Santa Ana Holidays

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Your Santa Ana Holiday

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana holiday package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're travelling with and whatever you want to spend, your dream Santa Ana holiday is just clicks away with Expedia.

Price found within the past 48 hours. Click for updated prices.
  • Interior detail
    Aug 11 - Aug 20

    Hotel Casa Panamá + Flight

    Casco Viejo
    9 nights
    4.0 star property
    7.6/10 - Good (691 reviews)
    "Todo muy cerca , muy buena ubicación"
    Reviewed May 22, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    £1,035
    £748
    per traveller
    found 21 hours ago
    Hotel Casa Panamá
  • Front of property
    Aug 11 - Aug 20

    Central Hotel Panama Casco Viejo + Flight

    Casco Viejo
    9 nights
    4.0 star property
    9.2/10 - Wonderful (1,004 reviews)
    "Great property in a great location near shops and a stones throw from many attractions. The property is very well maintained, clean, just the right bit of rustic and colonial architecture. Rooms are spacious. Breakfast is fabulous and the breakfast staff are so very attentive. Food is fresh like from farm to table. We definitely enjoyed our stay. This hotel is a gem in Casco Viejo."
    Reviewed May 26, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    Save 100% on your flight
    £2,117
    £1,238
    per traveller
    found 21 hours ago
    Central Hotel Panama Casco Viejo
  • Front of property
    Aug 11 - Aug 20

    Megapolis Hotel Panamá + Flight

    San Francisco
    9 nights
    4.5 star property
    8.4/10 - Very good (1,535 reviews)
    "Hotel was the old Hard Rock, reopened on their own name, the place is moldy, they cover it up by scent infusers. the fan in the bathroom makes noise, the pillows are old and heavy, the coffee machine didn't work, got a suite"
    Reviewed May 25, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    Save 100% on your flight
    £1,744
    £1,070
    per traveller
    found 21 hours ago
    Megapolis Hotel Panamá
  • Apartment, 3 Bedrooms (CM5) | Living room | 55-inch Smart TV with digital channels
    Aug 2 - Aug 15

    Casa Mallet by Wynwood House + Flight

    Casco Viejo
    12 nights
    4.0 star property
    9.8/10 - Exceptional (27 reviews)
    "In the middle of the old town, lovely rooftop. Beautiful apartment. Easy check in. WhatsApp line is available if anything was needed or if we had questions. "
    Reviewed March 12, 2026
    Return • London (LHR) - Panama City (PTY)
    LHR - PTY • 1 stop PTY - LHR • 1 stop
    £2,616
    £1,853
    per traveller
    found 1 day ago
    Casa Mallet by Wynwood House
  • View from property
    Aug 11 - Aug 20

    Las Americas Golden Tower Panama + Flight

    San Francisco
    9 nights
    4.0 star property
    9.0/10 - Wonderful (1,016 reviews)
    "The room was great with the view of the downtown.. will book it again when in Panama"
    Reviewed May 25, 2026
    Return • Georgetown (GEO) - Panama City (PTY)
    GEO - PTY • Direct PTY - GEO • Direct
    £1,268
    £921
    per traveller
    found 21 hours ago
    Las Americas Golden Tower Panama

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
View of the Panama City Old Town

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
The price is £91 per night from 28 May to 29 May
£91
28 May - 29 May
includes taxes & fees
9/10 Wonderful! (94 reviews)
"The building is great, the apartment was perfect, the staff superbe, and they take care of the building, guests and security. There is a supermarket across the street which makes your life so much easier. The issue, as others have mentioned, is that the building is at the limit of the safe area in ..."

