All Hotels by La Quinta Inn & Suites in Southwest Illinois - 2026 Updated Prices

A calm lake surrounded by trees and vegetation.

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Our top choices for Southwest Illinois La Quinta Inn & Suites

A modern lounge area with a sectional sofa, ottomans, and a round table.

A swimming pool with clear blue water, a tiled deck, and a glass wall offering a view of the outside.

A reception desk with a computer, a printer, and a sign that reads "TRAVEL happy". There are chairs and a large window in the background.

A hotel room with two beds, a desk, a chair, a television, and a painting on the wall.

1. Drury Inn & Suites St. Louis Fairview Heights

Fairview Heights

Arameia

£76

includes taxes & fees

28 Sept - 29 Sept

A hotel room with a large mirror, a bathtub, a bedside table with a lamp, and a green bed.

A spacious lobby with a reception desk, seating area, and a staircase leading to an upper level.

A spacious lobby with a sofa, chairs, a coffee table, and a computer desk.

A restaurant with tiled floors, wooden tables and chairs, a counter with a TV, and a window with a view.

2. Quality Inn O'Fallon - St. Louis - Shiloh

O'Fallon

Laura

£53

includes taxes & fees

18 Oct - 19 Oct

A bar area with a long counter, multiple chairs, and hanging light fixtures.

An indoor swimming pool with a metal ladder, a warning sign about cold weather, and a view of the outside.

A hotel room with two beds, a desk with a flat-screen TV, a chair, and a lamp.

A spacious lobby with a reception desk, seating area, and glass doors leading outside.

3. Drury Plaza Hotel Mt. Vernon

Mount Vernon

Kirstyn

£94

includes taxes & fees

27 Sept - 28 Sept

A hotel room with a bed, a chair, a nightstand, and a picture on the wall.

A hotel room with a large window, a mirror, a red armchair, a blue armchair, a small table, and a floor lamp.

A modern hotel entrance with a covered driveway, an American flag, and a building with large windows.

An indoor swimming pool with a blue and white tiled floor, a red border, and a staircase leading to a balcony with white chairs.

4. Quality Inn & Suites near St. Louis and I-255

Cahokia

OSCAR

£62

includes taxes & fees

5 Oct - 6 Oct

A spacious lobby with high ceilings, multiple seating areas, and large windows allowing natural light.

An indoor swimming pool with clear water, tiled walls, and a ceiling with square vents.

An outdoor patio area with a table and chairs, a red umbrella, and a brick building facade.

5. Drury Inn & Suites Marion

Marion

kevin

£93

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, each with a wooden headboard, white bedding, and a blue throw blanket. There is a nightstand with a lamp between the beds, and a framed picture on the wall.

An indoor swimming pool with clear water, a diving board, and lounge chairs along the poolside.

A hotel dining area with multiple tables and chairs, a kitchen in the background, and a bar area.

A hotel lobby with a seating area, a reception desk, and a computer station.

6. Comfort Suites Fairview Heights - St. Louis

Fairview Heights

Josh

£66

includes taxes & fees

29 Sept - 30 Sept

A restaurant with multiple tables and booths, large windows, and a modern interior design.

A modern kitchen with a central island, bar stools, and a dining area.

A hotel named "The Principal Hotel" with a brick facade, multiple windows, and a parking lot in front.

A wooden wall with the sign "THE PRINCIPAL HOTEL" and a row of books below.

7. The Principal Hotel

Columbia

Kenny

£74

includes taxes & fees

27 Sept - 28 Sept

A spacious lobby with a high ceiling, large windows, and a variety of seating options including sofas and chairs.

An indoor swimming pool with clear glass walls, a tiled edge, and a ceiling with metal beams. There are lounge chairs and tables around the pool area.

A spacious indoor area with a large table and chairs, a sofa, and a staircase leading to an upper level.

A hotel room with a large bed, a desk, a chair, and a television.

8. Drury Inn & Suites St. Louis Collinsville

Eastport

Lisa

£95

includes taxes & fees

27 Sept - 28 Sept

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Top Southwest Illinois Hotel Reviews

Comfort Inn Edwardsville - St. Louis

8/10 Good

"The room was clean and nice. Air conditioning worked. Breakfast was good. No complaints at all about the room, food or the staff. The elevator did giving off a smoke smell to it but tolerable."

Drury Inn & Suites St. Louis O'Fallon, IL

10/10 Excellent

"The inside and outside pool was very unique. One elevator did not work out for me and my family it took for ever to get to my room. The staff was very friendly and nice. My family and I liked staying at this hotel"

Drury Inn & Suites Marion

10/10 Excellent

"The breakfast was pretty good. The great thing I noticed was the real silverware, not the usual plastic. Kind of a small thing but noticed."

Radisson Hotel Fairview Heights - St. Louis

8/10 Good

"clean pretty quiet and close to i64"

Drury Inn & Suites St. Louis Collinsville

10/10 Excellent

"This was the first time I've stayed at a Drury Inn and Suites Hotel and I was impressed. The room was nice. The staff was helpful and professional and the hotel offered a happy hour with a small buffet and drinks as well as a breakfast. I'll definitely stay at another Drury while traveling."

Walker's Bluff Casino Resort

8/10 Good

"Staff was very helpful checking me and my dog in. Was just passing by for the night was a good place to stop and recharge before continuing my journey. Would definitely visit again if life takes me in the area"

Country Inn & Suites by Radisson, Fairview Heights, IL

10/10 Excellent

"Was perfect for our plans. Hotel was clean with friendly staff."

Baymont by Wyndham Marion

8/10 Good

"although not new the hotel was in good condition and the price was acceptable"

Motel 6 Caseyville, IL - Caseyville Il

10/10 Excellent

"Is very good and good staff"

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Our top choices for Southwest Illinois La Quinta Inn & Suites

1. Drury Inn & Suites St. Louis Fairview Heights