Title: £122 Cheap Flights from San Francisco to Knoxville (SFO to TYS) - Expedia.co.uk ![Skyline of downtown Knoxville, Tennessee, USA](https://images.trvl-media.com/place/602977/e5dfacc8-29fe-4ae7-93f0-6aa1cd8e604b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/602977/e5dfacc8-29fe-4ae7-93f0-6aa1cd8e604b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £122 Cheap Flights from San Francisco (SFO) to Knoxville (TYS) [View £122 flight on Tue, 24 Mar 2026](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:SFO,to:TYS,departure:24/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:121.80&airProductToken=AQpGCiAIxJgBEgM3NzIYsnEg47QBKKy9iAMwtr-IAzhFQABYAQoiCMSYARIENTQzNBjjtAEgk5YBKJ7AiAMw-8CIAzhFQAFYARIKCAEQARgBKgJETBgBIgQIARABKAQwAQ) - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only ## Popular airlines from San Francisco International Airport (SFO) to Alcoa - Knoxville Airport (TYS) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta [](https://www.expedia.co.uk/Flights-Search?leg1=from:SFO,to:TYS,departure:03/02/2026TANYT&leg2=from:TYS,to:SFO,departure:10/02/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"DL"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:SFO,to:TYS,departure:03/02/2026TANYT&leg2=from:TYS,to:SFO,departure:10/02/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United [](https://www.expedia.co.uk/Flights-Search?leg1=from:SFO,to:TYS,departure:03/02/2026TANYT&leg2=from:TYS,to:SFO,departure:10/02/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"UA"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AS.svg) Alaska Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:SFO,to:TYS,departure:03/02/2026TANYT&leg2=from:TYS,to:SFO,departure:10/02/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"AS"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_WN.svg) Southwest Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:SFO,to:TYS,departure:03/02/2026TANYT&leg2=from:TYS,to:SFO,departure:10/02/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"WN"}}]) - ![](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_F9.svg) Frontier Airlines [](https://www.expedia.co.uk/Flights-Search?leg1=from:SFO,to:TYS,departure:03/02/2026TANYT&leg2=from:TYS,to:SFO,departure:10/02/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&filters=[{"preferredAirlineFilterValue":{"carrierCode":"F9"}}]) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheap Flights from San Francisco (SFO) to Knoxville (TYS) Prices were available within the past 7 days and start at £122 for one-way flights and £358 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![Delta](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DL.gif) Sun, 22 Mar - Mon, 23 Mar SFO San Francisco TYS Knoxville £358 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SFO,to:TYS,departure:22/03/2026TANYT&leg2=from:TYS,to:SFO,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:357.60&airProductToken=AQpwCjUIxJgBEgMzMzUYsnEg47QBKNSuiAMw27CIAzhFQABYAWoJTUFJTkJBU0lDcghVQVZPQTBCUQo3CMSYARIENTM0NxjjtAEgk5YBKIKyiAMw57KIAzhFQAFYAWoJTUFJTkJBU0lDcghVQVZPQTBCUQpuCjYIxJgBEgQzMDQyGJOWASDgXCjOtogDMJ63iAM4RUAAWAFqCU1BSU5CQVNJQ3IIWEFWU0E1QkMKNAjEmAESAzY1NhjgXCCycSiauIgDMNq6iAM4RUABWAFqCU1BSU5CQVNJQ3IIWEFWU0E1QkMSCggBEAEYASoCREwYASIECAEQASgCKAMoBDAB) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sun, 22 Mar - Mon, 23 Mar SFO San Francisco TYS Knoxville £373 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SFO,to:TYS,departure:22/03/2026TANYT&leg2=from:TYS,to:SFO,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:372.60&airProductToken=AQpnCjEIwYIBEgQyNDE2GLJxIK4cKICpiAMwjauIAzhCQABYAWoFQkFTSUNyCFFWQUhaTkJaCjIIwYIBEgQ1NDU0GK4cIJOWASjsq4gDMNSsiAM4QkABWAFqBUJBU0lDcghRVkFIWk5CWgpoCjMIwYIBEgQzMjc0GJOWASCjsQEozbWIAzDwtogDOEJAAFgBagVCQVNJQ3IIUVZBSVhTQlgKMQjBggESAzk0NxijsQEgsnEooriIAzCYuogDOEJAAVgBagVCQVNJQ3IIUVZBSVhTQlgSCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sun, 