Title: TOP Business Hotels in Ortygia for 2026 | Expedia.co.uk [Ortygia Travel Guide](https://expedia.co.uk/Ortygia.dx6182482)[Hotels in Ortygia](https://expedia.co.uk/Ortygia-Hotels.d6182482.Travel-Guide-Hotels)[Holiday Rentals in Ortygia](https://expedia.co.uk/Ortygia-Holiday-Rentals.d6182482.Travel-Guide-HolidayRentals)[Flights to Ortygia](https://expedia.co.uk/Cheap-Flights-To-Ortygia.d6182482.Travel-Guide-Flights)[Things to do in Ortygia](https://expedia.co.uk/Things-To-Do-In-Ortygia.d6182482.Travel-Guide-Activities)[Ortygia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Ortygia.d6182482.Car-Hire-Guide)[Ortygia Holidays](https://expedia.co.uk/Ortygia.d6182482.Holidays-City-Breaks) ![Ortygia featuring night scenes, a coastal town and heritage elements](https://images.trvl-media.com/place/6182482/72c39cd0-05b7-420f-b747-4c7f90143a9b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Business Hotels in Ortygia - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Ortygia Business Hotels Tonight [25 Dec - 26 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6182482&startDate=2025-12-25&endDate=2025-12-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [26 Dec - 27 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6182482&startDate=2025-12-26&endDate=2025-12-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6182482&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [2 Jan - 4 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6182482&startDate=2026-01-02&endDate=2026-01-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Ortygia Hotel Reviews ![Algila' Ortigia Charme Hotel](https://images.trvl-media.com/lodging/2000000/1890000/1883500/1883438/d402c8e9_y.jpg) ### Algila' Ortigia Charme Hotel 10/10 Excellent "Overall, an excellent hotel in a great location. Beautiful building, comfortable bed, wonderful breakfast in the morning. Really can’t complain about anything. " [](https://expedia.co.uk/Syracuse-Hotels-Algila-Ortigia-Charme-Hotel.h1883438.Hotel-Information) ![Hotel Posta](https://images.trvl-media.com/lodging/1000000/920000/917800/917761/235f3413_y.jpg) ### Hotel Posta 10/10 Excellent "Great value, clean room, nice staff" [](https://expedia.co.uk/Syracuse-Hotels-Hotel-Posta.h917761.Hotel-Information) ![Palazzo Artemide - VRetreats](https://images.trvl-media.com/lodging/1000000/980000/974100/974007/5db9500b_y.jpg) ### Palazzo Artemide - VRetreats 10/10 Excellent "Great service……………" [](https://expedia.co.uk/Syracuse-Hotels-Palazzo-Artemide-VRetreats.h974007.Hotel-Information) ![Domus Mariae Albergo](https://images.trvl-media.com/lodging/3000000/2700000/2692900/2692832/fcb5d184_y.jpg) ### Domus Mariae Albergo 10/10 Excellent "Myself and my girlfriend stayed her for a short (a few days) trip in Ortigia, and the experience was great. The location is amazing, right on the beachfront near everything, and the staff go above and beyond. We weren't the easiest guests im sure, we had many small, but persistent requests and the staff were consistently friendly, and more than happy to meet our requests with grace and enthusiasm. Our stay in Ortigia was enhanced by the staff at the Dorus Mariae Albergo. I can't comment on breakfast, as we opted to have brunch at a nearby Bistro, but this is in no way a comment on the breakfasts at the hotel; this is simply how we like to holiday. Overall, a wonderful experience here, with wonderful staff in an absolutely beautiful location." [](https://expedia.co.uk/Syracuse-Hotels-Domus-Mariae-Albergo.h2692832.Hotel-Information) ![Charme Hotel Henry's House](https://images.trvl-media.com/lodging/8000000/7800000/7797300/7797247/f02c4712_y.jpg) ### Charme Hotel Henry's House 10/10 Excellent "Great location. Very friendly and helpful staff. Nice breakfast." [](https://expedia.co.uk/Syracuse-Hotels-Charme-Hotel-Henrys-House.h7797247.Hotel-Information) ![Grand Hotel Ortigia Siracusa](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/206c3f7f_y.jpg) ### Grand Hotel Ortigia Siracusa 10/10 Excellent "breakfast was good" [](https://expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information) ![Grand Hotel Des Ètrangers - The Leading Hotels of the World](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/c9e03ff2_y.jpg) ### Grand Hotel Des Ètrangers - The Leading Hotels of the World 10/10 Excellent "Great hotel and saff" [](https://expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information) ![Ortea Palace Hotel, Sicily, Autograph Collection](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/3b8d7262_y.jpg) ### Ortea Palace Hotel, Sicily, Autograph Collection 10/10 Excellent "Everything is excellent, except the shower which is very small and uncomfortable which makes it impossible to enjoy the bath." 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