Title: The 10 Best 5 Star Hotels in Syracuse - 2026 Updated Prices | Expedia.co.uk [Syracuse Travel Guide](https://expedia.co.uk/Syracuse.dx4912)[Hotels in Syracuse](https://expedia.co.uk/Syracuse-Hotels.d4912.Travel-Guide-Hotels)[Holiday Rentals in Syracuse](https://expedia.co.uk/Syracuse-Holiday-Rentals.d4912.Travel-Guide-HolidayRentals)[Flights to Syracuse](https://expedia.co.uk/Cheap-Flights-To-Syracuse.d4912.Travel-Guide-Flights)[Things to do in Syracuse](https://expedia.co.uk/Things-To-Do-In-Syracuse.d4912.Travel-Guide-Activities)[Syracuse Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Syracuse.d4912.Car-Hire-Guide)[Syracuse Holidays](https://expedia.co.uk/Syracuse.d4912.Holidays-City-Breaks) ![Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe](https://images.trvl-media.com/place/4912/0fad57c8-f045-437c-be3c-817a684ac32e.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Syracuse, Sicily - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Syracuse 5 Star Hotels Tonight [7 Jan - 8 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=4912&startDate=2026-01-07&endDate=2026-01-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [8 Jan - 9 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=4912&startDate=2026-01-08&endDate=2026-01-09&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [9 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=4912&startDate=2026-01-09&endDate=2026-01-11&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=4912&startDate=2026-01-16&endDate=2026-01-18&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Syracuse 5-star hotels ![Exterior](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/3b8d7262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, minibar, in-room safe, individually decorated](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/3cd441f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch served; local and international cuisine ](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/4f6bc901.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/18000000/17830000/17825900/17825841/d22de140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ortea Palace Hotel, Sicily, Autograph Collection [](https://www.expedia.co.uk/Syracuse-Hotels-Ortea-Palace-Luxury-Hotel.h17825841.Hotel-Information) Ortigia 9.4/10 Exceptional (254) "Great location and very friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James £188 includes taxes & fees 8 Jan - 9 Jan [](https://www.expedia.co.uk/Syracuse-Hotels-Ortea-Palace-Luxury-Hotel.h17825841.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/ac752df8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private beach nearby, black sand, beach shuttle, sun-loungers](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/400d9c2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch served; international cuisine, al fresco dining ](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/cc080552.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/f86f7ffa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Ortigia Siracusa [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information) Ortigia 9.0/10 Wonderful (573) "Every aspect of our stay was superb. The staff were friendly and helpfull. Our room was spotless, and the decor of the entire hotel was harmonious. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas £167 includes taxes & fees 9 Jan - 10 Jan [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/83105a89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, City View | Minibar, in-room safe, individually decorated, individually furnished](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/e1667130.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Room | Minibar, in-room safe, individually decorated, individually furnished](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/2f1018dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/02af6ccd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Caportigia Boutique Hotel [](https://www.expedia.co.uk/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information) Santa Lucia 9.4/10 Exceptional (257) "Fine quality hotel with exceptional service. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Peter £99 includes taxes & fees 18 Jan - 19 Jan [](https://www.expedia.co.uk/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information) ![Seasonal outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/cbf3a060.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Building design](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/3abb85fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/20f9f2e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Mediterranean cuisine](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/d1e57884.