Title: The 10 Best 5 Star Hotels in Syracuse - 2026 Updated Prices | Expedia.co.uk [Syracuse Travel Guide](https://expedia.co.uk/Syracuse.dx4912)[Hotels in Syracuse](https://expedia.co.uk/Syracuse-Hotels.d4912.Travel-Guide-Hotels)[Holiday Rentals in Syracuse](https://expedia.co.uk/Syracuse-Holiday-Rentals.d4912.Travel-Guide-HolidayRentals)[Flights to Syracuse](https://expedia.co.uk/Cheap-Flights-To-Syracuse.d4912.Travel-Guide-Flights)[Things to do in Syracuse](https://expedia.co.uk/Things-To-Do-In-Syracuse.d4912.Travel-Guide-Activities)[Syracuse Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Syracuse.d4912.Car-Hire-Guide)[Syracuse Holidays](https://expedia.co.uk/Syracuse.d4912.Holidays-City-Breaks) ![Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe](https://images.trvl-media.com/place/4912/0fad57c8-f045-437c-be3c-817a684ac32e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/4912/0fad57c8-f045-437c-be3c-817a684ac32e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Syracuse 5 Star Hotels Tonight [9 Apr - 10 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=4912&startDate=2026-04-09&endDate=2026-04-10&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [10 Apr - 11 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=4912&startDate=2026-04-10&endDate=2026-04-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [10 Apr - 12 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=4912&startDate=2026-04-10&endDate=2026-04-12&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Apr - 19 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=4912&startDate=2026-04-17&endDate=2026-04-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Syracuse 5-star hotels ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/ac752df8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/b126abef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private beach nearby, beach shuttle, sun-loungers, beach umbrellas](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/400d9c2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch served; international cuisine, al fresco dining ](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/cc080552.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Ortigia Siracusa [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information) Ortigia 9.0/10 Wonderful (585 reviews) "Great location and beautiful scenery " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Yuqi £234 includes taxes & fees 29 Apr - 30 Apr [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/3b8d7262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, minibar, in-room safe, individually decorated](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/3cd441f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/d22de140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch served; local and international cuisine ](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/4f6bc901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ortea Palace Hotel, Sicily, Autograph Collection [](https://www.expedia.co.uk/Syracuse-Hotels-Ortea-Palace-Luxury-Hotel.h17825841.Hotel-Information) Ortigia 9.4/10 Exceptional (259 reviews) "The hotel itself is a beautiful building with an interesting heritage as the main post office. The location is excellent offering a great starting point for a walking tour of Ortigia. Great stay." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Craig £328 includes taxes & fees 23 Apr - 24 Apr [](https://www.expedia.co.uk/Syracuse-Hotels-Ortea-Palace-Luxury-Hotel.h17825841.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/83105a89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Room | Minibar, in-room safe, individually decorated, individually furnished](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/2f1018dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/02af6ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/f2d141d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Caportigia Boutique Hotel [](https://www.expedia.co.uk/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information) Santa Lucia 9.4/10 Exceptional (270 reviews) "Excellent modern property, staff are all amazing. Walkable to everything." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Brian £179 includes taxes & fees 22 Apr - 23 Apr [](https://www.expedia.co.uk/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information) ![Seasonal outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/cbf3a060.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/20f9f2e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/2e723fb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Mediterranean cuisine](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/d1e57884.