Title: The 10 Best 4 Star Hotels in Upstate South Carolina - 2026 Updated Prices | Expedia.co.uk [Upstate South Carolina Travel Guide](https://expedia.co.uk/Upstate-South-Carolina.dx553248635975748552)[Hotels in Upstate South Carolina](https://expedia.co.uk/Upstate-South-Carolina-Hotels.d553248635975748552.Travel-Guide-Hotels)[Holiday Rentals in Upstate South Carolina](https://expedia.co.uk/Upstate-South-Carolina-Holiday-Rentals.d553248635975748552.Travel-Guide-HolidayRentals)[Flights to Upstate South Carolina](https://expedia.co.uk/Cheap-Flights-To-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Flights)[Things to do in Upstate South Carolina](https://expedia.co.uk/Things-To-Do-In-Upstate-South-Carolina.d553248635975748552.Travel-Guide-Activities)[Upstate South Carolina Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Upstate-South-Carolina.d553248635975748552.Car-Hire-Guide)[Upstate South Carolina Holidays](https://expedia.co.uk/Upstate-South-Carolina.d553248635975748552.Holidays-City-Breaks) ![It is only a 1 mile hike to this beauty. View a video about it here: https://www.hdcarolina.com/episode/riley-moore-falls #Waterfall](https://images.trvl-media.com/place/6122927/69b8ebaa-53a3-428e-ba53-37ac2de11862.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Ryan Watts # Compare and book 4 Star hotels in Upstate South Carolina, South Carolina - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Upstate South Carolina 4 Star Hotels Tonight [2 Dec - 3 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748552&startDate=2025-12-02&endDate=2025-12-03&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [3 Dec - 4 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748552&startDate=2025-12-03&endDate=2025-12-04&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748552&startDate=2025-12-05&endDate=2025-12-07&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [12 Dec - 14 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975748552&startDate=2025-12-12&endDate=2025-12-14&adults=2&star=40&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Upstate South Carolina 4 Star Hotels ![Lobby](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/924dd6ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Spa](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/0671c5e9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/dd539dcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Grand Bohemian Lodge Greenville, Autograph Collection Greenville Downtown 9.6/10 Exceptional (411) "The staff were really sweet and responsive. The views from the rooms are breathtaking! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Krystal £232 includes taxes & fees 18 Dec - 19 Dec [](https://www.expedia.co.uk/Greenville-Hotels-Grand-Bohemian-Lodge-Greenville.h71762652.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/580000/576000/575983/3e47bf88.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/580000/576000/575983/02c3589b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/580000/576000/575983/e5bdee00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/580000/576000/575983/93cc35df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Westin Poinsett Greenville Greenville Downtown 9.2/10 Wonderful (1003) "Room was much smaller than other Westin's but great location and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aanal £113 includes taxes & fees 22 Dec - 23 Dec [](https://www.expedia.co.uk/Greenville-Hotels-The-Westin-Poinsett-Greenville.h575983.Hotel-Information) ![In-room safe, blackout curtains, soundproofing, iron/ironing board](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/8f34da45.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/ee0e0eea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/0a5500d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/88000000/87690000/87688200/87688155/0de8634b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Shepherd Hotel Downtown Clemson Clemson 9.8/10 Exceptional (736) "Wonderful staff, great location" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shelly £140 includes taxes & fees 27 Dec - 28 Dec [](https://www.expedia.co.uk/Clemson-Hotels-The-Shepherd-Hotel-Downtown-Clemson.h87688155.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/7f5c10e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/6b940d91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/d2844575.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior detail](https://images.trvl-media.com/lodging/90000000/89690000/89689300/89689223/32050804.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Hartness Greenville 9.8/10 Exceptional (623) "Beautiful location, friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew £159 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Greenville-Hotels-Hotel-Hartness.h89689223.Hotel-Information) ![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/17500/17483/9b7f0f8f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/20000/17500/17483/6ae08031.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/17500/17483/11616a20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/17500/17483/d99800f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Greenville Marriott Greenville 8.6/10 Excellent (606) "we enjoyed the bar" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elizabeth £77 includes taxes & fees 20 Dec - 21 Dec [](https://www.expedia.co.uk/Greenville-Hotels-Greenville-Marriott.h17483.Hotel-Information) ![Two Bedroom Suite | Laptop workspace, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/a4b477d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Two Bedroom Suite | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/f7ce884a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/a1a743d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Three Bedroom Suite | Private kitchen | Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/39000000/38600000/38593300/38593248/6315cb3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Mint House Greenville - Downtown Greenville Downtown 9.2/10 Wonderful (771) "Excellent stay as always! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Elena £92 includes taxes & fees 24 Dec - 25 Dec [](https://www.expedia.co.uk/Greenville-Spartanburg-Hotels-Mint-House-Downtown-Greenville.h38593248.