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Des Ètrangers - The Leading Hotels of the World [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information) Ortigia 9.6/10 Exceptional (73) "Great hotel and saff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Galina [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/d439594a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Villa, 2 Bedrooms, Sea View (The Suitest) | Bathroom | Shower, rainfall showerhead, designer toiletries, hair dryer](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/efec5cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor treatment area](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/a7549475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/7a080071.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Minareto [](https://www.expedia.co.uk/Syracuse-Hotels-Minareto.h2822343.Hotel-Information) Syracuse 8.8/10 Excellent (267) "Winderfull views but the staff isn’t so supportive!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose [](https://www.expedia.co.uk/Syracuse-Hotels-Minareto.h2822343.Hotel-Information) ![Sauna, hot tub, Turkish bath/hammam, body treatments, body scrubs](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/77a257e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/ea5bf622.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/5c45e57b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/w5000h3331x0y3-d0f008d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dimora Caiammari Luxury Hotel & Spa [](https://www.expedia.co.uk/Syracuse-Hotels-Caiammari-Boutique-Hotel-Spa.h915406.Hotel-Information) Syracuse 9.4/10 Exceptional (211) "We experienced outstanding service from all of the staff, the breakfast buffet was lovely, lots of options and all homemade. We had a fantastic dinner in the restaurant one evening, which we booked ahead of our trip. " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) David [](https://www.expedia.co.uk/Syracuse-Hotels-Caiammari-Boutique-Hotel-Spa.h915406.Hotel-Information) ![Sports facility](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/7df225fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby, free beach shuttle, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/51043145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; international cuisine, pool views ](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/c0740844.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/62771193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wellness & Spa Hotel Principe di Fitalia [](https://www.expedia.co.uk/Syracuse-Hotels-Wellness-Spa-Hotel-Principe-Di-Fitalia.h9388897.Hotel-Information) Syracuse 9.6/10 Exceptional (94) "This was such a wonderful stay! Spotless beautiful property with friendly staff and delicious breakfast!!! Very impressed!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey £333 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Syracuse-Hotels-Wellness-Spa-Hotel-Principe-Di-Fitalia.h9388897.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Syracuse-Hotels.s50-0-d4912.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Syracuse-Hotels.s50-0-d4912.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Syracuse. ![Algila' Ortigia Charme Hotel](https://images.trvl-media.com/lodging/2000000/1890000/1883500/1883438/d402c8e9_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Algila' Ortigia Charme Hotel Via Vittorio Veneto 93 Syracuse SR £159 20 Jan - 21 Jan includes taxes & fees 9.4/10 Exceptional! (910 reviews) [](https://expedia.co.uk/Syracuse-Hotels-Algila-Ortigia-Charme-Hotel.h1883438.Hotel-Information) ![Mercure Siracusa Prometeo](https://images.trvl-media.com/lodging/2000000/1540000/1538700/1538612/b09648f6_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Mercure Siracusa Prometeo Viale Teracati 20 Syracuse SR £87 2 Feb - 3 Feb includes taxes & fees 8.8/10 Excellent! (477 reviews) [](https://expedia.co.uk/Syracuse-Hotels-Mercure-Siracusa-Prometeo.h1538612.Hotel-Information) ![Grand Hotel Villa Politi](https://images.trvl-media.com/lodging/2000000/1230000/1220700/1220650/73408607_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Grand Hotel Villa Politi Via Maria Politi Laudien 2 Syracuse SR £78 2 Feb - 3 Feb includes taxes & fees 8.6/10 Excellent! (921 reviews) [](https://expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Villa-Politi.h1220650.Hotel-Information) Still don't see what you're looking for? [See all properties in Syracuse.