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28 Aug - 30 Aug
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Our top choices for Mayo Clinic hotels

A hotel courtyard with a central pathway, potted plants, and a building with multiple balconies and windows.

1. Sonesta Select Scottsdale at Mayo Clinic Campus

Sonesta Select Scottsdale at Mayo Clinic Campus
3.0 star property
Mayo Clinic
8.4 out of 10, Very good, (1,114 reviews)
"Very nice area"
United States
Chad
The price is £59
includes taxes & fees
30 Aug - 31 Aug
Sonesta Select Scottsdale at Mayo Clinic Campus
A cluster of modern, multi-story buildings with a river in the foreground.

2. Inn at Eagle Mountain

Inn at Eagle Mountain
3.5 star property
1.9 mi from Mayo Clinic
9.0 out of 10, Wonderful, (1,006 reviews)
"very nice hotel"
United States
Lucia
The price is £74
includes taxes & fees
27 Aug - 28 Aug
Inn at Eagle Mountain
A well-maintained courtyard with a gazebo, palm trees, and a pathway leading to a building with a grey facade.

3. La Quinta Inn & Suites by Wyndham Phoenix Scottsdale

La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
3.0 star property
Central Scottsdale, 5.6 mi from Mayo Clinic
8.8 out of 10, Excellent, (1,855 reviews)
"Wonderful stay."
United States
Caroline
The price is £56
includes taxes & fees
2 Sept - 3 Sept
La Quinta Inn & Suites by Wyndham Phoenix Scottsdale
A spacious dining area with multiple tables and chairs, large windows, and a television mounted on the wall.

4. Comfort Suites Scottsdale Talking Stick Entertainment District

Comfort Suites Scottsdale Talking Stick Entertainment District
2.5 star property
6 mi from Mayo Clinic
9.2 out of 10, Wonderful, (1,996 reviews)
"We enjoyed our stay, will definitely be back!👍"
United States
Cecilia
The price is £62
includes taxes & fees
31 Aug - 1 Sept
Comfort Suites Scottsdale Talking Stick Entertainment District
A modern breakfast area with a counter displaying various food items and a sign reading "TOP IT BREAKFAST".

5. Tru By Hilton Scottsdale Salt River

Tru By Hilton Scottsdale Salt River
2.5 star property
5.6 mi from Mayo Clinic
8.8 out of 10, Excellent, (1,007 reviews)
"Great stay. Highly recommend"
United States
Andrea
The price is £63
includes taxes & fees
31 Aug - 1 Sept
Tru By Hilton Scottsdale Salt River
A modern infinity pool with a view of mountains and a sunset.

6. Talking Stick Resort

Talking Stick Resort
4.0 star property
5.6 mi from Mayo Clinic
9.4 out of 10, Exceptional, (5,091 reviews)
"Very nice place to stay"
United States
Daryl
The price is £121
includes taxes & fees
7 Sept - 8 Sept
Talking Stick Resort
An outdoor patio area with stone pillars, a fire pit, and seating arrangements.

7. Wekopa Casino Resort

Wekopa Casino Resort
4.0 star property
6.3 mi from Mayo Clinic
9.2 out of 10, Wonderful, (1,005 reviews)
"Excellent time, clean rooms great restaurants we enjoyed our time here."
United States
Kim
The price is £127
includes taxes & fees
26 Aug - 27 Aug
Wekopa Casino Resort
A lounge area with a curved seating arrangement, a staircase, and a view of an outdoor pool.

8. The McCormick Scottsdale

The McCormick Scottsdale
3.5 star property
8.1 mi from Mayo Clinic
8.4 out of 10, Very good, (1,340 reviews)
"The property was clean, bed was great and the view from our room was amazing!"
United States
Charissa
The price is £72
includes taxes & fees
31 Aug - 1 Sept
The McCormick Scottsdale
A hotel room with a red sofa, a wooden dining table set for two, a television, and a patterned carpet.

9. Sonesta Simply Suites Phoenix Scottsdale

Sonesta Simply Suites Phoenix Scottsdale
2.5 star property
5.4 mi from Mayo Clinic
7.8 out of 10, Good, (1,005 reviews)
"Good"
United States
Steve
The price is £59
includes taxes & fees
27 Aug - 28 Aug
Sonesta Simply Suites Phoenix Scottsdale
An outdoor seating area with sofas, tables, and umbrellas, featuring a fire feature in the center.

10. Hyatt Place North Scottsdale

Hyatt Place North Scottsdale
3.0 star property
8.8 mi from Mayo Clinic
9.2 out of 10, Wonderful, (1,231 reviews)
"Great location, rooms are excellent clean, breakfast was a nice touch. Would highly recommend, the family enjoyed the stay."
United States
Derrick
The price is £58
includes taxes & fees
7 Sept - 8 Sept
Hyatt Place North Scottsdale
A swimming pool with sun loungers and palm trees, surrounded by a building with multiple floors and balconies.

