Santa Ana Holidays from £680

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Your Santa Ana Holiday

From its sunny weather to its diversity and beyond, there's loads to love about Santa Ana. Discover the wonders of this awesome city with a Santa Ana holiday package that's made for you. Eager to explore your new surroundings? Miraflores Locks, Bridge of the Americas and Metropolitan Cathedral of Panama are among the best places to visit during a trip to Santa Ana. Whoever you're travelling with and whatever you want to spend, your dream Santa Ana holiday is just clicks away with Expedia.

Price found within the past 48 hours. Click for updated prices.
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Bella Vista
Price was £1,014, price is now £680 per person
£680
per person
14 May - 20 May
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
9/10 Wonderful! (5,182 reviews)
We stayed for 7 nights. The hotel is in a safe neighborhood and within walking distance to so many restaurants - I think the farthest we had to walk was 7 minutes to a restaurant. We stayed in a king bed room and the room was very spacious - there was a small fridge and iron with ironing board and a hair dryer in the bathroom. The bed was just ok, a little firm for my liking but I wouldn’t deduct any points for that. We had a great view out of the window of the city. The staff was friendly and the hotel was very pleasing to the eye. The breakfast was wonderful with so many options to choose from on the buffet. There was a nice pool area with a bar that served drinks. There was also a restaurant on site and a bar in the lobby area. We very much enjoyed our stay.

Reviewed on 10 Apr 2026

Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

4 out of 5
Casco Viejo
Save 100% on your flight
Price was £3,351, price is now £1,895 per person
£1,895
per person
14 May - 20 May
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
9/10 Wonderful! (1,000 reviews)
Excellent staff. Super friendly. And everyone recognized us in the hotel, including the fabulous manager. The food was top notch drinks were outstanding. We were there during the four days of Easter celebration. What a unique experience of the culture.

Reviewed on 9 Apr 2026

Megapolis Hotel Panamá

Megapolis Hotel Panamá

4.5 out of 5
San Francisco
Price was £1,254, price is now £821 per person
£821
per person
14 May - 20 May
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
8.4/10 Very Good! (1,482 reviews)
Did not go to the casino and didn't utilize parking

Reviewed on 9 Apr 2026

Las Americas Golden Tower Panama

Las Americas Golden Tower Panama

4 out of 5
San Francisco
Price was £988, price is now £693 per person
£693
per person
14 May - 20 May
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
9/10 Wonderful! (1,004 reviews)
No hot water in the shower and sink on the first day. Mold around the shower. Restricted toiletry items. The TV remote has two fonctions turning it on and turning it off. No access to a pen, a scrap of paper and any information about places to visit, restaurants and others. What to see on the web is not what you get . How can a hotel like be rated four stars?

Reviewed on 10 Apr 2026

Hyatt Regency Panama City

Hyatt Regency Panama City

5 out of 5
Bella Vista
Price was £1,091, price is now £812 per person
£812
per person
14 May - 20 May
found 1 day ago
Return flight included
Port of Spain (POS) to Panama City (PTY)
9.6/10 Exceptional! (235 reviews)
I Loved my stay at the Hyatt Regency! Very clean environment and the food was great. Oh and the staff were so friendly! Will be back soon!

Reviewed on 11 Apr 2026

Where to stay in Santa Ana

Find the best Santa Ana areas and neighborhoods for the activities you enjoy most. Learn more about Santa Ana
View of the Panama City Old Town

Casco Viejo

3.5/5(3 area reviews)

Unique features of Casco Viejo include the historical sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Top hotels in Santa Ana

Casco View Apartments

Casco View Apartments

3.5 out of 5
C. 16 Oeste Panama City Provincia de Panamá
The price is £104 per night from 12 Apr to 13 Apr
£104
12 Apr - 13 Apr
includes taxes & fees
9/10 Wonderful! (87 reviews)
Nice place, easy walk from Casco Viejo. The pool area was great, but room wasn’t the cleanest. We had to request bedding for the second bed but weren’t given a blanket.

Reviewed on 7 Apr 2026

Casco View Apartments
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is £109 per night from 4 May to 5 May
£109
4 May - 5 May
includes taxes & fees
9/10 Wonderful! (5,276 reviews)
We stayed for 7 nights. The hotel is in a safe neighborhood and within walking distance to so many restaurants - I think the farthest we had to walk was 7 minutes to a restaurant. We stayed in a king bed room and the room was very spacious - there was a small fridge and iron with ironing board and ...

Reviewed on 10 Apr 2026

Hotel Riu Plaza Panama
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

4 out of 5
Ave. Domingo Diaz Tocumen Panama
Fully refundable
The price is £109 per night from 4 May to 5 May
£109
4 May - 5 May
includes taxes & fees
8.6/10 Excellent! (2,507 reviews)
Only there for one night but had everything we needed.

