Photo by Southernmost Illinois Tourism Bureau
Find luxury hotels in Southern Illinois, IL
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southern Illinois Luxury Hotels
Our top choices for Southern Illinois luxury hotels
8.4 out of 10, Very good, (866 reviews)
- Plush beds and serene pool define luxury at Mt. Vernon retreat where spa awaits after exploration.
The price is £107
includes taxes & fees
23 Jul - 24 Jul
9.4 out of 10, Exceptional, (479 reviews)
- Indulge in a luxurious retreat featuring a full-service spa, indoor pool, and casino gaming in the heart of Carterville.
The price is £101
includes taxes & fees
21 Jul - 22 Jul
8.2 out of 10, Very good, (1,001 reviews)
- Upscale St. Louis hotel offers steakhouse, indoor pool, and 24-hour fitness centre.
The price is £98
includes taxes & fees
17 Aug - 18 Aug
10.0 out of 10, Exceptional, (12 reviews)
The price is £86
includes taxes & fees
22 Jul - 23 Jul
9.4 out of 10, Exceptional, (1,001 reviews)
- Lavish riverside luxury awaits at the Four Seasons St. Louis with spa indulgences and poolside bliss.
The price is £326
includes taxes & fees
22 Jul - 23 Jul
9.2 out of 10, Wonderful, (575 reviews)
- Ritz-Carlton elegance defines this St. Louis retreat with indulgent spa services and dining excellence.
The price is £432
includes taxes & fees
19 Jul - 20 Jul
The price is £163
includes taxes & fees
18 Aug - 19 Aug
9.0 out of 10, Wonderful, (1,995 reviews)
- Boutique retreat blends urban charm with luxury, from rooftop views to Egyptian cotton and rainfall showers.
The price is £128
includes taxes & fees
20 Jul - 21 Jul
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southern Illinois Hotel Reviews
Best Western Marion Hotel
8/10 Good
Explore a world of travel with Expedia
- 4 Star Hotels in Southern Illinois
- 5 Star Hotels in Marissa
- 5 Star Hotels in Southern Illinois
- Notting Hill Cottage
- Buncombe Hotels
- Americas Best Value Inn Marion
- Best Western Marion Hotel
- Betty's Vineyard House
- Downtown Carbondale. Cozy and Cheery Abode
- Hilltop Retreat
- Home2 Suites by Hilton Carbondale
- Oak Grove Cabins
- Playport South camp. Eclipse Hot Spot. South Zone primitive camp sites
- Carbondale Hotels
- Carlyle Hotels
- Americas Best Value Inn Vandalia
- Mariner's Village Resort
- Centralia Hotels
- Baymont by Wyndham Chester IL
- Giant City Lodge
- Restored 1910 Cottage Near Shawnee Forest
- Large Lake front
- Creal Springs Hotels
- Cobblestone Inn & Suites
- Carlton Cabin at Lake of Egypt Hideaway Near Shawnee Forest & lots of wineries
- Castle Cove Lakefront Home
- Log Cabin w/ Clawfoot Tub
- Quality Inn Grayville
- Shawnee Forest In Town Retreat
- Harrisburg Hotels
- Herrin Hotels
- Lakeside Shady Rest Home Away from Home blocks from Rend Lake and I57/I64
- Kinmundy Hotels
- Gay-Friendly Hotels in Marion
- Treehouse w/ Hot Tub near Shawnee National Forest
- Marion Hotels
- Mcleansboro Hotels
- Quality Inn Mount Vernon
- Odin Hotels
- Pet-Friendly Hotels in Olney
- Rodeway Inn Flora
- Lighthouse Lodge
- Saint Elmo Hotels
- Gay-Friendly Hotels in Salem
- Sports Hotels in Southern Illinois
- Spa Hotels in Southern Illinois
- Pet-Friendly Hotels in Southwest Illinois
- Sparta Hotels
- Waltonville Hotels
- Gay-Friendly Hotels in Whittington
- Pet-Friendly Hotels in Whittington
- Flights to Carbondale
- Flights to Flora
- Flights to Galatia
- Flights to Marion
- Flights to Marissa
- Flights to Mount Vernon
- Flights to Noble
- Flights to Odin
- Flights to Pocahontas
- Flights to Southern Illinois
- Flights from Southern Illinois
- Flights from Vandalia Municipal
- Flights from Makanda
- Flights from Christopher
- Flights from Tamaroa
- Flights from Ava
- Flights from Ewing
- Flights from Marissa
- Flights from Campbell Hill
- Flights from Stonefort
- Flights from Williamson County
- Flights from Boston (BOS) to Carbondale (MDH)
- Flights from London (LON) to Vandalia (VLA)
- Flights from Manchester (MAN) to Vandalia (VLA)
- Flights from Phoenix (PHX) to Vandalia (VLA)