Mayo Clinic Holidays from £795

Book a Hotel + Flight or Car together to unlock savings

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    Better together
    Save up to £335 when you book a flight and hotel together*
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    Find the right fit
    With over 300,000 hotels worldwide, it's easy to create a perfect package
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    Rest easy
    Plan, book, and manage your trip all in one place
Price found within the past 48 hours. Click for updated prices.
Hilton Garden Inn Phoenix North Happy Valley

Hilton Garden Inn Phoenix North Happy Valley

3 out of 5
Deer Valley
per person
6 Aug - 13 Aug
found 5 hours ago
Return direct flight included
London (LHR) to Phoenix (PHX)
8.6/10 Excellent! (1,001 reviews)
The staff was sooo incredible

Reviewed on 23 Jun 2025

Arizona Biltmore, LXR Hotels & Resorts

Arizona Biltmore, LXR Hotels & Resorts

5 out of 5
Camelback East
per person
6 Aug - 13 Aug
found 5 hours ago
Return direct flight included
London (LHR) to Phoenix (PHX)
9/10 Wonderful! (1,008 reviews)
Loved! Will be returning

Reviewed on 25 Jun 2025

Global Luxury Suites at Downtown Phoenix

Global Luxury Suites at Downtown Phoenix

4.5 out of 5
Downtown Phoenix
per person
6 Aug - 13 Aug
found 5 hours ago
Return direct flight included
London (LHR) to Phoenix (PHX)
8.8/10 Excellent! (38 reviews)
This was a really lovely complex! The pool is fantastic, gym, essentially the entire 25th floor! Absolutely lovely. Close to really good restaurants and the Phoenix farmers market! The only thing was that there was no hand soap or body soap in the condo! Otherwise, this was an absolute perfect spot for a quick getaway— 10 minutes from the airport as well!

Reviewed on 2 Jun 2025

Hilton Phoenix Tapatio Cliffs Resort

Hilton Phoenix Tapatio Cliffs Resort

4 out of 5
North Mountain
per person
6 Aug - 13 Aug
found 5 hours ago
Return direct flight included
London (LHR) to Phoenix (PHX)
8.2/10 Very Good! (1,885 reviews)
A hidden gem in the Phoenix area but their bathrooms could use a little upgrade.

Reviewed on 25 Jun 2025

Hilton Garden Inn Phoenix Airport North

Hilton Garden Inn Phoenix Airport North

3 out of 5
Downtown Phoenix
per person
6 Aug - 13 Aug
found 5 hours ago
Return direct flight included
London (LHR) to Phoenix (PHX)
8.6/10 Excellent! (1,968 reviews)
We stay there several times a year anf really think the staff is great

Reviewed on 25 Jun 2025

Where to stay in Mayo Clinic

Find the best Mayo Clinic areas and neighborhoods for the activities you enjoy most. Learn more about Mayo Clinic
Downtown Phoenix which includes signage and night scenes

Downtown Phoenix

3 out of top 10 points of interest in this area
4/5(25 area reviews)

Cheer on the Phoenix Suns at an NBA game or walk around the city’s historic precinct as you explore the state capital.

Find hotels in Downtown Phoenix

Top hotels in Mayo Clinic

Sonesta Select Scottsdale at Mayo Clinic Campus
Sonesta Select Scottsdale at Mayo Clinic Campus
3 out of 5
13444 E Shea Blvd, Scottsdale, AZ
Fully refundableReserve now, pay when you stay
The price is £63 per night from 26 Jun to 27 Jun
£63
26 Jun - 27 Jun
includes taxes & fees
8.2/10 Very Good! (1,011 reviews)
"Would definitely come back. Super peaceful and the views are unmatched"

Reviewed on 20 Jun 2025

Sonesta Select Scottsdale at Mayo Clinic Campus
Talking Stick Resort
Talking Stick Resort
4 out of 5
9800 E. Talking Stick Way, Scottsdale, AZ
Fully refundableReserve now, pay when you stay
9.2/10 Wonderful! (3,370 reviews)
"Had a great time at the pool a d enjoyed dinner time"

Reviewed on 23 Jun 2025

Get rates
Talking Stick Resort
Hilton Phoenix Tapatio Cliffs Resort
Hilton Phoenix Tapatio Cliffs Resort
4 out of 5
11111 N 7th St, Phoenix, AZ
Fully refundableReserve now, pay when you stay
The price is £112 per night from 2 Jul to 3 Jul
£112
2 Jul - 3 Jul
includes taxes & fees
8.2/10 Very Good! (1,887 reviews)
"It was nice."

