Title: TOP Business Hotels in Southern Illinois, IL for 2025 | Expedia.co.uk [Southern Illinois Travel Guide](https://expedia.co.uk/Southern-Illinois.dx6233859)[Hotels in Southern Illinois](https://expedia.co.uk/Southern-Illinois-Hotels.d6233859.Travel-Guide-Hotels)[Holiday Rentals in Southern Illinois](https://expedia.co.uk/Southern-Illinois-Holiday-Rentals.d6233859.Travel-Guide-HolidayRentals)[Flights to Southern Illinois](https://expedia.co.uk/Cheap-Flights-To-Southern-Illinois.d6233859.Travel-Guide-Flights)[Southern Illinois Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southern-Illinois.d6233859.Car-Hire-Guide)[Southern Illinois Holidays](https://expedia.co.uk/Southern-Illinois.d6233859.Holidays-City-Breaks) ![Southern Illinois featuring landscape views, a sunset and forest scenes](https://images.trvl-media.com/place/553248635944113522/0e29d2f8-2d58-457a-908d-4b89b13776d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Southernmost Illinois Tourism Bureau # Search Business Hotels in Southern Illinois - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Illinois Business Hotels Tonight [26 Nov - 27 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2025-11-26&endDate=2025-11-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [27 Nov - 28 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2025-11-27&endDate=2025-11-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [28 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top Southern Illinois Business Hotels ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/5000000/4980000/4970900/4970883/8864abcb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4980000/4970900/4970883/52d22dc0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/5000000/4980000/4970900/4970883/990471ff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, in-room safe, desk](https://images.trvl-media.com/lodging/5000000/4980000/4970900/4970883/95d1b540.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites Marion Northeast by IHG Marion 9.0/10 Wonderful (922) "Clean room, friendly staff, gym and pool" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samantha £83 includes taxes & fees 26 Dec - 27 Dec [](https://www.expedia.co.uk/Carbondale-Hotels-Holiday-Inn-Express-Hotel-Suites-Marion-Northeast.h4970883.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a8315e37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/f5a8458f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/0640f16c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a60abbba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Marion Marion 9.4/10 Exceptional (1008) "Great hotel and very clean " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jose £59 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/a5bed563.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/3040b640.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/b6b6aa46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Mt. Vernon Mount Vernon 9.6/10 Exceptional (1551) "Friendly staff, wonderful accommodations." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Susan £81 includes taxes & fees 4 Dec - 5 Dec [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b34f836a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/ab9640ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Non Smoking | In-room safe, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/553c1c26.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Gift shop](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/43f13195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Suites Mount Vernon Mount Vernon 8.8/10 Excellent (1013) "Good location, good breakfast" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Don £93 includes taxes & fees 30 Nov - 1 Dec [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Room, 2 Queen Beds, Non Smoking | Desk, soundproofing, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/f2163f3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/0c22f262.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/4c50f376.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/4b6a91f2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Effingham, IL Effingham 8.8/10 Excellent (1011) "Clean rooms and kind staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda £79 includes taxes & fees 16 Dec - 17 Dec [](https://www.expedia.co.uk/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/1c773b5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/fc4d1ad9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, individually decorated](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/89141360.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/e9ea4e97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel by Best Western Whittington Rend Lake Whittington 8.8/10 Excellent (897) "Great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen £65 includes taxes & fees 3 Dec - 4 Dec [](https://www.expedia.co.uk/Whittington-Hotels-SureStay-Hotel-By-Best-Western-Whittington-Rend-Lake.h7214281.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/c0186ee3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast meal](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/6efe0829.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/dfbf7d71.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1490000/1489300/1489254/189a91e2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Carbondale-Conference Center by IHG Carbondale 8.8/10 Excellent (635) "Nice staff, clean rooms, awesome beds and pillows!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kenneth £83 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/Carbondale-Hotels-Holiday-Inn-Carbondale-Conference-Center.h1489254.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/6cba26b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 6:00 AM to 11:00 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/453e2ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/25e2a26d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/8e4b3d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Effingham Effingham 9.2/10 Wonderful (1011) "Excellent property and service was outstanding " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven £79 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) ![Room, 1 Queen Bed, Accessible, Non Smoking | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/870000/861400/861371/04e0f544.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/870000/861400/861371/9818af49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/870000/861400/861371/064919b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/870000/861400/861371/264bbe49.