Serra Mesa Holidays from £912

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Your Serra Mesa Holiday

Make planning your travels easier by snapping up a holiday package to Serra Mesa. Let us handle all the details, so you can concentrate on savouring everything this neighbourhood has to offer. Begin your trip to Serra Mesa by visiting nearby attractions such as Snapdragon Stadium, Fashion Valley Mall and Mission Valley Mall. Stop daydreaming and start doing. When you're ready to book your dream holiday to Serra Mesa, Expedia will help you get there.

Price found within the past 48 hours. Click for updated prices.
Hotel La Jolla, Curio Collection by Hilton

Hotel La Jolla, Curio Collection by Hilton

4 out of 5
La Jolla Shores
per person
5 Oct - 10 Oct
found 1 day ago
Return flight included
London (LON) to San Diego (SAN)
8.4/10 Very Good! (392 reviews)
We stayed at this hotel and it was amazing, we got king suite, very clean and comfortable, area is amazing and super safe, 10/10, Btw restaurant is little expensive but overall good hotel, I recommend it to all.

Reviewed on 12 Aug 2025

The Sofia Hotel

The Sofia Hotel

3.5 out of 5
Downtown San Diego
Save 100% on your flight
per person
15 Oct - 19 Oct
found 18 hours ago
Return direct flight included
London (LHR) to San Diego (SAN)
8.4/10 Very Good! (1,510 reviews)
Very nice clean room. Comfortable bed. Great lighting in this room.

Reviewed on 12 Aug 2025

Sentral Gaslamp Quarter

Sentral Gaslamp Quarter

3 out of 5
Downtown San Diego
per person
15 Oct - 19 Oct
found 18 hours ago
Return direct flight included
London (LHR) to San Diego (SAN)
9.2/10 Wonderful! (243 reviews)
Room was not as big as In the photo. Booked what I thought was 400sqft but it definitely l, Maybe more like 250sqft. Otherwise rooom was clean, modern, bed very comfortable, quiet. Kitchenette was very nice. Staff was great, the service was amazing. No housekeeping though, no pool, and no restaurant on the premises. Close to many restaurant.

Reviewed on 11 Aug 2025

InterContinental San Diego by IHG

InterContinental San Diego by IHG

4 out of 5
Downtown San Diego
per person
15 Oct - 19 Oct
found 18 hours ago
Return direct flight included
London (LHR) to San Diego (SAN)
9.2/10 Wonderful! (1,012 reviews)
No Fridge, easily get over charged for the mini bar. Never use the mini bar, but got charged after checked out without any notification.

Reviewed on 12 Aug 2025

La Jolla Shores Hotel

La Jolla Shores Hotel

3 out of 5
La Jolla Shores
per person
5 Oct - 10 Oct
found 1 day ago
Return flight included
London (LON) to San Diego (SAN)
8.8/10 Excellent! (1,354 reviews)
Location was perfect. Would think it would be a little more updated and more "bougie" for it being La Jolla and for the price but it was clean, quiet and nice

Reviewed on 11 Aug 2025

Where to stay in Serra Mesa

Find the best Serra Mesa areas and neighborhoods for the activities you enjoy most. Learn more about Serra Mesa
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Downtown San Diego

2 out of top 10 points of interest in this area
4.5/5(138 area reviews)

Known for its fantastic nightlife, fascinating museums and beautiful waterfront views, there's plenty to explore in Downtown San Diego. Top attractions like Petco Park and Port of San Diego are major draws. Catch the metro at Civic Center Station or Civic Center Station to see more of the city.

Find hotels in Downtown San Diego

Top hotels in Serra Mesa

The Dana on Mission Bay

The Dana on Mission Bay

3.5 out of 5
1710 W Mission Bay Dr, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is £157 per night from 17 Aug to 18 Aug
£157
17 Aug - 18 Aug
includes taxes & fees
8.8/10 Excellent! (3,617 reviews)
"Good"

Reviewed on 9 Aug 2025

The Dana on Mission Bay
Manchester Grand Hyatt San Diego

Manchester Grand Hyatt San Diego

4 out of 5
1 Market Pl, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is £187 per night from 31 Aug to 1 Sept
£187
31 Aug - 1 Sept
includes taxes & fees
8.8/10 Excellent! (2,801 reviews)
"We had a great stay here."

