Title: The 10 Best 5 Star Hotels in Vendicari Natural Reserve - 2026 Updated Prices | Expedia.co.uk [Vendicari Natural Reserve Travel Guide](https://expedia.co.uk/Vendicari-Natural-Reserve.dx6182494)[Hotels in Vendicari Natural Reserve](https://expedia.co.uk/Vendicari-Natural-Reserve-Hotels.d6182494.Travel-Guide-Hotels)[Holiday Rentals in Vendicari Natural Reserve](https://expedia.co.uk/Vendicari-Natural-Reserve-Holiday-Rentals.d6182494.Travel-Guide-HolidayRentals)[Flights to Vendicari Natural Reserve](https://expedia.co.uk/Cheap-Flights-To-Vendicari-Natural-Reserve.d6182494.Travel-Guide-Flights)[Vendicari Natural Reserve Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Vendicari-Natural-Reserve.d6182494.Car-Hire-Guide)[Vendicari Natural Reserve Holidays](https://expedia.co.uk/Vendicari-Natural-Reserve.d6182494.Holidays-City-Breaks) ![Spiaggia di Cala Mosche. One of the many slightly hidden beaches of south-eastern Sicily](https://images.trvl-media.com/place/6034839/b859b779-e22e-4f36-91ce-29a600d3857b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Matthew Thode # Compare and book 5 Star hotels in Vendicari Natural Reserve, Sicily - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Vendicari Natural Reserve 5 Star Hotels Tonight [20 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6182494&startDate=2025-12-20&endDate=2025-12-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [21 Dec - 22 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6182494&startDate=2025-12-21&endDate=2025-12-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6182494&startDate=2025-12-26&endDate=2025-12-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [2 Jan - 4 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6182494&startDate=2026-01-02&endDate=2026-01-04&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Vendicari Natural Reserve 5-star hotels ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/ac752df8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/f86f7ffa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/b126abef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Private beach nearby, black sand, beach shuttle, sun-loungers](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/400d9c2e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Ortigia Siracusa [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information) Ortigia 9.0/10 Wonderful (571) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Liza £167 includes taxes & fees 9 Jan - 10 Jan 2026 [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information) ![Rooftop terrace](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/83105a89.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Room | Minibar, in-room safe, individually decorated, individually furnished](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/2f1018dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Room, City View | Minibar, in-room safe, individually decorated, individually furnished](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/e1667130.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/f2d141d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Caportigia Boutique Hotel [](https://www.expedia.co.uk/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information) Santa Lucia 9.4/10 Exceptional (257) "Fine quality hotel with exceptional service. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Peter £108 includes taxes & fees 7 Jan - 8 Jan 2026 [](https://www.expedia.co.uk/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information) ![Seasonal outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/cbf3a060.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Building design](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/3abb85fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/20f9f2e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Mediterranean cuisine](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/d1e57884.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Hotel Des Ètrangers - The Leading Hotels of the World [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information) Ortigia 9.6/10 Exceptional (73) "Great hotel and saff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Galina [](https://www.expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/d439594a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Villa, 2 Bedrooms, Sea View (The Suitest) | Bathroom | Shower, rainfall showerhead, designer toiletries, hair dryer](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/efec5cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/7a080071.