Title: TOP Hotels Suites in South Carolina Midlands, SC for 2026 | Expedia.co.uk [South Carolina Midlands Travel Guide](https://expedia.co.uk/South-Carolina-Midlands.dx6057938)[Hotels in South Carolina Midlands](https://expedia.co.uk/South-Carolina-Midlands-Hotels.d6057938.Travel-Guide-Hotels)[Holiday Rentals in South Carolina Midlands](https://expedia.co.uk/South-Carolina-Midlands-Holiday-Rentals.d6057938.Travel-Guide-HolidayRentals)[Flights to South Carolina Midlands](https://expedia.co.uk/Cheap-Flights-To-South-Carolina-Midlands.d6057938.Travel-Guide-Flights)[Things to do in South Carolina Midlands](https://expedia.co.uk/Things-To-Do-In-South-Carolina-Midlands.d6057938.Travel-Guide-Activities)[South Carolina Midlands Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-South-Carolina-Midlands.d6057938.Car-Hire-Guide)[South Carolina Midlands Holidays](https://expedia.co.uk/South-Carolina-Midlands.d6057938.Holidays-City-Breaks) ![South Carolina State House](https://images.trvl-media.com/place/6082681/1934af6a-1aa9-4e01-8cd3-8eb8fe4af18f.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Hotels Suites in South Carolina Midlands - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on South Carolina Midlands Hotels Suites Tonight [16 Dec - 17 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2025-12-16&endDate=2025-12-17&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [17 Dec - 18 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2025-12-17&endDate=2025-12-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Dec - 28 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=6057938&startDate=2025-12-26&endDate=2025-12-28&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for South Carolina Midlands hotels with suites ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/4b412627.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/99021580.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Business centre](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/11da224f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/93000000/92610000/92601000/92600969/40f69ad1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru By Hilton Santee [](https://www.expedia.co.uk/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) Santee 9.2/10 Wonderful (639) "Nice place to stay" ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Tanya £80 includes taxes & fees 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/Santee-Hotels-Tru-By-Hilton-Santee.h92600969.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/3000000/2810000/2803700/2803681/d098e4c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free continental breakfast ](https://images.trvl-media.com/lodging/3000000/2810000/2803700/2803681/ecf8f7be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, Multiple Beds | In-room safe, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/3000000/2810000/2803700/2803681/5ae74698.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/3000000/2810000/2803700/2803681/549be75d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Holiday Inn Express & Suites Newberry by IHG [](https://www.expedia.co.uk/Newberry-Hotels-Holiday-Inn-Express-Suites-Newberry.h2803681.Hotel-Information) Newberry 9.0/10 Wonderful (633) "Room was clean staff was great !" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) R Scott £69 includes taxes & fees 2 Jan - 3 Jan 2026 [](https://www.expedia.co.uk/Newberry-Hotels-Holiday-Inn-Express-Suites-Newberry.h2803681.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fad493a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/fefdad76.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/c9641979.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 2 Queen Beds, Non Smoking | Pillow-top beds, desk, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38340000/38336400/38336321/a63ff680.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Comfort Inn & Suites Florence Center Area [](https://www.expedia.co.uk/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) Florence 9.2/10 Wonderful (1169) "Enjoyed our stay there. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Cathy £81 includes taxes & fees 30 Dec - 31 Dec [](https://www.expedia.co.uk/Florence-Hotels-Comfort-Inn-Suites.h38336321.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/c8bc9166.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Serves lunch and dinner](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/a92f741a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/28b0a3ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/33000000/32780000/32772900/32772870/bee831df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Place Florence Downtown [](https://www.expedia.co.uk/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) Florence 8.8/10 Excellent (1006) "Great stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michaelle £84 includes taxes & fees 22 Dec - 23 Dec [](https://www.expedia.co.uk/Florence-Hotels-Hyatt-Place-Florence-Downtown.h32772870.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/e4f3361f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/96d5feb4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/0b9239a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/48000000/47090000/47086800/47086732/00586c85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson Florence, SC [](https://www.expedia.co.uk/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) Florence 9.0/10 Wonderful (2196) "Breakfast was great, room very clean ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leann £71 includes taxes & fees 24 Dec - 25 Dec [](https://www.expedia.co.uk/Florence-Hotels-Park-Inn-By-Radisson-Florence.h47086732.Hotel-Information) ![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/dfe24eeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/d654e116.