Title: The Best Hotels in Matlacha Isles, Cape Coral - 2026 Updated Prices | Expedia.co.uk [Holiday Rentals in Cape Coral](https://expedia.co.uk/Cape-Coral-Holiday-Rentals.d6521.Travel-Guide-HolidayRentals)[Flights to Cape Coral](https://expedia.co.uk/Cheap-Flights-To-Cape-Coral.d6521.Travel-Guide-Flights)[Things to do in Cape Coral](https://expedia.co.uk/Things-To-Do-In-Cape-Coral.d6521.Travel-Guide-Activities)[Matlacha Isles Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Matlacha-Isles.d553248635976471942.Car-Hire-Guide)[Matlacha Isles Holidays](https://expedia.co.uk/Matlacha-Isles.d553248635976471942.Holidays-City-Breaks) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [21 Jan - 22 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976471942&startDate=2026-01-21&endDate=2026-01-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [22 Jan - 23 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976471942&startDate=2026-01-22&endDate=2026-01-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976471942&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976471942&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Matlacha Isles hotels ![Beach nearby, white sand, sun-loungers, beach umbrellas](https://images.trvl-media.com/lodging/13000000/12760000/12750900/12750850/b1d7bdda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/13000000/12760000/12750900/12750850/cc027214.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Cottage, 1 Bedroom | Terrace/patio](https://images.trvl-media.com/lodging/13000000/12760000/12750900/12750850/7cddbc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![40-inch flat-screen TV with cable channels, TV, DVD player](https://images.trvl-media.com/lodging/13000000/12760000/12750900/12750850/7906eb2d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Seahorse Cottages on Sanibel - Adults Only [](https://www.expedia.co.uk/Fort-Myers-Hotels-Seahorse-Cottages-On-Sanibel-Adults-Only.h12750850.Hotel-Information) 13.1 mi from Matlacha Isles 9.6/10 Exceptional (82 reviews) "The Room was very clean and convenient with access to the beach and a nice ice cream/coffee shop." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kreg A. £166 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Seahorse-Cottages-On-Sanibel-Adults-Only.h12750850.Hotel-Information) ![3 restaurants, breakfast, lunch, dinner served; Italian cuisine ](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/9bc89705.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/bbf3ce91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite with Two Doubles, Beachfront, Balcony | Individually decorated, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/2e8856cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Studio with Two Doubles, Beachfront, Balcony | Individually decorated, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/3202bde7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lani Kai Beachfront Resort [](https://www.expedia.co.uk/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) 14.4 mi from Matlacha Isles 9.0/10 Wonderful (1,142 reviews) "The breakfast was good " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ileana £188 includes taxes & fees 22 Jan - 23 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/5000000/4520000/4513100/4513051/9c00e0a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4520000/4513100/4513051/824d933b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/5000000/4520000/4513100/4513051/b80b1ff5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/5000000/4520000/4513100/4513051/ea10bb34.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Baymont by Wyndham Punta Gorda/Port Charlotte [](https://www.expedia.co.uk/Port-Charlotte-Charlotte-Harbor-Hotels-Baymont-By-Wyndham-Punta-GordaPort-Charlotte.h4513051.Hotel-Information) 18 mi from Matlacha Isles 8.4/10 Very good (1,166 reviews) "The room was excellent and the staff were very friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronnie £97 includes taxes & fees 23 Jan - 24 Jan [](https://www.expedia.co.uk/Port-Charlotte-Charlotte-Harbor-Hotels-Baymont-By-Wyndham-Punta-GordaPort-Charlotte.h4513051.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/46330a76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/a840448a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/1fa522a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking | Premium bedding, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/800000/798500/798422/d3248701.