Mayo Clinic Holidays from £1,013
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £750 when you book a flight and hotel together*
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- Rest easyPackages with flights are ATOL protected
Price found within the past 48 hours. Click for updated prices.
Omni Scottsdale Resort & Spa at Montelucia
Paradise Hills
£1,975
per person
17 Oct - 22 Oct
found 1 day ago
Return flight included
London (LON) to Phoenix (PHX)
9.4/10 Exceptional! (1,113 reviews)
Gorgeous property, clean and spacious room w a view of Camelback Mountain. Spent a day at the spa which was lovely with wonderful amenities and a dedicated pool for spa guests. Enjoyed the other pools in the evening after the sun went down. Incredibly kind staff, and the in room dining was better than expected. Would definitely stay again!
Reviewed on 24 Aug 2026
Where to stay in Mayo Clinic
Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most. Learn more about Mayo Clinic
Downtown Phoenix
3 out of top 10 points of interest in this area
Cheer on the Phoenix Suns at an NBA game or walk around the city’s historic precinct as you explore the state capital.
Old Town
Gourmet restaurants interesting history and top sights from Scottsdale Waterfront to Western Spirit: Scottsdale's Museum of the West – discover Old Town, a destination also famous for its shopping.
Rio Verde Foothills
If you're looking for some top things to see and do in Rio Verde Foothills and surrounding area, you can visit Tom's Thumb Trail and Golf Club Scottsdale.
Camelback East
You might take some time to check out the abundant dining options in Camelback East. Spend some time visiting top spots like Biltmore Fashion Park, and catch the metro at 44th Street - Washington Station or 50th Street Station to see more of the area.
The Islands
The Islands might not have many top sights, but Chandler Center for the Arts and Golfland Sunsplash are two attractions nearby that you can check out.
Top hotels in Mayo Clinic
Hilton Phoenix Tapatio Cliffs Resort
11111 N 7th St Phoenix AZ
Fully refundableReserve now, pay when you stay
£116
31 Aug - 1 Sept
includes taxes & fees
8.8/10 Excellent! (3,024 reviews)
"Was excellent stay! Staff was fantastic and I love how you can text to ask questions or if you need things."
Reviewed on 25 Aug 2026
FOUNDRE Phoenix
1100 N Central Avenue Phoenix AZ
Fully refundableReserve now, pay when you stay
£91
27 Aug - 28 Aug
includes taxes & fees
9/10 Wonderful! (2,832 reviews)
"It’s so nice and pet friendly (: great little bar down stairs w good food too! Great location as well. I loved staying here."
Reviewed on 25 Aug 2026
Talking Stick Resort
9800 E. Talking Stick Way Scottsdale AZ
£120
30 Aug - 31 Aug
includes taxes & fees
9.4/10 Exceptional! (5,091 reviews)
"Good clean room, nice casino and poker room."
Reviewed on 25 Aug 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Frequently asked questions
How much does a Mayo Clinic travel package cost?
Our Mayo Clinic packages, which start from as low as £1,013, are the best way to save big. Pick and choose your preferred hotels, flights and more to create your ideal itinerary.
If I'm not able to travel, can I cancel my Mayo Clinic travel package?
If your holiday plans in Mayo Clinic have been upended, it's a relief to know that it is possible to cancel or amend your booking. If you made your booking in the last 24 hours, you may be eligible to receive a refund. If your booking was made more than 24 hours ago, your hotel, airline or car rental company may impose fees. For more information, visit our Customer Service Portal.
How do I get a cheap travel package to Mayo Clinic?
One of the easiest ways to save cash (and time) is to bundle your bookings with Expedia. Hotels, flights, activities and rental cars — we've got it all. Pick and choose a combination that suits your style and see your savings pile up. We know a travel package is never one-size-fits-all. That's why Expedia offers over 550 airlines and 1,000,000 hotel options worldwide, which lets you customize your Mayo Clinic adventure.
Does Expedia offer Book Now, Pay Later Mayo Clinic holidays?
Your bank balance shouldn't prevent you from escaping on holiday, so Expedia has worked out a solution to help. Thanks to our partnership with online lender Klarna, it's easier than ever to book a terrific getaway without making a dent in your savings. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your break. Check out these flexible payment options:
- Pay monthly holidays: Klarna offers convenient monthly payment plans that work for all budgets, so you can lock in that well-deserved holiday sooner.
- Pay in instalments holidays: Like the idea of paying down your holiday in multiple transactions? Then select this Book Now, Pay Later option with Klarna.
- Low deposit holidays: When you stumble on an awesome deal but your budget doesn't quite cover it yet, Klarna's low deposit holiday plan will help you lock in your getaway.
Where should I stay in Mayo Clinic?
Choose a hotel near Tournament Players Club of Scottsdale. This top sight is in the thick of the action and on the must-do lists of many holiday makers.
What are the top hotels in Mayo Clinic?
Get your holiday off to a fantastic start by booking a stay at 3 Palms. It's one of most sought-after properties in Mayo Clinic. Another welcoming option is Talking Stick Resort.
How far in advance should I book my Mayo Clinic holiday?
It depends on the airline, but you can usually compare international fares on Expedia up to 12 months in advance. While it's generally recommended to book ahead of time, lucky customers occasionally nab a cheaper flight only weeks before the date of departure.
What does an Expedia Mayo Clinic travel package include?
Hotels, car rentals and flights — we connect you to the very best deals. All you'll have to do is pick and choose your favourite combination. Once you've made your booking, you can add on the exciting stuff like activities and sightseeing tours. Our travel packages make it simple to customize an awesome Mayo Clinic trip.
What should I know before booking a Mayo Clinic travel package?
When you book your flights, hotels and car rentals together, you'll be rewarded with great discounts. Whether you're planning a beach escape in a villa or want to stay in a convenient hotel in the city, Expedia can help make it happen.
Can I choose my airline with a Mayo Clinic Expedia travel package?
Expedia offers access to more than 550 partner airlines globally, so you definitely can. Simply pick the airline you want and craft your ideal Mayo Clinic trip.
Things to do
SEA LIFE Arizona Aquarium Tickets
£15
per adult
84% of travellers recommend
Arizona Diamondbacks Baseball Game Ticket at Chase Field
£24
per adult
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.