22 Mar - Mon, 23 Mar SFO San Francisco TYS Knoxville £403 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SFO,to:TYS,departure:22/03/2026TANYT&leg2=from:TYS,to:SFO,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:402.70&airProductToken=AQppCjIIwYIBEgQzMDQ3GLJxIKOxASiipIgDMPCliAM4QkAAWAFqBUJBU0lDcghOVUFIWk5CWgozCMGCARIENDE3NhijsQEgk5YBKLCmiAMwsqeIAzhCQAFYAWoFQkFTSUNyCE5VQUhaTkJaCmgKMwjBggESBDMyNzQYk5YBIKOxASjNtYgDMPC2iAM4QkAAWAFqBUJBU0lDcghRVkFJWFNCWAoxCMGCARIDOTQ5GKOxASCycSjXt4gDMM25iAM4QkABWAFqBUJBU0lDcghRVkFJWFNCWBIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sun, 22 Mar - Mon, 23 Mar SFO San Francisco TYS Knoxville £411 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SFO,to:TYS,departure:22/03/2026TANYT&leg2=from:TYS,to:SFO,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:410.30&airProductToken=AQpnCjEIwYIBEgQxODc4GLJxIOKaASiop4gDMNipiAM4UUAAWAFqBE1BSU5yCFFWQUhaTk0xCjIIwYIBEgQ2MDQxGOKaASCTlgEoiqqIAzDcqogDOFFAAVgBagRNQUlOcghRVkFIWk5NMRIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sun, 22 Mar - Mon, 23 Mar SFO San Francisco TYS Knoxville £432 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SFO,to:TYS,departure:22/03/2026TANYT&leg2=from:TYS,to:SFO,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:431.70&airProductToken=AQppCjIIwYIBEgQxMTQ2GLJxIOKaASiuqIgDMOGqiAM4QkAAWAFqBUJBU0lDcghTVkFIWk5CWgozCMGCARIENTIyNxjimgEgk5YBKLqriAMwhayIAzhCQAFYAWoFQkFTSUNyCFNWQUhaTkJaCmgKMgjBggESAzY2MBiTlgEgo7EBKNWziAMw9LSIAzhCQABYAWoFQkFTSUNyCFFWQUlYU0JYCjIIwYIBEgQxMTc1GKOxASCycSjUtogDMMe4iAM4QkABWAFqBUJBU0lDcghRVkFJWFNCWBIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sun, 22 Mar - Mon, 23 Mar SFO San Francisco TYS Knoxville £433 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SFO,to:TYS,departure:22/03/2026TANYT&leg2=from:TYS,to:SFO,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:432.80&airProductToken=AQpoCjEIwYIBEgM0MDIYsnEgo7EBKOymiAMww6iIAzhCQABYAWoFQkFTSUNyCFNWQUhaTkJaCjMIwYIBEgQyNTQyGKOxASCTlgEo76mIAzDrqogDOEJAAVgBagVCQVNJQ3IIU1ZBSFpOQloSCggBEAEYASoCQUEYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sun, 22 Mar - Mon, 23 Mar SFO San Francisco TYS Knoxville £441 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SFO,to:TYS,departure:22/03/2026TANYT&leg2=from:TYS,to:SFO,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:440.40&airProductToken=AQpmCjAIwYIBEgM0MDIYsnEgo7EBKOymiAMww6iIAzhOQABYAWoETUFJTnIITlVBSFpOTTEKMgjBggESBDMyNzQYo7EBIJOWASj1qIgDMPSpiAM4TkABWAFqBE1BSU5yCE5VQUhaTk0xEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sun, 22 Mar - Mon, 23 Mar SFO San Francisco TYS Knoxville £443 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SFO,to:TYS,departure:22/03/2026TANYT&leg2=from:TYS,to:SFO,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:442.50&airProductToken=AQppCjIIwYIBEgQxODc4GLJxIOKaASiop4gDMNipiAM4QkAAWAFqBUJBU0lDcghRVkFIWk5CWgozCMGCARIENTIyNxjimgEgk5YBKLqriAMwhayIAzhCQAFYAWoFQkFTSUNyCFFWQUhaTkJaCmcKMgjBggESBDU1OTIYk5YBIK4cKK6ziAMwpbSIAzhCQABYAWoFQkFTSUNyCFFWQVpaTkJYCjEIwYIBEgQyMTEzGK4cILJxKMK3iAMw7LmIAzhCQAFYAWoFQkFTSUNyCE5WQVpZU0JYEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Sun, 22 Mar - Mon, 23 Mar SFO San Francisco TYS Knoxville £447 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SFO,to:TYS,departure:22/03/2026TANYT&leg2=from:TYS,to:SFO,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:446.80&airProductToken=AQplCjAIwYIBEgQyNDE2GLJxIK4cKICpiAMwjauIAzhRQABYAWoETUFJTnIIUVZBSFpOTTEKMQjBggESBDU0NTQYrhwgk5YBKOyriAMw1KyIAzhRQAFYAWoETUFJTnIIUVZBSFpOTTEKZgoyCMGCARIEMzI3NBiTlgEgo7EBKM21iAMw8LaIAzhRQABYAWoETUFJTnIIUVZBSVhTTTMKMAjBggESAzk0NxijsQEgsnEooriIAzCYuogDOFFAAVgBagRNQUlOcghRVkFJWFNNMxIKCAEQARgBKgJBQRgBIgQIARABKAIoAygEMAs) ![United](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/UA.gif) Sun, 