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor treatment area](https://images.trvl-media.com/lodging/3000000/2830000/2822400/2822343/a7549475.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Minareto [](https://www.expedia.co.uk/Syracuse-Hotels-Minareto.h2822343.Hotel-Information) Syracuse 8.8/10 Excellent (267) "Winderfull views but the staff isn’t so supportive!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose [](https://www.expedia.co.uk/Syracuse-Hotels-Minareto.h2822343.Hotel-Information) ![Sun deck](https://images.trvl-media.com/lodging/54000000/53700000/53695400/53695363/a0ffb83b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/54000000/53700000/53695400/53695363/72a9add3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Royal Suite, Hill View | Frette Italian sheets, premium bedding, down duvets, memory-foam beds](https://images.trvl-media.com/lodging/54000000/53700000/53695400/53695363/152ce9d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, dinner served; Italian cuisine, garden views ](https://images.trvl-media.com/lodging/54000000/53700000/53695400/53695363/b692a35d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Il San Corrado di Noto Luxury Resort [](https://www.expedia.co.uk/Noto-Hotels-Il-San-Corrado-Di-Noto-Luxury-Resort.h53695363.Hotel-Information) Noto 10/10 Exceptional (13) "A magnificent hotel. Absolutely beautiful and the staff is amazing! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Theresa [](https://www.expedia.co.uk/Noto-Hotels-Il-San-Corrado-Di-Noto-Luxury-Resort.h53695363.Hotel-Information) ![Sauna, hot tub, Turkish bath/hammam, body treatments, body scrubs](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/77a257e8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lunch, dinner, brunch served; Mediterranean cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/d3acb40a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/w5000h3331x0y3-d0f008d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/ea5bf622.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Dimora Caiammari Luxury Hotel & Spa [](https://www.expedia.co.uk/Syracuse-Hotels-Caiammari-Boutique-Hotel-Spa.h915406.Hotel-Information) Syracuse 9.2/10 Wonderful (210) "We experienced outstanding service from all of the staff, the breakfast buffet was lovely, lots of options and all homemade. We had a fantastic dinner in the restaurant one evening, which we booked ahead of our trip. " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) David [](https://www.expedia.co.uk/Syracuse-Hotels-Caiammari-Boutique-Hotel-Spa.h915406.Hotel-Information) ![Sports facility](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/7df225fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Beach nearby, free beach shuttle, beach umbrellas, beach towels](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/51043145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/62771193.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), sauna, hot tub, steam room](https://images.trvl-media.com/lodging/10000000/9390000/9388900/9388897/93cb206e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wellness & Spa Hotel Principe di Fitalia [](https://www.expedia.co.uk/Syracuse-Hotels-Wellness-Spa-Hotel-Principe-Di-Fitalia.h9388897.Hotel-Information) Syracuse 9.6/10 Exceptional (94) "This was such a wonderful stay! Spotless beautiful property with friendly staff and delicious breakfast!!! Very impressed!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeffrey [](https://www.expedia.co.uk/Syracuse-Hotels-Wellness-Spa-Hotel-Principe-Di-Fitalia.h9388897.Hotel-Information) ![Superior Double Room | 1 bedroom, premium bedding, down duvets, memory-foam beds](https://images.trvl-media.com/lodging/33000000/32470000/32463000/32462999/25aa3395.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Design Suite, Sea View | Terrace/patio](https://images.trvl-media.com/lodging/33000000/32470000/32463000/32462999/d591919f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/33000000/32470000/32463000/32462999/80b588bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/33000000/32470000/32463000/32462999/167c5e64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country House Villadorata [](https://www.expedia.co.uk/Noto-Hotels-Country-House-Villadorata.h32462999.Hotel-Information) Noto 9.6/10 Exceptional (14) "The property is well kept. Quiet and it is kept clean. However, there is lightning missing outside and especially in the room ( bathroom) way too dark. " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Giuseppina [](https://www.expedia.co.uk/Noto-Hotels-Country-House-Villadorata.h32462999.