Title: TOP Southwest Illinois Spa Hotels for 2025 - Spas in Southwest Illinois, IL | Expedia.co.uk [Southwest Illinois Travel Guide](https://expedia.co.uk/Southwest-Illinois.dx6058943)[Hotels in Southwest Illinois](https://expedia.co.uk/Southwest-Illinois-Hotels.d6058943.Travel-Guide-Hotels)[Holiday Rentals in Southwest Illinois](https://expedia.co.uk/Southwest-Illinois-Holiday-Rentals.d6058943.Travel-Guide-HolidayRentals)[Flights to Southwest Illinois](https://expedia.co.uk/Cheap-Flights-To-Southwest-Illinois.d6058943.Travel-Guide-Flights)[Southwest Illinois Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southwest-Illinois.d6058943.Car-Hire-Guide)[Southwest Illinois Holidays](https://expedia.co.uk/Southwest-Illinois.d6058943.Holidays-City-Breaks) ![Southern Illinois featuring cycling, autumn colours and forest scenes](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/208000/208701-Southern-Illinois.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find Spa Hotels in Southwest Illinois, IL - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southwest Illinois Spa Hotels Tonight [2 Nov - 3 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058943&startDate=2025-11-02&endDate=2025-11-03&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [3 Nov - 4 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058943&startDate=2025-11-03&endDate=2025-11-04&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [7 Nov - 9 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058943&startDate=2025-11-07&endDate=2025-11-09&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [14 Nov - 16 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6058943&startDate=2025-11-14&endDate=2025-11-16&adults=2&amenities=SPA_ON_SITE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Southwest Illinois Spa Hotels ![Sauna, hot tub, body treatments, hot stone massages](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/aecef3e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, seasonal outdoor pool](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/1aec7f72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bars/lounges](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/e7229757.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/a0fca68c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walker's Bluff Casino Resort Carterville 9.4/10 Exceptional (383) "Great place!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jeff [](https://www.expedia.co.uk/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/fe49057f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free breakfast ](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/5fa70c20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/479dc559.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1280000/1278600/1278542/eb2507f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG Cape Girardeau 9.4/10 Exceptional (1001) "Clean and welcoming. Tyler at the front desk for check in was engaging and friendly. He’s a gem!!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Penny £85 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Hotel-Suites-Cape-Girardeau-I-55.h1278542.Hotel-Information) ![Hot tub, body treatments, hydrotherapy, aromatherapy, body scrubs](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/f78a36b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/502ee41b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/c42cf5fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hot tub, body treatments, hydrotherapy, aromatherapy, body scrubs](https://images.trvl-media.com/lodging/2000000/1880000/1873300/1873292/422bb82f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ameristar Casino Resort and Spa St. Charles 8.4/10 Very good (1003) "Great place to stay.Will visit again." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Shameka £170 includes taxes & fees 16 Nov - 17 Nov [](https://www.expedia.co.uk/St-Louis-Hotels-Ameristar-Casino-Resort-And-Spa.h1873292.Hotel-Information) ![Couples treatment room(s), hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/56a41562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/89e020ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Couples treatment room(s), hot tub, body treatments, aromatherapy](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/941b0ba8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/5b370fff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel St Louis Downtown St. Louis 9.4/10 Exceptional (1003) "We’ve stayed at this hotel several times and keep coming back. Great hotel staff and property. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Darla £378 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information) ![Massages](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/1c63195a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Loft, 2 Queen Beds | 1 bedroom, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/639a96f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/fb7f173e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/cd6b7758.