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Visitors to this part of Costa Caribe share space with approximately 950,000 residents.
The national capital of Bogota is situated 410 miles south of Cartagena, while Santa Catalina lies 25 miles to the northeast.
If you want to get stuck straight into the most famed sights, San Felipe de Barajas Castle and the Puerta del Reloj should be right at the top of your list.
Rosario Islands Oceanarium is an undersea excursion for the entire family.
After some late-night thrills? Try your luck at the Rio Cartagena Casino, a fun-filled venue where the action never stops.
When the weather is fine, pack some lunch and find a shady corner at one of the area's pleasant green spaces, such as Cerro de La Popa or Centenary Park. Parque de La Marina and El Totumo Mud Volcano are two more nice places to while away a lazy day over a good book.
If you have trouble separating the words "vacation" and "beach" then this place is for you. There's plenty of scenic coastline here to satisfy even the most amphibious travelers. Marbella Beach and Bocagrande Beach should be at the top of your list. La Boquilla Beach and Isla Grande Beach are also recommended.
Nature enthusiasts often make their way to Corales del Rosario National Park and Islas del Rosario for a break.
See the world from a new perspective with a trip to one of the area's intriguing cultural institutions. The Naval Museum Cartagena and Simon Bolivar House and Museum offer a range of collections that are sure to capture your attention. Another two to look at are the Cartagena Museum of Modern Art and the Caribbean Naval Museum.
Visitors interested in natural science and history should spend some time exploring the specimens and objects at the Museo del Oro y Arqueología.
Enter a world of art ingenuity at the Cano Gallery.
Travel back to days gone by and uncover the secrets of the past at the Palacio de la Inquisición or the Casa de Rafael Núñez. The Palacio de la Inquisicion and the Colonial Museum are also prominent options.
Wander back through the ages with a visit to the Clock Tower or the Las Bovedas, just two of the historical sites here. When it comes to bygone times, the stories are countless. The University of Cartagena and Jardines de Paz are also great places to check out.
San Fernando Fort and Fuerte Pastelillo are old fortifications which stand as testament to Cartagena's military history. The age-old walls of Fuerte de San Sebastián del Pastelillo also have plenty of stories to tell.
Inquisition Palace is an impressive time capsule, boasting some of the best architecture and design in the region.
The region's spiritual side can be experienced at San Pedro Claver Church and Convent and San Francisco Church. If you'd like to explore some more religious sites, check for tours at Cartagena Cathedral and Santo Domingo Church and Monastery.
Whether you are traveling through Cartagena for work or for pleasure, you're not going to regret stopping by the Ciudad Movil Cultural Center or the Fine Arts.
Located in Bocagrande, this spa hotel is within 1 mile (2 km) of Hospital Naval de Cartagena and San Pedro Claver Church and Convent. Puerta del Reloj and San Felipe de Barajas Castle are also within 2 miles (3 km).
This family-friendly Cartagena resort is located on the waterfront, within a 10-minute walk of House of Gabriel Garcia Marquez and Puerta del Reloj. San Felipe de Barajas Castle and San Pedro Claver Church and Convent are also within 1 mile (2 km).
Located in Cartagena Walled City, this hotel is within a 10-minute walk of Santo Toribio Church, Puerta del Reloj and San Pedro Claver Church and Convent. San Felipe de Barajas Castle is 1 mi (1.6 km) away.
Located in La Boquilla, this hotel is 0.3 mi (0.4 km) from La Boquilla Beach and within 6 miles (10 km) of Puerta del Reloj and San Felipe de Barajas Castle. San Pedro Claver Church and Convent and Marbella Beach are also within 6 miles (10 km).
Nestled on the beach, this El Laguito resort is within 1 mi (2 km) of Rio Cartagena Casino, Bocagrande Beach and Castillo Grande Beach. Hospital Naval de Cartagena and Plaza Santo Domingo are also within 3 miles (5 km).
Located in Bocagrande, this beachfront hotel is connected to a shopping centre and within 3 mi (5 km) of Bocagrande Beach, Puerta del Reloj and San Felipe de Barajas Castle. San Pedro Claver Church and Convent is 2 mi (3.2 km) away.
Located in Bocagrande, this hotel is within 1 mi (2 km) of Hospital Naval de Cartagena and San Pedro Claver Church and Convent. Puerta del Reloj and San Felipe de Barajas Castle are also within 2 miles (3 km).
Situated on the beach, this hotel is within 2 miles (3 km) of Rafael Nunez Museum and House, San Felipe de Barajas Castle and Puerta del Reloj. San Pedro Claver Church and Convent is 1.8 mi (2.8 km) away.