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/e78e5670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/26200/26116/170f28f7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott Santee [](https://www.expedia.co.uk/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) Santee 9.8/10 Exceptional (1006) "Spotless clean room The staff was so courteous and friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amani £100 includes taxes & fees 24 Dec - 25 Dec [](https://www.expedia.co.uk/Orangeburg-Hotels-Fairfield-Inn-Suites-By-Marriott-Santee.h26116.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/99c8fb35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/f2adc30e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/c5155ebb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/35000000/34330000/34323400/34323336/eb4d1288.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Tru by Hilton Orangeburg [](https://www.expedia.co.uk/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) Orangeburg 9.2/10 Wonderful (1007) "Wonderful stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Josephine £86 includes taxes & fees 29 Dec - 30 Dec [](https://www.expedia.co.uk/Orangeburg-Hotels-Tru-By-Hilton-Orangeburg.h34323336.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/f8933df9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/0f2c01c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/502487e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Interior entrance](https://images.trvl-media.com/lodging/2000000/1520000/1513800/1513707/0a695ca8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton Garden Inn Columbia/Harbison [](https://www.expedia.co.uk/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) Columbia 9.0/10 Wonderful (1881) "Staff was wonderful and the room was very clean!I luv my stay !" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jenice £66 includes taxes & fees 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/Columbia-Hotels-Hilton-Garden-Inn-ColumbiaHarbison.h1513707.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/32fd6fc1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/7b1066c5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/e7174d53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Double Beds, Non Smoking | 1 bedroom, desk, blackout curtains, soundproofing](https://images.trvl-media.com/lodging/1000000/20000/11100/11037/8a1b879d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Howard Johnson by Wyndham Florence [](https://www.expedia.co.uk/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) Florence 8.6/10 Excellent (2495) "I nice place to stay, very quiet, good breakfast, nice staff, spotless room. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Timothy £52 includes taxes & fees 17 Dec - 18 Dec [](https://www.expedia.co.uk/Florence-Hotels-Howard-Johnson-By-Wyndham-Florence.h11037.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/bed9bec2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/bb785af0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, laptop workspace, bed sheets](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/421910eb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/50000000/49040000/49035900/49035821/a4b552f6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn & Suites Lexington Columbia [](https://www.expedia.co.uk/Columbia-Hotels-Hampton-Inn-Suites-Lexington.h49035821.Hotel-Information) Lexington 9.8/10 Exceptional (593) "Clean and comfortable room, friendly staff, great location." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Allison £86 includes taxes & fees 4 Jan - 5 Jan 2026 [](https://www.expedia.co.uk/Columbia-Hotels-Hampton-Inn-Suites-Lexington.h49035821.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-30&endDate=2025-12-31®ionId=6057938&adults=2&nearby_group=suites&sort=RECOMMENDED&openPlayBack=true) ## Top South Carolina Midlands Hotel Reviews ![Clarion Pointe Rock Hill Near University](https://images.trvl-media.com/lodging/1000000/30000/22100/22006/69d65d2e_y.jpg) ### Clarion Pointe Rock Hill Near University 10/10 Excellent "Very clean, great staff!" [](https://expedia.co.uk/Rock-Hill-Hotels-Clarion-Pointe-Rock-Hill-Near-Training-Camp.h22006.Hotel-Information) ![Graduate by Hilton Columbia SC](https://images.trvl-media.com/lodging/3000000/2520000/2515100/2515057/22f12a1f_y.jpg) ### Graduate by Hilton Columbia SC 10/10 Excellent "Room was not only beautiful but very clean. Staff was gracious - it was a perfect stay. " [](https://expedia.co.uk/Columbia-Hotels-Graduate-Columbia.h2515057.Hotel-Information) ![Country Inn & Suites by Radisson, Columbia, SC](https://images.trvl-media.com/lodging/1000000/210000/202900/202867/04e820c9_y.jpg) ### Country Inn & Suites by Radisson, Columbia, SC 10/10 Excellent "F" [](https://expedia.co.uk/Columbia-Hotels-Country-Inn-Suites-By-Radisson.h202867.Hotel-Information) ## Frequently asked questions ### How much do hotels with suites in South Carolina Midlands cost? ### What are the best hotels with suites in South Carolina Midlands? ### How many hotels with suites are there in South Carolina Midlands? ### What are the best cheap hotels with suites in South Carolina Midlands? ### Are there any family-friendly hotels with suites in South Carolina Midlands? ### Why book your hotel with suites in South Carolina Midlands with Expedia? ### How can I find cheap hotels with suites in South Carolina Midlands? ### What is there to do in South Carolina Midlands near my hotel with suites? ## Explore a world of travel with Expedia - 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