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Days Inn & Suites by Wyndham Fort Myers Near JetBlue Park [](https://www.expedia.co.uk/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) 17.4 mi from Matlacha Isles 8.0/10 Very good (1,544 reviews) "Great little hotel. Rooms and common areas look like they were recently renovated, everything was very clean and the staff was great. Thanks for the excellent stay." ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Geoffrey £74 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Days-Inn-Suites-By-Wyndham-Fort-Myers-Near-JetBlue-Park.h798422.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/2deb021c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/a683180f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/06cf7d58.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1750000/1746300/1746276/eec3b567.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Fort Myers Airport [](https://www.expedia.co.uk/Fort-Myers-Hotels-Comfort-Inn-Suites-Airport.h1746276.Hotel-Information) 17.3 mi from Matlacha Isles 8.8/10 Excellent (1,114 reviews) "Comfortable rooms and beds, good breakfast and easy access to baseball parks." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Javier £96 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Comfort-Inn-Suites-Airport.h1746276.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/104000000/103190000/103186900/103186827/3bf7e12d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/104000000/103190000/103186900/103186827/35ad9ea5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/104000000/103190000/103186900/103186827/0afa75e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Queen Suite Two Queen Beds | Individually decorated, individually furnished, desk, laptop workspace](https://images.trvl-media.com/lodging/104000000/103190000/103186900/103186827/74c618a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Woodspring Suites Fort Myers - Cape Coral [](https://www.expedia.co.uk/Fort-Myers-Hotels-Woodspring-Suites-Fort-Myers-Cape-Coral.h103186827.Hotel-Information) 11.3 mi from Matlacha Isles 7.2/10 Good (168 reviews) "The service at the front desk was exceptional, the new manager is doing an amazing job!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sandro £74 includes taxes & fees 22 Jan - 23 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Woodspring-Suites-Fort-Myers-Cape-Coral.h103186827.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/a702090f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/54b129e7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/6a1456e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed with Sofa bed, Non Smoking (Upgrade) | Premium bedding, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/110000000/109300000/109299300/109299203/3b030475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Fort Myers East I-75 [](https://www.expedia.co.uk/Fort-Myers-Hotels-Comfort-Suites.h109299203.Hotel-Information) 15.4 mi from Matlacha Isles 9.6/10 Exceptional (384 reviews) "Very nice receptionist, and the room is great! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Dawn £112 includes taxes & fees 1 Feb - 2 Feb [](https://www.expedia.co.uk/Fort-Myers-Hotels-Comfort-Suites.h109299203.Hotel-Information) ![1 King Bed Suite w/ Efficiency Non Smoking | Premium bedding, down duvets, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/30000/24300/24286/1efc615b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/30000/24300/24286/d4a6f3f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 King Bed Suite w/ Efficiency Non Smoking | Private kitchenette | Fridge, microwave, coffee/tea maker, eco-friendly cleaning products](https://images.trvl-media.com/lodging/1000000/30000/24300/24286/452cccb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24286/799c7b74.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Fort Myers Cape Coral [](https://www.expedia.co.uk/Fort-Myers-Hotels-Travelodge-By-Wyndham-Fort-Myers.h24286.Hotel-Information) 11.4 mi from Matlacha Isles 7.6/10 Good (215 reviews) "Clean room and staff was excellent " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) SURINDER £81 includes taxes & fees 24 Jan - 25 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Travelodge-By-Wyndham-Fort-Myers.h24286.Hotel-Information) ![Free continental breakfast on weekdays ](https://images.trvl-media.com/lodging/2000000/1670000/1662000/1661939/dce1fc55.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1670000/1662000/1661939/c6ebb5bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1670000/1662000/1661939/fa977bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1670000/1662000/1661939/4739cec8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Fort Myers - Colonial Blvd [](https://www.expedia.co.uk/Fort-Myers-Hotels-Hampton-Inn-Suites-Fort-Myers-Colonial-Blvd.h1661939.Hotel-Information) 13 mi from Matlacha Isles 9.4/10 Exceptional (1,000 reviews) "Great place to stay, will be back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Douglas £119 includes taxes & fees 1 Feb - 2 Feb [](https://www.expedia.co.uk/Fort-Myers-Hotels-Hampton-Inn-Suites-Fort-Myers-Colonial-Blvd.h1661939.