Title: TOP Business Hotels in Southern Illinois, IL for 2026 | Expedia.co.uk [Southern Illinois Travel Guide](https://expedia.co.uk/Southern-Illinois.dx6233859)[Hotels in Southern Illinois](https://expedia.co.uk/Southern-Illinois-Hotels.d6233859.Travel-Guide-Hotels)[Holiday Rentals in Southern Illinois](https://expedia.co.uk/Southern-Illinois-Holiday-Rentals.d6233859.Travel-Guide-HolidayRentals)[Flights to Southern Illinois](https://expedia.co.uk/Cheap-Flights-To-Southern-Illinois.d6233859.Travel-Guide-Flights)[Southern Illinois Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Southern-Illinois.d6233859.Car-Hire-Guide)[Southern Illinois Holidays](https://expedia.co.uk/Southern-Illinois.d6233859.Holidays-City-Breaks) ![Southern Illinois featuring landscape views, a sunset and forest scenes](https://images.trvl-media.com/place/553248635944113522/0e29d2f8-2d58-457a-908d-4b89b13776d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Southernmost Illinois Tourism Bureau ![](https://images.trvl-media.com/place/553248635944113522/0e29d2f8-2d58-457a-908d-4b89b13776d9.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Southern Illinois Business Hotels Tonight [22 Mar - 23 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2026-03-22&endDate=2026-03-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [23 Mar - 24 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2026-03-23&endDate=2026-03-24&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [27 Mar - 29 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2026-03-27&endDate=2026-03-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [3 Apr - 5 Apr](https://www.expedia.co.uk/Hotel-Search?regionId=6233859&startDate=2026-04-03&endDate=2026-04-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Southern Illinois business-friendly hotels ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/798d901b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/31850cab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/6058a5df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/24fa28eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Plaza Hotel Mt. Vernon [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) Mount Vernon 9.6/10 Exceptional (1,658 reviews) "Very clean rooms, quiet, food was ok" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mitch £91 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/80512ba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/7d4409d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/e5a5d8e5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/17000000/16350000/16341900/16341844/fcbb2184.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Mount Vernon by IHG [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Holiday-Inn-Express-Suites-Mount-Vernon.h16341844.Hotel-Information) Mount Vernon 9.0/10 Wonderful (1,005 reviews) "Breakfast very good staff excellent room clean and comfortable " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Scott £94 includes taxes & fees 19 Apr - 20 Apr [](https://www.expedia.co.uk/Mount-Vernon-Hotels-Holiday-Inn-Express-Suites-Mount-Vernon.h16341844.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/8e4b3d15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool, open 6:00 AM to 11:00 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/453e2ca5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/47490a5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/60000/50100/50093/3a991e8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham Effingham [](https://www.expedia.co.uk/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) Effingham 9.2/10 Wonderful (1,004 reviews) "Good location easy check-in, room was clean and a good breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James £81 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Effingham-Hotels-La-Quinta-Inn-Suites-By-Wyndham-Effingham.h50093.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/124000000/123400000/123390900/123390855/w1179h885x0y14-d6e2759b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Superior Suite | Interior](https://images.trvl-media.com/lodging/124000000/123400000/123390900/123390855/fe3f647b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/124000000/123400000/123390900/123390855/w1179h1267x0y0-987ea905.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Dining](https://images.trvl-media.com/lodging/124000000/123400000/123390900/123390855/w1179h886x0y0-9b9f8628.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Simply Home Inn & Suites [](https://www.expedia.co.uk/Robinson-Hotels-Simply-Home-Inn-Suites.h123390855.Hotel-Information) Robinson £94 includes taxes & fees 15 Apr - 16 Apr [](https://www.expedia.co.uk/Robinson-Hotels-Simply-Home-Inn-Suites.h123390855.Hotel-Information) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/cb0960c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking | Desk, soundproofing, iron/ironing board, rollaway beds](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/69929aee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/cbdc6ef6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/920000/914400/914400/4c50f376.