£76 Cheap Flights from Orlando (MCO) to Knoxville (TYS)

View £76 flight on Tue, 22 Sept 2026Opens in a new window

Popular airlines from Orlando International Airport (MCO) to Alcoa - Knoxville Airport (TYS)

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Cheap Flights from Orlando (MCO) to Knoxville (TYS)

Prices were available within the past 7 days and start at £76 for one-way flights and £151 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

Delta
Tue, 29 Sept - Wed, 30 Sept
MCO
Orlando
TYS
Knoxville
£151 Return, found 2 days ago
£151
Return
found 2 days ago
Select Delta flight, departing Tue, 29 Sept from Orlando to Knoxville, returning Wed, 30 Sept, priced at £151 found 2 days ago
American Airlines
Sat, 23 May - Wed, 27 May
MCO
Orlando
TYS
Knoxville
£159 Return, found 2 days ago
£159
Return
found 2 days ago
Select American Airlines flight, departing Sat, 23 May from Orlando to Knoxville, returning Wed, 27 May, priced at £159 found 2 days ago
Delta
Sat, 23 May - Wed, 27 May
MCO
Orlando
TYS
Knoxville
£166 Return, found 2 days ago
£166
Return
found 2 days ago
Select Delta flight, departing Sat, 23 May from Orlando to Knoxville, returning Wed, 27 May, priced at £166 found 2 days ago
Delta
Tue, 29 Sept - Tue, 6 Oct
MCO
Orlando
TYS
Knoxville
£170 Return, found 2 days ago
£170
Return
found 2 days ago
Select Delta flight, departing Tue, 29 Sept from Orlando to Knoxville, returning Tue, 6 Oct, priced at £170 found 2 days ago
Delta
Mon, 1 Jun - Thu, 18 Jun
MCO
Orlando
TYS
Knoxville
£177 Return, found 4 days ago
£177
Return
found 4 days ago
Select Delta flight, departing Mon, 1 Jun from Orlando to Knoxville, returning Thu, 18 Jun, priced at £177 found 4 days ago
Delta
Thu, 28 May - Tue, 9 Jun
MCO
Orlando
TYS
Knoxville
£183 Return, found 4 days ago
£183
Return
found 4 days ago
Select Delta flight, departing Thu, 28 May from Orlando to Knoxville, returning Tue, 9 Jun, priced at £183 found 4 days ago
Delta
Sun, 24 May - Mon, 8 Jun
MCO
Orlando
TYS
Knoxville
£185 Return, found 4 days ago
£185
Return
found 4 days ago
Select Delta flight, departing Sun, 24 May from Orlando to Knoxville, returning Mon, 8 Jun, priced at £185 found 4 days ago
Delta
Tue, 26 May - Fri, 29 May
MCO
Orlando
TYS
Knoxville
£186 Return, found 2 days ago
£186
Return
found 2 days ago
Select Delta flight, departing Tue, 26 May from Orlando to Knoxville, returning Fri, 29 May, priced at £186 found 2 days ago
Delta
Tue, 27 Oct - Tue, 10 Nov
MCO
Orlando
TYS
Knoxville
£188 Return, found 4 days ago
£188
Return
found 4 days ago
Select Delta flight, departing Tue, 27 Oct from Orlando to Knoxville, returning Tue, 10 Nov, priced at £188 found 4 days ago
United
Sat, 23 May - Wed, 27 May
MCO
Orlando
TYS
Knoxville
£467 Return, found 2 days ago
£467
Return
found 2 days ago
Select United flight, departing Sat, 23 May from Orlando to Knoxville, returning Wed, 27 May, priced at £467 found 2 days ago

Alternative airports near Knoxville

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to McGhee Tyson TYS. Cheapest and Closest option available. Average driving time to city centre is 22 minutes. Flights from £248
TYS
McGhee Tyson
CheapestClosest
Average driving time to city centre22 min
Flights from £248

Frequently asked questions

Which airlines fly direct from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
Enter MCO to TYS and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
To find a cheap flight from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The best airline to fly with from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson) will differ from traveller to traveller. If you like to fly early, WN offers early morning flights. If price is the most important factor, WN typically offers the lowest fares. AA offers the most daily flights from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson), which is brilliant if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
There are approximately 93 connecting flights per day from Orlando International (MCO) to McGhee Tyson (TYS). Some common connection points include Hartsfield-Jackson Atlanta International (ATL), O'Hare International (ORD), and Charlotte-Douglas International (CLT).
What is the earliest flight from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The earliest flight from Orlando International Airport (MCO) to McGhee Tyson (TYS) typically departs at approximately 5:00 AM local time, operated by American Airlines. This is a seasonal service active in December. An early departure like this can help you maximise your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
If you're flying from Orlando International Airport (MCO) to McGhee Tyson (TYS), you'll typically find the most flights on a Friday, with around 49 flights available. This gives you plenty of options for your travel plans. Major airlines on this route include American Airlines, United Airlines, and Delta Air Lines. Looking at the week, Fridays offer notably more flight options compared to other days, with about 19% more flights than the average weekday.
What are the most popular departure times for flights from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
The most popular departure times for flights from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson) are in the morning, between 9am and 12pm. About 24% of passengers prefer this time window. Many major carriers, including American Airlines, United Airlines and Delta Air Lines, offer flights during this window. This timing works well because it allows you to start your travel day a bit later while still arriving at your destination with plenty of time left in the day.
How long does it take to fly from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
A nonstop flight from MCO to TYS typically takes around 1 hour 50 minutes, covering approximately 533 miles. Connecting flights on this route usually add 4 hours 30 minutes to your travel time. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
Select the "Business class" and "First class" filters when looking for MCO to TYS flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight with Expedia?
It's easy to earn miles on a Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia. *Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Knoxville from Orlando Intl. (MCO)?
From Orlando Intl. (MCO), you can fly directly into McGhee Tyson (TYS) to reach Knoxville. Some flights may connect through major hubs like Ronald Reagan Washington National (DCA), Liberty Intl. (EWR), Raleigh - Durham Intl. (RDU) before reaching Knoxville. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson) at the last minute?
Typically, booking a last minute flight from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package?
Securing a Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson)?
If you booked your Orlando, FL (MCO-Orlando Intl.) to Knoxville, TN (TYS-McGhee Tyson) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
Orlando Intl.
Destination airport
McGhee Tyson
Return price
£151
Distance
852 km
Average flight time
1 hour 47 mins

Book with confidence

Compare flights from Orlando to Knoxville easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Orlando to Knoxville. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to McGhee Tyson in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from Orlando Intl. to McGhee Tyson.  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from Orlando Intl. (MCO) to McGhee Tyson (TYS)

The easiest way to view the best deals on flights from Orlando to Knoxville today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from Orlando Intl. to McGhee Tyson start at just £151 and range up to £467.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Orlando and Knoxville
  • booking your flight during September, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Orlando to Knoxville flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from Orlando Intl. to McGhee Tyson for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Orlando to Knoxville easily and book with confidence

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*Available to Expedia members.