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Vendicari-Natural-Reserve-Hotels.s50-0-d6182494.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Vendicari-Natural-Reserve-Hotels.s50-0-d6182494.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Vendicari Natural Reserve. ![Algila' Ortigia Charme Hotel](https://images.trvl-media.com/lodging/2000000/1890000/1883500/1883438/d402c8e9_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Algila' Ortigia Charme Hotel Via Vittorio Veneto 93 Syracuse SR £162 21 Dec - 22 Dec includes taxes & fees 9.4/10 Exceptional! (901 reviews) [](https://expedia.co.uk/Syracuse-Hotels-Algila-Ortigia-Charme-Hotel.h1883438.Hotel-Information) ![Eureka Palace Hotel Spa Resort](https://images.trvl-media.com/lodging/4000000/3820000/3814900/3814820/af67d93f_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Eureka Palace Hotel Spa Resort Strada Spinagallo 50 Syracuse SR [Get rates](https://expedia.co.uk/Hotel-Search?startDate=03%2F01%2F2026&endDate=04%2F01%2F2026&selected=3814820&PinnedHotelID=3814820&HadPinnedHotel=true®ionId=6182494) 8/10 Very Good! (316 reviews) [](https://expedia.co.uk/Syracuse-Hotels-Eureka-Palace-Hotel-Spa-Resort.h3814820.Hotel-Information) ![Palazzo Artemide - VRetreats](https://images.trvl-media.com/lodging/1000000/980000/974100/974007/5db9500b_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Palazzo Artemide - VRetreats Via Roma 66 Syracuse SR £174 21 Dec - 22 Dec includes taxes & fees 9.4/10 Exceptional! (652 reviews) [](https://expedia.co.uk/Syracuse-Hotels-Palazzo-Artemide-VRetreats.h974007.Hotel-Information) Still don't see what you're looking for? [See all properties in Vendicari Natural Reserve.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F12%2F2025&endDate=22%2F12%2F2025®ionId=6182494&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F12%2F2025&endDate=22%2F12%2F2025®ionId=6182494&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F12%2F2025&endDate=22%2F12%2F2025®ionId=6182494&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F12%2F2025&endDate=22%2F12%2F2025®ionId=6182494&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F12%2F2025&endDate=22%2F12%2F2025®ionId=6182494&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F12%2F2025&endDate=22%2F12%2F2025®ionId=6182494&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Vendicari Natural Reserve Check out the local area in Vendicari Natural Reserve—home to attractions like Vendicari Beach and Calamosche Beach. [See all hotels in Vendicari Natural Reserve](https://www.expedia.co.uk/Hotel-Search?startDate=2026-01-03&endDate=2026-01-04&adults=2®ionId=6182494) ![Spiaggia di Cala Mosche. One of the many slightly hidden beaches of south-eastern Sicily](https://images.trvl-media.com/place/6034839/b859b779-e22e-4f36-91ce-29a600d3857b.jpg?impolicy=fcrop&w=400&h=400&p=1&q=high) Photo by Matthew Thode ## Top Vendicari Natural Reserve Hotel Reviews ![Grand Hotel Ortigia Siracusa](https://images.trvl-media.com/lodging/2000000/1330000/1329500/1329454/206c3f7f_y.jpg) ### Grand Hotel Ortigia Siracusa 10/10 Excellent "breakfast was good" [](https://expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Ortigia-Siracusa.h1329454.Hotel-Information) ![Caportigia Boutique Hotel](https://images.trvl-media.com/lodging/18000000/17520000/17519100/17519019/f4662c00_y.jpg) ### Caportigia Boutique Hotel 10/10 Excellent "Fine quality hotel with exceptional service. " [](https://expedia.co.uk/Syracuse-Hotels-Caportigia-Boutique-Hotel.h17519019.Hotel-Information) ![Grand Hotel Des Ètrangers - The Leading Hotels of the World](https://images.trvl-media.com/lodging/1000000/980000/976400/976389/c9e03ff2_y.jpg) ### Grand Hotel Des Ètrangers - The Leading Hotels of the World 10/10 Excellent "Great hotel and saff" [](https://expedia.co.uk/Syracuse-Hotels-Grand-Hotel-Des-Etrangers.h976389.Hotel-Information) ![Dimora Caiammari Luxury Hotel & Spa](https://images.trvl-media.com/lodging/1000000/920000/915500/915406/15eadb11_y.jpg) ### Dimora Caiammari Luxury Hotel & Spa 10/10 Excellent "Warm, lovely " [](https://expedia.co.uk/Syracuse-Hotels-Caiammari-Boutique-Hotel-Spa.h915406.Hotel-Information) ## Find out more about Vendicari Natural Reserve ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - [3 Star Hotels in Chiaramonte Gulfi ](https://www.expedia.co.uk/3Star-Chiaramonte-Gulfi-Hotels.s30-0-d602207.Travel-Guide-Filter-Hotels) - 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