
Matlacha Isles Holidays from £549
Book a Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £250 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Your Matlacha Isles Holiday
Take the stress out of organising your next adventure by booking a Matlacha Isles holiday package. Take in the sounds and sights of this wonderful neighbourhood and enjoy what it has to offer. If you'd love to sightsee during your trip to Matlacha Isles, head straight for nearby attractions such as Royal Tee Golf Club. Expedia can help you turn your dream Matlacha Isles holiday into reality, no matter your travel plans or budget.

The Perry Hotel Naples
Reviewed on 23 Apr 2026

LaPlaya Beach & Golf Resort - A Noble House Resort
Reviewed on 22 Apr 2026


Landing Furnished Apartments Immokalee Road - Naples
Reviewed on 25 Mar 2026
Where to stay in Matlacha Isles

Pelican
While visiting Pelican, you might make a stop by sights like Tarpon Point and Chabad Jewish Center.
Top hotels in Matlacha Isles

Baymont by Wyndham Fort Myers Central
So we stayed here last minute after driving all day, we were happy to find the economy stay. We were greeting by a friendly staff and promptly checked into our room. Right up front this is not a 5 star hotel but I really like the location and it was quiet for a good rest. There are no coffee machine ...
Reviewed on 23 Apr 2026

Margaritaville Beach Resort Fort Myers
Great place all around. Very nice and helpful staff.
Reviewed on 23 Apr 2026

Sanibel Island Beach Resort
Nice, quiet, and very clean hotel, right in front of the beach. You will find everything you need for some relaxing days.
Reviewed on 23 Apr 2026
Frequently asked questions
Popular places to visit

Four Mile Cove Ecological Preserve
Enjoy the beautiful sunsets and explore Four Mile Cove Ecological Preserve, a lovely green space in Cape Coral. Amble around this family-friendly area's beautiful beaches or attend a baseball game.
Things to do

IMAG History & Science Center: Skip-the-Line Ticket

Marco Island: 10,000 Islands Shelling Boat Tour
* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.