11. DoubleTree Resort by Hilton Paradise Valley - Scottsdale

DoubleTree Resort by Hilton Paradise Valley - Scottsdale
4.0 star property
9.1 mi from Mayo Clinic
8.6 out of 10, Excellent, (1,751 reviews)
"The staff were very pleasant at check in. Our first stay at a Hilton and will definitely return."
United States
Tammy
The price is £88
includes taxes & fees
31 Aug - 1 Sept
DoubleTree Resort by Hilton Paradise Valley - Scottsdale
A pool area with a waterfall feature, lounge chairs, and a clear sky.

12. Hilton Vacation Club Scottsdale Villa Mirage

Hilton Vacation Club Scottsdale Villa Mirage
3.5 star property
8.1 mi from Mayo Clinic
8.8 out of 10, Excellent, (1,025 reviews)
"Great place to stay"
United States
Cruz
The price is £72
includes taxes & fees
27 Aug - 28 Aug
Hilton Vacation Club Scottsdale Villa Mirage
An outdoor seating area with string lights, a fire pit, and umbrellas.

13. Hilton Garden Inn Scottsdale Old Town

Hilton Garden Inn Scottsdale Old Town
3.0 star property
Brown and Stetson Business, 9.8 mi from Mayo Clinic
9.0 out of 10, Wonderful, (1,010 reviews)
"Property was very clean and in a great location, and the staff was very friendly."
United States
Kathrine
The price is £61
includes taxes & fees
4 Sept - 5 Sept
Hilton Garden Inn Scottsdale Old Town
A spacious lobby with a modern staircase, a comfortable seating area, and a large window providing natural light.

14. Sleep Inn North Scottsdale near Mayo Clinic

Sleep Inn North Scottsdale near Mayo Clinic
2.5 star property
Paradise Valley Village, 8.5 mi from Mayo Clinic
8.6 out of 10, Excellent, (1,008 reviews)
"Great hotel and great staff. Very clean hotel and rooms. Good free breakfast. I highly recommend if you visit Scottsdale!"
United States
Ashraf
The price is £63
includes taxes & fees
4 Sept - 5 Sept
Sleep Inn North Scottsdale near Mayo Clinic
A hotel room with a bed, desk, television, fireplace, and seating area.

15. Sonesta ES Suites Scottsdale Paradise Valley

Sonesta ES Suites Scottsdale Paradise Valley
3.0 star property
8.8 mi from Mayo Clinic
9.2 out of 10, Wonderful, (1,008 reviews)
"Great stay nice rooms for family hangouts"
United States
Jonathan
The price is £59
includes taxes & fees
31 Aug - 1 Sept
Sonesta ES Suites Scottsdale Paradise Valley
A dog sitting in front of a building with a door marked '315'.

16. Kimpton Miralina Resort & Villas by IHG

Kimpton Miralina Resort & Villas by IHG
4.0 star property
8.4 mi from Mayo Clinic
8.8 out of 10, Excellent, (2,163 reviews)
"Great location, great staff!"
United States
Linda
The price is £143
includes taxes & fees
29 Aug - 30 Aug
Kimpton Miralina Resort & Villas by IHG
A modern outdoor lounge area with sofas, chairs, and a glass-top coffee table with a fire feature.

17. Hyatt House North Scottsdale

Hyatt House North Scottsdale
3.5 star property
8.8 mi from Mayo Clinic
9.4 out of 10, Exceptional, (1,019 reviews)
"Great hotel with a very nice buffet breakfast. I've stayed there several times and it's always enjoyable and reasonably priced."
United States
Christopher
The price is £70
includes taxes & fees
30 Aug - 31 Aug
Hyatt House North Scottsdale
A modern kitchen with a central island, stainless steel appliances, and pendant lighting.

18. Staybridge Suites Scottsdale - Talking Stick by IHG

Staybridge Suites Scottsdale - Talking Stick by IHG
3.0 star property
6.1 mi from Mayo Clinic
9.4 out of 10, Exceptional, (1,008 reviews)
"Roo. Was clean..bed is heaven Breakfast was delicious always like staying here"
United States
Eric
The price is £94
includes taxes & fees
7 Sept - 8 Sept
Staybridge Suites Scottsdale - Talking Stick by IHG
A Courtyard by Marriott hotel with a landscaped entrance featuring a small waterfall and rock formations.

19. Courtyard by Marriott Scottsdale North

Courtyard by Marriott Scottsdale North
3.0 star property
8.5 mi from Mayo Clinic
8.6 out of 10, Excellent, (1,005 reviews)
"Great service"
United States
Sylvia
The price is £61
includes taxes & fees
30 Aug - 31 Aug
Courtyard by Marriott Scottsdale North
A swimming pool with lounge chairs and a covered seating area, surrounded by palm trees and a building with multiple windows.

