Title: TOP Business Hotels in South San Diego, CA for 2025 | Expedia.co.uk [South San Diego Travel Guide](https://expedia.co.uk/South-San-Diego.dx553248632063518562)[Hotels in South San Diego](https://expedia.co.uk/South-San-Diego-Hotels.d553248632063518562.Travel-Guide-Hotels)[Holiday Rentals in South San Diego](https://expedia.co.uk/South-San-Diego-Holiday-Rentals.d553248632063518562.Travel-Guide-HolidayRentals)[Flights to South San Diego](https://expedia.co.uk/Cheap-Flights-To-South-San-Diego.d553248632063518562.Travel-Guide-Flights)[Things to do in South San Diego](https://expedia.co.uk/Things-To-Do-In-South-San-Diego.d553248632063518562.Travel-Guide-Activities)[South San Diego Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-San-Diego.d553248632063518562.Car-Hire-Guide)[South San Diego Holidays](https://expedia.co.uk/South-San-Diego.d553248632063518562.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/1/1577a5f9f9b33dbc18377fc367dd66b8.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Business Hotels in South San Diego - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South San Diego Business Hotels Tonight [2 Nov - 3 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-11-02&endDate=2025-11-03&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [3 Nov - 4 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-11-03&endDate=2025-11-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [7 Nov - 9 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) In two weeks [14 Nov - 16 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=553248632063518562&startDate=2025-11-14&endDate=2025-11-16&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Top South San Diego Business Hotels ![Terrace/patio](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3836h2556x3y3-467b2b48.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3840h2558x0y3-98d4fb1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/w3839h2555x0y3-5f9fe6e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/50000000/49290000/49284700/49284697/720d452f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Imperial Beach San Diego Imperial Beach 9.4/10 Exceptional (914) "Our room was awesome " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura £116 includes taxes & fees 23 Nov - 24 Nov [](https://www.expedia.co.uk/Imperial-Beach-Hotels-Hampton-Inn-Suites-Imperial-Beach-San-Diego.h49284697.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/4cbc3cd6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/e7aa7734.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/743ac288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/580000/570900/570818/5d6482eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Pier South Resort, Autograph Collection by Marriott Imperial Beach 8.4/10 Very good (1006) "Beautiful place right by the ocean the staff was really nice and welcoming. Everything was beautiful." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) reynette £160 includes taxes & fees 23 Nov - 24 Nov [](https://www.expedia.co.uk/Imperial-Beach-Hotels-Pier-South-Resort.h570818.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/bfd1ccfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed, Non Smoking | Premium bedding, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/b3ebadf5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/2194e09f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/22900/22810/83180011.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn by Wyndham San Diego Chula Vista Chula Vista 8.6/10 Excellent (1449) "Clean room friendly staff easy parking " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Diego £82 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-La-Quinta-Inn-By-Wyndham-San-Diego-Chula-Vista.h22810.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/eda7e8ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/c607b0c2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1779e3cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Accessible, Non Smoking (Mobility, Transfer Shower) | In-room safe, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/2000000/1640000/1632400/1632358/1d234b24.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG Otay Mesa 8.0/10 Very good (1502) "Nice and quiet area. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Marvin £112 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/San-Diego-Hotels-Holiday-Inn-Express-Hotel-Suites-San-Diego-Otay-Mesa.h1632358.Hotel-Information) ![Deluxe Room, 1 King Bed | Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/2602a017.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/cc894470.