A coastal fortress with a stone wall and a tiled-roof building.

Compare and book 5 Star hotels in Syracuse, Sicily

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check availability on Syracuse 5 Star Hotels

Tonight
8 Oct - 9 Oct
Tomorrow
9 Oct - 10 Oct
This weekend
9 Oct - 11 Oct
Next weekend
16 Oct - 18 Oct

Our top choices for Syracuse 5-star hotels

A large, historic building with multiple floors, a prominent tower, and a waterfront marina with boats.
A balcony with a view of the sea and a cityscape, furnished with two chairs and a small table with a vase of flowers.
A grand atrium with a central column, ornate railings, and a large mural on the wall.
A balcony with a glass table and two red chairs, overlooking a coastal view with buildings and boats.

1. Ortea Palace Hotel, Sicily, Autograph Collection

Ortea Palace Hotel, Sicily, Autograph Collection
Ortigia
Mexico
ALFONSO
£252
includes taxes & fees
8 Nov - 9 Nov
Ortea Palace Hotel, Sicily, Autograph Collection
A balcony with a view of the sea, a cactus, and potted plants.
A poolside area with lounge chairs and umbrellas, a clear pool, and a building with multiple windows in the background.
A large, classical building with multiple windows and balconies, surrounded by a calm body of water with several yachts docked.
A large, multi-story building with a symmetrical facade, arched windows, and a central entrance with a colorful awning.

2. Grand Hotel Ortigia Siracusa

Grand Hotel Ortigia Siracusa
Ortigia
United States
SEAN
£243
includes taxes & fees
5 Nov - 6 Nov
Grand Hotel Ortigia Siracusa
A poolside area with lounge chairs and umbrellas, a clear blue pool, and a building with balconies.
A grand hallway with ornate columns, a tiled floor, and large potted plants.
A terrace with a view of the sea and a cruise ship, featuring outdoor seating and potted cacti.
A spacious dining area with round tables and blue chairs, large windows offering a city view, and a wooden ceiling structure.

3. Grand Hotel Des Ètrangers - The Leading Hotels of the World

Grand Hotel Des Ètrangers - The Leading Hotels of the World
Ortigia
Canada
Steven
£505
includes taxes & fees
20 Oct - 21 Oct
Grand Hotel Des Ètrangers - The Leading Hotels of the World
A rooftop terrace with lounge chairs, a hot tub, and a view of palm trees and buildings.
A modern hotel room with a stone wall, a staircase, a seating area with two chairs, a small table, and a desk with a phone and a lamp.
A multi-story building with a rooftop terrace, balconies, and a street view.
A modern hotel room with a stone accent wall, a grey sofa, a large mirror, a chandelier, and a neatly made bed with rolled towels.

4. Caportigia Boutique Hotel

Caportigia Boutique Hotel
Santa Lucia
Canada
Dena
£120
includes taxes & fees
7 Nov - 8 Nov
Caportigia Boutique Hotel
A spa room with a large window, a hot tub, and two candles.
A stone building with arched walkways and outdoor seating areas.
A spacious lobby with arched ceilings, a central round table with decorative items, and a modern chandelier.
A spacious living room with a high ceiling, white sofas, a coffee table, and a large mirror.

5. Dimora Caiammari Luxury Hotel & Spa

Dimora Caiammari Luxury Hotel & Spa
Syracuse
United Kingdom
Chris
£260
includes taxes & fees
28 Oct - 29 Oct
Dimora Caiammari Luxury Hotel & Spa
An aerial view of a resort with multiple swimming pools, palm trees, and a clear view of the coastline.
A modern bathroom with a freestanding bathtub, a small table with toiletries, and a view of the ocean.
A pathway lined with palm trees leading to a building with a red-tiled roof.
A table set with breakfast items overlooking a coastal view.

6. Minareto

Minareto
Syracuse
United Kingdom
Lekhbiro
£230
includes taxes & fees
6 Nov - 7 Nov
Minareto
A large swimming pool with a modern building in the background.
A woman relaxing in a spa bath with a modern design, including a ceiling with blue lighting and a tiled floor.
An outdoor dining area with tables and chairs, a pool, and palm trees in the background.
A sauna with wooden benches and a central stone pillar.

7. Wellness & Spa Hotel Principe di Fitalia

Wellness & Spa Hotel Principe di Fitalia
Syracuse
United States
Jeffrey
£287
includes taxes & fees
6 Nov - 7 Nov
Wellness & Spa Hotel Principe di Fitalia
Save an average of 15% on thousands of hotels when you're signed in

Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse.
Algila' Ortigia Charme Hotel

Algila' Ortigia Charme Hotel

Via Vittorio Veneto 93 Syracuse SR
£169
8 Nov - 9 Nov
includes taxes & fees
9.6/10 Exceptional! (1,001 reviews)
Algila' Ortigia Charme Hotel
UNA Hotels One Siracusa Wellness & SPA

UNA Hotels One Siracusa Wellness & SPA

Via Diodoro Siculo 4 Syracuse SR
£112
7 Nov - 8 Nov
includes taxes & fees
8.6/10 Excellent! (552 reviews)
UNA Hotels One Siracusa Wellness & SPA
Palazzo Artemide - VRetreats, SLH Collection

Palazzo Artemide - VRetreats, SLH Collection

Via Roma 66 Syracuse SR
£175
5 Nov - 6 Nov
includes taxes & fees
9.4/10 Exceptional! (694 reviews)
Palazzo Artemide - VRetreats, SLH Collection
Still don't see what you're looking for?
See all properties in Syracuse.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Syracuse

Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside.

See all hotels in Syracuse
An ancient amphitheater with stone ruins and a grassy field.

Top Syracuse Hotel Reviews

Find out more about Syracuse

Frequently asked questions

What are the best 5-star hotels in Syracuse?
Experience 5-star fabulousness at Grand Hotel Ortigia Siracusa, Ortea Palace Hotel, Sicily, Autograph Collection or Grand Hotel Des Ètrangers. These are some of the top-rated stays in Syracuse according to Expedia customer reviews. Pick your favourite and get a taste of the high life!
How much does it cost to stay in a 5-star hotel in Syracuse?
How much you pay for a 5-star hotel in Syracuse depends on things like when you plan to go and the length of your escape. A top tip for landing the best deal? Use our pricing filters to check out the available hotels for your chosen dates.
  • Search for the lowest price per night from £112
What makes a hotel 5 stars in Syracuse?
In Syracuse, a hotel needs to provide a specific amount of upscale amenities to earn a 5-star rating. These can include gourmet restaurants, saunas and spas, on-site gyms, premium bedding, luxury bathroom products and more. What also sets 5-star hotels apart is their extraordinary service. You can expect things like in-room massages, nightly turn-down services and concierge services. Some may even offer thoughtful touches like welcome gifts.

Explore a world of travel with Expedia