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F01%2F2026&endDate=09%2F01%2F2026®ionId=4912&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F01%2F2026&endDate=09%2F01%2F2026®ionId=4912&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F01%2F2026&endDate=09%2F01%2F2026®ionId=4912&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F01%2F2026&endDate=09%2F01%2F2026®ionId=4912&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F01%2F2026&endDate=09%2F01%2F2026®ionId=4912&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=08%2F01%2F2026&endDate=09%2F01%2F2026®ionId=4912&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Syracuse Ancient Greek ruins in the Archaeological Park include the impressive Teatro Greco where summer performances still take place. Wander through Ortygia's narrow streets to discover the Duomo, built around a former Greek temple with columns still visible from inside. [See all hotels in Syracuse](https://www.expedia.co.uk/Hotel-Search?startDate=2026-01-21&endDate=2026-01-22&adults=2®ionId=4912) ![Syracuse, panoramic phot of the Roman Amphitheatre at Syracuse (Siracusa), UNESCO World Heritage Site, Sicily, Italy, Europe](https://images.trvl-media.com/place/4912/0fad57c8-f045-437c-be3c-817a684ac32e.jpg?impolicy=fcrop&w=900&h=300&p=1&q=high) ## Top Syracuse Hotel Reviews ## Find out more about Syracuse ## Frequently asked questions ### What are the best 5-star hotels in Syracuse? ### How much does it cost to stay in a 5-star hotel in Syracuse? > - Search for the lowest price per night from £78 ### What makes a hotel 5 stars in Syracuse? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [3 Star Hotels in La Banca ](https://www.expedia.co.uk/3Star-La-Banca-Hotels.s30-0-d3000740126.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Marzamemi ](https://www.expedia.co.uk/3Star-Marzamemi-Hotels.s30-0-d6344103.Travel-Guide-Filter-Hotels) - 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[Gay-Friendly Hotels in Ortigia ](https://www.expedia.co.uk/Ortigia-Syracuse-Hotels-Gay-Friendly-Hotel.0-n553248635213212045-0-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - [Ortigia Hotels ](https://www.expedia.co.uk/Ortigia-Syracuse-Hotels.0-n553248635213212045-0.Travel-Guide-Filter-Hotels) - [Serviced Apartments in Ortygia ](https://www.expedia.co.uk/Ortygia-Apart-Hotels.d6182482-aaApartHotels.Travel-Guide-Accommodation) - [B&B in Ortygia ](https://www.expedia.co.uk/Ortygia-Bed-And-Breakfasts.d6182482-aaBedAndBreakfasts.Travel-Guide-Accommodation) - [Resorts in Ortygia ](https://www.expedia.co.uk/Ortygia-Hotel-Resorts.d6182482-aaHotelResorts.Travel-Guide-Accommodation) - [Adults Only Resorts & in Ortygia ](https://www.expedia.co.uk/Ortygia-Hotels-Adults-Only-Resorts.0-0-d6182482-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Beach Resorts & in Ortygia ](https://www.expedia.co.uk/Ortygia-Hotels-Beach-Hotels.0-0-d6182482-tBeachHotels.Travel-Guide-Filter-Hotels) - [Boutique Hotels in Ortygia ](https://www.expedia.co.uk/Ortygia-Hotels-Boutique-Hotel.0-0-d6182482-tBoutiqueHotel.Travel-Guide-Filter-Hotels) - 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[Cathedral of Syracuse ](https://www.expedia.co.uk/Cathedral-Of-Syracuse-Ortigia.d6103290.Attraction) - [Church of St. Mary of the Immaculate Conception ](https://www.expedia.co.uk/Church-Of-St-Mary-Of-The-Immaculate-Conception-Ortigia.d6327245.Attraction) - [Church of the Immaculate ](https://www.expedia.co.uk/Church-Of-The-Immaculate-Ortigia.d6329069.Attraction) - [Ciane River and Saline Nature Reserve ](https://www.expedia.co.uk/Ciane-River-And-Saline-Nature-Reserve-Syracuse.d553248621532498651.Attraction) - [Visit Fanusa ](https://www.expedia.co.uk/Fanusa.dx6284580) - [Fonte Aretusa ](https://www.expedia.co.uk/Fonte-Aretusa-Ortigia.d6103292.Attraction) - [Fountain of Diana ](https://www.expedia.co.uk/Fountain-Of-Diana-Ortigia.d553248621532498717.Attraction) - [Lungomare di Ortigia ](https://www.expedia.co.uk/Lungomare-Di-Ortigia-Ortigia.d6284111.Attraction) - [Museum of Cinema ](https://www.expedia.co.uk/Museum-Of-Cinema-Ortigia.d6326984.Attraction) - [Ortygia Holidays ](https://www.expedia.co.uk/Ortygia.d6182482.Holidays-City-Breaks) - 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[Temple of Apollo ](https://www.expedia.co.uk/Temple-Of-Apollo-Ortigia.d6103312.Attraction) - [Visit Terrauzza ](https://www.expedia.co.uk/Terrauzza.dx553248635118822829) - [Tropical Aquarium of Syracuse ](https://www.expedia.co.uk/Tropical-Aquarium-Of-Syracuse-Ortigia.d6329115.Attraction) - [Car hire near Cathedral of Syracuse ](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Cathedral-Of-Syracuse.d6103290.Car-Hire-Guide) - [Car hire near Province of Syracuse ](https://www.expedia.co.uk/Destinations-In-Province-Of-Syracuse.d6052967.Car-Hire-Destinations) - [Province of Syracuse Holiday Rentals ](https://www.expedia.co.uk/Destinations-In-Province-Of-Syracuse.d6052967.Holiday-Rental-Destinations) - [Ortygia Holiday Rentals ](https://www.expedia.co.uk/Ortygia-Holiday-Rentals.d6182482.Travel-Guide-HolidayRentals) - [Things to do in Ortygia ](https://www.expedia.co.uk/Things-To-Do-In-Ortygia.d6182482.Travel-Guide-Activities) - [Things to do in Province of Syracuse ](https://www.expedia.co.uk/Things-To-Do-In-Province-Of-Syracuse.d6052967.Travel-Guide-Activities) - 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