A bench, a bicycle, and a lake surrounded by trees.

Compare and book 4 Star hotels in Upstate South Carolina, South Carolina

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Check availability on Upstate South Carolina 4 Star Hotels

Tonight
22 Sept - 23 Sept
Tomorrow
23 Sept - 24 Sept
This weekend
25 Sept - 27 Sept
Next weekend
2 Oct - 4 Oct

Our top choices for Upstate South Carolina 4-star hotels

A restaurant with a bar area, green upholstered seating, and a view of trees through large windows.
A modern hotel lobby with a chandelier, wooden shelving, a reception desk, and a view of the outdoors.
A large, two-story house with a symmetrical facade, large windows, and a central entrance.
A bar with multiple shelves of liquor bottles and glasses hanging above.

1. Hotel Hartness

Hotel Hartness
Greenville
United States
Cornelius
£154
includes taxes & fees
4 Oct - 5 Oct
Hotel Hartness
A large, multi-story house with a prominent waterfall in the foreground, surrounded by lush greenery.
A modern interior with a fireplace, plush seating, and a stone accent wall.
An outdoor dining area with multiple tables and chairs, large windows, and a view of greenery.
A modern interior with a stone fireplace, leather sofas, and a wooden ceiling.

2. Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection
Greenville Downtown
United States
David
£330
includes taxes & fees
27 Sept - 28 Sept
Grand Bohemian Lodge Greenville, Autograph Collection
A hotel facade with arched windows, a fountain, and a sign for "The Westin."
A banquet hall with round tables, chandeliers, and ornate windows.
A lobby with patterned flooring, a grand staircase, and elegant furniture.

3. The Westin Poinsett Greenville

The Westin Poinsett Greenville
Greenville Downtown
United States
Karen
£154
includes taxes & fees
18 Oct - 19 Oct
The Westin Poinsett Greenville
A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.
A bedroom with a bed, bedside tables, a ceiling fan, and two windows with blinds.
A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.
A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.

4. Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa
Greenville Downtown
United States
Gregory
£89
includes taxes & fees
29 Sept - 30 Sept
Mint House Greenville Downtown by Kasa
A bar area with multiple hanging decorative lights, a counter with bar stools, and a seating area with chairs.
A spacious indoor venue with rows of white chairs adorned with purple sashes, large windows, and a modern ceiling design.
A banquet hall with round tables set for dining, large windows, and a stage with curtains.
A modern building with a large illuminated logo reading "TOPGOLF" on the facade.

5. Greenville Marriott

Greenville Marriott
Greenville
United States
John
£103
includes taxes & fees
4 Oct - 5 Oct
Greenville Marriott
A multi-level interior with a spiral staircase, wooden railings, and a seating area with tables and chairs.
A spacious restaurant with high ceilings, wooden flooring, and a mix of modern and classic furniture.
A spacious living area with a sofa, ottoman, and chairs, a dining area with a table, and a kitchen in the background.
An outdoor patio with wicker furniture, a round table, and a fountain.

6. The Shepherd Hotel Downtown Clemson

The Shepherd Hotel Downtown Clemson
Clemson
United States
Laurrie
£194
includes taxes & fees
28 Sept - 29 Sept
The Shepherd Hotel Downtown Clemson
A modern lounge area with a brick accent wall, a fireplace, and comfortable seating.
A multi-story hotel with a prominent entrance, a parking lot, and a landscaped area with a small tree.
A hotel room with a bed, a sofa, a dining table with chairs, a coffee machine, and a TV mounted on the wall.
A bar area with a counter, multiple chairs, and a display of bottles and glasses.

7. The Abernathy of Clemson

The Abernathy of Clemson
Clemson
United States
Robert
£122
includes taxes & fees
11 Oct - 12 Oct
The Abernathy of Clemson
A modern building with outdoor seating and a garden.
A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.
A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.
A row of modern, two-story buildings with a covered patio area.

8. The Station by Compo Hotels

The Station by Compo Hotels
Travelers Rest
United States
Anonymous traveller
£243
includes taxes & fees
23 Sept - 24 Sept
The Station by Compo Hotels
A two-story house with a tiled roof, a stone fire pit, and outdoor seating.
A spacious room with wooden beams, a large chandelier, and a cozy seating area with orange chairs and a white sofa.
A swimming pool with lounge chairs and a building with balconies.
A bar with a large window view of mountains and a chandelier.

9. Hotel Domestique

Hotel Domestique
Travelers Rest
United States
Chuck
£345
includes taxes & fees
24 Sept - 25 Sept
Hotel Domestique
A spacious living room with a stone fireplace, wooden beams, and a chandelier.
A modern kitchen with dark wood cabinets, a black refrigerator, a microwave, and a stainless steel sink. There are two bar stools at the island, and a flat-screen TV mounted on the wall.
A modern kitchen with white cabinetry, dark blue walls, and a patterned floor.
A modern kitchen with dark cabinetry, a stainless steel range, and a granite countertop.

10. Landing Apartments Greer - Sugar Creek

Landing Apartments Greer - Sugar Creek
Greer
United States
Amanda
Landing Apartments Greer - Sugar Creek
A wooden gazebo with a roof and a table and chairs inside, surrounded by trees and overlooking a lake.
A spacious hotel lobby with a bar area, seating arrangements, and large windows offering views.
A modern living room with a sofa, a coffee table, and a fireplace.
A modern kitchen with a stainless steel sink, pendant lighting, and a view to a living area with a sofa and a staircase.