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/c9d13d5c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Daily continental breakfast (USD 13.49 per person)](https://images.trvl-media.com/lodging/2000000/1480000/1475800/1475800/1303c0cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hercor Hotel - Urban Boutique Chula Vista 8.6/10 Excellent (1285) "Also the breakfast was amazing" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) William £72 includes taxes & fees 3 Nov - 4 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-Hercor-Hotel-Urban-Boutique.h1475800.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/0f00abe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/4bc7be07.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking, Refrigerator & Microwave | Desk, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/cf5335af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/1000000/20000/12700/12645/49e543d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Best Western Chula Vista/Otay Valley Hotel Otay 7.8/10 Good (1505) "I very much enjoyed my stay here. The bed was comfier than my own lol." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Alex £85 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-Best-Western-Chula-VistaOtay-Valley-Hotel.h12645.Hotel-Information) ![View from room](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/b70d99f9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, memory-foam beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/e0c0af28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/0df0eb3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Balcony](https://images.trvl-media.com/lodging/1000000/20000/18300/18213/28c3172b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Rambler Chula Vista 9.2/10 Wonderful (1981) "Best place I’ve ever stayed in SoCal" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Zynteea £87 includes taxes & fees 4 Nov - 5 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-The-Rambler-Motel.h18213.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/36da2a73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/a48c362c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/2e7509ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 10:00 AM to 7:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/18900/18870/6211d6de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn Chula Vista San Diego South Chula Vista 8.2/10 Very good (1172) "staff was amazing " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) lorraine £85 includes taxes & fees 9 Nov - 10 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-Comfort-Inn-Chula-Vista-San-Diego-South.h18870.Hotel-Information) ![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/673df2c4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/c6a042c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/16237f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/470000/461900/461837/d3d09d7e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Suites San Diego Otay Mesa Otay Mesa 7.2/10 Good (1004) "Hotel was great the staff was very attentive. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Anibal £86 includes taxes & fees 3 Nov - 4 Nov [](https://www.expedia.co.uk/San-Diego-Hotels-Quality-Suites-San-Diego-Otay-Mesa.h461837.Hotel-Information) ![Lobby lounge](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/3ced364d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/00abc97b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/3c739431.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby sitting area](https://images.trvl-media.com/lodging/33000000/32400000/32393800/32393708/69474629.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Ayres Hotel San Diego South - Chula Vista Otay Ranch 9.8/10 Exceptional (1117) "Great hotel clean, new!! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ROBERTO J £148 includes taxes & fees 5 Nov - 6 Nov [](https://www.expedia.co.uk/Chula-Vista-Hotels-Ayres-Hotel-San-Diego-South-Chula-Vista.h32393708.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-16&endDate=2025-11-17®ionId=553248632063518562&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top South San Diego Hotel Reviews ![Kings Inn San Diego](//images.trvl-media.com/lodging/1000000/20000/17000/16910/a5f26080_y.jpg) ### Kings Inn San Diego 10/10 Excellent "I’m a big fan of the friendly staff that greets me every time I check in. This stay was based on business that I had in San Diego. I specifically chose this hotel because it feels like home away from home. The rooms are clean, smells good, and I love the extra blanket. My room was close to the pool and parking lot but I heard nothing. They have breakfast and dinner. Both convenient and delicious. " [](https://expedia.co.uk/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) ![Best Western Plus Marina Gateway Hotel](//images.trvl-media.com/lodging/3000000/2820000/2816700/2816688/f3777dfe_y.jpg) ### Best