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Des Ètrangers - The Leading Hotels of the World [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information) Ortigia 9.6/10 Exceptional (73 reviews) "Location, staff were amazing" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Jared £540 includes taxes & fees 14 Apr - 15 Apr [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information) ![Sauna, hot tub, Turkish bath/hammam, body treatments, body scrubs](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/77a257e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/w5000h3331x0y3-d0f008d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/5c45e57b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner, brunch served; Mediterranean cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/d3acb40a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dimora Caiammari Luxury Hotel & Spa [](https://www.expedia.co.uk/Syracuse-Hotels-Caiammari-Boutique-Hotel-Spa.h915406.Hotel-Information) Syracuse 9.4/10 Exceptional (211 reviews) "We experienced outstanding service from all of the staff, the breakfast buffet was lovely, lots of options and all homemade. We had a fantastic dinner in the restaurant one evening, which we booked ahead of our trip. " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) David £277 includes taxes & fees 11 Apr - 12 Apr [](https://www.expedia.co.uk/Syracuse-Hotels-Caiammari-Boutique-Hotel-Spa.h915406.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/d439594a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/6824ea78.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor treatment area](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/a7549475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Villa, 2 Bedrooms, Sea View (The Suitest) | Bathroom | Shower, rainfall showerhead, designer toiletries, hair dryer](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/efec5cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Minareto [](https://www.expedia.co.uk/Syracuse-Hotels-Minareto.h2822343.Hotel-Information) Syracuse 8.8/10 Excellent (267 reviews) "Very convenient for swimming and relaxing. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Stanislau £289 includes taxes & fees 3 May - 4 May [](https://www.expedia.co.uk/Syracuse-Hotels-Minareto.h2822343.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Syracuse-Hotels.s50-0-d4912.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Syracuse-Hotels.s50-0-d4912.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse. ![Algila' Ortigia Charme Hotel](https://images.trvl-media.com/lodging/2000000/1890000/1883500/1883438/b9b70cd2_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Algila' Ortigia Charme Hotel Via Vittorio Veneto 93 Syracuse SR £355 29 Apr - 30 Apr includes taxes & fees 9.6/10 Exceptional! (938 reviews) [](https://expedia.co.uk/Syracuse-Hotels-Algila-Ortigia-Charme-Hotel.h1883438.Hotel-Information) ![Grande Albergo Alfeo](https://images.trvl-media.com/lodging/3000000/2980000/2974800/2974756/7a8e0b2f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Grande Albergo Alfeo Via Nino Bixio 5 Syracuse SR £98 12 Apr - 13 Apr includes taxes & fees 8.6/10 Excellent! (658 reviews) [](https://expedia.co.uk/Syracuse-Hotels-Grande-Albergo-Alfeo.h2974756.Hotel-Information) ![Eureka Palace Hotel Spa Resort](https://images.trvl-media.com/lodging/4000000/3820000/3814900/3814820/af67d93f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Eureka Palace Hotel Spa Resort Strada Spinagallo 50 Syracuse SR £83 28 Apr - 29 Apr includes taxes & fees 8/10 Very Good! (329 reviews) [](https://expedia.co.uk/Syracuse-Hotels-Eureka-Palace-Hotel-Spa-Resort.h3814820.Hotel-Information) Still don't see what you're looking for? [See all properties in Syracuse.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F04%2F2026&endDate=11%2F04%2F2026®ionId=4912&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F04%2F2026&endDate=11%2F04%2F2026®ionId=4912&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F04%2F2026&endDate=11%2F04%2F2026®ionId=4912&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F04%2F2026&endDate=11%2F04%2F2026®ionId=4912&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F04%2F2026&endDate=11%2F04%2F2026®ionId=4912&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=10%2F04%2F2026&endDate=11%2F04%2F2026®ionId=4912&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Syracuse Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside. [See