Search Hotels in Serra Mesa, San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Save instantly and earn perks with One Key
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Serra Mesa hotels

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
17.5 mi from Serra Mesa
9.0 out of 10, Wonderful, (1,255 reviews)
"Clean room, helpful and courteous staff, and fitness room was better than expected."
United States
Leyla
The price is £103
includes taxes & fees
19 Apr - 20 Apr
Best Western Americana Inn

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
17.9 mi from Serra Mesa
9.4 out of 10, Exceptional, (1,845 reviews)
"The staff was extremely helpful, nice, clean, welcoming and respectful."
United States
Marcella
The price is £83
includes taxes & fees
14 Apr - 15 Apr
Sycuan Casino Resort

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
11.5 mi from Serra Mesa
9.4 out of 10, Exceptional, (1,088 reviews)
"Staff are excellent!!!"
United States
MARIA HAZEL
The price is £106
includes taxes & fees
10 May - 11 May
Holiday Inn Express San Diego South - Chula Vista by IHG

Sheraton San Diego Resort

Sheraton San Diego Resort
4.0 star property
6.2 mi from Serra Mesa
8.4 out of 10, Very good, (3,458 reviews)
"Nice hotel with great location "
United States
DIANA
The price is £176
includes taxes & fees
29 Apr - 30 Apr
Sheraton San Diego Resort

Hampton Inn & Suites San Diego Airport Liberty Station

Hampton Inn & Suites San Diego Airport Liberty Station
2.5 star property
6.6 mi from Serra Mesa
9.2 out of 10, Wonderful, (1,712 reviews)
"Great location for the airport stay"
United States
Christopher
The price is £146
includes taxes & fees
26 Apr - 27 Apr
Hampton Inn & Suites San Diego Airport Liberty Station

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
5.6 mi from Serra Mesa
7.4 out of 10, Good, (4,235 reviews)
"Front desk nice rooms clean "
United States
Alexis
The price is £84
includes taxes & fees
12 Apr - 13 Apr
Wyndham Garden San Diego Near SeaWorld

Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla
4.0 star property
University City, 6.4 mi from Serra Mesa
8.8 out of 10, Excellent, (1,909 reviews)
"Very clean property, nice location. Breakfast was great. "
United States
Vicki
The price is £195
includes taxes & fees
10 May - 11 May
Embassy Suites by Hilton San Diego La Jolla

GreenTree Inn San Diego Mission Bay

GreenTree Inn San Diego Mission Bay
2.5 star property
Pacific Beach, 4.5 mi from Serra Mesa
8.0 out of 10, Very good, (2,024 reviews)
"Staff that works there were kind and very friendly."
United States
Jhonkeiver
The price is £89
includes taxes & fees
16 Apr - 17 Apr
GreenTree Inn San Diego Mission Bay

Marriott Marquis San Diego Marina

Marriott Marquis San Diego Marina
4.0 star property
6.7 mi from Serra Mesa
9.2 out of 10, Wonderful, (2,087 reviews)
"good atmosphere, good staff, friendly staff, good food, pool is amazing, restaurants are affordable and excellent."
United States
Artsrun
The price is £242
includes taxes & fees
8 May - 9 May
Marriott Marquis San Diego Marina

HYATT house San Diego/Sorrento Mesa

HYATT house San Diego/Sorrento Mesa
3.0 star property
7.3 mi from Serra Mesa
9.0 out of 10, Wonderful, (1,001 reviews)
"Great staff, rooms are very clean and comfortable. "
United States
Chris
The price is £130
includes taxes & fees
3 May - 4 May
HYATT house San Diego/Sorrento Mesa

Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel
2.5 star property
6.3 mi from Serra Mesa
7.8 out of 10, Good, (1,276 reviews)
"Parking was great no problems staff wonderful help with everything great breakfast great location will be back"
United States
David
The price is £95
includes taxes & fees
12 Apr - 13 Apr
Best Western San Diego/Miramar Hotel

Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa
2.5 star property
2.2 mi from Serra Mesa
9.2 out of 10, Wonderful, (1,008 reviews)
"The rooms was a nice size and clean. The staff was nice and their breakfast was better than expected. "
United States
elisa
The price is £131
includes taxes & fees
12 Apr - 13 Apr
Hampton Inn San Diego-Kearny Mesa

