Title: Cheap Flights from Santa Isabel from £48 - Expedia.co.uk ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_flights_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Cheap Flights from Santa Isabel from £48 [View £48 flight on Sat, 4 Apr 2026](https://expedia.co.uk/Flights-Search?trip=oneway&leg1=from:SJU,to:SDQ,departure:04/04/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:47.03&airProductToken=AQo0CjIIxJoBEgM1MDMYsqIBIPKAASixvYkDMPa9iQM4waABQABYAWoFU01BUlRyBkFQMUJPVxIKCAsQARgIKgJETRgBIgQIARABKAIwAw) - [Return](?flightType=roundtrip) - [One-way](?flightType=oneway) - [Multi-city](?flightType=multicity) ### Travellers Adults ChildrenAges 2 to 17 InfantsYounger than 2 EconomyPremium economyBusiness classFirst class Leaving from Going to Departing Returning Add a place to stay Add a car Direct flights only [Hotels in Santa Isabel](https://expedia.co.uk/Santa-Isabel-Hotels.d6035096.Travel-Guide-Hotels)[Santa Isabel Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Isabel.d6035096.Car-Hire-Guide)[Santa Isabel Holidays](https://expedia.co.uk/Santa-Isabel.d6035096.Holidays-City-Breaks) ## Popular airlines from Santa Isabel - ![American Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_AA.svg) American Airlines - ![JetBlue Airways](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_B6.svg) JetBlue Airways - ![Delta](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_DL.svg) Delta - ![United](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_UA.svg) United - ![Frontier Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_F9.svg) Frontier Airlines - ![Spirit Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_NK.svg) Spirit Airlines - ![Southwest Airlines](https://forever.travel-assets.com/flex/flexmanager/images/2024/09/23/landing_airline_sq_logo_WN.svg) Southwest Airlines ![notification illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__notification.svg) ### Be in the know Get alerts if flight prices drop or rise\* ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Book smarter Save up to 25% on select hotels after you book a flight\* ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Earn twice Earn your airline miles on top of our rewards [Sign in](https://www.expedia.co.uk/login) ## Cheapest flights from Santa Isabel These prices were available within the past 7 days. Prices quoted are per person, return, for the period specified. Prices and availability are subject to change. Additional terms apply. All deals One way Return ![Arajet](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/DM.gif) Sun, 15 Mar - Sun, 22 Mar SJU San Juan SDQ Santo Domingo £101 Return found 4 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SJU,to:SDQ,departure:15/03/2026TANYT&leg2=from:SDQ,to:SJU,departure:22/03/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:100.67&airProductToken=AQo0CjIIxJoBEgM1MDEYsqIBIPKAASii3IcDMOfchwM4waABQABYAWoFU01BUlRyBkFQMUJPVwo0CjIIxJoBEgM1MDAY8oABILKiASjyqYgDMLeqiAM4waABQABYAWoFU01BUlRyBkFQMUJPVxIKCAsQARgIKgJETRgBIgQIARABKAIwAw) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Fri, 17 Oct - Sun, 19 Oct SJU San Juan EWR New York £113 Return found 5 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SJU,to:EWR,departure:17/10/2025TANYT&leg2=from:EWR,to:SJU,departure:19/10/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:112.60&airProductToken=AQoxCi8IwmwSBDE4OTAYsqIBIMSNASjMz_oCMMDR-gI4TEAAWAFqAkROcghQSTRQVVhMMQoxCi8IwmwSBDE4ODkYxI0BILKiASiH4foCMPLi-gI4TEAAWAFqAkROcghQSTRQVVhMMRIKCAEQARgBKgJCNhgBIgQIARABKAIoBCgGMAE) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Sat, 1 Nov - Sun, 2 Nov SJU San Juan FLL Fort Lauderdale £119 Return found 2 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SJU,to:FLL,departure:01/11/2025TANYT&leg2=from:FLL,to:SJU,departure:02/11/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:118.50&airProductToken=AQowCi4IwmwSBDE3NTQYsqIBIOVaKP34-wIwqPr7AjhMQABYAWoCRE5yCFBJMlFVRUwxCjAKLgjCbBIEMjI1MxjlWiCyogEo7P_7AjCHgfwCOExAAFgBagJETnIIUEkyUVVFTDESCggBEAEYASoCQjYYASIECAEQASgCKAQoBjAB) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Wed, 15 Oct - Tue, 21 Oct BQN Aguadilla FLL Fort Lauderdale £130 Return found 12 