all hotels in Syracuse](https://www.expedia.co.uk/Hotel-Search?startDate=2026-04-23&endDate=2026-04-24&adults=2®ionId=4912) ![Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe](https://images.trvl-media.com/place/4912/0fad57c8-f045-437c-be3c-817a684ac32e.jpg?impolicy=fcrop&w=900&h=300&p=1&q=high) ## Top Syracuse Hotel Reviews ![Grand Hotel Ortigia Siracusa](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/ac752df8_y.jpg) ### Grand Hotel Ortigia Siracusa 10/10 Excellent "Beautiful facility, classic. Wonderful restaurant for breakfast and dinner." [](https://expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information) ![Caportigia Boutique Hotel](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/83105a89_y.jpg) ### Caportigia Boutique Hotel 10/10 Excellent "Excellent modern property, staff are all amazing. Walkable to everything." [](https://expedia.co.uk/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information) ![Ortea Palace Hotel, Sicily, Autograph Collection](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/3b8d7262_y.jpg) ### Ortea Palace Hotel, Sicily, Autograph Collection 10/10 Excellent "The hotel itself is a beautiful building with an interesting heritage as the main post office. The location is excellent offering a great starting point for a walking tour of Ortigia. Great stay." [](https://expedia.co.uk/Syracuse-Hotels-Ortea-Palace-Luxury-Hotel.h17825841.Hotel-Information) ![Grand Hotel Des Ètrangers - The Leading Hotels of the World](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/cbf3a060_y.jpg) ### Grand Hotel Des Ètrangers - The Leading Hotels of the World 10/10 Excellent "Great hotel and saff" [](https://expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information) ## Find out more about Syracuse ## Frequently asked questions ### What are the best 5-star hotels in Syracuse? ### How much does it cost to stay in a 5-star hotel in Syracuse? > - Search for the lowest price per night from £83 ### What makes a hotel 5 stars in Syracuse? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [3 Star Hotels in La Banca ](https://www.expedia.co.uk/3Star-La-Banca-Hotels.s30-0-d3000740126.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Marzamemi ](https://www.expedia.co.uk/3Star-Marzamemi-Hotels.s30-0-d6344103.Travel-Guide-Filter-Hotels) - 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[Cathedral of Syracuse ](https://www.expedia.co.uk/Cathedral-Of-Syracuse-Ortigia.d6103290.Attraction) - [Church of St. Mary of the Immaculate Conception ](https://www.expedia.co.uk/Church-Of-St-Mary-Of-The-Immaculate-Conception-Ortigia.d6327245.Attraction) - [Church of the Immaculate ](https://www.expedia.co.uk/Church-Of-The-Immaculate-Ortigia.d6329069.Attraction) - [Ciane River and Saline Nature Reserve ](https://www.expedia.co.uk/Ciane-River-And-Saline-Nature-Reserve-Syracuse.d553248621532498651.Attraction) - [Visit Fanusa ](https://www.expedia.co.uk/Fanusa.dx6284580) - [Fonte Aretusa ](https://www.expedia.co.uk/Fonte-Aretusa-Ortigia.d6103292.Attraction) - [Fountain of Diana ](https://www.expedia.co.uk/Fountain-Of-Diana-Ortigia.d553248621532498717.Attraction) - [Lungomare di Ortigia ](https://www.expedia.co.uk/Lungomare-Di-Ortigia-Ortigia.d6284111.Attraction) - [Museum of Cinema ](https://www.expedia.co.uk/Museum-Of-Cinema-Ortigia.d6326984.Attraction) - [Ortygia Holidays ](https://www.expedia.co.uk/Ortygia.d6182482.Holidays-City-Breaks) - 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[Temple of Apollo ](https://www.expedia.co.uk/Temple-Of-Apollo-Ortigia.d6103312.Attraction) - [Visit Terrauzza ](https://www.expedia.co.uk/Terrauzza.dx553248635118822829) - [Tropical Aquarium of Syracuse ](https://www.expedia.co.uk/Tropical-Aquarium-Of-Syracuse-Ortigia.d6329115.Attraction) - [Car hire near Cathedral of Syracuse ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Cathedral-Of-Syracuse.d6103290.Car-Hire-Guide) - [Car hire near Province of Syracuse ](https://www.expedia.co.uk/Destinations-In-Province-Of-Syracuse.d6052967.Car-Hire-Destinations) - [Province of Syracuse Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Province-Of-Syracuse.d6052967.Holiday-Rental-Destinations) - [Ortygia Holiday Rentals ](https://www.expedia.co.uk/Ortygia-Holiday-Rentals.d6182482.Travel-Guide-HolidayRentals) - [Things to do in Ortygia ](https://www.expedia.co.uk/Things-To-Do-In-Ortygia.d6182482.Travel-Guide-Activities) - [Things to do in Province of Syracuse ](https://www.expedia.co.uk/Things-To-Do-In-Province-Of-Syracuse.d6052967.Travel-Guide-Activities) - 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