20. Hyatt Place Phoenix/Mesa

Hyatt Place Phoenix/Mesa
3.0 star property
11.1 mi from Mayo Clinic
9.2 out of 10, Wonderful, (1,989 reviews)
"Clean room nice bed great breakfast loved the pool !"
United States
Andrea
The price is £63
includes taxes & fees
6 Sept - 7 Sept
Hyatt Place Phoenix/Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Mayo Clinic

Find the best Mayo Clinic areas for the activities you enjoy most.
A cityscape at dusk with illuminated buildings, including a Chase bank and a Sheraton hotel.

Downtown Phoenix

Cheer on the Phoenix Suns at an NBA game or walk around the city’s historic precinct as you explore the state capital.

A sculpture of a horse in motion, surrounded by cacti and palm trees, with buildings and a street in the background.

Old Town

Gourmet restaurants interesting history and top sights from Scottsdale Waterfront to Western Spirit: Scottsdale's Museum of the West – discover Old Town, a destination also famous for its shopping.

A hiker on a rocky trail with mountains in the background.

Rio Verde Foothills

If you're looking for some top things to see and do in Rio Verde Foothills and surrounding area, you can visit Tom's Thumb Trail and Golf Club Scottsdale.

A cave with a view of palm trees and a distant cityscape.

Camelback East

You might take some time to check out the abundant dining options in Camelback East. Spend some time visiting top spots like Biltmore Fashion Park, and catch the metro at 44th Street - Washington Station or 50th Street Station to see more of the area.

An aerial view of a residential area with a lake, boats, and houses.

The Islands

The Islands might not have many top sights, but Chandler Center for the Arts and Golfland Sunsplash are two attractions nearby that you can check out.

Top Mayo Clinic Hotel Reviews

Hilton Phoenix Tapatio Cliffs Resort

Hilton Phoenix Tapatio Cliffs Resort

10/10 Excellent
"Was excellent stay! Staff was fantastic and I love how you can text to ask questions or if you need things."
Cory 3-night trip
Posted less than an hour ago
Hilton Phoenix Tapatio Cliffs Resort

Frequently asked questions

What are the best hotels in Mayo Clinic that travellers recommend?
For a highly recommended hotel in Mayo Clinic, consider the Sonesta Select Scottsdale at Mayo Clinic Campus.

This 3-star hotel has an 8.2 rating and is praised by guests for its comfortable, clean rooms and friendly, helpful staff. Its location is perfect, being just 0.3 km from Mayo Clinic Scottsdale. Guests also appreciate the easy parking and comfortable beds. The hotel offers an outdoor pool, a hot tub, and premium bedding for a restful stay.
What are the best family hotels in Mayo Clinic?
For families visiting Mayo Clinic, the Sonesta Select Scottsdale at Mayo Clinic Campus is a highly recommended option.

This 3-star hotel, with an 8.2 rating, is praised by guests for its comfortable and clean rooms, as well as its friendly and helpful staff. Families will appreciate the availability of free cribs, rollaway extra beds, and sofa beds, ensuring everyone has a comfortable stay. Connecting rooms are also an option for larger families. For those who enjoy outdoor activities, mountain biking is available at a nearby location. Guests also highlight the great and beautiful location, along with easy parking, making it a convenient choice for families.
What are the top pet-friendly hotels in Mayo Clinic?
For top pet-friendly accommodation in Mayo Clinic, the Sonesta Select Scottsdale at Mayo Clinic Campus is an excellent choice.

This 3-star hotel, with an 8.2 rating, warmly welcomes both dogs and cats, making it a great spot for travellers with furry companions. Guests frequently highlight the comfortable and clean rooms, as well as the friendly and helpful staff. The location is described as great and beautiful, offering a pleasant stay for both you and your pets. The hotel also provides food and water bowls, ensuring your pets have everything they need. Additionally, guests appreciate the easy parking, adding to the convenience of your visit.
What are the best budget hotels in Mayo Clinic?
For a budget-friendly hotel near Mayo Clinic, the Sonesta Select Scottsdale at Mayo Clinic Campus is an excellent option.

This 3-star hotel has an 8.2 rating and offers comfortable, clean rooms with free internet and complimentary toiletries. Guests frequently praise the friendly, helpful staff and the perfect, beautiful location, as well as the easy parking and comfortable beds.
What are the most romantic hotels in Mayo Clinic for couples?
For couples seeking a romantic getaway in Mayo Clinic, the Sonesta Select Scottsdale at Mayo Clinic Campus is a highly-rated option.

This 3-star hotel, with an 8.2 rating, is often praised by guests for its comfortable and clean rooms, as well as its friendly and helpful staff. Its beautiful location and easy parking contribute to a relaxing stay. The hotel also features a hot tub, great for unwinding together, and offers free internet and WiFi.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Mayo Clinic.
How much is the nightly rate at a Mayo Clinic hotel?
Hotel prices in Mayo Clinic often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

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