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, Effingham, IL [](https://www.expedia.co.uk/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) Effingham 8.8/10 Excellent (1,003 reviews) "Clean room, comfy beds, easy and friendly check in. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Renee £70 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Effingham-Hotels-Country-Inn-Suites-By-Radisson.h914400.Hotel-Information) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3840h2556x0y4-dd5ad558.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3837h2560x3y0-57613b0f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/5f2b59be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3837h2560x3y0-d7de35fc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Delta Inn [](https://www.expedia.co.uk/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) Effingham 9.2/10 Wonderful (1,008 reviews) "Great staff, clean room, and good breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gayle £76 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) ![Sauna, hot tub, body treatments, hot stone massages](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/8fcd4708.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/3a123ac6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 restaurants, breakfast, lunch, dinner served; American cuisine ](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/84958281.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/98000000/97070000/97064800/97064786/a0fca68c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Walker's Bluff Casino Resort [](https://www.expedia.co.uk/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information) Carterville 9.4/10 Exceptional (421 reviews) "Our room was clean, and very spacious! the establishment was very nice! We had reservations at Ruthie’s and it was amazing like always " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amy £121 includes taxes & fees 30 Mar - 31 Mar [](https://www.expedia.co.uk/Carterville-Hotels-Walkers-Bluff-Casino-Resort.h97064786.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/0b9bb173.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/f5a8458f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a8315e37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/50000/42100/42025/a60abbba.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites Marion [](https://www.expedia.co.uk/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) Marion 9.4/10 Exceptional (1,002 reviews) "Lovely hotel with exceptionally nice staff and clean and great room!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Eileen £83 includes taxes & fees 20 Apr - 21 Apr [](https://www.expedia.co.uk/Carbondale-Hotels-Drury-Inn-Marion.h42025.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/1c773b5e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, individually decorated](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/89141360.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/2700f966.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, individually decorated](https://images.trvl-media.com/lodging/8000000/7220000/7214300/7214281/83c59bdb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### SureStay Hotel by Best Western Whittington Rend Lake [](https://www.expedia.co.uk/Whittington-Hotels-SureStay-Hotel-By-Best-Western-Whittington-Rend-Lake.h7214281.Hotel-Information) Whittington 8.8/10 Excellent (935 reviews) "Great place to stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Stephen £64 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Whittington-Hotels-SureStay-Hotel-By-Best-Western-Whittington-Rend-Lake.h7214281.Hotel-Information) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/480000/479200/479116/e725ca3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/480000/479200/479116/w3839h2559x0y0-9e51aba1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/480000/479200/479116/167b574c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/480000/479200/479116/aa673734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn Carbondale [](https://www.expedia.co.uk/Carbondale-Hotels-Hampton-Inn-Carbondale.h479116.Hotel-Information) Carbondale 8.4/10 Very good (626 reviews) "Clean Room, Friendly Staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Joe £95 includes taxes & fees 29 Mar - 30 Mar [](https://www.expedia.co.uk/Carbondale-Hotels-Hampton-Inn-Carbondale.h479116.