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/5f870412.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/42212932.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Refrigerator & Microwave | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/f6f6cea7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/20000/17200/17131/d9380a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Fort Myers Inn & Suites [](https://www.expedia.co.uk/Fort-Myers-Hotels-Best-Western-Fort-Myers-Inn-Suites.h17131.Hotel-Information) 12.9 mi from Matlacha Isles 8.8/10 Excellent (1,131 reviews) "Clean room, old property and fresh, varied options for breakfast" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) supriya £89 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Best-Western-Fort-Myers-Inn-Suites.h17131.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/60000/50700/50640/c2f92274.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/50700/50640/3d373ab2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![40-inch LCD TV with cable channels, TV](https://images.trvl-media.com/lodging/1000000/60000/50700/50640/da383170.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/60000/50700/50640/105102fa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Knights Inn Punta Gorda [](https://www.expedia.co.uk/Port-Charlotte-Charlotte-Harbor-Hotels-Knights-Inn-Punta-Gorda.h50640.Hotel-Information) 17.7 mi from Matlacha Isles 7.2/10 Good (956 reviews) "Yes" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John £76 includes taxes & fees 23 Jan - 24 Jan [](https://www.expedia.co.uk/Port-Charlotte-Charlotte-Harbor-Hotels-Knights-Inn-Punta-Gorda.h50640.Hotel-Information) ![Interior](https://images.trvl-media.com/lodging/49000000/48990000/48980100/48980077/e1e3cc1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/49000000/48990000/48980100/48980077/b5528b4e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/49000000/48990000/48980100/48980077/e103c721.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/49000000/48990000/48980100/48980077/ce2b505a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Fort Myers Airport by IHG [](https://www.expedia.co.uk/Fort-Myers-Hotels-Holiday-Inn-Express-Suites-Fort-Myers-Southeast.h48980077.Hotel-Information) 18 mi from Matlacha Isles 9.6/10 Exceptional (1,003 reviews) "The rooms were clean and coffee was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kyle £119 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Holiday-Inn-Express-Suites-Fort-Myers-Southeast.h48980077.Hotel-Information) ![Sun deck](https://images.trvl-media.com/lodging/17000000/16660000/16651900/16651890/2c59b397.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/17000000/16660000/16651900/16651890/8bc2b39a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Suite, Kitchen, Pool View | Living area | TV](https://images.trvl-media.com/lodging/17000000/16660000/16651900/16651890/763b4722.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Kayaking](https://images.trvl-media.com/lodging/17000000/16660000/16651900/16651890/94b7632c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Latitude 26 Waterfront Boutique Resort - Fort Myers Beach [](https://www.expedia.co.uk/Fort-Myers-Hotels-Latitude-26-Waterfront-Boutique-Resort-Fort-Myers-Beach.h16651890.Hotel-Information) 12.7 mi from Matlacha Isles 8.8/10 Excellent (1,000 reviews) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrea £131 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Latitude-26-Waterfront-Boutique-Resort-Fort-Myers-Beach.h16651890.Hotel-Information) ![On the beach, sun-loungers, beach towels](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/f97bdde8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/aa9b23b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![On the beach, sun-loungers, beach towels](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/6b3a0fb3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sanibel Island Beach Resort [](https://www.expedia.co.uk/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) 14.1 mi from Matlacha Isles 9.2/10 Wonderful (1,548 reviews) "Sweet staff, amazing beach access, pool, restaurant on site. Good value and great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Freda £232 includes taxes & fees 22 Jan - 23 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/300000/297100/297037/7da2f9ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/300000/297100/297037/70b165e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/300000/297100/297037/5f13a421.