Casco Viejo, the historic district of Panama City

£360 Cheap Flights from Chicago (ORD) to Panama City (PTY)

View £360 flight on Sun, 14 Jun 2026Opens in a new window

Popular airlines from Chicago O'Hare International Airport (ORD) to Tocumen Intl. Airport (PTY)

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Cheap Flights from Chicago (ORD) to Panama City (PTY)

Prices were available within the past 7 days and start at £360 for one-way flights and £553 for round trip, for the period specified. Prices and availability are subject to change. Additional terms apply.

American Airlines
Mon, 21 Sept - Mon, 28 Sept
ORD
Chicago
PTY
Panama City
£553 Return, found 1 day ago
£553
Return
found 1 day ago
Select American Airlines flight, departing Mon, 21 Sept from Chicago to Panama City, returning Mon, 28 Sept, priced at £553 found 1 day ago
Delta
Mon, 21 Sept - Mon, 28 Sept
ORD
Chicago
PTY
Panama City
£553 Return, found 1 day ago
£553
Return
found 1 day ago
Select Delta flight, departing Mon, 21 Sept from Chicago to Panama City, returning Mon, 28 Sept, priced at £553 found 1 day ago
avianca
Mon, 20 Jul - Fri, 31 Jul
ORD
Chicago
PTY
Panama City
£577 Return, found 6 days ago
£577
Return
found 6 days ago
Select avianca flight, departing Mon, 20 Jul from Chicago to Panama City, returning Fri, 31 Jul, priced at £577 found 6 days ago
avianca
Sat, 22 Aug - Wed, 26 Aug
ORD
Chicago
PTY
Panama City
£585 Return, found 5 days ago
£585
Return
found 5 days ago
Select avianca flight, departing Sat, 22 Aug from Chicago to Panama City, returning Wed, 26 Aug, priced at £585 found 5 days ago
avianca
Sat, 22 Aug - Wed, 26 Aug
ORD
Chicago
PTY
Panama City
£586 Return, found 5 days ago
£586
Return
found 5 days ago
Select avianca flight, departing Sat, 22 Aug from Chicago to Panama City, returning Wed, 26 Aug, priced at £586 found 5 days ago
avianca
Thu, 27 Aug - Sun, 30 Aug
ORD
Chicago
PTY
Panama City
£586 Return, found 3 days ago
£586
Return
found 3 days ago
Select avianca flight, departing Thu, 27 Aug from Chicago to Panama City, returning Sun, 30 Aug, priced at £586 found 3 days ago
Copa
Mon, 21 Sept - Mon, 28 Sept
ORD
Chicago
PTY
Panama City
£586 Return, found 1 day ago
£586
Return
found 1 day ago
Select Copa flight, departing Mon, 21 Sept from Chicago to Panama City, returning Mon, 28 Sept, priced at £586 found 1 day ago
avianca
Tue, 16 Jun - Sat, 22 Aug
ORD
Chicago
PTY
Panama City
£587 Return, found 19 hours ago
£587
Return
found 19 hours ago
Select avianca flight, departing Tue, 16 Jun from Chicago to Panama City, returning Sat, 22 Aug, priced at £587 found 19 hours ago
avianca
Fri, 25 Sept - Fri, 13 Nov
ORD
Chicago
PTY
Panama City
£589 Return, found 17 hours ago
£589
Return
found 17 hours ago
Select avianca flight, departing Fri, 25 Sept from Chicago to Panama City, returning Fri, 13 Nov, priced at £589 found 17 hours ago
United
Mon, 21 Sept - Mon, 28 Sept
ORD
Chicago
PTY
Panama City
£642 Return, found 1 day ago
£642
Return
found 1 day ago
Select United flight, departing Mon, 21 Sept from Chicago to Panama City, returning Mon, 28 Sept, priced at £642 found 1 day ago

Alternative airports near Panama City

Prices were available within the past 7 days. Prices and availability are subject to change.

Select flight to Tocumen Intl. PTY. Cheapest option available. Average driving time to city centre is 16 minutes. Flights from £585
PTY
Tocumen Intl.
Cheapest
Average driving time to city centre16 min
Flights from £585