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
4.9 mi from Serra Mesa
9.2 out of 10, Wonderful, (1,067 reviews)
"Clean room, friendly staff, and only a 15 minute walk to Old Town. Also conveniently located close to the airport just a short shuttle drive away. "
United States
Olivia
The price is £120
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express San Diego Airport - Old Town by IHG

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
10 mi from Serra Mesa
9.2 out of 10, Wonderful, (3,773 reviews)
"Clean room, comfy bed, and the staff were awesome. Pool and hot tub were the perfect temp."
United States
Danielle
The price is £122
includes taxes & fees
12 Apr - 13 Apr
Best Western Plus Marina Gateway Hotel

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
14.9 mi from Serra Mesa
9.6 out of 10, Exceptional, (622 reviews)
"By far, one of the best hotels we have stayed at! Very clean, friendly and knowledgeable front desk staff, amenities galore and right across the street from family friendly entertainment venues like play city and ninja factory. The pool was amazing - we had all a great time! "
United States
Daniel
The price is £154
includes taxes & fees
3 May - 4 May
SpringHill Suites by Marriott Chula Vista Eastlake

Wyndham San Diego Bayside

Wyndham San Diego Bayside
4.0 star property
6.1 mi from Serra Mesa
8.4 out of 10, Very good, (6,140 reviews)
"Clean room and great location "
United States
Evanthia
The price is £165
includes taxes & fees
3 May - 4 May
Wyndham San Diego Bayside

Embassy Suites by Hilton San Diego Bay Downtown

Embassy Suites by Hilton San Diego Bay Downtown
4.0 star property
6.6 mi from Serra Mesa
9.0 out of 10, Wonderful, (1,721 reviews)
"Wonderful hotel and great location!! "
United States
Jan
The price is £223
includes taxes & fees
10 May - 11 May
Embassy Suites by Hilton San Diego Bay Downtown

The Encinitan Hotel & Suites

The Encinitan Hotel & Suites
3.0 star property
19.1 mi from Serra Mesa
8.2 out of 10, Very good, (1,474 reviews)
"Great value being so close to all the attractions "
United States
Charlton
The price is £117
includes taxes & fees
12 Apr - 13 Apr
The Encinitan Hotel & Suites

Old Town Inn

Old Town Inn
2.5 star property
5.1 mi from Serra Mesa
9.2 out of 10, Wonderful, (1,855 reviews)
"Clean room, friendly staff. Very nice Boutique Motel"
United States
Scott
The price is £142
includes taxes & fees
12 Apr - 13 Apr
Old Town Inn

Bahia Resort Hotel

Bahia Resort Hotel
3.5 star property
Central Mission Beach, 6.6 mi from Serra Mesa
8.6 out of 10, Excellent, (1,972 reviews)
"Everything is perfect..location, staff, rooms, amenities, cleanliness."
United States
Ryan
The price is £186
includes taxes & fees
10 May - 11 May
Bahia Resort Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Serra Mesa

Find the best Serra Mesa areas for the activities you enjoy most.

Downtown San Diego

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Pacific Beach

Relax in beachside cafés in the morning, surf clean breaks in the afternoon and dance with a youthful club crowd at night at this coastal San Diego strip.

Mission Beach

If you're spending some time in Mission Beach, Mission Bay and Mission Beach are top sights worth seeing.

Gaslamp Quarter

San Diego’s historic heart has shed its seedy past to emerge as one of the city’s premier dining, shopping and entertainment hubs.

Ocean Beach

Ocean Beach is beloved for its stunning beaches. Take some time to explore sights in the area like Dog Beach and Sunset Cliffs Natural Park.

Top Serra Mesa Hotel Reviews

Frequently asked questions

What are the best hotels in Serra Mesa that travellers recommend?
Two of the best hotels in Serra Mesa that receive consistently high recommendations from travellers are the Sheraton Mission Valley San Diego Hotel and the Town and Country San Diego.