Western Plus Marina Gateway Hotel 10/10 Excellent "Room was nice, staff was nice!" [](https://expedia.co.uk/National-City-Hotels-Best-Western-Plus-Marina-Gateway-Hotel.h2816688.Hotel-Information) ![Comfort Inn Sea World Area](//images.trvl-media.com/lodging/1000000/550000/544700/544662/44f458a2_y.jpg) ### Comfort Inn Sea World Area 10/10 Excellent "Room was cleaned every day. Water pressure was great. Beds where comfortable and the hotel area was clean. Air conditioner was very loud in the room" [](https://expedia.co.uk/San-Diego-Hotels-Comfort-Inn-Sea-World-Area.h544662.Hotel-Information) ![The DEXTRO Little Italy, BW Premier Collection](//images.trvl-media.com/lodging/1000000/180000/170400/170338/84efd019_y.jpg) ### The DEXTRO Little Italy, BW Premier Collection 10/10 Excellent "Good service, room was clean. " [](https://expedia.co.uk/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Bay Club Hotel & Marina](//images.trvl-media.com/lodging/1000000/10000/2600/2514/8c022c3d_y.jpg) ### Bay Club Hotel & Marina 10/10 Excellent "Second time staying here. Great couples get away. We book this place for the great location. We love the marina view from our room! Close enough to activities in San Diego but far enough away from the hustle so you can enjoy peace and quiet. The hotel is a bit dated and the walls seem thin, but it’s clean and comfortable. " [](https://expedia.co.uk/San-Diego-Hotels-Bay-Club-Hotel-Marina.h2514.Hotel-Information) ![Hampton Inn & Suites by Hilton San Diego SeaWorld](//images.trvl-media.com/lodging/13000000/12970000/12963400/12963301/cc52443d_y.jpg) ### Hampton Inn & Suites by Hilton San Diego SeaWorld 10/10 Excellent "Romm are clean and neat as well as hallways. " [](https://expedia.co.uk/San-Diego-Hotels-Hampton-Inn-Suites-San-Diego-Point-Loma.h12963301.Hotel-Information) ![Courtyard by Marriott San Diego Downtown Little Italy](//images.trvl-media.com/lodging/1000000/20000/13300/13205/0339a25b_y.jpg) ### Courtyard by Marriott San Diego Downtown Little Italy 10/10 Excellent "Staff is amazing 3 time staying here for a reason really. Great place " [](https://expedia.co.uk/San-Diego-Hotels-The-Little-Italy-Hotel-In-Downtown-San-Diego.h13205.Hotel-Information) ![Sheraton San Diego Resort](//images.trvl-media.com/lodging/1000000/20000/11200/11109/w4000h2662x0y0-91d299a1_y.jpg) ### Sheraton San Diego Resort 10/10 Excellent "I don’t know where to start. From the shuttle in to the shuttle out, everything was perfect!" [](https://expedia.co.uk/San-Diego-Hotels-Sheraton-San-Diego-Hotel-And-Marina.h11109.Hotel-Information) ![Wyndham Garden San Diego Near SeaWorld](//images.trvl-media.com/lodging/1000000/50000/41000/40962/76b78879_y.jpg) ### Wyndham Garden San Diego Near SeaWorld 10/10 Excellent "The staff were friendly. The room was clean but there were some issues in the room. Shower head was not completely sealed. There there spots on the ceiling in the bathroom and the some baseboards were messed up. " [](https://expedia.co.uk/San-Diego-Hotels-Wyndham-Garden-San-Diego-Near-SeaWorld.h40962.Hotel-Information) ## Frequently asked questions ### How much do business hotels in South San Diego cost? > Expect to pay between and per night for business hotels in South San Diego. Terrific deals on properties that are suitable for work-related guests are just a few clicks away on Expedia. This price was available on Expedia within the past 7 days, for a hotel booking with a check-in date within the next year. Prices reflect current offers and availability is subject to change. Additional terms may apply. ### How many business hotels are there in South San Diego? > When you need to travel for work in South San Diego, you'll have business hotels to pick from. ### Why book your business hotel in South San Diego with Expedia? > With amenities like meeting rooms, laundry facilities and on-site cafés, our business-friendly properties come with everything you'll need to close your important deal — and then kick back! Enter your travel destination and preferred dates and we'll help you plan the rest. ### How can I find cheap business hotels in South San Diego? > Expedia can help you narrow down your search for cheap business hotels in South San Diego. Head to the "traveller experience" filter and click on "business friendly." This will show you properties with amenities designed to help you work and rest comfortably, like included breakfast and free WiFi. 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[Things to do in Chula Vista](https://www.expedia.co.uk/Things-To-Do-In-Chula-Vista.d7442.Travel-Guide-Activities) - [Book Business Hotels in South San Diego on Expedia.com](https://www.expedia.com/South-San-Diego-Hotels-Business-Hotel.0-0-d553248632063518562-tBusinessHotel.Travel-Guide-Filter-Hotels)