Santa Ana Holidays from £602

Book a Hotel + Flight or Car together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to £750 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Packages with flights are ATOL protected

Your Santa Ana Holiday

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana holiday package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're travelling with and whatever you want to spend, your dream Santa Ana holiday is just clicks away with Expedia.

Price found within the past 48 hours. Click for updated prices.
Las Clementinas

Las Clementinas

3.5 out of 5
Casco Viejo
Price was £719, price is now £602 per person
£602
per person
21 Aug - 23 Aug
found 1 hour ago
Return flight included
Montego Bay (MBJ) to Panama City (PTY)
9.4/10 Exceptional! (194 reviews)
Great food and location

Reviewed on 11 Jul 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Price was £841, price is now £615 per person
£615
per person
21 Aug - 23 Aug
found 1 hour ago
Return flight included
Montego Bay (MBJ) to Panama City (PTY)
9.2/10 Wonderful! (1,001 reviews)
All good

Reviewed on 8 Jul 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was £1,702, price is now £1,250 per person
£1,250
per person
17 Aug - 22 Aug
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
8.4/10 Very good! (1,574 reviews)
The breakfast was extraordinary, tasty flavorful. The service at bazaar by the staff was accommodating and helpful. The view from my room was spectacular. I found the staff to be well mannered and approachable. I will visit again.

Reviewed on 10 Jul 2026

Riande Aeropuerto Hotel & Casino

Riande Aeropuerto Hotel & Casino

4 out of 5
Price was £1,528, price is now £1,217 per person
£1,217
per person
17 Aug - 22 Aug
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
8.4/10 Very good! (1,815 reviews)
Breakfast was great

Reviewed on 11 Jul 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Bella Vista
Price was £1,545, price is now £1,298 per person
£1,298
per person
17 Aug - 22 Aug
found 1 day ago
Return direct flight included
London (LON) to Panama City (PTY)
9.6/10 Exceptional! (355 reviews)
Nice

Reviewed on 2 Jul 2026

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
The price is £95 per night from 15 Jul to 16 Jul
£95
15 Jul - 16 Jul
includes taxes & fees
9/10 Wonderful! (100 reviews)
"Great layout with modern convenience for my family, sofa bed was generous and comfortable. Thoughtful kitchen tools made our stay easy."

Reviewed on 20 Jun 2026

Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is £127 per night from 26 Jul to 27 Jul
£127
26 Jul - 27 Jul
includes taxes & fees
9/10 Wonderful! (5,722 reviews)
"Hotel was amazing especially for the price, located in a great spot."

Reviewed on 11 Jul 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is £93 per night from 20 Jul to 21 Jul
£93
20 Jul - 21 Jul
includes taxes & fees
8.6/10 Excellent! (2,626 reviews)
"Everything perfectly…..!"

Reviewed on 11 Jul 2026

Crowne Plaza Panama Airport by IHG
See all 1,711 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Ana travel package cost?
Starting from as low as £602, a package is your passport to low-cost travel. Build your own Santa Ana escape by picking from our great range of hotels, flights and rental cars.
If I'm not able to travel, can I cancel my Santa Ana travel package?
It is possible to cancel your Santa Ana booking if your plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel free of charge if you booked in the last 24 hours. Head to our Customer Service Portal to find out more.
How do I get a cheap travel package to Santa Ana?
Bundle your hotels and flights, add extras such as activities or a rental car, and save with a Santa Ana travel package. You won't just score exciting discounts on your escape — you'll have lots of choice too. When you book with Expedia, you can choose from more than 550 airlines and 1,000,000 hotels across the globe. Your affordable holiday starts right here, right now!
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Yes. Expedia has partnered with online lender Klarna to help you easily pay for your holiday in instalments. Simply select the payment plan best suited to your needs during the checkout process and take the stress out of budgeting for your next trip. Be sure to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your holiday buck. Check out our flexible payment options below:

  • Pay monthly holidays: Realise your holiday dreams sooner with Klarna's monthly instalment plans. If paying a little each month works for you, choose this option during the checkout process.
  • Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Hitting the "book now" button is much easier with this payment plan. Put down a small deposit on your escape and then start working on your travel itinerary.

Where should I stay in Santa Ana?
Urban explorers come from all corners of the globe to see Metropolitan Cathedral of Panama and Miraflores Locks in Santa Ana. Book yourself a room within a stone's throw of these popular attractions and visit them whenever you want.
What are the top hotels in Santa Ana?
Get your trip off to a good start by booking a room at The Executive Hotel. It's one of most sought-after hotels in Santa Ana. Another comfortable option is JW Marriott Panama.
How far in advance should I book my Santa Ana holiday?
Search Expedia to compare international flights ASAP. In most cases, you can purchase a ticket up to a year prior to departure. If it's too early for your preferred air carrier, or you've left things to the last minute, fear not. Low prices to Santa Ana occasionally appear within weeks of the date of departure.
What does an Expedia Santa Ana travel package include?
Hotels, flights and a reliable car for all your fun road trip adventures. Simply choose your preferred bundle and gain access to great discounts. Once you've made your booking, add on some sightseeing tours and watch your savings grow. When it comes to crafting your Santa Ana escape, you're in control!
What should I know before booking a Santa Ana travel package?
A travel package can be tailored to your budget and is a simple way to make your budget go further. How little or much you include is up to you. Rental cars, hotels and flights — decide on a combination that suits your plans.
Can I choose my airline with a Santa Ana Expedia travel package?
With a travel package, you're the one in charge. Whether you'd like to fly to Santa Ana in economy or first class, simply pick from the available airline options. Expedia has access to over 550 airline partners across the world.

Stay near popular Santa Ana attractions

El Machetazo Santa Ana

You can browse for the perfect souvenirs at El Machetazo Santa Ana during your visit to Panama City. Amble around the area's parks or visit its shops.
See properties

Things to do

Panama Canal Half Transit Experience

Panama Canal Partial Transit

£113
per adult
84% of travellers recommend
Panama Canal Partial Transit
Half day of Panama city and canal tour: shared and private

Half day of Panama city and canal tour: shared and private

£50
per adult
98% of travellers recommend
Half day of Panama city and canal tour: shared and private
Panama City: POIN Swing Experience

Panama City: POIN Swing Experience

£24
per adult
100% of travellers recommend
Panama City: POIN Swing Experience
See all activities in Panama City

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.