Title: £416 Cheap American Airlines flights from London to Knoxville (LHR→TYS) - Expedia.co.uk ![Skyline of downtown Knoxville, Tennessee, USA](https://images.trvl-media.com/place/602977/e5dfacc8-29fe-4ae7-93f0-6aa1cd8e604b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/602977/e5dfacc8-29fe-4ae7-93f0-6aa1cd8e604b.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # £416 Cheap American Airlines flights from London to Knoxville (LHR→TYS) [View £416 flight on Wed, 23 Sept 2026](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:LHR,to:TYS,departure:23/09/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:415.39&airProductToken=AQppCjIIwYIBEgM3MzEY64kBIOKaASjvxZgDMIvKmAM4QkAAWAFqBUJBU0lDcghPTFg1QzVCNAozCMGCARIENjA3NxjimgEgk5YBKNvKmAMwr8uYAzhCQAFYAWoFQkFTSUNyCE9MWDVDNUI0EgoIAhABGAIqAkFBGAEiBAgBEAEoAigDKAQwCw) - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## American Airlines flights from London to Knoxville (LHR→TYS) Prices were available within the past 7 days and start at £416 for one-way flights and £607 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, 18 Mar - Wed, 25 Mar LHR London TYS Knoxville £607 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LHR,to:TYS,departure:18/03/2026TANYT&leg2=from:TYS,to:LHR,departure:25/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:606.99&airProductToken=AQppCjIIwYIBEgM3MzUY64kBIOKaASjV-ocDMPv-hwM4QkAAWAFqBUJBU0lDcghPTFg4QzFCNAozCMGCARIENTE0NBjimgEgk5YBKJuAiAMw5oCIAzhCQAFYAWoFQkFTSUNyCE9MWDhDMUI0CmkKMwjBggESBDYwNTkYk5YBIOKaASjbzIgDMLPNiAM4QkAAWAFqBUJBU0lDcghPTFg4QzFCNAoyCMGCARIDNzMyGOKaASDriQEoq86IAzCL0ogDOEJAAVgBagVCQVNJQ3IIT0xYOEMxQjQSCggCEAEYAioCQUEYASIECAEQASgCKAMoBDAL) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Wed, 18 Mar - Wed, 25 Mar LHR London TYS Knoxville £610 Return found 1 day ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:LHR,to:TYS,departure:18/03/2026TANYT&leg2=from:TYS,to:LHR,departure:25/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:609.99&airProductToken=AQppCjIIwYIBEgM3MzEY64kBIOKaASiz-IcDMM_8hwM4QkAAWAFqBUJBU0lDcghPTFg4QzFCNAozCMGCARIENTk2NxjimgEgk5YBKL79hwMwlf6HAzhCQAFYAWoFQkFTSUNyCE9MWDhDMUI0CmgKMwjBggESBDI1NDIYk5YBIKOxASj9zIgDMKHOiAM4QkAAWAFqBUJBU0lDcghPTFg4QzFCNAoxCMGCARICNzgYo7EBIOuJASjxzogDMJzTiAM4QkABWAFqBUJBU0lDcghPTFg4QzFCNBIKCAIQARgCKgJBQRgBIgQIARABKAIoAygEMAs) ## Alternative airports near Knoxville Prices were available within the past 7 days. Prices and availability are subject to change. [](https://www.expedia.co.uk/Flights-Search?leg1=from:LHR,to:TYS,departure:26/02/2026TANYT&leg2=from:TYS,to:LHR,departure:12/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) TYS McGhee Tyson CheapestClosest 22 min [Flights from £668 ](https://www.expedia.co.uk/Flights-Search?leg1=from:LHR,to:TYS,departure:26/02/2026TANYT&leg2=from:TYS,to:LHR,departure:12/03/2026TANYT&trip=roundtrip&passengers=adults:1,children:0,infantinlap:N&mode=search&pageId=0&sortOrder=INCREASING&sortType=PRICE) __Flight from London to Knoxville route information__ | Origin airport | Heathrow | | ------------------- | ---------------------------------------------------------------------------------------------------------------------------------------------------------- | | Destination airport | McGhee Tyson | | Airlines serving | Aer Lingus, Air Canada, Air France, American Airlines, British Airways, Brussels Airlines, Delta, Finnair, Iberia, KLM, Lufthansa, United, Virgin Atlantic | | Popular airline | British Airways | | Distance | 6525 km | ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=FTG_SPRING_PROMO_) ## Frequently asked questions ### How much is an American Airlines flight from Heathrow Airport (LHR) to McGhee Tyson Airport (TYS)? ### What is the cheapest month to fly from LHR to TYS with American Airlines? ### Does American Airlines fly nonstop from Heathrow Airport (LHR) to McGhee Tyson Airport (TYS)? ### What airports does American Airlines fly into in Knoxville? ### Can I change or cancel my American Airlines flight from Heathrow Airport (LHR) to McGhee Tyson Airport (TYS)? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - [4 Star Hotels in West Knoxville ](https://www.expedia.co.uk/4Star-West-Knoxville-Hotels.s40-0-d6059852.Travel-Guide-Filter-Hotels) - [Hotels with Indoor Pools in Alcoa ](https://www.expedia.co.uk/Alcoa-Hotels-Hotels-With-Indoor-Pools.0-0-d5985-tHotelswithIndoorPools.Travel-Guide-Filter-Hotels) - [Alcoa Hotels ](https://www.expedia.co.uk/Alcoa-Hotels.d5985.Travel-Guide-Hotels) - 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