Santa Ana Holidays from £596

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Your Santa Ana Holiday

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana holiday package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're travelling with and whatever you want to spend, your dream Santa Ana holiday is just clicks away with Expedia.

Price found within the past 48 hours. Click for updated prices.
Decapolis Hotel Panama City

Decapolis Hotel Panama City

San Francisco
£596
per person
2 Oct - 8 Oct
found 2 hours ago
Return flight included
Georgetown (GEO) to Panama City (PTY)
8.6/10 Excellent! (1,716 reviews)
Megapolis Hotel Panamá

Megapolis Hotel Panamá

San Francisco
£718
per person
2 Oct - 8 Oct
found 2 hours ago
Return flight included
Georgetown (GEO) to Panama City (PTY)
8.4/10 Very good! (1,671 reviews)
The room service was good. We got no discount voucher as promised for anything. The refrigerator was never stocked. We booked for 3 and only got 2 bottles of water at any given time. They were short on towels and rags. No valet service was available to assist with our bags in the morning of our departure as they do not have any available for early hours. The outlet mall was not bad but most stores were unoccupied so the selections were extremely limited. When we wanted to book our tours, that desk was unmanned several times before we actually got through.

Reviewed on 25 Aug 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Casco Viejo
Save 100% on your flight
£668
per person
2 Oct - 8 Oct
found 2 hours ago
Return flight included
Georgetown (GEO) to Panama City (PTY)
9.2/10 Wonderful! (1,005 reviews)
My initial experience with the property was great, which is why I returned and even referred others. Unfortunately, my second experience was completely different. I was charged a deposit specifically to hold my room, but when I was able to check in, I was told the room had been given away. Had I been clearly informed in advance that paying the deposit did not guarantee the room would be held, I would have made other arrangements. What was most frustrating was the lack of accountability. The property blamed Expedia, while Expedia pointed back to the property, leaving me without a resolution despite having been charged to secure the reservation. The property was also extremely inflexible and not completely transparent about its policies up front. This was particularly disappointing after having such a positive first experience and recommending the property to others. I am requesting that Expedia review what occurred, including why I was charged to hold a room that ultimately was not held for me.

Reviewed on 26 Aug 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

Bella Vista
£704
per person
2 Oct - 8 Oct
found 2 hours ago
Return flight included
Georgetown (GEO) to Panama City (PTY)
9.6/10 Exceptional! (415 reviews)
La Concordia Boutique Hotel

La Concordia Boutique Hotel

Casco Viejo
£727
per person
2 Oct - 8 Oct
found 2 hours ago
Return flight included
Georgetown (GEO) to Panama City (PTY)
9.6/10 Exceptional! (233 reviews)

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

A cityscape with modern skyscrapers, including a distinctive twisting tower.

Bella Vista

2 out of top 10 points of interest in this area

Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.

A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

A bridge over a body of water with several boats.

San Francisco

1 out of top 10 points of interest in this area

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

C. 16 Oeste Panama City Provincia de Panamá
£77
31 Aug - 1 Sept
includes taxes & fees
Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
£111
15 Sept - 16 Sept
includes taxes & fees
Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
Fully refundable
£107
5 Sept - 6 Sept
includes taxes & fees
Crowne Plaza Panama Airport by IHG
See all 1,807 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Frequently asked questions

How much does a Santa Ana travel package cost?
Starting from as low as £596, a package is your passport to low-cost travel. Build your own Santa Ana escape by picking from our great range of hotels, flights and rental cars.
If I'm not able to travel, can I cancel my Santa Ana travel package?
It is possible to cancel your Santa Ana booking if your plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel free of charge if you booked in the last 24 hours. Head to our Customer Service Portal to find out more.
How do I get a cheap travel package to Santa Ana?
Bundle your hotels and flights, add extras such as activities or a rental car, and save with a Santa Ana travel package. You won't just score exciting discounts on your escape — you'll have lots of choice too. When you book with Expedia, you can choose from more than 550 airlines and 1,000,000 hotels across the globe. Your affordable holiday starts right here, right now!
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Yes. Expedia has partnered with online lender Klarna to help you easily pay for your holiday in instalments. Simply select the payment plan best suited to your needs during the checkout process and take the stress out of budgeting for your next trip. Be sure to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your holiday buck. Check out our flexible payment options below:
  • Pay monthly holidays: Realise your holiday dreams sooner with Klarna's monthly instalment plans. If paying a little each month works for you, choose this option during the checkout process.
  • Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Hitting the "book now" button is much easier with this payment plan. Put down a small deposit on your escape and then start working on your travel itinerary.
Where should I stay in Santa Ana?
Urban explorers come from all corners of the globe to see Metropolitan Cathedral of Panama and Miraflores Locks in Santa Ana. Book yourself a room within a stone's throw of these popular attractions and visit them whenever you want.
What are the top hotels in Santa Ana?
Get your trip off to a good start by booking a room at The Executive Hotel. It's one of most sought-after hotels in Santa Ana. Another comfortable option is JW Marriott Panama.
How far in advance should I book my Santa Ana holiday?
Search Expedia to compare international flights ASAP. In most cases, you can purchase a ticket up to a year prior to departure. If it's too early for your preferred air carrier, or you've left things to the last minute, fear not. Low prices to Santa Ana occasionally appear within weeks of the date of departure.
What does an Expedia Santa Ana travel package include?
Hotels, flights and a reliable car for all your fun road trip adventures. Simply choose your preferred bundle and gain access to great discounts. Once you've made your booking, add on some sightseeing tours and watch your savings grow. When it comes to crafting your Santa Ana escape, you're in control!
What should I know before booking a Santa Ana travel package?
A travel package can be tailored to your budget and is a simple way to make your budget go further. How little or much you include is up to you. Rental cars, hotels and flights — decide on a combination that suits your plans.
Can I choose my airline with a Santa Ana Expedia travel package?
With a travel package, you're the one in charge. Whether you'd like to fly to Santa Ana in economy or first class, simply pick from the available airline options. Expedia has access to over 550 airline partners across the world.

Stay near popular Santa Ana attractions

El Machetazo Santa Ana

You can browse for the perfect souvenirs at El Machetazo Santa Ana during your visit to Panama City. Amble around the area's parks or visit its shops.
See properties

Things to do

Half day of Panama city and canal tour: shared and private

Half day of Panama city and canal tour: shared and private

£50
per adult
98% of travellers recommend
Half day of Panama city and canal tour: shared and private
Panama Canal: The Most Complete Monkey Island Experience

Panama Canal: The Most Complete Wildlife Experience

£45
per adult
94% of travellers recommend
Panama Canal: The Most Complete Wildlife Experience
Panama Canal Half Transit Experience

Panama Canal Partial Transit

£113
per adult
86% of travellers recommend
Panama Canal Partial Transit
See all activities in Panama City

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.