11. Tee Times & Lake Days! Luxe Keowee Key Living

Tee Times & Lake Days! Luxe Keowee Key Living
Salem
Tee Times & Lake Days! Luxe Keowee Key Living
A wooden gazebo with a roof, surrounded by trees, overlooking a lake.
A cozy living room with a fireplace, leather armchair, and a large window.
A spacious living area with a high ceiling, wooden beams, a grey sofa, a brown leather chair, and a dining table with a plant.
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.

12. Designer Retreat w/ Pool, Golf + Beach Access!

Designer Retreat w/ Pool, Golf + Beach Access!
Salem
United States
Anonymous traveller
Designer Retreat w/ Pool, Golf + Beach Access!
A lakeside property with a marina, multiple buildings, and surrounding greenery.
A lakeside property with a dock and boats, surrounded by dense forest and a clear view of the lake.

13. Wooded Keowee Key Retreat Near Golf & Trails

Wooded Keowee Key Retreat Near Golf & Trails
Salem
Wooded Keowee Key Retreat Near Golf & Trails
A bedroom with a bed, a chair, and a potted aloe plant on a table.
A multi-story building with a symmetrical facade, large windows, and two flags on top.
A modern living room with a flat-screen TV, two leather chairs, a wooden dining table, and a potted plant.
A modern kitchen with stainless steel appliances, a dining area with a table and chairs, and a TV mounted on a wooden cabinet.

14. Landing Furnished Apartments - Spartanburg, SC

Landing Furnished Apartments - Spartanburg, SC
Spartanburg
Landing Furnished Apartments - Spartanburg, SC
A modern kitchen with a central island, stainless steel appliances, and pendant lighting.
A modern kitchen with white cabinets, stainless steel appliances, and a central island with bar stools.
A modern kitchen with white cabinets, a stainless steel refrigerator, and pendant lighting.
A two-story house with a front porch, a garage, and a small front yard with landscaping.

15. Steps to Lake Greenwood: Waterfront Gem w/ Patio

Steps to Lake Greenwood: Waterfront Gem w/ Patio
Greenwood
United States
Luetrina
Steps to Lake Greenwood: Waterfront Gem w/ Patio
A hallway with a wooden bench, a chandelier, a door, and a wall with a sign.
A multi-story hotel with a parking lot and a view of a lake.
A kitchen with white cabinets, a stainless steel refrigerator, a microwave, and a sink.

16. Lake Keowee Condo w/ Balcony & Resort Amenities!

Lake Keowee Condo w/ Balcony & Resort Amenities!
Salem
Lake Keowee Condo w/ Balcony & Resort Amenities!
A swimming pool with a view of the lake and docked boats.
A spacious living area with a high ceiling, a large window with a view of trees, a kitchen with a bar, and a comfortable seating area with a sofa and ottomans.
A modern living room with a large window, a flat-screen TV, a leather sofa, a coffee table, and a bookshelf.
A marina with boats docked, surrounded by greenery and trees.

17. Keowee Key Condo w/ Lake Access & Community Pools!

Keowee Key Condo w/ Lake Access & Community Pools!
Salem
Keowee Key Condo w/ Lake Access & Community Pools!
A marina with boats docked, a lifeguard station, and a dock with lounge chairs.
A spacious dining area with a wooden table, chairs, and a chandelier. A cozy seating area with a sofa and chairs is visible in the background.
A multi-story hotel with a parking lot and a view of a lake.
A sandy beach with a calm lake surrounded by trees.

18. Lake Keowee Condo: Resort Pools & Lake Access!

Lake Keowee Condo: Resort Pools & Lake Access!
Salem
Lake Keowee Condo: Resort Pools & Lake Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A swimming pool with a view of a lake and docked boats.
A dining area with a wooden table and chairs, a kitchen with white cabinets, and a staircase with a white railing.
A spacious living room with a fireplace, a television, and a staircase leading to an upper level.

19. Salem Vacation Rental w/ Lake Keowee Access!

Salem Vacation Rental w/ Lake Keowee Access!
Salem
Salem Vacation Rental w/ Lake Keowee Access!
A gazebo with a wooden roof and open sides, surrounded by trees and overlooking a body of water.
A large indoor swimming pool with clear lanes, a covered roof, and seating areas along the sides.
A sandy beach with a calm lake surrounded by trees.
An aerial view of a residential area with houses, a golf course, and a lake in the background.

20. Views, Pools & Marina: Lake Keowee Condo!

Views, Pools & Marina: Lake Keowee Condo!
Salem
Views, Pools & Marina: Lake Keowee Condo!
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Learn more about Upstate South Carolina

Check out the local area in Upstate South Carolina—home to attractions like Heritage Park and CCNB Amphitheatre.

See all hotels in Upstate South Carolina
A multi-tiered waterfall cascading over rocks in a forested area.
Photo by Ryan Watts

Top Upstate South Carolina Hotel Reviews

Mint House Greenville Downtown by Kasa

Mint House Greenville Downtown by Kasa

8/10 Good
"Nice spacious room. Only complaints were elevator sounds and a mysterious banging for 45 minutes that started around 4 am. However, I never sleep well the first night in a strange room. Great location!"
Daniel 1-night trip
Posted less than an hour ago
Mint House Greenville Downtown by Kasa
Grand Bohemian Lodge Greenville, Autograph Collection

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent
"Beautiful hotel with all the amenities! Large rooms and bathrooms, great coffee maker and steamer for clothes. Beautiful views outside of restaurant. Will definitely return!"
Eric 2-night trip
Posted 9 hours ago
Grand Bohemian Lodge Greenville, Autograph Collection

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