Matlacha Isles Travel Guide
Cape Coral
Visit Matlacha Isles
Things to do
Sunset Cruise Fort Myers Beach
£36
per adult
100% of travellers recommend
Dolphin Wildlife Cruise Fort Myers Beach
£48
per adult
100% of travellers recommend
Fort Myers Dolphin & Manatee Kayak or Paddleboard Tour
£54
per adult
90% of travellers recommend
Top hotels in Matlacha Isles
Marriott Sanibel Harbour Resort & Spa
17260 Harbour Pointe Dr Fort Myers FL
The price is £199 per night from 8 Nov to 9 Nov
£199
8 Nov - 9 Nov
includes taxes & fees
Stay at this spa resort in Fort Myers. Enjoy 3 outdoor pools, a full-service spa and 4 restaurants. Our guests praise the helpful staff and the property condition ...
Margaritaville Beach Resort Fort Myers
251 Crescent Street Fort Myers Beach FL
The price is £179 per night from 1 Nov to 2 Nov
£179
1 Nov - 2 Nov
includes taxes & fees
Stay at this beach hotel in Fort Myers Beach. Enjoy free Wi-Fi, a full-service spa and 4 restaurants. Our guests praise the pool and the helpful staff in their ...
The Lighthouse Resort Inn & Suites
1051 5th St Fort Myers Beach FL
The price is £112 per night from 27 Oct to 28 Oct
£112
27 Oct - 28 Oct
includes taxes & fees
Stay at this hotel in Fort Myers Beach. Enjoy free Wi-Fi, free parking and 2 outdoor pools. Our guests praise the pool and the helpful staff in their reviews. ...
Holiday Inn Express Cape Coral-Fort Myers Area by IHG
1538 Cape Coral Pkwy E Cape Coral FL
The price is £84 per night from 1 Nov to 2 Nov
£84
1 Nov - 2 Nov
includes taxes & fees
Stay at this business-friendly hotel in Cape Coral. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff ...
9.4/10 Exceptional! (1,726 reviews)
"Overall"
Reviewed on 25 Oct 2026
Lani Kai Beachfront Resort
1400 Estero Blvd Fort Myers Beach FL
The price is £146 per night from 1 Nov to 2 Nov
£146
1 Nov - 2 Nov
includes taxes & fees
Stay at this beach hotel in Fort Myers Beach. Enjoy free Wi-Fi, 3 restaurants and a beach locale. Popular attractions Key West Express and Crescent Beach Family ...
Sanibel Island Beach Resort
1231 Middle Gulf Dr Sanibel FL
The price is £170 per night from 27 Oct to 28 Oct
£170
27 Oct - 28 Oct
includes taxes & fees
Stay at this beach hotel in Sanibel. Enjoy free Wi-Fi, free parking and a beach locale. Our guests praise the pool and the restaurant in their reviews. Popular ...
9.2/10 Wonderful! (2,389 reviews)
"This is my second visit and I was never able to use the coffee machine in the room."
Reviewed on 25 Oct 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in Matlacha Isles
Find the best Matlacha Isles areas for the activities you enjoy most.
Pelican
While visiting Pelican, you might make a stop by sights like Tarpon Point and Chabad Jewish Center.
Caloosahatchee
If you're spending some time in Caloosahatchee, Dolphin Marina and Cape Coral Yacht Club Beach are top sights worth seeing.
Hancock
While visiting Hancock, you might make a stop by sights like Four Mile Cove Ecological Preserve and Pine Island Shopping Center.
Yacht Club
While Yacht Club isn't home to many top sights, Cape Coral Yacht Club Beach and Dolphin Marina are some notable places to visit nearby.
Burnt Store
When in Burnt Store, you can plan a visit to Coral Oaks Golf Course and Burnt Store Marina, some noteworthy sights in the nearby area.
