Title: TOP Luxury Hotels in Texas Medical Center, Houston for 2026 - Texas Medical Center Upscale Hotels | Expedia.co.uk [Holiday Rentals in Houston](https://expedia.co.uk/Houston-Holiday-Rentals.d178265.Travel-Guide-HolidayRentals)[Flights to Houston](https://expedia.co.uk/Cheap-Flights-To-Houston.d178265.Travel-Guide-Flights)[Things to do in Houston](https://expedia.co.uk/Things-To-Do-In-Houston.d178265.Travel-Guide-Activities)[Texas Medical Center Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Texas-Medical-Center.d6143504.Car-Hire-Guide)[Texas Medical Center Holidays](https://expedia.co.uk/Texas-Medical-Center.d6143504.Holidays-City-Breaks) ![Houston_TexasChildrensHospital_553248635389801905_9](https://images.trvl-media.com/place/553248635389801905/db4dee74-4310-41e3-8220-625d7fc800e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635389801905/db4dee74-4310-41e3-8220-625d7fc800e9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Texas Medical Center Luxury Hotels Tonight [17 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6143504&startDate=2026-01-17&endDate=2026-01-18&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [18 Jan - 19 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6143504&startDate=2026-01-18&endDate=2026-01-19&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6143504&startDate=2026-01-23&endDate=2026-01-25&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6143504&startDate=2026-01-30&endDate=2026-02-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Texas Medical Center luxury hotels ![American cuisine](https://images.trvl-media.com/lodging/1000000/20000/16200/16154/647bab8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/16200/16154/75d213df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Egyptian cotton sheets, premium bedding, down duvets, pillow-top beds](https://images.trvl-media.com/lodging/1000000/20000/16200/16154/87753400.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/20000/16200/16154/d72506d7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Houston Marriott Medical Center/Museum District [](https://www.expedia.co.uk/Houston-Hotels-Houston-Marriott-Medical-CenterMuseum-District.h16154.Hotel-Information) Texas Medical Center 9.0/10 Wonderful (1,000 reviews) "Great experience" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gordon £165 includes taxes & fees 31 Jan - 1 Feb [](https://www.expedia.co.uk/Houston-Hotels-Houston-Marriott-Medical-CenterMuseum-District.h16154.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/430000/428800/428779/4c06ef00.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio, 1 King Bed with Sofa bed, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/430000/428800/428779/2dedb7c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/430000/428800/428779/7becac76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Studio, 1 Double Bed with Sofa bed, Accessible, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/430000/428800/428779/f414f5ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Extended Stay America Suites Houston Med Ctr Braeswood Bl [](https://www.expedia.co.uk/Houston-Hotels-Extended-Stay-America-Suites-Houston-Med-Ctr-Braeswood-Bl.h428779.Hotel-Information) Texas Medical Center 5.8/10 (1,005 reviews) "Clean" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William £51 includes taxes & fees 18 Jan - 19 Jan [](https://www.expedia.co.uk/Houston-Hotels-Extended-Stay-America-Suites-Houston-Med-Ctr-Braeswood-Bl.h428779.