Reviewed on 10 Aug 2025

Manchester Grand Hyatt San Diego
Wyndham San Diego Bayside

Wyndham San Diego Bayside

4 out of 5
1355 N Harbor Drive, San Diego, CA
Fully refundableReserve now, pay when you stay
The price is £150 per night from 3 Sept to 4 Sept
£150
3 Sept - 4 Sept
includes taxes & fees
8.2/10 Very Good! (5,862 reviews)
"Great location. Staff was very helpful"

Reviewed on 12 Aug 2025

Wyndham San Diego Bayside
See all 8,834 properties in Serra Mesa
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
All Inclusive Holidays
All Inclusive Holidays
Beach Holidays
Beach Holidays
Family Friendly Holidays
Family Friendly Holidays

Frequently asked questions

How much does a Serra Mesa travel package cost?
Explore the best of Serra Mesa from as low as £912. Choose from a great selection of flights, hotels and rental cars to suit every budget. You can pick up even better deals when you add a few sightseeing tours to your travel package.
If I'm not able to travel, can I cancel my Serra Mesa travel package?
Whether it's your hotel or flight, yes, you can cancel or amend it. Booked your Serra Mesa travel package in the last 24 hours? You may be able to make changes for free. For bookings made more than 24 hours ago, you may incur a charge from your airline, hotel or car rental company. For more information, check out our Customer Service Portal. We're here to help you every step of the way.
How do I get a cheap travel package to Serra Mesa?
Combining your hotel and flight with Expedia won't just save you time — it'll save you cash too. A Serra Mesa travel package makes it a breeze to put together your ideal trip. With more than 550 airlines all over the world to choose from, finding convenient flights that fit your busy schedule won't be difficult. Not only that, we've got over 1,000,000 properties globally to select from. Talk about choice! No matter who you are, Expedia can show you the world.
Does Expedia offer Book Now, Pay Later Serra Mesa holidays?
Expedia has teamed up with online lender Klarna to make your next break easier on your bank balance. Paying by instalment means you can spread the costs of your dream holiday, leaving you with more money to spend while you're away. Klarna has several payment plans to choose from, so you're sure to find something that fits your budget. Browse these flexible payment options:

  • Pay monthly holidays: If paying bite-sized amounts each month works for you, Klarna can help. Paying in convenient monthly instalments will make that dream getaway possible.
  • Pay in instalments holidays: Like the idea of paying for your holiday in multiple transactions? Then check out this Book Now, Pay Later option from Klarna.
  • Low deposit holidays: If paying a small percentage of your trip (rather than the total upfront) makes it easier to hit that "book now" button, choose a low deposit holiday payment plan with Klarna.

Where should I stay in Serra Mesa?
A journey to Serra Mesa has to include SeaWorld and San Diego Zoo. Stay at a hotel nearby for quick access to these impressive tourist attractions.
What are the top hotels in Serra Mesa?
Book a room at Manchester Grand Hyatt San Diego. It's one of the neighbourhood's most in-demand hotels. Another reputable option in Serra Mesa is Paradise Point Resort And Spa.
How far in advance should I book my Serra Mesa holiday?
It's always wise to book early. Air carriers usually advertise flights nearly 12 months ahead of departure, and this is an excellent opportunity to score some of the lowest prices. Just been told you need to take some holiday time in a few weeks? No need to worry. Expedia are never short of fantastic deals to send you on the getaway of your dreams, at an affordable price.
What does an Expedia Serra Mesa travel package include?
Select from any combination of rental cars, flights and hotels. Once you've made your booking, you can also add on experiences and tours. Want to pick your fare class? That's also possible. The choice is yours when it comes to crafting your perfect Serra Mesa escape.
What should I know before booking a Serra Mesa travel package?
When you book your flights, hotels and car rentals together, you'll pick up amazing discounts. Whether you're planning a wilderness getaway in a cabin or want to stay in a fancy hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Serra Mesa Expedia travel package?
Yes — and it's easy too. Expedia has access to more than 550 partner airlines worldwide. Our packages give you the freedom to pick from available flight, hotel or activity options that suit you.

Popular places to visit

San Diego Zoo featuring zoo animals, landscape views and a pond

San Diego Zoo

See nature up-close and personal at one of the country’s largest and most educational zoos.

San Diego Zoo
San Diego Convention Center

San Diego Convention Center

During your trip, find out what's happening in San Diego Convention Center, a top convention centre in San Diego. Experience the area's entertainment choices and acclaimed art galleries.

San Diego Convention Center
Mission Bay featuring a beach

Mission Bay

Mingle with eccentric locals at bohemian beaches, soak up the sun on a Jet Ski and fish from marshy islands at San Diego’s premier water park.

Mission Bay

Things to do

LEGOLAND® California Resort

LEGOLAND® California Resort

£56
per adult
82% of travellers recommend
LEGOLAND® California Resort
San Diego City Lights Night Tour

San Diego City Lights Night Tour

£34
per adult
94% of travellers recommend
San Diego City Lights Night Tour
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway

£92
per adult
86% of travellers recommend
San Diego Explorer Pass: Save up to 50 Percent - Includes USS Midway
See all activities in San Diego

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.