£474 Cheap American Airlines flights from London to Knoxville (LHR→TYS)

Landing cheap one-way American Airlines flights from LHR to TYS from £474 on Expedia is a cinch — just filter by "Price (lowest to highest)." Or check out our affordable round-trip fares £712 for your next break.*

*These prices were available on Expedia within the past 7 days, for flights departing within the next year. Prices and availability are subject to change. Additional terms apply.

January is one of the least expensive months to jet off to Knoxville with American Airlines. You could also find excellent prices on return and one-way fares in December.

Fill in your dates, hit search and select the "Nonstop" filter on Expedia to find any direct flights from LHR to TYS with American Airlines or other carriers.

Board an American Airlines flight from Heathrow Airport (LHR) to Knoxville, and you'll probably touch down at McGhee Tyson Airport (TYS). This is the airline's main hub in this destination.

It's generally possible to cancel or reschedule your flight, although there may be additional charges if your booking was made over 24 hours ago. Need flexible options? Make use of Expedia's "No cancel fee" and "Changes included" filters to find flights that won't charge you extra if you need to alter your plans. To modify your booking, go to "Trips," select your flight and click on "Manage Booking" for further information.