Title: TOP Business Hotels in South San Diego, CA for 2026 | Expedia.co.uk [South San Diego Travel Guide](https://expedia.co.uk/South-San-Diego.dx553248632063518562)[Hotels in South San Diego](https://expedia.co.uk/South-San-Diego-Hotels.d553248632063518562.Travel-Guide-Hotels)[Holiday Rentals in South San Diego](https://expedia.co.uk/South-San-Diego-Holiday-Rentals.d553248632063518562.Travel-Guide-HolidayRentals)[Flights to South San Diego](https://expedia.co.uk/Cheap-Flights-To-South-San-Diego.d553248632063518562.Travel-Guide-Flights)[Things to do in South San Diego](https://expedia.co.uk/Things-To-Do-In-South-San-Diego.d553248632063518562.Travel-Guide-Activities)[South San Diego Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-San-Diego.d553248632063518562.Car-Hire-Guide)[South San Diego Holidays](https://expedia.co.uk/South-San-Diego.d553248632063518562.Holidays-City-Breaks) ![Captured this guy doing a wheelie during a beautiful sunset! #imperialbeach #EndlessSummer #autographhotels #Marriott #piersouthresort](https://images.trvl-media.com/place/177683/d4a8a1a3-bd23-4c6a-826e-e0c1c12dddaa.jpg?impolicy=fcrop&w=1200&h=500&q=medium) Photo by Karen Leone # Search Business Hotels in South San Diego - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South San Diego Business Hotels Tonight [19 Dec - 20 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-12-19&endDate=2025-12-20&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [20 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-12-20&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for South San Diego business-friendly hotels ![Terrace/patio](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3836h2556x3y3-467b2b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/e9cd53ec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3840h2558x0y3-98d4fb1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/720d452f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Imperial Beach San Diego [](https://www.expedia.co.uk/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information) Imperial Beach 9.4/10 Exceptional (951) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Crystal £107 includes taxes & fees 22 Dec - 23 Dec [](https://www.expedia.co.uk/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/4cbc3cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/e7aa7734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/743ac288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/5d6482eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pier South Resort, Autograph Collection by Marriott [](https://www.expedia.co.uk/Imperial-Beach-Hotels-Pier-South-Resort.h570818.Hotel-Information) Imperial Beach 8.4/10 Very good (1002) "Staff was amazing room with the view was just stunning " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alisa £144 includes taxes & fees 20 Dec - 21 Dec [](https://www.expedia.co.uk/Imperial-Beach-Hotels-Pier-South-Resort.h570818.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/eda7e8ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1779e3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/c607b0c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/e54b117c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG [](https://www.expedia.co.uk/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) Otay Mesa 8.0/10 Very good (1560) "Great place to stay. Really clean and helpful staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Zulma £101 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/57e60275.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby lounge](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/fb95526d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed | Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/2602a017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily continental breakfast (USD 13.49 per person)](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/1303c0cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hercor Hotel - Urban Boutique [](https://www.expedia.co.uk/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information) Chula Vista 8.6/10 Excellent (1320) "Great value and location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Andrew £69 includes taxes & fees 21 Dec - 22 Dec [](https://www.expedia.co.uk/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information) ![Standard Room, 1 King Bed, Non Smoking, Refrigerator & Microwave | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/cf5335af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/a1205ac4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/6ad23cf3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/6ca639f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Chula Vista/Otay Valley Hotel [](https://www.expedia.co.uk/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) Otay 7.8/10 Good (1549) "The breakfast was good there were healthy options. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Selene £83 includes taxes & fees 6 Jan - 7 Jan 2026 [](https://www.expedia.co.uk/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) ![Coffee service](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/bc01198b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/add58e18.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/62279bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 Queen Bed, Accessible, Bathtub | Mini fridge](https://images.trvl-media.com/lodging/13000000/12500000/12496300/12496281/17786c6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn San Diego South - Chula Vista [](https://www.expedia.co.uk/Chula-Vista-Hotels-SureStay-Plus-Hotel-By-Best-Western-Chula-Vista-West.h12496281.Hotel-Information) Chula Vista 7.8/10 Good (1002) "Good food for breakfast " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aaron £59 includes taxes & fees 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/Chula-Vista-Hotels-SureStay-Plus-Hotel-By-Best-Western-Chula-Vista-West.h12496281.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/bfd1ccfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/83180011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/84883664.