Frequently asked questions

Which airlines fly direct from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
Enter ORD to PTY and your travel dates, then apply the 'Nonstop' filter to see only direct flights.
How do I find cheap flights from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
To find a cheap flight from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.), be flexible with your dates. Traveling outside of peak vacation months and booking a mid-week flight can help you save. Early morning and late night flights are often more affordable, too. Expedia allows you to compare flight times, airlines and routes all in one place to find low fares. You can also set up Price Tracking and receive alerts when fares go up or down.
What is the best airline to fly with from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
The best airline to fly with from Chicago, IL (ORD-O'Hare Intl.) (ORD) to Panama City (PTY-Tocumen Intl.) (PTY) will differ from traveler to traveler. If you like to fly early, CM offers early morning flights. If price is the most important factor, CM typically offers the lowest fares. UA offers the most daily flights from Chicago, IL (ORD-O'Hare Intl.) (ORD) to Panama City (PTY-Tocumen Intl.) (PTY), which is great if flexibility is what you value most. The best carrier for this journey could also be the one you have a loyalty membership with, as flying with that airline or another airline within the same alliance could help you collect points or enjoy lounge access.
What is the best time to fly from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
The best time to fly is usually mid-week (Tuesday or Wednesday) and during early morning hours as flights tend to be cheaper, less crowded, and generally more on-time. Avoid major holidays and peak vacation seasons for smoother travel. Combining off-peak days and hours often gives the best combination of cost, comfort, and convenience.
How many flights per day from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
When flying from Chicago O'Hare International (ORD) to Panama City Tocumen International (PTY), you'll find approximately 2 nonstop flights per day. For even more choice, look at flights that include layovers, as there are around 112 connecting flights daily. Some common connection points include El Dorado International (BOG), George Bush Intercontinental (IAH), and Pearson International (YYZ).
What is the earliest flight from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
The earliest flight from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.) typically departs at approximately 12:00 AM local time, operated by American Airlines. This is a seasonal service active in December. An early departure like this can help maximize your time at your destination. To compare early flights on Expedia, select the "Early Morning" and "Morning" filters in your search.
What day of the week has the most flights from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
You'll typically find the most flights from Chicago O'Hare International Airport (ORD) to Panama City Tocumen International Airport (PTY) on a Thursday, with around 50 flights available. This gives you a good selection of options for your travel plans. Major airlines on this route include United Airlines, American Airlines, and Delta Air Lines. Flight schedules are consistent throughout the week.
What are the most popular departure times for flights from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
The most popular departure times for flights from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.) are in the early morning, from 6am to 9am. About 41% of passengers prefer this time. Many major carriers, including Copa Airlines, United Airlines and American Airlines, offer flights during this window. This timing works well because you can start your journey bright and early, arriving in Panama City with plenty of time to settle in.
How long does it take to fly from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
Flying nonstop from ORD to PTY takes around 5 hours 20 minutes, with the route covering approximately 2,332 miles. Flights with a layover typically take 3 hours 30 minutes longer than direct options. Keep in mind that actual flight times can vary due to wind patterns, weather, and air traffic.
Can you fly business or first class from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
Select the "Business class" and "First class" filters when looking for ORD to PTY flights on Expedia. This is the easiest way to compare prices, routes and flight times for your trip.
How do I earn miles on a Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.) flight with Expedia?
It's easy to earn miles on a Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.) flight when you book with Expedia. Before you confirm your booking, simply select your frequent flyer program and enter your program number. As a member of One Key™, you can also earn OneKeyCash™* on top of your airline miles when you book with Expedia.*Excludes taxes and fees. OneKeyCash is not redeemable for cash and can only be used on Expedia and other participating brands.
What airports do you fly into for Panama City from O'Hare Intl. (ORD)?
From O'Hare Intl. (ORD), you can fly into Northwest Florida Beaches Intl. (ECP) and Tocumen Intl. (PTY) in Panama City. Some flights may connect through major hubs like Detroit Metropolitan Wayne County (DTW), Indianapolis Intl. (IND), Nashville Intl. (BNA) before reaching Panama City. Compare routes and airports on Expedia to find the best flight options for your travel plans.
Is it cheaper to buy a plane ticket from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.) at the last minute?
Typically, booking a last minute flight from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.) will be more expensive than booking in advance. As the departure date approaches, there are usually fewer seats available which can drive up the cost. However, if there's some wiggle room with your travel dates and times, you could bag a cheap last-minute fare.
Is it cheaper to book a Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package?
Securing a Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.) flight and hotel package is usually cheaper than booking separately. With Expedia, you can enjoy the ease of organizing your travels all in one place. Select from our extensive range of stays and then add flights, activities and car rentals to your booking. Bundle everything together, and you could save hundreds of dollars.
Can I cancel or change the date of my flight from Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.)?
If you booked your Chicago, IL (ORD-O'Hare Intl.) to Panama City (PTY-Tocumen Intl.) flight within the last 24 hours, you may be able to modify or cancel it without any fees. Depending on the airline and the type of ticket you have, additional charges may apply for changes beyond this timeframe. Airline policies and contact information can be found in your itinerary or confirmation email. Or, head to our Customer Service portal if you'd like more information.

Travel information

Origin airport
O'Hare Intl.
Destination airport
Tocumen Intl.
Airlines serving
Aeromexico, American Airlines, Copa, Delta, United, avianca
Return price
£553
Distance
3731 km
Average flight time
5 hours 20 mins

Book with confidence

Compare flights from Chicago to Panama City easily and book with confidence

For travelling on business or for pleasure, Expedia makes it easy to book your flights from Chicago to Panama City. Operating between them flights per day, 20 airlines cover the route. And fly direct, getting you to Tocumen Intl. in just hours. If you have a preferred carrier, use our advanced search tool to find the right flight from O'Hare Intl. to Tocumen Intl..  

To make things even better, in the advanced search, you can also choose to fly economy, premium economy, business or first class, select your maximum number of stops, and pick your preferred departure and arrival time. You can also opt for refundable and direct flights. 

Grab a great deal on your flight from O'Hare Intl. (ORD) to Tocumen Intl. (PTY)

The easiest way to view the best deals on flights from Chicago to Panama City today is to enter your travel dates and hit search. From here, you can sort your results by price to see the cheapest flights first. Right now, return flights from O'Hare Intl. to Tocumen Intl. start at just £553 and range up to £642.  

To find an even better deal, try  

  • being flexible on your dates – midweek flights can be cheaper
  • looking for other airports near Chicago and Panama City
  • booking your flight during September, the cheapest month on this route
  • varying your flight times – early morning and late at night are sometimes cheaper 

Why you should book your Chicago to Panama City flight with Expedia!

We cater for all flight types, cabin classes and airlines. So whether you’re booking flights from O'Hare Intl. to Tocumen Intl. for a budget break or a business trip with a bit of pleasure thrown in, we make it easy to secure the seat that’s right for you.  

Thanks to our supersized inventory that offers great choice all in one place, you know you’ll get a great deal with Expedia. Especially if you bundle your flight together with your hotel, you will unlock amazing savings. For added peace of mind, you can choose flexible bookings or filter to find refundable options, so you won’t pay a fee to change your flight.  

Compare flights from Chicago to Panama City easily and book with confidence

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*Available to Expedia members.