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Mt. Vernon IL Mount Vernon 7.8/10 Good (1000) "parking was easy and secure, clean rooms, quiet hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen £50 includes taxes & fees 14 Dec - 15 Dec [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Super-8-By-Wyndham-Mt-Vernon-IL.h861371.Hotel-Information) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/480000/479200/479116/e725ca3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/480000/479200/479116/3106b365.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/480000/479200/479116/627f1574.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/480000/479200/479116/aa673734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Carbondale Carbondale 8.4/10 Very good (610) "Room was spotless, check in was quick, all personnel were courteous. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William £87 includes taxes & fees 7 Dec - 8 Dec [](https://www.expedia.co.uk/Carbondale-Hotels-Hampton-Inn-Carbondale.h479116.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-11&endDate=2025-12-12®ionId=6233859&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_FR-DE-MX-UK_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## Black Friday Sale Save up to 40% on select hotels. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_BF_PROMO_6233859) ## Top Southern Illinois Hotel Reviews ![Drury Inn & Suites St. Louis O'Fallon, IL](https://images.trvl-media.com/lodging/2000000/1550000/1544100/1544028/d2bc121f_y.jpg) ### Drury Inn & Suites St. Louis O'Fallon, IL 10/10 Excellent "Location was perfect for our stay. The room was clean and the food was great!" [](https://expedia.co.uk/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-OFallon.h1544028.Hotel-Information) ![Comfort Suites Mount Vernon](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/b34f836a_y.jpg) ### Comfort Suites Mount Vernon 10/10 Excellent "Clean and competitively priced." [](https://expedia.co.uk/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Super 8 by Wyndham O'Fallon](https://images.trvl-media.com/lodging/1000000/20000/11100/11071/055d0e3b_y.jpg) ### Super 8 by Wyndham O'Fallon 10/10 Excellent "My room was very clean and the staff was very friendly! They had plenty of breakfast options and I felt safe as a solo traveler here. The price was very reasonable for a great stay!" [](https://expedia.co.uk/Collinsville-Hotels-Super-8-By-Wyndham-OFallon.h11071.Hotel-Information) ![Drury Plaza Hotel Mt. Vernon](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/f9296f7b_y.jpg) ### Drury Plaza Hotel Mt. Vernon 10/10 Excellent "Everything was great! " [](https://expedia.co.uk/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Drury Inn & Suites St. Louis Fairview Heights](https://images.trvl-media.com/lodging/1000000/50000/41900/41802/c56c0460_y.jpg) ### Drury Inn & Suites St. Louis Fairview Heights 10/10 Excellent "Every clean everyone was so nice and polite will definitely stay again " [](https://expedia.co.uk/Collinsville-Hotels-Drury-Inn-Suites-St-Louis-Fairview-Heights.h41802.Hotel-Information) ![Holiday Inn Express Metropolis by IHG](https://images.trvl-media.com/lodging/1000000/220000/211900/211819/0b536094_y.jpg) ### Holiday Inn Express Metropolis by IHG 10/10 Excellent "Room was great! Breakfast was delicious. Staff was wonderful. 😊" [](https://expedia.co.uk/Metropolis-Hotels-Holiday-Inn-Express-Metropolis.h211819.Hotel-Information) ![Red Lion Inn & Suites Pontoon Beach](https://images.trvl-media.com/lodging/1000000/20000/17400/17338/284b6d11_y.jpg) ### Red Lion Inn & Suites Pontoon Beach 10/10 Excellent "Clean,nice" [](https://expedia.co.uk/St-Louis-Hotels-Red-Lion-Inn-Suites-Pontoon-Beach.h17338.Hotel-Information) ![Holiday Inn Express & Suites Edwardsville by IHG](https://images.trvl-media.com/lodging/9000000/8970000/8964000/8963997/b57accf4_y.jpg) ### Holiday Inn Express & Suites Edwardsville by IHG 10/10 Excellent "Yes " [](https://expedia.co.uk/Collinsville-Hotels-Holiday-Inn-Express-Suites-Edwardsville.h8963997.Hotel-Information) ![Best Western Plus Pontoon Beach](https://images.trvl-media.com/lodging/3000000/2700000/2695400/2695352/01153352_y.jpg) ### Best Western Plus Pontoon Beach 10/10 Excellent "The room was great, the staff was so polite and helpful. We were pleased with breakfast. My children loved the machine they could get hot chocolate from. " [](https://expedia.co.uk/St-Louis-Hotels-Best-Western-Plus-Pontoon-Beach.h2695352.Hotel-Information) ## Frequently asked questions ### How much do business hotels in Southern Illinois cost? > Business hotels in Southern Illinois range between £50 and £93 per night. This means you can lock in a property with conveniences like workspaces and conference rooms at a price that doesn't break the bank. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### How many business hotels are there in Southern Illinois? > There are 149 business hotels in Southern Illinois. When work takes you out of town, Expedia makes it easy to find the ideal space with the amenities you need. ### Why book your business hotel in Southern Illinois with Expedia? > At Expedia, our business is to help you land a suitable stay at the right price. From 5-star corporate-friendly properties to affordable motor inns filled with all the amenities you need, you'll have your next work trip booked in a few quick clicks. ### How can I find cheap business hotels in Southern Illinois? > When you're travelling for work in Southern Illinois, our "business friendly" filter will help you find a suitable hotel. From free WiFi and included breakfast to concierge services and conference spaces, they have the amenities you need to get down to business. 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[Visit McLeansboro](https://www.expedia.co.uk/McLeansboro.dx3000346419) - [Visit Mount Vernon](https://www.expedia.co.uk/Mount-Vernon.dx2463) - [Pheasant Hollow Winery](https://www.expedia.co.uk/Pheasant-Hollow-Winery-Whittington.d6312899.Attraction) - [William Jennings Bryan Boyhood Home and Museum](https://www.expedia.co.uk/William-Jennings-Bryan-Boyhood-Home-And-Museum-Salem.d6187105.Attraction) - [Car hire Whittington](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Whittington.d56062.Car-Hire-Guide) - [People Carrier Car Hire in Flora](https://www.expedia.co.uk/Van-Car-Rentals-In-Flora.d178211-tVan.Car-Rental-Guide-Class) - [Dix Holiday Rentals](https://www.expedia.co.uk/Dix-Holiday-Rentals.d6023670.Travel-Guide-HolidayRentals) - [Enfield Holiday Rentals](https://www.expedia.co.uk/Enfield-Holiday-Rentals.d3000433975.Travel-Guide-HolidayRentals) - [Flora Holiday Rentals](https://www.expedia.co.uk/Flora-Holiday-Rentals.d178211.Travel-Guide-HolidayRentals) - [Nashville Holiday Rentals](https://www.expedia.co.uk/Nashville-Holiday-Rentals.d180762.Travel-Guide-HolidayRentals) - 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