
South Region Luxury Holidays
Book a Luxury Hotel + Flight or Car together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to £335 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPackages with flights are ATOL protected
Top flight + Luxury hotel deals in South Region


Gran Melia Iguazú
Reviewed on 20 Mar 2026

Loi Suites Iguazú Hotel
Reviewed on 24 Mar 2026

Iguazu Grand Resort Spa & Casino
Reviewed on 27 Mar 2026

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Reviewed on 6 Apr 2026
5* Luxury holidays in South Region

Iguazu Grand Resort Spa & Casino
Reviewed on 27 Mar 2026

Gran Melia Iguazú
Reviewed on 20 Mar 2026

Loi Suites Iguazú Hotel
Reviewed on 24 Mar 2026
All you need to know about luxury holidays in South Region
What can I expect from a luxury South Region holiday?
Luxury on holiday is all about relaxing and feeling good. Whether you choose a sumptuous spa, Michelin-starred restaurant or super-king bed is your call. Use our amenities filters to find the things that tick all your boxes.
How can I find all-inclusive luxury holidays in South Region?
Tick the all-inclusive and 5-star filters to find the crème de la crème of South Region holidays. With everything included in the package price, you can drink and dine to your heart’s content, without worrying about that bill at the end.
Can I book a cheap luxury holiday to South Region?
A luxury holiday doesn’t have to break the bank. Travel out of peak season, choose a hotel or resort a little way out or go for a last-minute getaway and you’ll find some cracking deals. Sort by price to find luxury holidays to South Region starting at £988. Prices and availability are subject to change. Additional terms may apply.
Are there luxury spa holidays in South Region?
For sunset massages on the shoreline and view-filled saunas, use our spa filter to find your ideal South Region spa hotel. Book a whole weekend soaking away your stresses, or hop into the spa after the beach, some golf or a local advent-ahhhh.
What should I look for when booking a luxury family holiday in South Region?
Luxury isn’t just for adults. Those little touches designed for little people make a family holiday genuinely stress free … which is the greatest luxury of all. Look for spacious suites, pools toddlers can splash in, and breakfast buffets with waffles, pancakes and Nutella galore.
Can I book luxury last-minute holidays to South Region?
You can wangle a top-notch luxury holiday in South Region for a fraction of the normal price by booking last minute. Just enter your dates and see what’s available – if you’re flexible ... even better!
Can I book a luxury holiday in South Region with free cancellation and/or flexible dates?
If you’re splashing out on a luxury holiday, make sure your money is safe by booking with free cancellation. Just use the fully refundable filter and make sure you read all the terms and conditions.
Why should I book my luxury travel to South Region with Expedia?
Nobody does luxury quite like Expedia. With so many gorgeous properties in South Region to choose from, as well as access to first-class flight deals and hire cars with horsepower, there’s no better place to book.
Top Luxury South Region Hotels

Hotel das Cataratas, A Belmond Hotel, Iguassu Falls
Great service. Nice room and perfect location
Reviewed on 6 Apr 2026

Iguazu Grand Resort Spa & Casino
O hotel tem ótimas instalações e o atendimento da recepção é muito bom,a área de lazer e de apoio também é muito boa. Mas quanto a parte para a gastronomia deixa muito à desejar com lanches fracos,o restaurante pouco contribue nos obrigando a buscar outras opções fora do hotel e o restaurante La ...
Reviewed on 6 Apr 2026

Gran Melia Iguazú
Luxury hotel inside the park. We stayed 1 night it was so convenient to visit 2 viewpoints. They also have the best breakfast buffet.
Reviewed on 7 Apr 2026
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* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.