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-04-06&endDate=2026-04-07®ionId=6233859&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Southern Illinois Hotel Reviews ![Quality Inn & Suites Metropolis I-24](https://images.trvl-media.com/lodging/1000000/20000/17100/17025/b08fbb78_y.jpg) ### Quality Inn & Suites Metropolis I-24 4/10 Poor "Stayed here because we needed a place to sleep on our drive home. The reviews were good. Check in went well, although the very nice gentleman that waited on us was extremely hard to understand. Once we got to our room, I found pee all over the toilet like it hadn't been cleaned. We cleaned it as we were exhausted after driving 11 hours. Then we noticed how dirty the gloor was. Found a cheese puff on the floor and the carpet was just filthy. Then we had to kill a spider on the wall and there were 1/2 dozen stink bugs coming in around the air conditioner. My hubby killed all the bugs, but we saw more in the hallway. It was a very inexpensive room, so I guess we got what we paid for. The breakfast in the morning was adequate, but very carb laden for the options. The floors in the breakfast area were so sticky, I almost lost my shoe. Again, the price was very low, so..." [](https://expedia.co.uk/Metropolis-Hotels-Quality-Inn-Suites-Metropolis-I-24.h17025.Hotel-Information) ![Red Lion Inn & Suites Pontoon Beach](https://images.trvl-media.com/lodging/1000000/20000/17400/17338/16715ab0_y.jpg) ### Red Lion Inn & Suites Pontoon Beach 8/10 Good "Were happy until we developed water leak in bathroom. Had to move to different facility...no rooms avail. Staff very nice. Beds great. Lots of hot water." [](https://expedia.co.uk/St-Louis-Hotels-Red-Lion-Inn-Suites-Pontoon-Beach.h17338.Hotel-Information) ![Best Western Delta Inn](https://images.trvl-media.com/lodging/1000000/10000/3400/3382/w3840h2556x0y4-dd5ad558_y.jpg) ### Best Western Delta Inn 10/10 Excellent "Very quiet. Excellent room. " [](https://expedia.co.uk/Effingham-Hotels-Best-Western-Delta-Inn.h3382.Hotel-Information) ![Quality Inn O'Fallon IL - St. Louis](https://images.trvl-media.com/lodging/1000000/70000/64700/64675/0a6ab208_y.jpg) ### Quality Inn O'Fallon IL - St. Louis 2/10 Terrible "Mildew on the bathroom walls. Bathroom very small. Shower head was loose and could not be adjusted. Bed was uncomfortable. Refrigerator did not get cool. " [](https://expedia.co.uk/Collinsville-Hotels-Quality-Inn-OFallon-I-64.h64675.Hotel-Information) ![Sleep Inn O'Fallon near I-64](https://images.trvl-media.com/lodging/1000000/170000/168400/168383/e8d9d871_y.jpg) ### Sleep Inn O'Fallon near I-64 8/10 Good "This is a fair place to stay and the front desk is nice , no complaints just the toilets have rings around them as if they are not being cleaned " [](https://expedia.co.uk/Collinsville-Hotels-Sleep-Inn.h168383.Hotel-Information) ![Comfort Suites Mount Vernon](https://images.trvl-media.com/lodging/2000000/1390000/1387400/1387309/5b15716e_y.jpg) ### Comfort Suites Mount Vernon 4/10 Poor "Hot tub was not hot. Beds were very uncomfortable. Breakfast not served until 7 am. Too late for early departures and no coffee available in lobby. " [](https://expedia.co.uk/Mount-Vernon-Hotels-Comfort-Suites-Mount-Vernon.h1387309.Hotel-Information) ![Comfort Suites Fairview Heights - St. Louis](https://images.trvl-media.com/lodging/2000000/1420000/1418700/1418658/cd5aa302_y.jpg) ### Comfort Suites Fairview Heights - St. Louis 2/10 Terrible "The pool was cold and cloudy. No towels. Asked for another towel for our shower and couldn’t get one asked for another blanket for the pull out. Gave me a sheet " [](https://expedia.co.uk/Collinsville-Hotels-Comfort-Suites-Fairview-Heights.h1418658.Hotel-Information) ![Drury Plaza Hotel Mt. Vernon](https://images.trvl-media.com/lodging/1000000/50000/42100/42021/798d901b_y.jpg) ### Drury Plaza Hotel Mt. Vernon 10/10 Excellent "Great place to stay" [](https://expedia.co.uk/Mount-Vernon-Hotels-Drury-Inn-Suites-Mt-Vernon.h42021.Hotel-Information) ![Radisson Hotel Fairview Heights - St. Louis](https://images.trvl-media.com/lodging/1000000/910000/904900/904826/edc9d870_y.jpg) ### Radisson Hotel Fairview Heights - St. Louis 8/10 Good "Overall it did what we needed but the bed was sagging in the middle, the sheets were cleaned but very stained as well as the towels so it made me nervous to whether it was actually stains or just dirty. There was a toenail in the middle of the carpet. Love that but besides all that staff was friendly and we were able to book last minute. We told the front desk about the bed and were compensated for that so thankful he did that. " [](https://expedia.co.uk/Fairview-Heights-Hotels-Four-Points-By-Sheraton-St-Louis-Fairview-Heights.h904826.Hotel-Information) ## Frequently asked questions ### How much do business hotels in Southern Illinois cost? ### How many business hotels are there in Southern Illinois? ### Why book your business hotel in Southern Illinois with Expedia? ### How can I find cheap business hotels in Southern Illinois? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - More ways to book - [Adults Only Resorts & in Alto Pass ](https://www.expedia.co.uk/Alto-Pass-Hotels-Adults-Only-Resorts.0-0-d73449-tAdultsOnlyResorts.Travel-Guide-Filter-Hotels) - [Benton Hotels ](https://www.expedia.co.uk/Benton-Hotels.d6866.Travel-Guide-Hotels) - [Bluford Hotels ](https://www.expedia.co.uk/Bluford-Hotels.d3000346134.Travel-Guide-Hotels) - [Centralia Hotels ](https://www.expedia.co.uk/Centralia-Hotels.d55627.Travel-Guide-Hotels) - [Hotels with Air Conditioning in Chester ](https://www.expedia.co.uk/Chester-Hotels-Hotel-With-Air-Conditioning.0-0-d6139861-thotelwithairconditioning.Travel-Guide-Filter-Hotels) - 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