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-31&endDate=2026-02-01®ionId=6143504&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Texas Medical Center ### Texas Medical Centerand its attractions for luxury travelers In the heart of the Texas Medical Center, luxury travellers can indulge in a unique blend of high-end experiences. Begin your day with a rejuvenating treatment at the renowned MD Anderson Cancer Center’s wellness centre, offering specialized services designed to pamper and refresh. For a taste of culture, the nearby Houston Museum District features the Menil Collection, where you can explore stunning art exhibits in an elegantly designed space. Stroll through Hermann Park, where you can enjoy a picturesque afternoon on a pedal boat or a peaceful picnic with the family, surrounded by lush greenery. For the adventurous spirit, the Houston Zoo is just a stone's throw away, providing an engaging and educational experience for your children with interactive exhibits that spark curiosity. After a day of exploration, retreat to opulent hotels that promise unparalleled comfort and personalised service—think spacious suites with panoramic views of the city skyline, gourmet dining options, and spa treatments that cater to your every need. The Texas Medical Center area perfectly marries convenience with luxury, ensuring you experience the best of Houston while feeling pampered throughout your stay. ### Find the best luxury hotels and resorts in Texas Medical Center For those seeking an indulgent stay in the heart of Texas Medical Center, these top luxury hotels offer exquisite amenities and unparalleled service. [**InterContinental Houston by IHG**](https://www.expedia.co.uk/Houston-Hotels-InterContinental-Houston-Medical-Center.h23830866.Hotel-Information) - **Why it's great for a luxury retreat:** The InterContinental Houston by IHG stands out as a premier choice for luxury travelers, earning an outstanding review rating of 9.2\. This hotel offers elegant rooms with premium bedding and designer bathrobes, alongside exceptional concierge service to cater to guests’ every need. Valet parking is also readily available, further enhancing convenience during their stay. - **Other amenities:** Guests can indulge in delicious meals at the on-site restaurant or relax on the terrace with a drink. The outdoor pool is perfect for a refreshing dip, while the 24-hour fitness facilities ensure guests stay active. The hotel also provides electric car charging stations and comprehensive housekeeping services, allowing for a seamless luxury experience throughout their stay. - **Neighborhood:** Texas Medical Center - **Nearby attractions:** MD Anderson Cancer Center - 1.1 km [**Houston Marriott Medical Center/Museum District**](https://www.expedia.co.uk/Houston-Hotels-Houston-Marriott-Medical-CenterMuseum-District.h16154.Hotel-Information) - **Why it's great for a luxury retreat:** The Houston Marriott Medical Center/Museum District is a luxurious venue that boasts a solid review rating of 9.0\. Guests enjoy the comfort of premium bedding and the upscale amenities of a club lounge, providing a refined experience for travelers seeking luxury. Valet parking services add to the ease of access, making it a preferred choice for visitors. - **Other amenities:** The hotel features a 24-hour fitness centre for those looking to stay active, alongside cribs for families travelling with infants. Guests can benefit from the nearby golf courses and enjoy the convenience of an airport shuttle. Daily housekeeping and complimentary toiletries further elevate the luxury experience, ensuring guests feel pampered throughout their stay. - **Neighborhood:** Texas Medical Center - **Nearby attractions:** MD Anderson Cancer Center - 0.7 km [**The Westin Houston Medical Center/Museum District**](https://www.expedia.co.uk/Houston-Hotels-The-Westin-Houston-Medical-Center.h39618635.Hotel-Information) - **Why it's great for a luxury retreat:** The Westin Houston Medical Center/Museum District is a luxurious retreat that scores a remarkable review rating of 9.0\. Guests are treated to premium bedding, bathrobes, and a stunning poolside bar, creating an inviting atmosphere for relaxation. The concierge services add an element of sophistication, ensuring that every request is met with exemplary service. - **Other amenities:** The outdoor pool is accompanied by sun loungers and umbrellas, perfect for lounging on warm days. A rooftop garden provides a serene escape, while the 24-hour fitness centre caters to wellness-focused guests. Additional features include express check-in for convenience, a restaurant with diverse dining options, and daily housekeeping to maintain a pristine