Santa Ana Holidays from £502
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Your Santa Ana Holiday
From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana holiday package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're travelling with and whatever you want to spend, your dream Santa Ana holiday is just clicks away with Expedia.
Price found within the past 48 hours. Click for updated prices.
Riande Aeropuerto Hotel & Casino
Tocumen Airport
£515
per person
13 Nov - 17 Nov
found 24 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
8.6/10 Excellent! (1,819 reviews)
Nice place for a 1 night stay. Nothing fancy. Rooms and hotel a little outdated but the breakfast was good. So a nice place for a 1 night stay during a layover.
Reviewed on 10 Oct 2026
Hotel Riu Plaza Panama
Bella Vista
£548
per person
13 Nov - 17 Nov
found 24 hours ago
Return flight included
Kingston (KIN) to Panama City (PTY)
9/10 Wonderful! (5,990 reviews)
Housekeeping did an excellent job cleaning the room daily. However, there were some maintenance items that needed attention. Half of the plug receptacles in the room were inoperable. The frosted glass wall between the bathroom and room was very pretty. However when anyone got up in the middle of the night to use the toilet, the lights shined right through and lit up the entire room. All of the staff were very friendly and very helpful. They made our stay pleasant. The daily breakfast buffet had a wonderful selection of dishes and fresh juices. Everything was delicious. The bar and restaurant at the pool had good drinks and food. However, I did not like the policy of no outside food or drinks when sitting at the pool. So if you purchased something from the coffee/snack shop you could not take it to the pool area. Additionally, after spending a day in/at the pool, we were told we could not take the towel out of the pool area. Couldn’t take a piece of fruit out of the breakfast buffet. Too many restrictive rules. The employees acted like they were the police at every area of the hotel. When I questioned one of them asking why they are acting like the police, he replied that he would get in trouble if he let anything slip. It appeared he was being watched. Not just him, but all of the employees. I was not intentionally trying to break any rules. I have stayed at many other Riu Resorts in different countries and I did not feel like we were policed everywhere like at this resort.
Reviewed on 11 Oct 2026
Where to stay in Santa Ana
Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
Casco Viejo
Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.
Bella Vista
1 out of top 10 points of interest in this area
Travellers love Bella Vista for its popular shops, and you can see more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station. You might spend time checking out top sights like Via Espana and Iglesia del Carmen.
El Cangrejo
The ample dining options and casino gaming are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.
San Francisco
1 out of top 10 points of interest in this area
San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.
San Felipe
While visiting San Felipe, you might make a stop by sights like Independence Square and Interoceanic Canal Museum.
Top hotels in Santa Ana
Hotel Caracas - Casco Viejo
Plaza De Santa Ana Panama City Provincia di Panama
Fully refundableReserve now, pay when you stay
£29
26 Oct - 27 Oct
includes taxes & fees
8/10 Very good! (19 reviews)
"Good location but basic otherwise. Staff not overly helpful on the whole."
Reviewed on 27 Sept 2026
Casco View Life Residences
C. 16 Oeste Panama City Provincia de Panamá
£92
12 Oct - 13 Oct
includes taxes & fees
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
£110
21 Oct - 22 Oct
includes taxes & fees
9/10 Wonderful! (6,053 reviews)
"Housekeeping did an excellent job cleaning the room daily. However, there were some maintenance items that needed attention. Half of the plug receptacles in the room were inoperable. The frosted glass wall between the bathroom and room was very pretty. However when anyone got up in the middle of ..."
Reviewed on 11 Oct 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Santa Ana travel package cost?
Starting from as low as £502, a package is your passport to low-cost travel. Build your own Santa Ana escape by picking from our great range of hotels, flights and rental cars.
If I'm not able to travel, can I cancel my Santa Ana travel package?
It is possible to cancel your Santa Ana booking if your plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel free of charge if you booked in the last 24 hours. Head to our Customer Service Portal to find out more.
How do I get a cheap travel package to Santa Ana?
Bundle your hotels and flights, add extras such as activities or a rental car, and save with a Santa Ana travel package. You won't just score exciting discounts on your escape — you'll have lots of choice too. When you book with Expedia, you can choose from more than 550 airlines and 1,000,000 hotels across the globe. Your affordable holiday starts right here, right now!
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Yes. Expedia has partnered with online lender Klarna to help you easily pay for your holiday in instalments. Simply select the payment plan best suited to your needs during the checkout process and take the stress out of budgeting for your next trip. Be sure to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your holiday buck. Check out our flexible payment options below:
- Pay monthly holidays: Realise your holiday dreams sooner with Klarna's monthly instalment plans. If paying a little each month works for you, choose this option during the checkout process.
- Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option from Klarna.
- Low deposit holidays: Hitting the "book now" button is much easier with this payment plan. Put down a small deposit on your escape and then start working on your travel itinerary.
Where should I stay in Santa Ana?
Urban explorers come from all corners of the globe to see Metropolitan Cathedral of Panama and Miraflores Locks in Santa Ana. Book yourself a room within a stone's throw of these popular attractions and visit them whenever you want.
What are the top hotels in Santa Ana?
Get your trip off to a good start by booking a room at The Executive Hotel. It's one of most sought-after hotels in Santa Ana. Another comfortable option is JW Marriott Panama.
How far in advance should I book my Santa Ana holiday?
Search Expedia to compare international flights ASAP. In most cases, you can purchase a ticket up to a year prior to departure. If it's too early for your preferred air carrier, or you've left things to the last minute, fear not. Low prices to Santa Ana occasionally appear within weeks of the date of departure.
What does an Expedia Santa Ana travel package include?
Hotels, flights and a reliable car for all your fun road trip adventures. Simply choose your preferred bundle and gain access to great discounts. Once you've made your booking, add on some sightseeing tours and watch your savings grow. When it comes to crafting your Santa Ana escape, you're in control!
What should I know before booking a Santa Ana travel package?
A travel package can be tailored to your budget and is a simple way to make your budget go further. How little or much you include is up to you. Rental cars, hotels and flights — decide on a combination that suits your plans.
Can I choose my airline with a Santa Ana Expedia travel package?
With a travel package, you're the one in charge. Whether you'd like to fly to Santa Ana in economy or first class, simply pick from the available airline options. Expedia has access to over 550 airline partners across the world.
Stay near popular Santa Ana attractions
El Machetazo Santa Ana
You can browse for the perfect souvenirs at El Machetazo Santa Ana during your visit to Panama City. Amble around the area's parks or visit its shops.
Things to do
Panama Canal: The Most Complete Wildlife Experience
£36
per adult
98% of travellers recommend
Panama City: All-Inclusive Catamaran Cruise to Taboga Island
£74
per adult
94% of travellers recommend
Half day of Panama city and canal tour: shared and private
£50
per adult
96% of travellers recommend
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.