Title: TOP Boutique Hotels in Greenville - Spartanburg, SC for 2025 | Expedia.co.uk [Greenville - Spartanburg Travel Guide](https://expedia.co.uk/Greenville-Spartanburg.dx6035267)[Hotels in Greenville - Spartanburg](https://expedia.co.uk/Greenville-Spartanburg-Hotels.d6035267.Travel-Guide-Hotels)[Holiday Rentals in Greenville - Spartanburg](https://expedia.co.uk/Greenville-Spartanburg-Holiday-Rentals.d6035267.Travel-Guide-HolidayRentals)[Flights to Greenville - Spartanburg](https://expedia.co.uk/Cheap-Flights-To-Greenville-Spartanburg.d6035267.Travel-Guide-Flights)[Things to do in Greenville - Spartanburg](https://expedia.co.uk/Things-To-Do-In-Greenville-Spartanburg.d6035267.Travel-Guide-Activities)[Greenville - Spartanburg Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Greenville-Spartanburg.d6035267.Car-Hire-Guide)[Greenville - Spartanburg Holidays](https://expedia.co.uk/Greenville-Spartanburg.d6035267.Holidays-City-Breaks) ![Greenville - Spartanburg which includes views, tranquil scenes and mountains](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/63000/63748-Greenville-Spartanburg.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Boutique Hotels in Greenville - Spartanburg ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Greenville - Spartanburg Boutique Hotels Tonight [11 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6035267&startDate=2025-10-11&endDate=2025-10-12&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [12 Oct - 13 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6035267&startDate=2025-10-12&endDate=2025-10-13&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6035267&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6035267&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Greenville - Spartanburg Boutique Hotels ![Bar (on property)](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/1f0407e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/4694c80e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/598f5b2c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/24c29149.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Domestique Travelers Rest 9.6/10 Exceptional (30) "Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away." £378 includes taxes & fees 29 Oct - 30 Oct [](https://www.expedia.co.uk/Travelers-Rest-Hotels-Hotel-Domestique.h9704647.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=6035267&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Greenville - Spartanburg Hotel Reviews ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [4 Star Hotels in Greenville](https://www.expedia.co.uk/4Star-Greenville-Hotels.s40-0-d1388.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Greenville](https://www.expedia.co.uk/5Star-Greenville-Hotels.s50-0-d1388.Travel-Guide-Filter-Hotels) - [Colonel Elias Earle Historic District Hotels](https://www.expedia.co.uk/Colonel-Elias-Earle-Historic-District-Greenville-Hotels.0-n6348165-0.Travel-Guide-Filter-Hotels) - [Hotels with a View in South Carolina](https://www.expedia.co.uk/Destinations-In-South-Carolina-Hotel-With-A-View.0-0-d242-thotelwithaview.Hotel-Filter-Destinations) - [Hotels with Air Conditioning in South Carolina](https://www.expedia.co.uk/Destinations-In-South-Carolina-Hotel-With-Air-Conditioning.0-0-d242-thotelwithairconditioning.Hotel-Filter-Destinations) - 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[Woodside Cotton Mill Village Historic District Hotels](https://www.expedia.co.uk/Woodside-Cotton-Mill-Village-Historic-District-Greenville-Hotels.0-n6348166-0.Travel-Guide-Filter-Hotels) - [Flights to Greenville](https://www.expedia.co.uk/Cheap-Flights-To-Greenville.d1388.Travel-Guide-Flights) - [Flights from Greenville Downtown](https://www.expedia.co.uk/lp/airports/gmu/flights-from-greenville-downtown-airport) - [Flights from Greenville](https://www.expedia.co.uk/lp/flights/1388/flights-from-greenville) - [Flights from Augusta (AGS) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/ags/gmu/augusta-to-greenville) - [Flights from Anderson (AND) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/and/gmu/anderson-to-greenville) - [Flights from Atlanta (ATL) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/atl/gmu/atlanta-to-greenville) - [Flights from Detroit (DTW) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/dtw/gmu/detroit-to-greenville) - [Flights from Newark Liberty Intl. Airport (EWR) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/ewr/gmu/newark-liberty-intl-airport-to-greenville) - [Flights from Gaithersburg (GAI) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/gai/gmu/gaithersburg-to-greenville) - [Flights from Greenwood (GRD) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/grd/gmu/greenwood-to-greenville) - [Flights from Hagerstown (HGR) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/hgr/gmu/hagerstown-to-greenville) - [Flights from Islip (ISP) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/isp/gmu/islip-to-greenville) - [Flights from Jacksonville (JAX) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/jax/gmu/jacksonville-to-greenville) - [Flights from Las Vegas (LAS) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/las/gmu/las-vegas-to-greenville) - [Flights from Los Angeles (LAX) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/lax/gmu/los-angeles-to-greenville) - [Flights from Morgantown (MGW) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/mgw/gmu/morgantown-to-greenville) - [Flights from Dayton (MGY) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/mgy/gmu/dayton-to-greenville) - [Flights from New Orleans (MSY) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/msy/gmu/new-orleans-to-greenville) - [Flights from Rocky Mount (RWI) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/rwi/gmu/rocky-mount-to-greenville) - [Flights from Louisville (SDF) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/sdf/gmu/louisville-to-greenville) - [Flights from St. Louis (STL) to Greenville (GMU)](https://www.expedia.co.uk/lp/flights/stl/gmu/st-louis-to-greenville) - [Bi Lo Center](https://www.expedia.co.uk/Bi-Lo-Center-Greenville-Downtown.d553248621558035357.Attraction) - [Visit Woodside Cotton Mill Village Historic District](https://www.expedia.co.uk/Greenville-Woodside-Cotton-Mill-Village-Historic-District.dx6348166) - [Greenville Holidays](https://www.expedia.co.uk/Greenville.d1388.Holidays-City-Breaks) - [Visit Greenville](https://www.expedia.co.uk/Greenville.dx1388) - [Patewood Memorial Hospital](https://www.expedia.co.uk/Patewood-Memorial-Hospital-Greenville.d6130783.Attraction) - [Wade Hampton Mall Shopping Center](https://www.expedia.co.uk/Wade-Hampton-Mall-Shopping-Center-Greenville.d553248621563220423.Attraction) - [Warehouse Theatre](https://www.expedia.co.uk/Warehouse-Theatre-Greenville-Downtown.d553248621532656721.Attraction) - [Alamo Rent A Car Rental Cars in Greenville](https://www.expedia.co.uk/Alamo-Rent-A-Car-Car-Rentals-In-Greenville.d1388-c6.Car-Rental-Guide-Suppliers) - [Avis Rental Cars in Greenville](https://www.expedia.co.uk/Avis-Car-Rentals-In-Greenville.d1388-c41.Car-Rental-Guide-Suppliers) - [Budget Rental Cars in Greenville](https://www.expedia.co.uk/Budget-Car-Rentals-In-Greenville.d1388-c39.Car-Rental-Guide-Suppliers) - [Car hire Greenville](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Greenville.d1388.Car-Hire-Guide) - [Economy Car Hire in Greenville](https://www.expedia.co.uk/Economy-Car-Rentals-In-Greenville.d1388-tEconomy.Car-Rental-Guide-Class) - [Enterprise Rental Cars in Greenville](https://www.expedia.co.uk/Enterprise-Car-Rentals-In-Greenville.d1388-c15.Car-Rental-Guide-Suppliers) - [Hertz Rental Cars in Greenville](https://www.expedia.co.uk/Hertz-Car-Rentals-In-Greenville.d1388-c40.Car-Rental-Guide-Suppliers) - [Luxury Car Hire in Greenville](https://www.expedia.co.uk/Luxury-Car-Rentals-In-Greenville.d1388-tLuxury.Car-Rental-Guide-Class) - [National Car Rental Rental Cars in Greenville](https://www.expedia.co.uk/National-Car-Rental-Car-Rentals-In-Greenville.d1388-c42.Car-Rental-Guide-Suppliers) - [People Carrier Car Hire in Greenville](https://www.expedia.co.uk/Van-Car-Rentals-In-Greenville.d1388-tVan.Car-Rental-Guide-Class) - [Greenville Holiday Rentals](https://www.expedia.co.uk/Greenville-Holiday-Rentals.d1388.Travel-Guide-HolidayRentals) - [Things to do in Greenville](https://www.expedia.co.uk/Things-To-Do-In-Greenville.d1388.Travel-Guide-Activities) - [Book Boutique Hotels in Greenville - Spartanburg on Expedia.com](https://www.expedia.com/Greenville-Spartanburg-Hotels-Boutique-Hotel.0-0-d6035267-tBoutiqueHotel.Travel-Guide-Filter-Hotels)