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/56d69457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/e914f3bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/cbe6a617.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Custom King Full | In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/18000000/17230000/17229400/17229377/179daec9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Abernathy of Clemson Clemson 9.6/10 Exceptional (555) "location is amazing! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) colleen [](https://www.expedia.co.uk/Anderson-Hotels-The-Abernathy-Of-Clemson.h17229377.Hotel-Information) ![Apartment, 2 Bedrooms | Living area | 40-inch TV with digital channels](https://images.trvl-media.com/lodging/112000000/111140000/111130300/111130227/39a13760.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 3 Bedrooms | Individually decorated, individually furnished, iron/ironing board](https://images.trvl-media.com/lodging/112000000/111140000/111130300/111130227/7d816d56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 1 Bedroom | Private kitchen | Full-sized fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/112000000/111140000/111130300/111130227/6a920723.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Apartment, 3 Bedrooms | Living area | 40-inch TV with digital channels](https://images.trvl-media.com/lodging/112000000/111140000/111130300/111130227/689c7682.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Place Apartments by Landing Greenville 7.6/10 Good (41) "Great place for a different experience Enjoyed the train " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Edward [](https://www.expedia.co.uk/Greenville-Hotels-Barsala-At-The-American-Spinning-Mill-Apartments.h111130227.Hotel-Information) ![Trailside Wedge Cottage | Terrace/patio](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/346fcb37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![ADA Vista Wedge Cottage | 1 bedroom, down duvets, individually decorated, individually furnished](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/38cc695c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/2f99255c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Trailside Wedge Cottage | Living area | Smart TV](https://images.trvl-media.com/lodging/89000000/88370000/88362000/88361952/f19cdb36.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Station by Compo Hotels Travelers Rest 10/10 Exceptional (15) "great place perfect for more privacy vs. a standard hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John £225 includes taxes & fees 11 Dec - 12 Dec [](https://www.expedia.co.uk/Travelers-Rest-Hotels-The-Station-By-Compo-Hotels.h88361952.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/1f0407e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/53680281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fountain](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/24c29149.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/10000000/9710000/9704700/9704647/4694c80e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Domestique Travelers Rest 9.6/10 Exceptional (30) "Overall it was an exceptional experience and would highly recommend to anyone looking for a quiet get away." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Chuck £270 includes taxes & fees 1 Jan - 2 Jan 2026 [](https://www.expedia.co.uk/Travelers-Rest-Hotels-Hotel-Domestique.h9704647.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/286fc023.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/7b9d65c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/a75f160d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Luxury Single Room | Premium bedding, memory-foam beds, individually decorated](https://images.trvl-media.com/lodging/84000000/83030000/83025300/83025265/8c83b96e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Liberty Hall Bed and Breakfast Pendleton 10/10 Exceptional (76) "The owners are amazing. Comfy rooms, stellar breakfast and good people. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Renee £132 includes taxes & fees 20 Dec - 21 Dec [](https://www.expedia.co.uk/Pendleton-Hotels-Liberty-Hall-Bed-And-Breakfast.h83025265.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Upstate-South-Carolina-Hotels.s40-0-d553248635975748552.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F4Star-Upstate-South-Carolina-Hotels.s40-0-d553248635975748552.Travel-Guide-Filter-Hotels) ## Learn more about Upstate South Carolina Check out the local area in Upstate South Carolina—home to attractions like Discovery Island Water Park and Heritage Park. [See all hotels in Upstate South Carolina](https://www.expedia.co.uk/Hotel-Search?startDate=2025-12-17&endDate=2025-12-18&adults=2®ionId=553248635975748552) ![It is only a 1 mile hike to this beauty. View a video about it here: https://www.hdcarolina.com/episode/riley-moore-falls #Waterfall](https://images.trvl-media.com/place/6122927/69b8ebaa-53a3-428e-ba53-37ac2de11862.jpg?impolicy=fcrop&w=900&h=600&p=1&q=high) Photo by Ryan Watts ## Top Upstate South Carolina Hotel Reviews ![Grand Bohemian Lodge Greenville, Autograph Collection](https://images.trvl-media.com/lodging/72000000/71770000/71762700/71762652/6a375dd3_y.jpg) ### Grand Bohemian Lodge Greenville, Autograph Collection 10/10 Excellent "Loved the location, attention to design details in all spaces, complimentary cocktails and delicious lunch in hotel restaurant. Really used the swamp rabbit trail right outside…" [](https://expedia.co.uk/Greenville-Hotels-Grand-Bohemian-Lodge-Greenville.h71762652.Hotel-Information) ## Find out more about Upstate South Carolina ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [1 Star Hotels in South Carolina Midlands](https://www.expedia.co.uk/1Star-South-Carolina-Midlands-Hotels.s10-0-d6057938.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Greenville - Spartanburg](https://www.expedia.co.uk/3Star-Greenville-Spartanburg-Hotels.s30-0-d6035267.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Greenville](https://www.expedia.co.uk/4Star-Greenville-Hotels.s40-0-d1388.Travel-Guide-Filter-Hotels) - [4 Star Hotels in South Carolina Midlands](https://www.expedia.co.uk/4Star-South-Carolina-Midlands-Hotels.s40-0-d6057938.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Columbia](https://www.expedia.co.uk/5Star-Columbia-Hotels.s50-0-d764.Travel-Guide-Filter-Hotels) - 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