environment. - **Neighborhood:** Texas Medical Center - **Nearby attractions:** MD Anderson Cancer Center - 0.7 km [**Blossom Hotel Houston**](https://www.expedia.co.uk/Houston-Hotels-Blossom-Houston-Hotel.h58985846.Hotel-Information) - **Why it's great for a luxury retreat:** Blossom Hotel Houston is a luxurious haven for travelers, an impressive guest review rating of 9.0\. Guests can expect premium bedding and designer toiletries that enhance their stay, along with attentive valet parking services. The on-site spa provides a range of treatments, from body therapies to massages, ensuring a rejuvenating experience for every guest. - **Other amenities:** The hotel features a rooftop terrace where guests can unwind while enjoying stunning views. An outdoor pool invites relaxation under the Texas sun, complemented by pool sun loungers for comfort. A 24-hour fitness centre caters to health enthusiasts, while daily housekeeping ensures a pristine environment. For those needing flexibility, early check-in and late check-out options are available, enhancing the luxurious experience. - **Neighborhood:** Texas Medical Center - **Nearby attractions:** MD Anderson Cancer Center - 1.4 km [**Hilton Houston Plaza/Medical Center**](https://www.expedia.co.uk/Houston-Hotels-Hilton-Houston-Plaza-Medical-Center.h25188.Hotel-Information) - **Why it's great for a luxury retreat:** The Hilton Houston Plaza/Medical Center offers a refined luxury experience with an excellent review rating of 8.4\. Guests are welcomed with premium bedding and can enjoy a poolside bar, making relaxation effortless. The concierge service is available to assist with reservations and local insights, ensuring a tailored experience for every traveler. - **Other amenities:** The hotel features an outdoor pool and ample sun loungers for enjoying the Texas sun. A 24-hour fitness centre allows guests to maintain their workout routines, while on-site dining options provide convenience. Guests also have access to self-parking and the option of room amenities like refrigerators and microwaves, ensuring a comfortable stay. - **Neighborhood:** Texas Medical Center - **Nearby attractions:** MD Anderson Cancer Center - 0.9 km, Hermann Park - 1.1 km ## Top Texas Medical Center Hotel Reviews ![Hilton Americas-Houston](https://images.trvl-media.com/lodging/1000000/980000/976200/976144/09dd0b59_y.jpg) ### Hilton Americas-Houston 10/10 Excellent "Clean and remodeled room, amazing staff, and great support for the Houston marathon participants " [](https://expedia.co.uk/Houston-Hotels-Hilton-Americas-Houston.h976144.Hotel-Information) ![The Whitehall Houston](https://images.trvl-media.com/lodging/1000000/700000/693700/693655/f1d85056_y.jpg) ### The Whitehall Houston 10/10 Excellent "Great friendly staff who went above and beyond to accommodate me. I arrived at the property at 1:00 pm and even though my check-in time was at 3:00, they offered to check me in 2 hours early without any hesitation. They knew I was running the Houston marathon on my return date and assured me that they will accommodate an hour for a late checkout. Very professional staff and attentive to guest’s needs. Highly recommend The Whitehall Houston!! " [](https://expedia.co.uk/Houston-Hotels-The-Whitehall-Houston.h693655.Hotel-Information) ![The Royal Sonesta Houston Galleria](https://images.trvl-media.com/lodging/1000000/880000/878700/878652/9874e960_y.jpg) ### The Royal Sonesta Houston Galleria 10/10 Excellent "Love" [](https://expedia.co.uk/Houston-Hotels-Royal-Sonesta-Houston-Galleria.h878652.Hotel-Information) ![Hilton Houston Plaza/Medical Center](https://images.trvl-media.com/lodging/1000000/30000/25200/25188/294f3d50_y.jpg) ### Hilton Houston Plaza/Medical Center 10/10 Excellent "Room was nice and newly renovated. Check in was a breeze. Sleep was comfortable!" [](https://expedia.co.uk/Houston-Hotels-Hilton-Houston-Plaza-Medical-Center.h25188.Hotel-Information) ![Magnolia Hotel Houston, A Tribute Portfolio Hotel](https://images.trvl-media.com/lodging/1000000/910000/907500/907459/0b2adb37_y.jpg) ### Magnolia Hotel Houston, A Tribute