22 Mar - Mon, 23 Mar SFO San Francisco TYS Knoxville £515 Return found 5 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SFO,to:TYS,departure:22/03/2026TANYT&leg2=from:TYS,to:SFO,departure:23/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:514.50&airProductToken=AQpqCjMI1YIBEgQxNDc5GLJxIINpKLWmiAMw0qeIAzhIQABYAWoHRUNPTk9NWXIISEFBME9LRU4KMwjVggESAzY4NBiDaSCTlgEor6iIAzDWqYgDOEhAAVgBagdFQ09OT01ZcghIQUEwT0tFThIKCAEQARgBKgJVQRgBIgQIARABKAIoAygEMAE) __Flight from San Francisco to Knoxville route information__ | Origin airport | San Francisco Intl. | | ------------------- | ------------------- | | Destination airport | McGhee Tyson | | Return price | £358 | | Distance | 3385 km | | Average flight time | 9 hours 32 mins | ## Compare flights from San Francisco to Knoxville easily and book with confidence For travelling on business or for pleasure, Expedia makes it easy to book your flights from San Francisco to Knoxville. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to McGhee Tyson in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from San Francisco Intl. to McGhee Tyson. To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. Grab a great deal on your flight from San Francisco Intl. (SFO) to McGhee Tyson (TYS) The easiest way to view the best deals on flights from San Francisco to Knoxville today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from San Francisco Intl. to McGhee Tyson start at just £358 and range up to £515\. To find an even better deal, try - being flexible on your dates – midweek flights can be cheaper - looking for other airports near San Francisco and Knoxville - booking your flight during March, the cheapest month on this route - varying your flight times – early morning and late at night are sometimes cheaper Why you should book your San Francisco to Knoxville flight with Expedia! We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from San Francisco Intl. to McGhee Tyson for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you. Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight. ## Frequently asked questions ### How much is a flight from SFO to McGhee Tyson Airport (TYS)? ### Do I need to pay a cancellation fee if I cancel my flight from San Francisco Intl. Airport (SFO) to Knoxville Airport? ### How do I find cheap flights from SFO to Knoxville Airport that have flexible change policies? ### How far is the flight from SFO to McGhee Tyson Airport (TYS)? ### Which airlines fly direct from San Francisco Intl. Airport (SFO) to Knoxville Airport? ### Are San Francisco Intl. 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[Flights from Nashville (BNA) to Gatlinburg (GKT) ](https://www.expedia.co.uk/lp/flights/bna/gkt/nashville-to-gatlinburg) - [Flights from Nashville (BNA) to Tri-Cities (TRI) ](https://www.expedia.co.uk/lp/flights/bna/tri/nashville-to-tri-cities) - [Flights from Boston (BOS) to Tri-Cities (TRI) ](https://www.expedia.co.uk/lp/flights/bos/tri/boston-to-tri-cities) - [Flights from Bristol (BRS) to Tri-Cities (TRI) ](https://www.expedia.co.uk/lp/flights/brs/tri/bristol-to-tri-cities) - [Flights from Baltimore (BWI) to Tri-Cities (TRI) ](https://www.expedia.co.uk/lp/flights/bwi/tri/baltimore-to-tri-cities) - [Flights from Cairo (CAI) to Tri-Cities (TRI) ](https://www.expedia.co.uk/lp/flights/cai/tri/cairo-to-tri-cities) - [Flights from Cali (CLO) to Tri-Cities (TRI) ](https://www.expedia.co.uk/lp/flights/clo/tri/cali-to-tri-cities) - [Flights from Charlotte (CLT) to Gatlinburg (GKT) ](https://www.expedia.co.uk/lp/flights/clt/gkt/charlotte-to-gatlinburg) - [Flights from Charlotte (CLT) to Tri-Cities (TRI) ](https://www.expedia.co.uk/lp/flights/clt/tri/charlotte-to-tri-cities) - 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