Reviewed on 21 Jun 2025

Hilton Phoenix Tapatio Cliffs Resort
See all 13,166 properties in Mayo Clinic
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

All Inclusive Holidays

All Inclusive Holidays

Beach Holidays

Beach Holidays

Family Friendly Holidays

Family Friendly Holidays

Frequently asked questions

How much does a Mayo Clinic travel package cost?
Our Mayo Clinic packages, which start from as low as £795, are the best way to save big. Pick and choose your preferred hotels, flights and more to create your ideal itinerary.
If I'm not able to travel, can I cancel my Mayo Clinic travel package?
If your holiday plans in Mayo Clinic have been upended, it's a relief to know that it is possible to cancel or amend your booking. If you made your booking in the last 24 hours, you may be eligible to receive a refund. If your booking was made more than 24 hours ago, your hotel, airline or car rental company may impose fees. For more information, visit our Customer Service Portal.
How do I get a cheap travel package to Mayo Clinic?
One of the easiest ways to save cash (and time) is to bundle your bookings with Expedia. Hotels, flights, activities and rental cars --- we've got it all. Pick and choose a combination that suits your style and see your savings pile up. We know a travel package is never one-size-fits-all. That's why Expedia offers over 550 airlines and 1,000,000 hotel options worldwide, which lets you customize your Mayo Clinic adventure.
Does Expedia offer Book Now, Pay Later Mayo Clinic holidays?
Your bank balance shouldn't prevent you from escaping on holiday, so Expedia has worked out a solution to help. Thanks to our partnership with online lender Klarna, it's easier than ever to book a terrific getaway without making a dent in your savings. Klarna offers flexible payment options during the checkout process that take the stress out of budgeting for your break. Check out these flexible payment options:
  • Pay monthly holidays: Klarna offers convenient monthly payment plans that work for all budgets, so you can lock in that well-deserved holiday sooner.
  • Pay in instalments holidays: Like the idea of paying down your holiday in multiple transactions? Then select this Book Now, Pay Later option with Klarna.
  • Low deposit holidays: When you stumble on an awesome deal but your budget doesn't quite cover it yet, Klarna's low deposit holiday plan will help you lock in your getaway.

Where should I stay in Mayo Clinic?
Choose a hotel near Tournament Players Club of Scottsdale. This top sight is in the thick of the action and on the must-do lists of many holiday makers.
What are the top hotels in Mayo Clinic?
Get your holiday off to a fantastic start by booking a stay at 3 Palms. It's one of most sought-after properties in Mayo Clinic. Another welcoming option is Talking Stick Resort.
How far in advance should I book my Mayo Clinic holiday?
It depends on the airline, but you can usually compare international fares on Expedia up to 12 months in advance. While it's generally recommended to book ahead of time, lucky customers occasionally nab a cheaper flight only weeks before the date of departure.
What does an Expedia Mayo Clinic travel package include?
Hotels, car rentals and flights --- we connect you to the very best deals. All you'll have to do is pick and choose your favourite combination. Once you've made your booking, you can add on the exciting stuff like activities and sightseeing tours. Our travel packages make it simple to customize an awesome Mayo Clinic trip.
What should I know before booking a Mayo Clinic travel package?
When you book your flights, hotels and car rentals together, you'll be rewarded with great discounts. Whether you're planning a beach escape in a villa or want to stay in a convenient hotel in the city, Expedia can help make it happen.
Can I choose my airline with a Mayo Clinic Expedia travel package?
Expedia offers access to more than 550 partner airlines globally, so you definitely can. Simply pick the airline you want and craft your ideal Mayo Clinic trip.

Popular places to visit

Camelback Mountain

Camelback Mountain

4.5/5(15 reviews)

A distinct “hump” in the landscape offers panoramic views over the Valley of the Sun.

Camelback Mountain
Westgate Entertainment District

Westgate Entertainment District

4/5(3 reviews)

You can browse for the perfect souvenirs at Westgate Entertainment District during your stay in Glendale. Experience the area's lively festivals or attend a sporting event.

Westgate Entertainment District
Phoenix Raceway

Phoenix Raceway

Catch an event at Phoenix Raceway during your trip to Avondale. In the area, you can attend a football match or hockey game.

Phoenix Raceway

Things to do

Phoenix: Self-Drive ATV/UTV Rental in the Sonoran Desert

Phoenix: Self-Drive ATV/UTV Rental in the Sonoran Desert

£76
per traveller
100% of travellers recommend
Phoenix: Self-Drive ATV/UTV Rental in the Sonoran Desert
Phoenix Sunrise Hot Air Balloon Ride

Phoenix Sunrise Hot Air Balloon Ride

£154
per adult
94% of travellers recommend
Phoenix Sunrise Hot Air Balloon Ride
Saguaro Lake: Guided Kayaking Tour

Saguaro Lake: Guided Kayaking Tour

£95
per adult
Saguaro Lake: Guided Kayaking Tour
See all activities in Phoenix

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.