The 4-star Sheraton Mission Valley San Diego Hotel, with an 8.6 rating, is an excellent option for those who appreciate convenience and comfort. Guests frequently praise the friendly and great staff, clean and big rooms, and excellent service. This hotel offers 24-hour room service, bathrobes, and premium bedding, and is conveniently located near Fashion Valley Mall (1.6 km) and Mission Valley Mall (0.6 km).

Another highly recommended option is the 4-star Town and Country San Diego, which also has an 8.6 rating. Guests often highlight the great and wonderful location, nice and comfortable rooms, and friendly staff. This hotel features designer toiletries, a heated pool, and is situated close to Fashion Valley Mall (0.6 km) and Hotel Circle (0.6 km).
What are the best family hotels in Serra Mesa?
For family-friendly accommodation in Serra Mesa, consider the TownePlace Suites by Marriott San Diego Central or the Town and Country San Diego.

The 3-star TownePlace Suites by Marriott San Diego Central, with an excellent 9.0 rating, offers comfortable and clean rooms, often with sofa beds, which are great for families. Guests frequently praise the complimentary breakfast, which includes buffet and continental options, and the convenient pool.

Another excellent choice is the 4-star Town and Country San Diego, rated 8.6. This hotel is very close to Fashion Valley Mall and Hotel Circle. It features multiple pools, including a dedicated children's pool, and a playground. Families will appreciate amenities such as connecting rooms, complimentary cribs, and kids' meals available at the restaurant.
What are the best spa hotels in Serra Mesa?
For spa hotels in Serra Mesa, consider WorldMark San Diego - Mission Valley or Best Western Seven Seas.

The 3.5-star WorldMark San Diego - Mission Valley, with an 8.4 rating, offers accessible spa facilities and a lovely outdoor pool. Guests often mention the spacious rooms with balconies and the friendly staff. It is also conveniently located just 1.0 km from the Fashion Valley Mall.

Another excellent option is the 3-star Best Western Seven Seas, rated 7.8. This hotel provides accessible spa facilities and complimentary self-parking. Guests frequently comment on the comfortable and clean rooms and the helpful staff. It is situated a short 0.8 km from the Fashion Valley Mall.
What hotels in Serra Mesa offer free breakfast?
For hotels in Serra Mesa offering complimentary breakfast, consider the Springhill Suites San Diego Mission Valley, TownePlace Suites by Marriott San Diego Central, Sheraton Mission Valley San Diego Hotel, Homewood Suites by Hilton San Diego Mission Valley/Zoo, or the Super 8 by Wyndham San Diego Hotel Circle.

The 3.5-star Springhill Suites San Diego Mission Valley, with an excellent 9.2 rating, provides a free continental breakfast and guests consistently praise the spacious and clean rooms, as well as the friendly and helpful staff. It is also conveniently located near Escala Dog Park and Civita Dog Park.

Another fantastic option is the 3-star TownePlace Suites by Marriott San Diego Central, rated 9.0. This hotel offers a free buffet and continental breakfast, and guests frequently highlight the comfortable and clean rooms, excellent staff, and its great location, being just 0.4 km from Centrum Dog Park.

The 4-star Sheraton Mission Valley San Diego Hotel, with an 8.6 rating, includes a free continental breakfast if you book a Club Level Room with lounge access. Guests often mention the friendly staff and the clean, large rooms at this establishment.

For a comfortable stay with a complimentary breakfast, the 3-star Homewood Suites by Hilton San Diego Mission Valley/Zoo, rated 8.4, is a great choice. They offer a free continental breakfast, which guests describe as delicious, and the rooms are noted for being comfortable and clean.

Finally, the Super 8 by Wyndham San Diego Hotel Circle, with a 7.2 rating, also provides a free continental breakfast. Guests appreciate the friendly staff, good-sized and clean rooms, and the convenient location.
What are the top pet-friendly hotels in Serra Mesa?
For top pet-friendly hotels in Serra Mesa, consider the TownePlace Suites by Marriott San Diego Central, the Hilton Garden Inn San Diego Mission Valley Stadium, and the Sheraton Mission Valley San Diego Hotel.

The 3-star TownePlace Suites by Marriott San Diego Central, with a 9.0 rating, is a great choice for those travelling with dogs. It is conveniently located near Centrum Dog Park, just 0.4 km away, and the Convoy District, which is 0.2 km away. Guests frequently comment on the comfortable and clean rooms, the excellent and friendly staff, and the convenient parking.