Portfolio Hotel 10/10 Excellent "Clean.. loved the cookies and milk" [](https://expedia.co.uk/Houston-Hotels-Magnolia-Hotel-Houston.h907459.Hotel-Information) ![DoubleTree by Hilton Houston Medical Center Hotel & Suites](https://images.trvl-media.com/lodging/1000000/10000/6700/6636/w3835h2553x0y4-ca278b6c_y.jpg) ### DoubleTree by Hilton Houston Medical Center Hotel & Suites 10/10 Excellent "Very nice and clean and comfortable" [](https://expedia.co.uk/Houston-Hotels-Wyndham-Houston-Medical-Center-Hotel-And-Suites.h6636.Hotel-Information) ![Omni Houston Hotel](https://images.trvl-media.com/lodging/1000000/20000/17800/17746/37423ee4_y.jpg) ### Omni Houston Hotel 10/10 Excellent "Very courteous and efficient " [](https://expedia.co.uk/Houston-Hotels-Omni-Houston-Hotel.h17746.Hotel-Information) ![Club Quarters Hotel Downtown, Houston](https://images.trvl-media.com/lodging/2000000/1160000/1157000/1156923/44a9a3fd_y.jpg) ### Club Quarters Hotel Downtown, Houston 10/10 Excellent "Great " [](https://expedia.co.uk/Houston-Hotels-Club-Quarters-Hotel-In-Houston.h1156923.Hotel-Information) ![DoubleTree by Hilton Hotel Houston - Greenway Plaza](https://images.trvl-media.com/lodging/1000000/30000/20200/20177/682ca680_y.jpg) ### DoubleTree by Hilton Hotel Houston - Greenway Plaza 10/10 Excellent "It was nice I didn’t care for the mattress " [](https://expedia.co.uk/Houston-Hotels-DoubleTree-By-Hilton-Hotel-Houston-Greenway-Plaza.h20177.Hotel-Information) ## Frequently asked questions ### Are you searching for the perfect hotel for your luxury getaway to Texas Medical Center? ### What's the best high-end hotel in Texas Medical Center? ### What's there to see and do in Texas Medical Center? ### How can I get around Texas Medical Center? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [4 Star Hotels in Downtown Houston ](https://www.expedia.co.uk/4Star-Downtown-Houston-Houston-Hotels.s40-n800037-0.Travel-Guide-Filter-Hotels) - [4 Star Hotels in Houston ](https://www.expedia.co.uk/4Star-Houston-Hotels.s40-0-d178265.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Houston ](https://www.expedia.co.uk/5Star-Houston-Hotels.s50-0-d178265.Travel-Guide-Filter-Hotels) - [Astrodome Hotels ](https://www.expedia.co.uk/Astrodome-Houston-Hotels.0-n553248635976007975-0.Travel-Guide-Filter-Hotels) - [Bellaire Hotels ](https://www.expedia.co.uk/Bellaire-Hotels.d78408.Travel-Guide-Hotels) - [Hotels near Daikin Park ](https://www.expedia.co.uk/Daikin-Park-Hotels.0-l6034772-0.Travel-Guide-Filter-Hotels) - [Harris County Hotels ](https://www.expedia.co.uk/Destinations-In-Harris-County.d553248635975094933.Hotel-Destinations) - [Cheap Hotels in Downtown Houston ](https://www.expedia.co.uk/Downtown-Houston-Houston-Hotels-Budget-Hotels.0-n800037-0-tBudgetHotels.Travel-Guide-Filter-Hotels) - [Business Hotels in Downtown Houston ](https://www.expedia.co.uk/Downtown-Houston-Houston-Hotels-Business-Hotel.0-n800037-0-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Historic Hotels in Downtown Houston ](https://www.expedia.co.uk/Downtown-Houston-Houston-Hotels-Historic-Hotel.0-n800037-0-tHistoricHotel.Travel-Guide-Filter-Hotels) - [Hotels Suites in Downtown Houston ](https://www.expedia.co.uk/Downtown-Houston-Houston-Hotels-Hotel-Suites.0-n800037-0-thotelsuites.Travel-Guide-Filter-Hotels) - [Hotels with Pool in Downtown Houston ](https://www.expedia.co.uk/Downtown-Houston-Houston-Hotels-Hotels-With-Pool.0-n800037-0-tHotelswithPool.Travel-Guide-Filter-Hotels) - [Luxury Hotels in Downtown Houston ](https://www.expedia.co.uk/Downtown-Houston-Houston-Hotels-Luxury-Hotel.0-n800037-0-tLuxuryHotel.Travel-Guide-Filter-Hotels) - [Downtown Houston Hotels ](https://www.expedia.co.uk/Downtown-Houston-Houston-Hotels.0-n800037-0.Travel-Guide-Filter-Hotels) - [East Downtown Houston Hotels ](https://www.expedia.co.uk/East-Downtown-Houston-Houston-Hotels.0-n6004016-0.Travel-Guide-Filter-Hotels) - [Fourth Ward Hotels ](https://www.expedia.co.uk/Fourth-Ward-Houston-Hotels.0-n553248635976395435-0.Travel-Guide-Filter-Hotels) - [Hotels near George R. 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