Reviewed on 29 Apr 2026

Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is £118 per night from 15 Jun to 16 Jun
£118
15 Jun - 16 Jun
includes taxes & fees
9/10 Wonderful! (5,484 reviews)
"Accessible to everywhere clean rooms and excellent breakfast, great customer service"

Reviewed on 26 May 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is £112 per night from 15 Jun to 16 Jun
£112
15 Jun - 16 Jun
includes taxes & fees
8.6/10 Excellent! (2,556 reviews)
"Todo excelente"

Reviewed on 26 May 2026

Crowne Plaza Panama Airport by IHG
See all 1,753 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Ana travel package cost?
Starting from as low as , a package is your passport to low-cost travel. Build your own Santa Ana escape by picking from our great range of hotels, flights and rental cars.
If I'm not able to travel, can I cancel my Santa Ana travel package?
It is possible to cancel your Santa Ana booking if your plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel free of charge if you booked in the last 24 hours. Head to our Customer Service Portal to find out more.
How do I get a cheap travel package to Santa Ana?
Bundle your hotels and flights, add extras such as activities or a rental car, and save with a Santa Ana travel package. You won't just score exciting discounts on your escape — you'll have lots of choice too. When you book with Expedia, you can choose from more than 550 airlines and 1,000,000 hotels across the globe. Your affordable holiday starts right here, right now!
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Yes. Expedia has partnered with online lender Klarna to help you easily pay for your holiday in instalments. Simply select the payment plan best suited to your needs during the checkout process and take the stress out of budgeting for your next trip. Be sure to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your holiday buck. Check out our flexible payment options below:

  • Pay monthly holidays: Realise your holiday dreams sooner with Klarna's monthly instalment plans. If paying a little each month works for you, choose this option during the checkout process.
  • Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Hitting the "book now" button is much easier with this payment plan. Put down a small deposit on your escape and then start working on your travel itinerary.

Where should I stay in Santa Ana?
Urban explorers come from all corners of the globe to see Metropolitan Cathedral of Panama and Miraflores Locks in Santa Ana. Book yourself a room within a stone's throw of these popular attractions and visit them whenever you want.
What are the top hotels in Santa Ana?
Get your trip off to a good start by booking a room at The Executive Hotel. It's one of most sought-after hotels in Santa Ana. Another comfortable option is JW Marriott Panama.
How far in advance should I book my Santa Ana holiday?
Search Expedia to compare international flights ASAP. In most cases, you can purchase a ticket up to a year prior to departure. If it's too early for your preferred air carrier, or you've left things to the last minute, fear not. Low prices to Santa Ana occasionally appear within weeks of the date of departure.
What does an Expedia Santa Ana travel package include?
Hotels, flights and a reliable car for all your fun road trip adventures. Simply choose your preferred bundle and gain access to great discounts. Once you've made your booking, add on some sightseeing tours and watch your savings grow. When it comes to crafting your Santa Ana escape, you're in control!
What should I know before booking a Santa Ana travel package?
A travel package can be tailored to your budget and is a simple way to make your budget go further. How little or much you include is up to you. Rental cars, hotels and flights — decide on a combination that suits your plans.
Can I choose my airline with a Santa Ana Expedia travel package?
With a travel package, you're the one in charge. Whether you'd like to fly to Santa Ana in economy or first class, simply pick from the available airline options. Expedia has access to over 550 airline partners across the world.

Popular places to visit

Panoramic view at the Downtown of Panama City - Panama

Cinta Costera

After visiting Cinta Costera, make a plan to see the other sights and activities in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera

Albrook Shopping Mall

You can find the perfect gifts to bring home with a trip to Albrook Shopping Mall, a favourite shopping spot in Ancon. Amble around this culturally rich area's seaside and enjoy its top-notch restaurants.

Albrook Shopping Mall

Fuerte Amador Resort & Marina

Explore the waterfront in Ancon with a trip to Fuerte Amador Resort & Marina. Visit the shops and top-notch restaurants in this vibrant area.

Fuerte Amador Resort & Marina

Things to do

Panama Canal Half Transit Experience

Panama Canal Partial Transit

£110
per adult
86% of travellers recommend
Panama Canal Partial Transit
Panama City Visit an Indian town Embera and waterfall with lunch

Panama City Visit an Indian town Embera and waterfall with lunch

£31
per adult
96% of travellers recommend
Panama City Visit an Indian town Embera and waterfall with lunch
Panama City: POIN Swing Experience

Panama City: POIN Swing Experience

£21
per adult
100% of travellers recommend
Panama City: POIN Swing Experience
See all activities in Panama City

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.