The 3-star Hilton Garden Inn San Diego Mission Valley Stadium, rated 8.0, also welcomes dogs. This hotel is located 1.6 km from Stadium Golf Centre & Batting Cages. Guests often highlight the nice and clean rooms and the friendly and helpful staff.

Another excellent option is the 4-star Sheraton Mission Valley San Diego Hotel, which has an 8.6 rating and permits dogs. It is well-situated near Mission Valley Mall, only 0.6 km away, and Fashion Valley Mall, which is 1.6 km away. This hotel provides food and water bowls for pets and guests consistently praise the friendly and helpful staff, as well as the clean and spacious rooms.
What are the best budget hotels in Serra Mesa?
For excellent budget-friendly hotels in Serra Mesa, consider the TownePlace Suites by Marriott San Diego Central and the Homewood Suites by Hilton San Diego Mission Valley/Zoo.

The 3-star TownePlace Suites by Marriott San Diego Central, with a 9.0 rating, offers comfortable and clean rooms, and guests frequently praise the excellent and friendly staff. It provides complimentary WiFi, a free continental breakfast, and free cribs upon request. Its location is highly recommended, and parking is convenient. It's also just 0.4 km from Centrum Dog Park.

Another great option is the 3-star Homewood Suites by Hilton San Diego Mission Valley/Zoo, rated 8.4. This hotel provides complimentary toiletries, free breakfast, and free WiFi. Guests often mention the comfortable and clean rooms, delicious breakfast, and convenient location.
What are the most romantic hotels in Serra Mesa for couples?
For couples seeking a romantic getaway in Serra Mesa, the Sheraton Mission Valley San Diego Hotel and the Town and Country San Diego are excellent options.

The 4-star Sheraton Mission Valley San Diego Hotel, with a rating of 8.6, offers a range of appealing features for couples. Guests can enjoy 24-hour room service, plush bathrobes, and premium bedding for a luxurious stay. The hotel is conveniently located near a shopping district and provides a hot tub and balconies for relaxation.

Another fantastic choice is the 4-star Town and Country San Diego, also rated 8.6. This hotel boasts a wonderful location, just 0.6 km from Fashion Valley Mall. It features a heated outdoor pool, a waterslide, and private cabanas, superb for a relaxing day together. Guests frequently highlight the comfortable rooms and excellent amenities, including a hot tub and balconies.
What are the best hotels in Serra Mesa near Fashion Valley Mall?
For hotels in Serra Mesa near Fashion Valley Mall, the WorldMark San Diego - Mission Valley is an excellent choice.

The 3.5-star WorldMark San Diego - Mission Valley, with an 8.4 rating, is conveniently located just 1.0 km from Fashion Valley Mall. This hotel is family-friendly and offers spacious rooms with balconies, a kitchen, and a sofa bed, making it ideal for longer stays. Guests appreciate the outdoor pool and the free laundry facilities.
When is the best time to go to Serra Mesa?
The best time to go to Serra Mesa is during spring (March to May) or autumn (September to November) when the weather is most pleasant for outdoor activities.

During these seasons, you'll experience comfortable temperatures, typically ranging from 18°C to 24°C, with less humidity than the summer months. This makes it ideal for exploring the local parks, visiting nearby attractions, or enjoying a meal on an outdoor terrace without the intense heat or larger crowds of summer.

If you're planning a family holiday, late spring or early autumn is particularly good. The weather is superb for visiting the nearby world-renowned zoo or exploring the numerous beaches just a short drive away. You'll find the conditions just right for a relaxed and enjoyable trip.

For couples looking for a romantic getaway, these shoulder seasons offer a more tranquil experience.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in Serra Mesa.
How can I save on a Serra Mesa hotel booking with Expedia?
Members always get our best prices. Find our best Serra Mesa hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a Serra Mesa hotel?
Hotel prices in Serra Mesa often vary, but you can find a great deal on Expedia. Different factors affect nightly hotel rates, such as the time of year or the days of the week you want to book. To find the best deals for your stay, be flexible with your dates, and sort search results by "Price: low to high" for our cheapest rates.

Explore a world of travel with Expedia