Our top choices for Northeast Missouri hotels

Sleep Inn & Suites Hannibal West

Hannibal

Sheila

includes taxes & fees

21 Jun - 22 Jun

Oak Hill Inn & Suites

Canton

Elizabeth

includes taxes & fees

9 Jun - 10 Jun

Pillow-top beds, desk, blackout curtains, soundproofing

Depot Inn and Suites

La Plata

Michael

includes taxes & fees

31 May - 1 Jun

Club Suite, 1 King Bed, Hot Tub | Private spa tub

Pinemark Inn & Suites

St. Clair

Steven

includes taxes & fees

2 Jun - 3 Jun

Hyatt Select St. Louis Airport

Woodson Terrace

Marty

includes taxes & fees

3 Jun - 4 Jun

Quality Inn Foristell

Foristell

George

includes taxes & fees

17 Jun - 18 Jun

The Wildwood Hotel

Wildwood

kathy

includes taxes & fees

22 Jun - 23 Jun

Holiday Inn Express & Suites St Peters by IHG

St. Peters

John

includes taxes & fees

7 Jun - 8 Jun

Comfort Inn Sullivan

Sullivan

CLAUDIA

includes taxes & fees

17 Jun - 18 Jun

Super 8 by Wyndham Kirksville-University Area

Kirksville

Charles

includes taxes & fees

14 Jun - 15 Jun

Desk, iron/ironing board, WiFi, bed sheets

Best Western On The River

Hannibal

Mary

includes taxes & fees

7 Jun - 8 Jun

Desk, blackout curtains, iron/ironing board, free WiFi

Town & Country Inn and Suites

Quincy

Lynda

includes taxes & fees

28 May - 29 May

Best Western Plus Washington Hotel

Washington

Rod

includes taxes & fees

9 Jun - 10 Jun

Pear Tree Inn St. Louis Airport

St. Ann

Vesta

includes taxes & fees

17 Jun - 18 Jun

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Fenton

Randy

includes taxes & fees

28 May - 29 May

Quality Inn & Suites Hannibal West

Hannibal

Jennifer

includes taxes & fees

21 Jun - 22 Jun

Drury Inn & Suites Southwest St. Louis

Valley Park

Ya-Ping

includes taxes & fees

31 May - 1 Jun

Holiday Inn Express & Suites Wentzville St Louis West by IHG

Wentzville

Patty

includes taxes & fees

31 May - 1 Jun

Wingate by Wyndham St. Louis Airport

St. Ann

Cameron

includes taxes & fees

28 May - 29 May

Drury Inn & Suites St. Louis Airport

Edmundson

Kimberly

includes taxes & fees

22 Jun - 23 Jun

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Holiday Rentals in Northeast Missouri

Cabin

Cannon Dam Cabins

Perry

"management great, cabins very comfortable and roomy, good location"

Apartment

White House at Grand Central

Grand Center

"The space was very clean, cozy and quiet. There was plenty of room to be comfortable to both rest and have time to get work done or relax in the living room area. The location was very convenient for everything we were visiting St Louis for! (We could walk to both the Fabulous Fox Theatre and Foundry - about 15 min each, and it was a very short trip to the Enterprise Center)"

Apartment

Near Wineries: Country Condo in New Haven

New Haven

"Clean and loved original architecture."

Apartment

Lakefront Studio Guest Home on Hermann Wine Trail!

New Haven

"Loved this property, very clean and well kept! Very pretty, lovely view. "

Apartment

Walk to Carondelet Park: Quiet Couple's Getaway

Carondelet

"We had a nice stay, close to things we wanted to do"

Cottage

Home w/ Trail Access on 19 Acres in Wright City!

Wright City

"Great house in a beautiful setting. We enjoyed the quiet solitude and woodsy area. Very clean accommodations with every amenity available. "

Cottage

Peaceful Guest Home w/ Patio on 152-acre Farm

Berger

"Very clean,family friendly, even though it was 7 miles out of town they were very Accommodating,they came to puck us up at the train station and there's a van that will take you into town and you can take the trolley to all the wineries,shopping, we all loved our stay,i would definitely recommend to anyone who enjoys the fram life, they have lots of history, and animals, thank you Susan and Mike for all that you did to make our stay memorable, we would definitely come back. "

Apartment

'the Ruebling House' Historic Defiance Apartment!

Defiance

"This was are first family Vacation and are stay was amazing nice and clean with plenty of space. I would definitely recommend to a friend."

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Stay near popular Northeast Missouri attractions

Busch Stadium

4.7/5 (4,850 reviews)

Catch an event at Busch Stadium during your trip to St. Louis. Experience the area's acclaimed art galleries or attend a baseball game.

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Learn more about Northeast Missouri

Great live music, sports teams and popular sights from St. Louis Zoo to St. Louis Union Station—explore Northeast Missouri, a family-friendly destination also known for its theatres.

See all hotels in Northeast Missouri

Top Northeast Missouri Hotel Reviews

Clayton Plaza Hotel & Extended Stay

6/10 Okay

"This hotel was aged and mediocre. The room had stuff all over the ceiling and the jacuzzi in the room had a film in it. Once we turned it on, one side barely worked. The breakfast that was served was less than desirable with it being cold and flavorless. The pool was under renovations which was disappointing. Overall, our stay was comfortable but not worth the price we paid nor was it anywhere near what the hotel was advertised to be."

Pear Tree Inn St. Louis Near Union Station

8/10 Good

"The free breakfast was excellent. Good food and plenty of options for everyone. The complementary drinks/sodas/nachos bar every evening was an unexpected surprise. The staff were all extremely friendly and helpful and the hot tub felt wonderful after a long day. The room was nice, but the bathroom was smaller than expected and didnt have an exhaust fan so the ceiling was peeling from all the moisture.. The bathroom is really my only complaint."

Forest Park Hotel by MDR

10/10 Excellent

"We had a very pleasant stay at Forest Park Hotel. The room was very clean. The mattresses were extremely comfortable. We both slept really well. The staff was friendly and the front desk attendant told us to let him know if there were any issues. So friendly and accommodating. I would definitely stay here again."

21C Museum Hotel St Louis

6/10 Okay

"The hotel is downtown, and not within walking distance of anything. The hospitality side of the hotel was LACKING....housekeeping would not make the bed, take out the trash or refill the coffee and tea. When I asked the front desk about making the bed, the response was "We don't do that unless you ask for it." I asked for it.......didn't happen for the 3 days we were there. The breakfast cafe in the hotel was decent....if you didn't mind waiting for up to 45 minutes for your order. Apparently, they do not have a good short order cook for the kitchen. I would not stay at this property again, especially considering the premium we paid for the room."