Northeast Missouri adults only hotels from £50

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Top Adults only hotels in Northeast Missouri

Depot Inn and Suites
3.5 out of 5
1245 N. Brown St., La Plata, MO
9.6/10 Exceptional! (561 reviews)
"This property was one of the cleanest properties that I’ve stayed in. Bed was nice and comfy and staff was pleasant. Will be staying here every time I visit my son in college in Kirksville."

Reviewed on 22 Aug 2025

Depot Inn and Suites
Pinemark Inn & Suites
2 out of 5
866 South Outer Road, St. Clair, MO
The price is £104 per night from 28 Aug to 29 Aug
£104
28 Aug - 29 Aug
includes taxes & fees
9.4/10 Exceptional! (1,002 reviews)
Definitely will stay again
"Cute mom and pop motel! Clean rooms and yummy breakfast"

Reviewed on 24 Aug 2025

Pinemark Inn & Suites
Pear Tree Inn St. Louis Airport
2.5 out of 5
10810 Pear Tree Ln, St. Ann, MO
The price is £78 per night from 1 Sept to 2 Sept
£78
1 Sept - 2 Sept
includes taxes & fees
9.2/10 Wonderful! (2,670 reviews)
"Didnt like the rooftop generators buzzing a night from the Bandanas resturant. Need insulated windows on 3rd floor side"

Reviewed on 23 Aug 2025

Pear Tree Inn St. Louis Airport
Oak Hill Inn & Suites
2.5 out of 5
1701 Oak St, Canton, MO
The price is £80 per night from 1 Sept to 2 Sept
£80
1 Sept - 2 Sept
includes taxes & fees
9.2/10 Wonderful! (803 reviews)
"A little outdated but nothing wrong."

Reviewed on 21 Aug 2025

Oak Hill Inn & Suites
Best Western Plus Washington Hotel
2.5 out of 5
2621 E 5th St, Washington, MO
The price is £109 per night from 3 Sept to 4 Sept
£109
3 Sept - 4 Sept
includes taxes & fees
9/10 Wonderful! (587 reviews)
"Love"

Reviewed on 17 Aug 2025

Best Western Plus Washington Hotel
The Wildwood Hotel
3.5 out of 5
2801 Fountain Pl, Wildwood, MO
9/10 Wonderful! (1,559 reviews)
"Very clean and staff were nice and attentive. The breakfast was disappointing, that’s my only negative."

Reviewed on 24 Aug 2025

The Wildwood Hotel
River City Casino & Hotel
4 out of 5
777 River City Casino Blvd, St. Louis, MO
The price is £140 per night from 17 Sept to 18 Sept
£140
17 Sept - 18 Sept
includes taxes & fees
9/10 Wonderful! (1,338 reviews)
Cozy
"Staff was very helpful checking us in and directing us to our room. Food was superb! We had pasta & Chinese."

Reviewed on 22 Aug 2025

River City Casino & Hotel
Pear Tree Inn St. Louis Near Union Station
3 out of 5
2211 Market Street, St. Louis, MO
The price is £85 per night from 1 Sept to 2 Sept
£85
1 Sept - 2 Sept
includes taxes & fees
8.8/10 Excellent! (1,588 reviews)
"The evening snacks and drinks were a great little bonus"

Reviewed on 25 Aug 2025

Pear Tree Inn St. Louis Near Union Station
Super 8 by Wyndham Kirksville-University Area
2.5 out of 5
1101 Country Club Dr, Kirksville, MO
The price is £50 per night from 31 Aug to 1 Sept
£50
31 Aug - 1 Sept
includes taxes & fees
8.8/10 Excellent! (81 reviews)
"Most comfortable bed that I had slept in at hotel and excellent breakfast and customer service"

Reviewed on 21 Aug 2025

Super 8 by Wyndham Kirksville-University Area
Baymont by Wyndham Kirksville University Area
2.5 out of 5
2702 South Franklin, Kirksville, MO
The price is £60 per night from 1 Sept to 2 Sept
£60
1 Sept - 2 Sept
includes taxes & fees
7.6/10 Good! (876 reviews)
"Love staying here! Just wish the pool was functional, especially in the hot summer months."

Reviewed on 24 Jul 2025

Baymont by Wyndham Kirksville University Area
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Frequently Asked Questions

How can I find the best adults only resorts in Northeast Missouri?

The best adults only resort for you is deeply personal. First off, decide what you want from your dream holiday, then use our filters to bring it to life. Find resorts with hot tubs, spas and incredible views, then check out the reviews to see how other guests enjoyed their stay.

How much does a Northeast Missouri adults-only hotel cost?

With Expedia, you can find adults only hotels from £50 to per night. Prices and availability are subject to change. Additional terms may apply.

How can I find an adults only all-inclusive holiday in Northeast Missouri?

It’s simple. Just select the all-inclusive filter to find the best resorts where you can eat, drink and holiday to your heart’s content.

What can I expect from Northeast Missouri 5-star all-inclusive adults only hotels?

Luxury comes as standard in the 5-star resorts of Northeast Missouri. Step into spotless surroundings, stellar service and all the amenities your heart desires, from spas and pools to casinos and cocktail bars.

Why should I book a Northeast Missouri adults only hotel with entertainment?

When you book an adult only hotel with entertainment, pack your bags to get dolled up for the very best of comedy, cabaret, music, magic and much more – all just steps from your room.

How can I find the best deals on adults only resorts in Northeast Missouri?

To find amazing deals in Northeast Missouri and for a quieter experience, book your holiday in . The more flexible you can be with your dates, the better your chances are of getting a fantastic wallet-friendly deal. You can always check out our latest cheap deals for a little inspiration.

Do adults only hotels in Northeast Missouri offer free cancellation?

Some adults only hotels here offer free cancellation. Some don’t. It’s always best to check before you book. You can filter by free cancellation and pay later options to find resorts with that extra flexibility you want.

Why should I book my adults only resort in Northeast Missouri with Expedia?

At Expedia, we put everything you need to book your dream trip in one place. With a vast selection of incredible adult only accommodation at your fingertips, all that’s left to do is set your sights on what’s right for you.