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/2194e09f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Diego Chula Vista [](https://www.expedia.co.uk/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information) Chula Vista 8.6/10 Excellent (1493) "Everything was great, staff , Room , clean , great place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis £83 includes taxes & fees 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/a90f2d6f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee/tea maker](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/18bcfb40.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/d8ecd896.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/2000000/1800000/1798100/1798071/58b6effd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 Suites San Ysidro, CA -San Diego South Bay [](https://www.expedia.co.uk/San-Ysidro-Hotels-Knights-Inn-San-Ysidro.h1798071.Hotel-Information) San Ysidro 7.8/10 Good (1409) "Excelente hotel " ![Mexico](https://a.travel-assets.com/egds/marks/flags/mx.svg) Adrian Andrés £60 includes taxes & fees 23 Dec - 24 Dec [](https://www.expedia.co.uk/San-Ysidro-Hotels-Knights-Inn-San-Ysidro.h1798071.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/b70d99f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee shop](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/41516864.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Memory-foam beds, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/e0c0af28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/0df0eb3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Rambler [](https://www.expedia.co.uk/Chula-Vista-Hotels-The-Rambler-Motel.h18213.Hotel-Information) Chula Vista 9.2/10 Wonderful (1996) "Rooms were spotless, staff was courteous!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jesse £76 includes taxes & fees 14 Jan - 15 Jan 2026 [](https://www.expedia.co.uk/Chula-Vista-Hotels-The-Rambler-Motel.h18213.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/36da2a73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/2e7509ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/434ca240.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/a48c362c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Chula Vista San Diego South [](https://www.expedia.co.uk/Chula-Vista-Hotels-Comfort-Inn-Chula-Vista-San-Diego-South.h18870.Hotel-Information) Chula Vista 8.2/10 Very good (1247) "we had a great stay!!!!! Highly recommended!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Richelle £80 includes taxes & fees 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/Chula-Vista-Hotels-Comfort-Inn-Chula-Vista-San-Diego-South.h18870.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-02&endDate=2026-01-03®ionId=553248632063518562&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top South San Diego Hotel Reviews ![The DEXTRO Little Italy, BW Premier Collection](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "The room was comfortable & the staff was incredibly friendly. The location is also ideal for exploration and looking around. Really solid pick." [](https://expedia.co.uk/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Bay Club Hotel & Marina](https://images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "Exactly as described " [](https://expedia.co.uk/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Manchester Grand Hyatt San Diego](https://images.trvl-media.com/lodging/1000000/20000/12100/12073/edc3001f_y.jpg) ### Manchester Grand Hyatt San Diego 10/10 Excellent "When I asked about breakfast they said I didn’t have it" [](https://expedia.co.uk/San-Diego-Hotels-Manchester-Grand-Hyatt-San-Diego.h12073.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](https://images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Nice room and beds" [](https://expedia.co.uk/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Sheraton San Diego Resort](https://images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "Great hotel! Enjoyed our rooms and the staff was very accommodating to our party with two small children." [](https://expedia.co.uk/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![Hard Rock Hotel San Diego](https://images.trvl-media.com/lodging/2000000/1740000/1731600/1731557/fbbdfc57_y.jpg) ### Hard Rock Hotel San Diego 10/10 Excellent "Clean. Great room " [](https://expedia.co.uk/San-Diego-Hotels-Hard-Rock-Hotel-San-Diego.h1731557.Hotel-Information) ![Wyndham San Diego Bayside](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/c44ff51d_y.jpg) ### Wyndham San Diego Bayside 10/10 Excellent "great spot to catch a cruise. awesome view of the bay" [](https://expedia.co.uk/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Embassy Suites by Hilton San Diego La Jolla](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/49079311_y.jpg) ### Embassy Suites by Hilton San Diego La Jolla 10/10 Excellent "Clean room. Good customer service" [](https://expedia.co.uk/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) ![Hampton Inn & Suites by Hilton San Diego SeaWorld](https://images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 10/10 Excellent "Spotless... traveling alone and after staying the night before in the 2nd worse place I have ever stayed - sounds dramatic but I really feared for my life! I could notfeare stayed" [](https://expedia.co.uk/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ## Frequently asked questions ### How much do business hotels in South San Diego cost? ### How many business hotels are there in South San Diego? ### Why book your business hotel in South San Diego with Expedia? ### How can I find cheap business hotels in South San Diego? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [Sports Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Adventure-Sport-Hotel.0-0-d5921-tAdventureSportHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Business-Hotel.0-0-d5921-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-Bar.0-0-d5921-thotelwithabar.Travel-Guide-Filter-Hotels) - [Hotels with a View in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-View.0-0-d5921-thotelwithaview.Travel-Guide-Filter-Hotels) - 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