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### 21C Museum Hotel St Louis Downtown West 9.0/10 Wonderful (1435) "Beautiful space, unique atmosphere and very clean. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tiffany £135 includes taxes & fees 23 Nov - 24 Nov [](https://www.expedia.co.uk/St-Louis-Hotels-21C-Museum-Hotel-St-Louis.h89164592.Hotel-Information) ![Body treatments, aromatherapy, hot stone massages, deep-tissue massages](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/b7162ce8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/9a597e77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/w4000h2663x0y0-dfd3faff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/8fec4778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ritz-Carlton, St. Louis Clayton 9.2/10 Wonderful (551) "Room was very spacious. The property was immaculate and the service was attentive without be over bearing." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James Anthony £478 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-17&endDate=2025-11-18®ionId=6058943&adults=2&amenities=SPA_ON_SITE&sort=RECOMMENDED&openPlayBack=true) ## Find out more about Southwest Illinois ### Top Southwest Illinois attractions for a relaxing vacation Southwest Illinois offers a delightful blend of relaxation and adventure for travellers seeking hotels with spas. Start your journey in the charming town of Alton, where you can explore the scenic Mississippi Riverfront and unwind with a leisurely cruise, surrounded by stunning views. Just a short drive away, the historic Lewis and Clark Confluence Tower offers panoramic vistas of the river and beyond, a perfect spot for some tranquil moments. For those who appreciate nature, the beautiful gardens at the National Shrine of Our Lady of the Snows in Belleville provide a serene backdrop for reflection and relaxation. If you're up for a little thrill, the nearby Cahokia Mounds State Historic Site invites you to step back in time, exploring ancient Native American earthworks while enjoying the peaceful atmosphere. After a day of exploration, retreat to one of the region's luxurious hotels that feature exceptional spa services, where you can indulge in rejuvenating treatments designed to pamper and restore. With attentive guest service and a focus on quality, these establishments ensure a comfortable stay as you immerse yourself in the unique culture and natural beauty of Southwest Illinois. ## Top Southwest Illinois Hotel Reviews ![Drury Inn & Suites St. Louis O'Fallon, IL](//images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/d2bc121f_y.jpg) ### Drury Inn & Suites St. Louis O'Fallon, IL 10/10 Excellent "Everything was great" [](https://expedia.co.uk/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-OFallon.h1544028.Hotel-Information) ![Drury Plaza Hotel Mt. Vernon](//images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b_y.jpg) ### Drury Plaza Hotel Mt. Vernon 10/10 Excellent "Super friendly staff. Everything was spotless. Perfect stay" [](https://expedia.co.uk/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Comfort Suites Mount Vernon](//images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b34f836a_y.jpg) ### Comfort Suites Mount Vernon 10/10 Excellent "Great room!!!" [](https://expedia.co.uk/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Drury Inn & Suites Marion](//images.trvl-media.com/lodging/1000000/50000/42100/42025/a8315e37_y.jpg) ### Drury Inn & Suites Marion 10/10 Excellent "The breakfast was good, and in the evening having coffee and a soft drink fountain available was very nice. My only suggestion would be to provide a more firm pillow." [](https://expedia.co.uk/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) ![Drury Inn & Suites St. Louis Fairview Heights](//images.trvl-media.com/lodging/1000000/50000/41900/41802/c56c0460_y.jpg) ### Drury Inn & Suites St. Louis Fairview Heights 10/10 Excellent "Staff member Romello was Awesome. He went above and beyond for us. His customer service skills are exceptional." [](https://expedia.co.uk/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Fairview-Heights.h41802.Hotel-Information) ![Best Western Plus Pontoon Beach](//images.trvl-media.com/lodging/3000000/2700000/2695400/2695352/01153352_y.jpg) ### Best Western Plus Pontoon Beach 10/10 Excellent "Breakfast was great and friendly employees" [](https://expedia.co.uk/St-Louis-Hotels-Best-Western-Plus-Pontoon-Beach.h2695352.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [4 Star Hotels in Swansea](https://www.expedia.co.uk/4Star-Swansea-Hotels.s40-0-d164131.Travel-Guide-Filter-Hotels) - [5 Star Hotels in Marissa](https://www.expedia.co.uk/5Star-Marissa-Hotels.s50-0-d3000434506.Travel-Guide-Filter-Hotels) - [Addieville Hotels](https://www.expedia.co.uk/Addieville-Hotels.d3000420807.Travel-Guide-Hotels) - [Hotels with Gym in Alton](https://www.expedia.co.uk/Alton-Hotels-Hotel-With-Gym.0-0-d6108-thotelwithgym.Travel-Guide-Filter-Hotels) - 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