Title: TOP Luxury Hotels in South San Diego, CA for 2025 - South San Diego Upscale Hotels | Expedia.co.uk [South San Diego Travel Guide](https://expedia.co.uk/South-San-Diego.dx553248632063518562)[Hotels in South San Diego](https://expedia.co.uk/South-San-Diego-Hotels.d553248632063518562.Travel-Guide-Hotels)[Holiday Rentals in South San Diego](https://expedia.co.uk/South-San-Diego-Holiday-Rentals.d553248632063518562.Travel-Guide-HolidayRentals)[Flights to South San Diego](https://expedia.co.uk/Cheap-Flights-To-South-San-Diego.d553248632063518562.Travel-Guide-Flights)[Things to do in South San Diego](https://expedia.co.uk/Things-To-Do-In-South-San-Diego.d553248632063518562.Travel-Guide-Activities)[South San Diego Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-San-Diego.d553248632063518562.Car-Hire-Guide)[South San Diego Holidays](https://expedia.co.uk/South-San-Diego.d553248632063518562.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/1/1577a5f9f9b33dbc18377fc367dd66b8.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in South San Diego, CA ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South San Diego Luxury Hotels Tonight [28 Oct - 29 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-10-28&endDate=2025-10-29&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [29 Oct - 30 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-10-29&endDate=2025-10-30&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [31 Oct - 2 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-10-31&endDate=2025-11-02&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [7 Nov - 9 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-11-07&endDate=2025-11-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Top South San Diego Luxury Hotels ![View from room](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/b70d99f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/28c3172b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/0df0eb3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, memory-foam beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/e0c0af28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Rambler Chula Vista 9.0/10 Wonderful (1970) "I enjoyed my stay at the hotel, very nice, clean and good price within my budget. Would stay again !" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jennifer £86 includes taxes & fees 30 Oct - 31 Oct [](https://www.expedia.co.uk/Chula-Vista-Hotels-The-Rambler-Motel.h18213.Hotel-Information) ![Deluxe Room, 1 King Bed | Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/2602a017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily continental breakfast (USD 13.49 per person)](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/1303c0cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/fb95526d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/cc894470.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hercor Hotel - Urban Boutique Chula Vista 8.6/10 Excellent (1276) "it was a great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Steven £69 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information) ![Studio Suite, 1 King Bed with Sofa bed, Accessible, Non Smoking (Mobility Accessible) | Pillow-top beds, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/2000000/1790000/1783400/1783348/w2994h2000x3y0-cc073d9b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/2000000/1790000/1783400/1783348/c653de3a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker](https://images.trvl-media.com/lodging/2000000/1790000/1783400/1783348/69131cc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/2000000/1790000/1783400/1783348/da2fd4cd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson Suites by Wyndham San Diego Chula Vista/BayFt Chula Vista 6.8/10 (1001) "Definitely not as advertised. All rooms were non-smoking but the staff smoked 5 feet from our door and our room smelled the whole time from smoke and marijuana. The neighborhood was very sketchy. They had a gate around the property which helped ease our anxiety but the exit gate was chained up so we had to back up the whole distance around the hotel. They also advertised breakfast. They have nothing. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Tammy £70 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-Howard-Johnson-Suite-Hotel-By-Wyndham.h1783348.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/1000000/60000/57300/57248/b510fde2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 2 Queen Beds, Non Smoking | Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/60000/57300/57248/97d07adf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/60000/57300/57248/1f0a5a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/60000/57300/57248/cebdbfb5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Palmeras Chula Vista Chula Vista 7.2/10 Good (1941) "Good hotel " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nubia £59 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-Hotel-Palmeras-Chula-Vista.h57248.Hotel-Information) ![Miscellaneous](https://images.trvl-media.com/lodging/2000000/1640000/1630300/1630286/40601c62.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/2000000/1640000/1630300/1630286/c4b4e77a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/2000000/1640000/1630300/1630286/1dcb5057.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Miscellaneous](https://images.trvl-media.com/lodging/2000000/1640000/1630300/1630286/665db20b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### El Primero Hotel Chula Vista 9.2/10 Wonderful (1000) "I stayed in town by myself for two nights and felt very safe there. A very charming place to stay and charming people! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sierra £78 includes taxes & fees 30 Oct - 31 Oct [](https://www.expedia.co.uk/Chula-Vista-Hotels-El-Primero-Hotel.h1630286.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/bfd1ccfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/83180011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/84883664.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking | Premium bedding, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/b3ebadf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Diego Chula Vista Chula Vista 8.6/10 Excellent (1438) "Very clean, staff was very helpful, Parking was great I forgot about breakfast." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Martha £81 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information) ![Pillow-top beds, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/9aa59122.