Compare and book 4 Star hotels in Lower Keys, Florida

    price find illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Lower Keys 4 Star Hotels

Top Lower Keys 4 Star Hotels

3-bedroom house in Lower Keys with Hot Tub, Sleeps 10+, Pet Freindly
Outdoor spa tub

3-bedroom house in Lower Keys with Hot Tub, Sleeps 10+, Pet Freindly

4.0 star property
3-bedroom house in Lower Keys with Hot Tub, Sleeps 10+, Pet Freindly
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Lower Keys

Experience the relaxing area of Lower Keys—bars, boating and sights from Florida Keys Beaches to Sugarloaf Beach.

See all hotels in Lower Keys
Big Pine Key showing a bay or harbour, a coastal town and general coastal views

Top Lower Keys Hotel Reviews

Frequently asked questions

What are the best 4-star hotels in Lower Keys?
Little Palm Island Resort & Spa - A Noble House Resort is highly recommended by many Expedia customers. Situated in Summerland Key, Lower Keys, this 4-star hotel features loads of amenities to help make your stay more comfortable.
How much does it cost to stay in a 4-star hotel in Lower Keys?
With Expedia's sort and search filters, locking in a superb deal on a 4-star hotel in Lower Keys just got easier. Start by entering your chosen arrival date and length of your break. Then sort the results by price and pick a hotel that best matches your style and budget.

  • Search for the lowest price

What's the difference between 5-star and 4-star hotels in Lower Keys?
Give yourself the luxury treatment during your Lower Keys holiday by checking in to a 4-star hotel. As well as featuring upmarket accommodation, these properties are typically packed with amenities like complimentary bathrobes, large beds and plenty more. A 5-star hotel will go above and beyond to make your stay an even more indulgent and special one. Concierge assistance, elegant décor and gourmet dining are only the start of the superior conveniences and services you'll likely have access to.