Title: TOP Hotels Suites in Southern Illinois, IL for 2026 | Expedia.co.uk [Southern Illinois Travel Guide](https://expedia.co.uk/Southern-Illinois.dx6233859)[Hotels in Southern Illinois](https://expedia.co.uk/Southern-Illinois-Hotels.d6233859.Travel-Guide-Hotels)[Holiday Rentals in Southern Illinois](https://expedia.co.uk/Southern-Illinois-Holiday-Rentals.d6233859.Travel-Guide-HolidayRentals)[Flights to Southern Illinois](https://expedia.co.uk/Cheap-Flights-To-Southern-Illinois.d6233859.Travel-Guide-Flights)[Southern Illinois Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southern-Illinois.d6233859.Car-Hire-Guide)[Southern Illinois Holidays](https://expedia.co.uk/Southern-Illinois.d6233859.Holidays-City-Breaks) ![](https://images.trvl-media.com/place/553248635944113522/0e29d2f8-2d58-457a-908d-4b89b13776d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Southernmost Illinois Tourism Bureau ![](https://images.trvl-media.com/place/553248635944113522/0e29d2f8-2d58-457a-908d-4b89b13776d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Illinois Hotels Suites Tonight [8 Apr - 9 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2026-04-08&endDate=2026-04-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [9 Apr - 10 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2026-04-09&endDate=2026-04-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [10 Apr - 12 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2026-04-10&endDate=2026-04-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Apr - 19 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2026-04-17&endDate=2026-04-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Southern Illinois hotels with suites ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/798d901b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/24fa28eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/66dc4e91.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/31850cab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Mt. Vernon [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) Mount Vernon 9.6/10 Exceptional (1,663 reviews) "Beautiful hotel and loved the kickback and breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lori £87 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/0b9bb173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a60abbba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/f5a8458f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/94013a8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Marion [](https://www.expedia.co.uk/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) Marion 9.4/10 Exceptional (1,007 reviews) "Lovely hotel with exceptionally nice staff and clean and great room!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eileen £96 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/cb0960c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/a72de9ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/4c50f376.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking | Desk, soundproofing, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/69929aee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Effingham, IL [](https://www.expedia.co.uk/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) Effingham 8.8/10 Excellent (1,007 reviews) "Clean room, comfy beds, easy and friendly check in. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Renee £72 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) ![Breakfast, dinner and brunch served](https://images.trvl-media.com/lodging/107000000/106860000/106856200/106856168/b212e706.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room amenity](https://images.trvl-media.com/lodging/107000000/106860000/106856200/106856168/224b65ce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/107000000/106860000/106856200/106856168/5d07ff1f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/107000000/106860000/106856200/106856168/41c6fbb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Principal Hotel [](https://www.expedia.co.uk/Columbia-Hotels-The-Principal-Hotel.h106856168.Hotel-Information) Columbia 9.8/10 Exceptional (228 reviews) "I love staying here whenever i come to town." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) bonnie £83 includes taxes & fees 27 Apr - 28 Apr [](https://www.expedia.co.uk/Columbia-Hotels-The-Principal-Hotel.h106856168.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/16f1378e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/953ff133.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Jetted Tub | Premium bedding, down duvets, desk, blackout curtains](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/64c87a0a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11480000/11474500/11474428/ee5a3a7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Effingham by IHG [](https://www.expedia.co.uk/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) Effingham 9.4/10 Exceptional (999 reviews) "Room was clean, staff was very pleasant, breakfast was delicious and plentiful and we were able to enjoy all amenities. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura £94 includes taxes & fees 3 May - 4 May [](https://www.expedia.co.uk/Effingham-Hotels-Holiday-Inn-Express-And-Suites-Effingham.h11474428.