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/300000/297100/297037/2ab04080.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Fort Myers Northeast [](https://www.expedia.co.uk/Fort-Myers-Hotels-Comfort-Inn-Fort-Myers-Northeast.h297037.Hotel-Information) 16 mi from Matlacha Isles 7.8/10 Good (683 reviews) "Nice stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carole £98 includes taxes & fees 23 Jan - 24 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Comfort-Inn-Fort-Myers-Northeast.h297037.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18700/18633/8562a92c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18700/18633/22099762.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/20000/18700/18633/a75555a9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/18700/18633/777d18b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites Fort Myers I-75 [](https://www.expedia.co.uk/Fort-Myers-Hotels-Quality-Suites-Fort-Myers-I-75.h18633.Hotel-Information) 16.8 mi from Matlacha Isles 8.2/10 Very good (1,000 reviews) "Room was clean, front desk pleasant." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carol £86 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Quality-Suites-Fort-Myers-I-75.h18633.Hotel-Information) ![Coffee service](https://images.trvl-media.com/lodging/1000000/20000/18900/18848/06c908cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/20000/18900/18848/31861d8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/18900/18848/63af51b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18848/2796734c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Travelodge by Wyndham Fort Myers Airport [](https://www.expedia.co.uk/Fort-Myers-Hotels-Travelodge-By-Wyndham-Fort-Myers-Airport.h18848.Hotel-Information) 16.8 mi from Matlacha Isles 7.4/10 Good (1,002 reviews) "Was " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brian £55 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Travelodge-By-Wyndham-Fort-Myers-Airport.h18848.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2850000/2847800/2847745/3f55519b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/3000000/2850000/2847800/2847745/0fdbdc99.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/3000000/2850000/2847800/2847745/29d24bb7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/3000000/2850000/2847800/2847745/w5616h3741x0y0-fd66ddcf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Fort Myers/at The Forum [](https://www.expedia.co.uk/Fort-Myers-Hotels-Hyatt-Place-Fort-Myersat-The-Forum.h2847745.Hotel-Information) 15.4 mi from Matlacha Isles 8.2/10 Very good (1,000 reviews) "The check in staff was wonderful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cynthia £119 includes taxes & fees 25 Jan - 26 Jan [](https://www.expedia.co.uk/Fort-Myers-Hotels-Hyatt-Place-Fort-Myersat-The-Forum.h2847745.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22400/22386/ffbd89e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/22400/22386/eb0f595f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22400/22386/d477de54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/22400/22386/a6afb300.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Fort Myers Cape Coral [](https://www.expedia.co.uk/Fort-Myers-Hotels-Courtyard-By-Marriott-Fort-Myers-Cape-Coral.h22386.Hotel-Information) 12.7 mi from Matlacha Isles 8.2/10 Very good (1,000 reviews) "Great service, would stay again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Matthew £104 includes taxes & fees 1 Feb - 2 Feb [](https://www.expedia.co.uk/Fort-Myers-Hotels-Courtyard-By-Marriott-Fort-Myers-Cape-Coral.h22386.Hotel-Information) ![Property grounds](https://images.trvl-media.com/lodging/18000000/17240000/17238900/17238826/6e0e9983.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 King Bed | Down duvets, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/18000000/17240000/17238900/17238826/66852202.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Aerial view](https://images.trvl-media.com/lodging/18000000/17240000/17238900/17238826/c629410b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/18000000/17240000/17238900/17238826/2e281d38.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Boca Grande Hotel [](https://www.expedia.co.uk/Port-Charlotte-Charlotte-Harbor-Hotels-Boca-Grande-Hotel.h17238826.Hotel-Information) 17.9 mi from Matlacha Isles 8.8/10 Excellent (592 reviews) "The staff are exceptional. Victoria was so helpful and Margarita went above and beyond. I am a single woman travelling alone and felt very well taken care of. I would highly recommend this property." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Diana £129 includes taxes & fees 26 Jan - 27 Jan [](https://www.expedia.co.uk/Port-Charlotte-Charlotte-Harbor-Hotels-Boca-Grande-Hotel.h17238826.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-04&endDate=2026-02-05®ionId=553248635976471942&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Where to stay in Matlacha Isles Find the best Matlacha Isles areas for the activities you enjoy most. - Pelican - Caloosahatchee - Yacht Club - Mariner - Hancock ![](https://mediaim.expedia.com/destination/9/350251ac0d9ccc7ca1cb30ed3f0f1512.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/9/6787174d3f020d364df18c0504ee6a50.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/9/0db9ea0d958f3eddc014a2724a550e04.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/9/f6aa46e3ec22aaa67f528102c099f4db.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/9/0383eed5f73bce5b51600c8b78edb8e2.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248635976481346) ![Pelican map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:oacaDfs%7BsNq_C_z%40an%40al%40m%7B%40sH%7Bo%40dPrGsaGz%40%7DqClLse%40%7C%40se%40fdIbAdSjDhvAeAhg%40t%60B%7CX%7EmEvDdeCswCxcBa%7CAha%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=E70lew0W6sFXzCxHzRLVFKaS8Mg=) ### Pelican While visiting Pelican, you might make a stop by sights like Tarpon Point and Chabad Jewish Center. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976481346) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496945-cape-coral.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496204-cape-coral.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496304-cape-coral.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496233-cape-coral.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496139-cape-coral.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248635975748682) ![Caloosahatchee map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:_l_aDbxisNce%40ImL%7DEg%60Ah%40uvGX%7D%40oaKhPcAlh%40%60nAnc%40dLxl%40qG%7Es%40b%5Bl%5EiGpl%40%60%5D%60PgJnPzZfJvc%40lj%40%7ETx%7E%40vFyBra%40sMlMiPd%60ApPlx%40oFjD&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Cya_maxw6zlgfysES9DHBgO1unY=) ### Caloosahatchee If you're spending some time in Caloosahatchee, Cape Coral Yacht Club Beach and Dolphin Marina are top sights worth seeing. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748682) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248635976659287) ![Yacht Club map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:wo%60aDlwisN%7DGeBsb%40s%5BwJe%5EwIeNzKeXJaI%60HqMH%7D_%40oS%40BuVjEEAwCtLNhCcKhHzDlPbEhOzGxKlC%7EG%7B%40hb%40xAWhKeL%7EViP%60w%40cAdo%40nKvXq%40hFgd%40f%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=9v6IXRj89bAFRtqo7x5Ob4JRxkI=) ### Yacht Club While Yacht Club isn't home to many top sights, Cape Coral Yacht Club Beach and Dolphin Marina are some notable places to visit nearby. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976659287) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248635976470523) ![Mariner map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:etqaDpkssN_oMcA%3FalFkd%40kmAhe%40%3FNgd%40viGlBxHzCfg%40%3Fr%5EgQ%7EeAx%7DClc%40n_BrG%60k%40%7D%40j%60A&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=4CJoAD0sRorEN_B-6JMiJBcI87w=) ### Mariner While visiting Mariner, you might make a stop by sights like Mike Greenwell's Bat-A-Ball & Family Fun Park and Yucca Pens Unit State Wildlife Management Area. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976470523) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/495000/495865-south-florida.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496727-north-fort-myers.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/496000/496600-north-fort-myers.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/1/26729640c04cf35e3216cbbc607fc1c6.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://mediaim.expedia.com/destination/1/2774ef6de242fcb260ae5796be4d6871.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248635976420438) ![Hancock map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:oyraDxtmsN_qFusOp%40mwEi%40gBjy%40oaAvI%7EKm%40tPbe%40%60f%40fj%40uGYdI%7BPfH_BnOvJ%7CHxNmH%7ERe%40jBrDyWjUxHzu%40xNlGv%5D%7EBrIfHv_%40lx%40v%5BfLx%60%40bd%40xQhH%60FhIbn%40wGb%5Dm%40hCmGph%40cL%7CCvyF%60%40%7CsFgqA%3FaN%7EAax%40CcNj%40%7B_%40rHuYvK&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=iSHUTH5d48PG0kePXw5a0CSgbnA=) ### Hancock While visiting Hancock, you might make a stop by sights like Four Mile Cove Ecological Preserve and Pine Island Shopping Center. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976420438) ## Top Matlacha Isles Hotel Reviews ![Sanibel Island Beach Resort](https://images.trvl-media.com/lodging/18000000/17300000/17298900/17298818/w2247h1500x326y0-2ea06bb5_y.jpg) ### Sanibel Island Beach Resort 10/10 Excellent "We loved Sanibel Island Beach Resort. Staff was attentive, rooms were clean, and the property was beautiful. The direct access to he beach was a plus!" [](https://expedia.co.uk/Fort-Myers-Hotels-Sanibel-Island-Beach-Resort.h17298818.Hotel-Information) ![Tween Waters Island Resort & Spa](https://images.trvl-media.com/lodging/1000000/180000/170800/170769/a5c54d2c_y.jpg) ### Tween Waters Island Resort & Spa 10/10 Excellent "Everthing was perfect! I would definetly stay again. " [](https://expedia.co.uk/Fort-Myers-Hotels-Tween-Waters-Island-Resort-Spa.h170769.Hotel-Information) ![Hilton Garden Inn Ft Myers](https://images.trvl-media.com/lodging/1000000/850000/848800/848740/d8bd559a_y.jpg) ### Hilton Garden Inn Ft Myers 10/10 Excellent "Wonderful " [](https://expedia.co.uk/Fort-Myers-Hotels-Hilton-Garden-Inn-Ft-Myers.h848740.Hotel-Information) ![Holiday Inn Express Cape Coral-Fort Myers Area by IHG](https://images.trvl-media.com/lodging/1000000/30000/26900/26860/ab39b98c_y.jpg) ### Holiday Inn Express Cape Coral-Fort Myers Area by IHG 10/10 Excellent "Yes" [](https://expedia.co.uk/Fort-Myers-Hotels-Holiday-Inn-Express-Cape-Coral-Fort-Myers-Area.h26860.Hotel-Information) ![Lani Kai Beachfront Resort](https://images.trvl-media.com/lodging/1000000/440000/438800/438796/b5b17142_y.jpg) ### Lani Kai Beachfront Resort 10/10 Excellent "Great svc rooftop bar" [](https://expedia.co.uk/Fort-Myers-Hotels-Lani-Kai-Beachfront-Resort.h438796.Hotel-Information) ![Sundial Beach Resort & Spa](https://images.trvl-media.com/lodging/1000000/10000/2000/1939/5481c209_y.jpg) ### Sundial Beach Resort & Spa 10/10 Excellent "Clean and comfortable" [](https://expedia.co.uk/Sanibel-Hotels-Sundial-Beach-Resort-Spa.h1939.Hotel-Information) ![Margaritaville Beach Resort Fort Myers ](https://images.trvl-media.com/lodging/96000000/95130000/95127000/95126992/w3998h2821x0y0-a77e6574_y.jpg) ### Margaritaville Beach Resort Fort Myers 10/10 Excellent "Everything was wonderful! Our room was very nice so was the staff. The pool is amazing and so happy it’s heated. The pool games and dj was super fun! The pool servers and service super!" [](https://expedia.co.uk/Fort-Myers-Beach-Hotels-Margaritaville-Beach-Resort-Fort-Myers.h95126992.Hotel-Information) ![Edison Beach House](https://images.trvl-media.com/lodging/12000000/11760000/11753200/11753200/fb0b7d7c_y.jpg) ### Edison Beach House 10/10 Excellent "Great place right on Fort Meyers Beach. Front desk staff was friendly and efficient. Housekeeping staff did an excellent job talking care of our room. Will definitely come back next time we come to Fort Meyers Beach. " [](https://expedia.co.uk/Fort-Myers-Hotels-Edison-Beach-House.h11753200.Hotel-Information) ![Pink Shell Beach Resort and Marina](https://images.trvl-media.com/lodging/1000000/20000/15700/15603/5f038ed2_y.jpg) ### Pink Shell Beach Resort and Marina 10/10 Excellent "Amazing resort! The view from our room was gorgeous inside and out. The entire resort was very clean from the room to the pools to the dining. The breakfast offered something for everyone (omelets, pancakes, waffles, fruit, potatoes, yogurt, cereal, juice and much more). The staff goes out of their way to make everything perfect. We will definitely be back!" [](https://expedia.co.uk/Fort-Myers-Hotels-Pink-Shell-Beach-Resort-And-Marina.h15603.Hotel-Information) ## Frequently asked questions ### Can I cancel my hotel reservation on Expedia? ### How can I save on a Matlacha Isles hotel booking with Expedia? ### How much is the nightly rate at a Matlacha Isles hotel? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [5 Star Hotels in Florida Gulf Coast ](https://www.expedia.co.uk/5Star-Florida-Gulf-Coast-Hotels.s50-0-d553248635974622901.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Pine Island ](https://www.expedia.co.uk/5Star-Pine-Island-Hotels.s50-0-d553248635083900600.Travel-Guide-Filter-Hotels) - [Alden Pines Hotels ](https://www.expedia.co.uk/Alden-Pines-Hotels.d553248635976474573.Travel-Guide-Hotels) - [Bokeelia Hotels ](https://www.expedia.co.uk/Bokeelia-Hotels.d6177515.Travel-Guide-Hotels) - [Gay-Friendly Hotels in Burnt Store ](https://www.expedia.co.uk/Burnt-Store-Cape-Coral-Hotels-Gay-Friendly-Hotel.0-n553248635976481229-0-tGayFriendlyHotel.Travel-Guide-Filter-Hotels) - 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