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/2ba90811.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/18c3e6b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/810000/806400/806327/025fd645.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Americana Inn San Ysidro 9.0/10 Wonderful (1171) "This is my go to place when traveling across the border and back. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Isabel £89 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/San-Ysidro-Hotels-Best-Western-Americana-Inn.h806327.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/36da2a73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/434ca240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/2e7509ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 10:00 AM to 7:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/6211d6de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Chula Vista San Diego South Chula Vista 8.2/10 Very good (1164) "Really enjoyed my stay. Loved their breakfast 😋" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) esmeralda £84 includes taxes & fees 4 Nov - 5 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-Comfort-Inn-Chula-Vista-San-Diego-South.h18870.Hotel-Information) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/673df2c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/16237f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/d3d09d7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/55248c07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites San Diego Otay Mesa Otay Mesa 7.2/10 Good (1002) "Clean, friendly staff and yummy breakfast :)" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Iliana £86 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/930000/922700/922626/138c0a18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 Queen Bed, Non Smoking | Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/930000/922700/922626/3b5dd499.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 1 Queen Bed, Non Smoking | Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/930000/922700/922626/884c8f64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/930000/922700/922626/74bcbaf7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Big 7 Motel Chula Vista I-5 Chula Vista 6.2/10 (942) "Great air" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) todd. Allen £66 includes taxes & fees 30 Oct - 31 Oct [](https://www.expedia.co.uk/Chula-Vista-Hotels-Big-7-Motel.h922626.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-12&endDate=2025-11-13®ionId=553248632063518562&adults=2&star=50&sort=RECOMMENDED&openPlayBack=true) ## Top South San Diego Hotel Reviews ![Courtyard by Marriott San Diego Downtown Little Italy](//images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b_y.jpg) ### Courtyard by Marriott San Diego Downtown Little Italy 10/10 Excellent "Staff is amazing 3 time staying here for a reason really. Great place " [](https://expedia.co.uk/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](//images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 10/10 Excellent "The staff was friendly. The rooms were clean. It had a great bar and outdoor area to relax. " [](https://expedia.co.uk/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Sheraton San Diego Resort](//images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "I don’t know where to start. From the shuttle in to the shuttle out, everything was perfect!" [](https://expedia.co.uk/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![Comfort Inn San Diego Airport At The Harbor](//images.trvl-media.com/lodging/1000000/10000/8800/8727/17ffc972_y.jpg) ### Comfort Inn San Diego Airport At The Harbor 10/10 Excellent "Short walk to the Harbor Walk and eateries. Parking may be challenging. The pool deck and pool were clean and inviting. Busy street, there will be noise. " [](https://expedia.co.uk/San-Diego-Hotels-Comfort-Inn-San-Diego-Airport-At-The-Harbor.h8727.Hotel-Information) ![Wyndham Garden San Diego Near SeaWorld](//images.trvl-media.com/lodging/1000000/50000/41000/40962/76b78879_y.jpg) ### Wyndham Garden San Diego Near SeaWorld 10/10 Excellent "The staff were friendly. The room was clean but there were some issues in the room. Shower head was not completely sealed. There there spots on the ceiling in the bathroom and the some baseboards were messed up. " [](https://expedia.co.uk/San-Diego-Hotels-Wyndham-Garden-San-Diego-Near-SeaWorld.h40962.Hotel-Information) ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "An excellent classic beachfront hotel. We have visited the property for several years, but this is the first time that we stayed in the hotel. It lived up to all of our expectations. Located on the famous Coronado Beach, the hotel offers six different dining alternatives, each maintaining a distinctive focus and personality. Loved Nobu in particular. Nice shops. Amazing beach!!" [](https://expedia.co.uk/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ![Hilton San Diego Mission Valley](//images.trvl-media.com/lodging/1000000/20000/16100/16019/w3839h2160x1y0-98566ca3_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "standard room, only thing we kind of have issues with was our key wasn't working properly when leaving the parking, so we would just press on the call button then they'll eventually open the gate." [](https://expedia.co.uk/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![The Dana on Mission Bay](//images.trvl-media.com/lodging/1000000/50000/41000/40953/08585098_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Comfortable beds and good sized rooms. Property is outdat" [](https://expedia.co.uk/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Wyndham San Diego Bayside](//images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "Yes" [](https://expedia.co.uk/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Sports Hotels in Anaheim](https://www.expedia.co.uk/Anaheim-Hotels-Adventure-Sport-Hotel.0-0-d5921-tAdventureSportHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Anaheim](https://www.expedia.co.uk/Anaheim-Hotels-Business-Hotel.0-0-d5921-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Anaheim](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-Bar.0-0-d5921-thotelwithabar.Travel-Guide-Filter-Hotels) - [Hotels with a View in Anaheim](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-View.0-0-d5921-thotelwithaview.Travel-Guide-Filter-Hotels) - 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