Title: TOP Business Hotels in South San Diego, CA for 2026 | Expedia.co.uk [South San Diego Travel Guide](https://expedia.co.uk/South-San-Diego.dx553248632063518562)[Hotels in South San Diego](https://expedia.co.uk/South-San-Diego-Hotels.d553248632063518562.Travel-Guide-Hotels)[Holiday Rentals in South San Diego](https://expedia.co.uk/South-San-Diego-Holiday-Rentals.d553248632063518562.Travel-Guide-HolidayRentals)[Flights to South San Diego](https://expedia.co.uk/Cheap-Flights-To-South-San-Diego.d553248632063518562.Travel-Guide-Flights)[Things to do in South San Diego](https://expedia.co.uk/Things-To-Do-In-South-San-Diego.d553248632063518562.Travel-Guide-Activities)[South San Diego Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-San-Diego.d553248632063518562.Car-Hire-Guide)[South San Diego Holidays](https://expedia.co.uk/South-San-Diego.d553248632063518562.Holidays-City-Breaks) ![Captured this guy doing a wheelie during a beautiful sunset! #imperialbeach #EndlessSummer #autographhotels #Marriott #piersouthresort](https://images.trvl-media.com/place/177683/d4a8a1a3-bd23-4c6a-826e-e0c1c12dddaa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Karen Leone ![](https://images.trvl-media.com/place/177683/d4a8a1a3-bd23-4c6a-826e-e0c1c12dddaa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South San Diego Business Hotels Tonight [11 Mar - 12 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2026-03-11&endDate=2026-03-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [12 Mar - 13 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2026-03-12&endDate=2026-03-13&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [20 Mar - 22 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for South San Diego business-friendly hotels ![Studio Suite, 1 King Bed with Sofa bed, Balcony | View from room](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![5 restaurants, breakfast, lunch, dinner served; Mexican cuisine ](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/252aa24a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/14f99248.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 outdoor pools, open 7:00 AM to 10:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/1f402c59.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton San Diego Resort [](https://www.expedia.co.uk/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) Harbor Island 8.4/10 Very good (3,368 reviews) "Love this hotel will always stay here when I come to San Diego " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Darlene £140 includes taxes & fees 1 Apr - 2 Apr [](https://www.expedia.co.uk/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ![3 bars/lounges, lobby lounge, cocktail bar, cocktail bar](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/ce2dc6d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, minibar, desk](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/8ea4f9d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/abbee14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/fd80224d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lafayette Hotel & Club [](https://www.expedia.co.uk/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) University Heights 9.2/10 Wonderful (1,514 reviews) "Stunning hotel, I could have stayed there all day looking at every little design detail. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Holly £196 includes taxes & fees 19 Mar - 20 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/26000/25973/9ae91e6b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/26000/25973/da6358b5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/1000000/30000/26000/25973/ee821476.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/30000/26000/25973/bfccee20.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Jolla Shores Hotel [](https://www.expedia.co.uk/La-Jolla-Hotels-La-Jolla-Shores-Hotel.h25973.Hotel-Information) La Jolla Shores 8.8/10 Excellent (1,370 reviews) "Beachfront location was perfect and staff was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jack £219 includes taxes & fees 6 Apr - 7 Apr [](https://www.expedia.co.uk/La-Jolla-Hotels-La-Jolla-Shores-Hotel.h25973.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/7aa1b6a7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Room, 2 Double Beds, Non Smoking | Desk, blackout curtains, soundproofing, free WiFi](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/9072a14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/1a9b4d28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, soundproofing, free WiFi](https://images.trvl-media.com/lodging/35000000/34910000/34909900/34909853/06274c72.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Valli Hi Motel [](https://www.expedia.co.uk/San-Ysidro-Hotels-Valli-Hi-Motel.h34909853.Hotel-Information) San Ysidro 8.4/10 Very good (1,010 reviews) "Excelente " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Julio [](https://www.expedia.co.uk/San-Ysidro-Hotels-Valli-Hi-Motel.h34909853.Hotel-Information) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/bc7617fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/ddddbc6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/5a519562.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/6ca639f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Chula Vista/Otay Valley Hotel [](https://www.expedia.co.uk/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) Otay 7.8/10 Good (1,637 reviews) "Clean rooms and the breakfast was amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vanessa £85 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3836h2556x3y3-467b2b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3839h2555x0y3-5f9fe6e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![49-inch flat-screen TV with cable channels, TV](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3830h2553x4y4-0f56bb42.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/e9cd53ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Imperial Beach San Diego [](https://www.expedia.co.uk/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information) Imperial Beach 9.4/10 Exceptional (1,001 reviews) "It’s always a great place to stay. The staff are so nice and friendly, rooms are very nice." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Carolyn £122 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/3f975189.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/e00d8cf9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/a1b42446.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1779e3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG [](https://www.expedia.co.uk/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) Otay Mesa 8.0/10 Very good (1,660 reviews) "Clean, great breakfast, good service." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sara £109 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) ![Coffee/tea maker](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/18bcfb40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/e796672a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/b359fdeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/58b6effd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 Suites San Ysidro, CA -San Diego South Bay [](https://www.expedia.co.uk/San-Ysidro-Hotels-Knights-Inn-San-Ysidro.h1798071.Hotel-Information) San Ysidro 7.8/10 Good (1,531 reviews) "Clean and quick place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Hector £58 includes taxes & fees 24 Mar - 25 Mar [](https://www.expedia.co.uk/San-Ysidro-Hotels-Knights-Inn-San-Ysidro.h1798071.Hotel-Information) ![Free on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/bd6623c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/586d04dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/55248c07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/70282182.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites San Diego Otay Mesa [](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) Otay Mesa 7.0/10 Good (1,009 reviews) "Great staff.. location close to the airport!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vivian £91 includes taxes & fees 5 Apr - 6 Apr [](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) ![Free daily breakfast ](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/6f835687.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/14aef6f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/e9cdd186.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Accessible, Bathtub | Mini fridge](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/17786c6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn San Diego South - Chula Vista [](https://www.expedia.co.uk/Chula-Vista-Hotels-SureStay-Plus-Hotel-By-Best-Western-Chula-Vista-West.h12496281.Hotel-Information) Chula Vista 7.8/10 Good (1,002 reviews) "Staff was great!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) jennifer £68 includes taxes & fees 22 Mar - 23 Mar [](https://www.expedia.co.uk/Chula-Vista-Hotels-SureStay-Plus-Hotel-By-Best-Western-Chula-Vista-West.h12496281.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-25&endDate=2026-03-26®ionId=553248632063518562&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_SPRING_PROMO_553248632063518562) ## Top South San Diego Hotel Reviews ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/c491024e_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 6/10 Okay "did not look" [](https://expedia.co.uk/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/7e147d0f_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "I had a great experience. Friendly and helpful staff" [](https://expedia.co.uk/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![The Dana on Mission Bay](https://images.trvl-media.com/lodging/1000000/50000/41000/40953/8e8c5197_y.jpg) ### The Dana on Mission Bay 10/10 Excellent "Everything was absolutely perfect! The staff were exceptionally friendly and helpful. The room was just perfect. We loved the location; close to the pool, the restaurant, and the lobby. The bed was very comfortable and we enjoyed the view of the marina. I enjoyed the “early bird” free coffee and watching the sun come up over the marina. We loved the heated pool and the jacuzzi. The grounds were beautiful. The food, drinks, and the staff at the Firefly were exceptional. We were pleased that there was a shuttle to SeaWorld. We will definitely be back! " [](https://expedia.co.uk/San-Diego-Hotels-The-Dana-On-Mission-Bay.h40953.Hotel-Information) ![Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld Near Old Town 8/10 Good "If you’re without a car, and you’re wanting to wander around San Diego and not get a rental or do Uber for every trip. This hotel is pretty far away from the beach. Central location if you’re looking for that as a place to be ground zero. Pretty much 20-30 minutes from everything in La Jolla, Mission Bay Mission Beach Balboa Park. " [](https://expedia.co.uk/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/a77f85c3_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "The room was great and they were able to get us into it right away - the staff is amazing!!! Super walkable area and close to tram and stadium. We were even able to buy our zoo tickets at the front desk cheaper than at the zoo." [](https://expedia.co.uk/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Hyatt Regency Mission Bay Spa and Marina](https://images.trvl-media.com/lodging/1000000/10000/900/858/543624c5_y.jpg) ### Hyatt Regency Mission Bay Spa and Marina 6/10 Okay "We were on a four night stay, After the second night we asked for a replenishment of coffee and towels. I expressed my belief that the room should be furnished with coffee daily. The host was cooperative and offered to comp one nights parking which I felt was acceptable. That didn't happen, we were not compensated one nights parking. Also, on the days the coffee WAS replenished, no sugar, creamer or stir sticks were supplied. " [](https://expedia.co.uk/San-Diego-Hotels-Hyatt-Regency-Mission-Bay-Spa-And-Marina.h858.Hotel-Information) ![Omni San Diego Hotel at the Ballpark](https://images.trvl-media.com/lodging/1000000/990000/982500/982408/029abbb9_y.jpg) ### Omni San Diego Hotel at the Ballpark 10/10 Excellent "Perfect location for the Gaslamp Quarter! Near the san diego rail and also perfect distance to walk to many nearby places! Stayed for my birthday weekend and the staff were very accommodating! They even gave me cute cupcakes! I would definitely stay here again! Thank you Omni!! " [](https://expedia.co.uk/San-Diego-Hotels-Omni-San-Diego-Hotel.h982408.Hotel-Information) ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/4003f7ef_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "It feels wonderful when the Front desk staff recognizes you and gives you a nice warm welcome. " [](https://expedia.co.uk/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 8/10 Good "The location of this property was very scenic with the bay directly across from it, The hotel itself was very clean and the staff was very courteous and helpful. Our room was in the tower building which was nice but the rooms, though clean, were outdated and could use some refurbishing. Other than that, I would recommend this hotel." [](https://expedia.co.uk/San-Diego-Hotels-Sheraton-San-Diego-Resort.h11109.Hotel-Information) ## Frequently asked questions ### How much do business hotels in South San Diego cost? ### How many business hotels are there in South San Diego? ### Why book your business hotel in South San Diego with Expedia? ### How can I find cheap business hotels in South San Diego? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Sports Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Adventure-Sport-Hotel.0-0-d5921-tAdventureSportHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Business-Hotel.0-0-d5921-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-Bar.0-0-d5921-thotelwithabar.Travel-Guide-Filter-Hotels) - [Hotels with a View in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-View.0-0-d5921-thotelwithaview.Travel-Guide-Filter-Hotels) - 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