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:BQN,to:FLL,departure:15/10/2025TANYT&leg2=from:FLL,to:BQN,departure:21/10/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:129.60&airProductToken=AQovCi0IwmwSBDIwNzIYgWwg5Voo9bn6AjCNu_oCOExAAFgBagJETnIIUEk0UVJFTDEKLwotCMJsEgQyMDcxGOVaIIFsKOj7-gIw_vz6AjhMQABYAWoCRE5yCFBJNFFSRUwxEgoIARABGAEqAkI2GAEiBAgBEAEoAigEKAYwAQ) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Fri, 17 Oct - Sun, 19 Oct SJU San Juan JFK New York £135 Return found 5 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SJU,to:JFK,departure:17/10/2025TANYT&leg2=from:JFK,to:SJU,departure:19/10/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:134.60&airProductToken=AQovCi0IwmwSAzkwNBiyogEgqVEo9c36AjDiz_oCOExAAFgBagJETnIIUEk0UFVYTDEKLwotCMJsEgMzMDMYqVEgsqIBKOjn-gIw3-n6AjhMQABYAWoCRE5yCFBJNFBVWEwxEgoIARABGAEqAkI2GAEiBAgBEAEoAigEKAYwAQ) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Fri, 14 Nov - Tue, 25 Nov BQN Aguadilla MCO Orlando £151 Return found 3 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:BQN,to:MCO,departure:14/11/2025TANYT&leg2=from:MCO,to:BQN,departure:25/11/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:150.60&airProductToken=AQogCh4IwmwSAzMyORiBbCDMcCjTi_0CMImN_QI4TEAAWAEKIAoeCMJsEgM0MzAYzHAggWwoi4r-AjCui_4COExAAFgBEgoIARABGAEqAkI2GAEiBAgBEAEoBDAB) ![World Ticket Ltd](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/w1.gif) Wed, 15 Oct - Sun, 26 Oct SJU San Juan SDQ Santo Domingo £168 Return found 1 hour ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SJU,to:SDQ,departure:15/10/2025TANYT&leg2=from:SDQ,to:SJU,departure:26/10/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:167.40&airProductToken=AQojCiEI12ISBDQwMTIYsqIBIPKAASiouPoCMO24-gI4QUAAWAEKIwohCNdiEgQ0MDExGPKAASCyogEokrT7AjDXtPsCOEFAAFgBEgoIARABGAEqAlcyGAEiBAgBEAEoBDAB) ![JetBlue Airways](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/b6.gif) Thu, 18 Dec - Tue, 13 Jan PSE Ponce MCO Orlando £173 Return found 19 hours ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:PSE,to:MCO,departure:18/12/2025TANYT&leg2=from:MCO,to:PSE,departure:13/01/2026TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:172.60&airProductToken=AQouCiwIwmwSAzM2OBjPJCDMcCj-i4ADML2NgAM4TEAAWAFqAkROcghVSTJBUkVMMQouCiwIwmwSAzc2NxjMcCDPJCjSsIIDMPyxggM4TEAAWAFqAkROcghQSTRQVUVMMRIKCAEQARgBKgJCNhgBIgQIARABKAIoBCgGMAE) ![Copa](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/CM.gif) Tue, 14 Oct - Tue, 28 Oct SJU San Juan SDQ Santo Domingo £200 Return found 6 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SJU,to:SDQ,departure:14/10/2025TANYT&leg2=from:SDQ,to:SJU,departure:28/10/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:199.80&airProductToken=AQpoCjIIw5oBEgM0NTEYsqIBIO_EASi7qPoCMO6p-gI4QUAAWAFqBUJBU0lDcghBTEE3T1oyUwoyCMOaARIDMTI4GO_EASDygAEoqKz6AjC_rfoCOEFAAVgBagVCQVNJQ3IIQUxBN09aMlMKaAoyCMOaARIDMjY3GPKAASDvxAEoysf7AjDiyPsCOEFAAFgBagVCQVNJQ3IIQUxBN09aMlMKMgjDmgESAzQ1MBjvxAEgsqIBKMjM-wIw9M37AjhBQAFYAWoFQkFTSUNyCEFMQTdPWjJTEgoIARABGAEqAkNNGAEiBAgBEAEoAigDKAQwAQ) ![American Airlines](//images.trvl-media.com/media/content/expus/graphics/static_content/fusion/v0.1b/images/airlines/AA.gif) Fri, 31 Oct - Mon, 3 Nov SJU San Juan MCO Orlando £250 Return found 4 days ago [](https://expedia.co.uk/Flights-Search?trip=roundtrip&leg1=from:SJU,to:MCO,departure:31/10/2025TANYT&leg2=from:MCO,to:SJU,departure:03/11/2025TANYT&passengers=children:0,adults:1,seniors:0,infantinlap:N&mode=search&options=sortby:price&paandi=true&flp=mdl:flights-flex-module,price:249.20&airProductToken=AQpmCjEIwYIBEgM5NjcYsqIBIIwCKIzt-wIwtu77AjhCQABYAWoFQkFTSUNyCFFOTjRBSEJaCjEIwYIBEgQyNjY3GIwCIMxwKO7v-wIwr_D7AjhCQAFYAWoFQkFTSUNyCFFOTjRBSEJaCmcKMQjBggESBDE2NzEYzHAgjAIolIr8AjDcivwCOEJAAFgBagVCQVNJQ3IITk5ONEFIQloKMgjBggESBDIxNDEYjAIgsqIBKKqL_AIwxYz8AjhCQAFYAWoFQkFTSUNyCE5OTjRBSEJaEgoIARABGAEqAkFBGAEiBAgBEAEoAigDKAQwCw) ## How to Find Cheap Flights from Santa Isabel #### How much is a flight from Santa Isabel?        This week, flights from Santa Isabel are available between £101–£250.  #### How to find cheap flights from Santa Isabel? Expedia makes it easy to compare cheap flights from Santa Isabel to many destinations. Check out excellent deals on both domestic and international flights from Santa Isabel. Once you select an offer, use our filters and sort by “Price (Lowest)” to see the cheapest and most suitable options.  #### How can I get the best deal on flights from Santa Isabel? Expedia gives you access to all the hottest deals on plane tickets so you can get the most amount of value for the lowest price possible. An excellent strategy for finding the best deal on flights is to be flexible with your dates. For each offer, you can compare prices for similar time frames using our “Show flexible dates” feature. Depending on your destination, direct flights from Santa Isabel may be more expensive. Airlines with strict bag policies or fees can also impact your costs.  #### What is the best airline to fly from Santa Isabel? At Expedia, we give you all the available options from our reputable partners. Select the airline that best suits your preferences and membership loyalties. You can fly from Santa Isabel with: Arajet, JetBlue Airways, Delta, World Ticket Ltd, American Airlines, Copa.  #### What is the best month to fly from Santa Isabel? Prices on plane tickets vary considerably throughout the year due to seasonal demand. Historically, the cheapest time to buy flights from Santa Isabel airport(s) is March.  #### When is the best time to book flights from Santa Isabel? ARC & Expedia Group historical data suggests that booking flights three weeks before departure and on a weekend, usually on a Sunday, can save you up to 20% on your fare. \* #### Are there any last-minute flights from Santa Isabel? Expedia is the place to find last-minute flights from Santa Isabel, making it easy for you to compare prices on flights in the near future for different combinations of travel dates and from multiple airlines. We source the best deals for you and display the best offers available over the next two weeks.  #### Why book with Expedia? Booking flights from Santa Isabel with Expedia is the obvious choice to get low prices, save money and see more value for every pound spent. We show you the best deals happening right now and provide a vast inventory of airlines and flight routes to choose from. You can customise your journey to your timeline, route preferences, budget, rewards programmes and more. Not only will you get a stellar deal, but you’ll also get rewards points back and the opportunity for additional discounts when bundling with a hotel or car hire. #### Can I change/cancel my flight?  Some flights can be changed or cancelled, but fees and refunds will depend on the unique terms of your flight agreement. Airlines have different rules and restrictions for exchanging or refunding flights. For more information, go to your itinerary or visit our customer service portal. We recommend choosing flights with no change fees for maximum flexibility. Filter by “Flexible change policies” to see flights with no change fees. \**Data specialists from both ARC and Expedia Group analyzed ARC’s global flight data to distill actionable information to help people save money on travel. While it’s impossible to guarantee when to find the lowest prices, after examining the variables, we were able to observe trends. Best day of the week to book and travel recommendation is based on average round-trip ticket prices for January through early October, for both 2019 and 2020, sourced from ARC’s global airline sales database.*. ## Travel information ## Flights from Santa Isabel: Essential Travel Information | Cheapest flight from Santa Isabel | £101 (roundtrip) | | --- | --- | | Best airlines to fly from Santa Isabel | Arajet, JetBlue Airways, Delta, World Ticket Ltd, American Airlines, Copa | | Cheapest month to fly from Santa Isabel | March | | Santa Isabel IATA code | SJU | | Santa Isabel Country/State | Puerto Rico | | Airline ticket deals from Santa Isabel | £101 - £250 | ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - [Coamo Hotels](https://www.expedia.co.uk/Coamo-Hotels.d500175.Travel-Guide-Hotels) - [Isla Caja de Muertos Hotels](https://www.expedia.co.uk/Isla-Caja-De-Muertos-Hotels.d6360657.Travel-Guide-Hotels) - [Juana Diaz Hotels](https://www.expedia.co.uk/Juana-Diaz-Hotels.d6231766.Travel-Guide-Hotels) - 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[Flights from London (LHR) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/lhr/pse/london-to-ponce) - [Flights from Lille (LIL) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/lil/pse/lille-to-ponce) - [Flights from Madrid (MAD) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/mad/pse/madrid-to-ponce) - [Flights from Orlando (MCO) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/mco/pse/orlando-to-ponce) - [Flights from Medellín (MDE) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/mde/pse/medellin-to-ponce) - [Flights from Miami (MIA) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/mia/pse/miami-to-ponce) - [Flights from Milwaukee (MKE) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/mke/pse/milwaukee-to-ponce) - [Flights from Muskegon (MKG) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/mkg/pse/muskegon-to-ponce) - [Flights from Madison (MSN) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/msn/pse/madison-to-ponce) - [Flights from Minneapolis (MSP) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/msp/pse/minneapolis-to-ponce) - [Flights from Manitowoc (MTW) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/mtw/pse/manitowoc-to-ponce) - [Flights from New York (NYC) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/nyc/pse/new-york-to-ponce) - [Flights from Ocala (OCF) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/ocf/pse/ocala-to-ponce) - [Flights from Wyk auf Foehr (OHR) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/ohr/pse/wyk-auf-foehr-to-ponce) - [Flights from Chicago (ORD) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/ord/pse/chicago-to-ponce) - [Flights from Orlando (ORL) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/orl/pse/orlando-to-ponce) - [Flights from Port-au-Prince (PAP) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/pap/pse/port-au-prince-to-ponce) - [Flights from Portland (PDX) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/pdx/pse/portland-to-ponce) - [Flights from Pilot Point (PIP) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/pip/pse/pilot-point-to-ponce) - [Flights from Port of Spain (POS) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/pos/pse/port-of-spain-to-ponce) - [Flights from Pago Pago (PPG) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/ppg/pse/pago-pago-to-ponce) - [Flights from Punta Cana (PUJ) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/puj/pse/punta-cana-to-ponce) - [Flights from Rockford (RFD) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/rfd/pse/rockford-to-ponce) - [Flights from Santo Domingo (SDQ) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/sdq/pse/santo-domingo-to-ponce) - [Flights from Seattle (SEA) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/sea/pse/seattle-to-ponce) - [Flights from Olongapo (SFS) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/sfs/pse/olongapo-to-ponce) - [Flights from San José (SJO) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/sjo/pse/san-jose-to-ponce) - [Flights from San Juan (SJU) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/sju/pse/san-juan-to-ponce) - [Flights from Salt Lake City (SLC) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/slc/pse/salt-lake-city-to-ponce) - [Flights from Sarasota (SRQ) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/srq/pse/sarasota-to-ponce) - [Flights from Stockholm (STO) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/sto/pse/stockholm-to-ponce) - [Flights from Tirana (TIA) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/tia/pse/tirana-to-ponce) - [Flights from Tiko (TKC) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/tkc/pse/tiko-to-ponce) - [Flights from Torrance (TOA) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/toa/pse/torrance-to-ponce) - [Flights from Tampa (TPA) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/tpa/pse/tampa-to-ponce) - [Flights from Utica (UCA) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/uca/pse/utica-to-ponce) - [Flights from Ust-Ilimsk (UIK) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/uik/pse/ust-ilimsk-to-ponce) - [Flights from Charleville Mezieres (XCZ) to Ponce (PSE)](https://www.expedia.co.uk/lp/flights/xcz/pse/charleville-mezieres-to-ponce) - 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