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/8e4b3d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/6cba26b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/3a991e8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/47490a5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Effingham [](https://www.expedia.co.uk/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) Effingham 9.2/10 Wonderful (1,002 reviews) " Very pleased with our stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nancy £86 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) ![Sauna, hot tub, body treatments, hot stone massages](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/8fcd4708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/3a123ac6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Casino](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/2902012c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/84958281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walker's Bluff Casino Resort [](https://www.expedia.co.uk/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information) Carterville 9.4/10 Exceptional (424 reviews) "Great place!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paula £98 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321975/868ce541.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321975/cc771758.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321975/38f0381c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/2000000/1330000/1322000/1321975/11916b3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Effingham [](https://www.expedia.co.uk/Effingham-Hotels-Hampton-Inn-Suites-Effingham.h1321975.Hotel-Information) Effingham 9.6/10 Exceptional (726 reviews) "Nice place" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Corey £116 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Hampton-Inn-Suites-Effingham.h1321975.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3840h2556x0y4-dd5ad558.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3837h2560x3y0-d7de35fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/40f05879.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3837h2560x3y0-57613b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Delta Inn [](https://www.expedia.co.uk/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) Effingham 9.2/10 Wonderful (1,001 reviews) "Great staff, clean room, and good breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gayle £82 includes taxes & fees 5 May - 6 May [](https://www.expedia.co.uk/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/5b15716e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/cd6d884a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Accessible, Non Smoking | In-room safe, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b3496784.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/5c7b1e92.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Mount Vernon [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) Mount Vernon 9.0/10 Wonderful (1,024 reviews) "Clean room, friendly staff, great rate, and great amenities. Would definitely stay again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Lisa £95 includes taxes & fees 12 Apr - 13 Apr [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-04-22&endDate=2026-04-23®ionId=6233859&adults=2&nearby_group=suites&sort=RECOMMENDED&openPlayBack=true) ## Top Southern Illinois Hotel Reviews ![Comfort Suites Mount Vernon](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/5b15716e_y.jpg) ### Comfort Suites Mount Vernon 10/10 Excellent "Na" [](https://expedia.co.uk/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Comfort Suites Fairview Heights - St. Louis](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418658/cd5aa302_y.jpg) ### Comfort Suites Fairview Heights - St. Louis 2/10 Terrible "Pool was down and there was no communication of this till we got there. The room was dirty. Sheets had cigarette burn" [](https://expedia.co.uk/Collinsville-Hotels-Comfort-Suites-Fairview-Heights.h1418658.Hotel-Information) ![Drury Inn & Suites St. Louis Fairview Heights](https://images.trvl-media.com/lodging/1000000/50000/41900/41802/91646e6b_y.jpg) ### Drury Inn & Suites St. Louis Fairview Heights 10/10 Excellent "Had a good breakfast and food and drinks in the evening. Has a nice pool and hot tub." [](https://expedia.co.uk/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Fairview-Heights.h41802.Hotel-Information) ![Drury Inn & Suites St. Louis O'Fallon, IL](https://images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/2e5b0061_y.jpg) ### Drury Inn & Suites St. Louis O'Fallon, IL 10/10 Excellent "The free breakfast & appetizers/dinner is wonderful♥️ The staff all seem happy & positive♥️ Very clean♥️ " [](https://expedia.co.uk/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-OFallon.h1544028.Hotel-Information) ![Drury Plaza Hotel Mt. Vernon](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/798d901b_y.jpg) ### Drury Plaza Hotel Mt. Vernon 10/10 Excellent "Checkin cas fast and room was clean " [](https://expedia.co.uk/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ## Frequently asked questions ### How much do hotels with suites in Southern Illinois cost? ### What are the best hotels with suites in Southern Illinois? ### How many hotels with suites are there in Southern Illinois? ### What are the best cheap hotels with suites in Southern Illinois? ### Are there any family-friendly hotels with suites in Southern Illinois? ### Why book your hotel with suites in Southern Illinois with Expedia? ### How can I find cheap hotels with suites in Southern Illinois? ### What is there to do in Southern Illinois near my hotel with suites? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Adults Only Resorts & in Alto Pass ](https://www.expedia.co.uk/Alto-Pass-Hotels-Adults-Only-Resorts.0-0-d73449-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - 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