Reviewed on 10 Apr 2026

Crowne Plaza Panama Airport by IHG
See all 1,404 properties in Santa Ana
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Santa Ana travel package cost?
Starting from as low as £680, a package is your passport to low-cost travel. Build your own Santa Ana escape by picking from our great range of hotels, flights and rental cars.
If I'm not able to travel, can I cancel my Santa Ana travel package?
It is possible to cancel your Santa Ana booking if your plans have been upended. Whether you'll incur a fee or not depends on your airline, hotel or car rental company. You may be able to change or cancel free of charge if you booked in the last 24 hours. Head to our Customer Service Portal to find out more.
How do I get a cheap travel package to Santa Ana?
Bundle your hotels and flights, add extras such as activities or a rental car, and save with a Santa Ana travel package. You won't just score exciting discounts on your escape — you'll have lots of choice too. When you book with Expedia, you can choose from more than 550 airlines and 1,000,000 hotels across the globe. Your affordable holiday starts right here, right now!
Does Expedia offer Book Now, Pay Later Santa Ana holidays?
Yes. Expedia has partnered with online lender Klarna to help you easily pay for your holiday in instalments. Simply select the payment plan best suited to your needs during the checkout process and take the stress out of budgeting for your next trip. Be sure to bundle your flights, hotel and car hire with Expedia to get the biggest bang for your holiday buck. Check out our flexible payment options below:

  • Pay monthly holidays: Realise your holiday dreams sooner with Klarna's monthly instalment plans. If paying a little each month works for you, choose this option during the checkout process.
  • Pay in instalments holidays: Into the idea of paying down your holiday in multiple transactions? Then go for this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: Hitting the "book now" button is much easier with this payment plan. Put down a small deposit on your escape and then start working on your travel itinerary.

Where should I stay in Santa Ana?
Urban explorers come from all corners of the globe to see Metropolitan Cathedral of Panama and Miraflores Locks in Santa Ana. Book yourself a room within a stone's throw of these popular attractions and visit them whenever you want.
What are the top hotels in Santa Ana?
Get your trip off to a good start by booking a room at The Executive Hotel. It's one of most sought-after hotels in Santa Ana. Another comfortable option is JW Marriott Panama.
How far in advance should I book my Santa Ana holiday?
Search Expedia to compare international flights ASAP. In most cases, you can purchase a ticket up to a year prior to departure. If it's too early for your preferred air carrier, or you've left things to the last minute, fear not. Low prices to Santa Ana occasionally appear within weeks of the date of departure.
What does an Expedia Santa Ana travel package include?
Hotels, flights and a reliable car for all your fun road trip adventures. Simply choose your preferred bundle and gain access to great discounts. Once you've made your booking, add on some sightseeing tours and watch your savings grow. When it comes to crafting your Santa Ana escape, you're in control!
What should I know before booking a Santa Ana travel package?
A travel package can be tailored to your budget and is a simple way to make your budget go further. How little or much you include is up to you. Rental cars, hotels and flights — decide on a combination that suits your plans.
Can I choose my airline with a Santa Ana Expedia travel package?
With a travel package, you're the one in charge. Whether you'd like to fly to Santa Ana in economy or first class, simply pick from the available airline options. Expedia has access to over 550 airline partners across the world.

Popular places to visit

Old and traditional Yatch Club at Cinta Costera, Panama City, Panama.

Cinta Costera

4/5(5 reviews)

After visiting Cinta Costera, make a plan to see the other sights and activities in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera

Albrook Shopping Mall

4/5(5 reviews)

You can find the perfect gifts to bring home with a trip to Albrook Shopping Mall, a favourite shopping spot in Ancon. Amble around this vibrant area's seaside and enjoy its top-notch restaurants.

Albrook Shopping Mall

Fuerte Amador Resort & Marina

Explore the waterfront in Ancon with a trip to Fuerte Amador Resort & Marina. Visit the shops and top-notch restaurants in this vibrant area.

Fuerte Amador Resort & Marina

Things to do

Panama Canal Half Transit Experience

Panama Canal Partial Transit

£112
per adult
86% of travellers recommend
Panama Canal Partial Transit
Panama City: POIN Swing Experience

Panama City: POIN Swing Experience

£24
per adult
100% of travellers recommend
Panama City: POIN Swing Experience
The OG Crawl by The Panama Barcrawl -

The OG Crawl by The Panama Barcrawl - (Panama City, Panama)

£49
per adult
100% of travellers recommend
The OG Crawl by The Panama Barcrawl - (Panama City, Panama)
See all activities in Panama City

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.