooner with Klarna's monthly instalment plans. If paying a little each month works for you, choose this option during the checkout process.
  • Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Hitting the "book now" button is much easier with this payment plan. Put down a small deposit on your escape and then start working on your travel itinerary.

Where should I stay in Santa Ana?
Urban explorers come from all corners of the globe to see Metropolitan Cathedral of Panama and Miraflores Locks in Santa Ana. Book yourself a room within a stone's throw of these popular attractions and visit them whenever you want.
What are the top hotels in Santa Ana?
Get your trip off to a good start by booking a room at The Executive Hotel. It's one of most sought-after hotels in Santa Ana. Another comfortable option is JW Marriott Panama.
How far in advance should I book my Santa Ana holiday?
Search Expedia to compare international flights ASAP. In most cases, you can purchase a ticket up to a year prior to departure. If it's too early for your preferred air carrier, or you've left things to the last minute, fear not. Low prices to Santa Ana occasionally appear within weeks of the date of departure.
What does an Expedia Santa Ana travel package include?
Hotels, flights and a reliable car for all your fun road trip adventures. Simply choose your preferred bundle and gain access to great discounts. Once you've made your booking, add on some sightseeing tours and watch your savings grow. When it comes to crafting your Santa Ana escape, you're in control!
What should I know before booking a Santa Ana travel package?
A travel package can be tailored to your budget and is a simple way to make your budget go further. How little or much you include is up to you. Rental cars, hotels and flights — decide on a combination that suits your plans.
Can I choose my airline with a Santa Ana Expedia travel package?
With a travel package, you're the one in charge. Whether you'd like to fly to Santa Ana in economy or first class, simply pick from the available airline options. Expedia has access to over 550 airline partners across the world.

Popular places to visit

Cinta Costera

Cinta Costera

4/5(5 reviews)

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Fuerte Amador Resort & Marina

Fuerte Amador Resort & Marina

Explore the waterfront in Ancon with a trip to Fuerte Amador Resort & Marina. Visit the shops and top-notch restaurants in this vibrant area.

Fuerte Amador Resort & Marina
Metropolitan Cathedral of Panama

Metropolitan Cathedral of Panama

4/5(5 reviews)

Learn about the local history of Panama City with a stop at Metropolitan Cathedral of Panama. Visit the shops and top-notch restaurants in this vibrant area.

Metropolitan Cathedral of Panama

Things to do

Slingshot Tour Panama

Slingshot Tour Panama

£88
per adult
80% of travellers recommend
Slingshot Tour Panama
Day Tour

Day Tour in San Blas Islands All Included Visiting 4 Islands

£110
per adult
94% of travellers recommend
Day Tour in San Blas Islands All Included Visiting 4 Islands
Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

£37
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
See all activities in Panama City

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.