Title: TOP Boutique Hotels in Ortygia for 2025 | Expedia.co.uk [Ortygia Travel Guide](https://expedia.co.uk/Ortygia.dx6182482)[Hotels in Ortygia](https://expedia.co.uk/Ortygia-Hotels.d6182482.Travel-Guide-Hotels)[Holiday Rentals in Ortygia](https://expedia.co.uk/Ortygia-Holiday-Rentals.d6182482.Travel-Guide-HolidayRentals)[Flights to Ortygia](https://expedia.co.uk/Cheap-Flights-To-Ortygia.d6182482.Travel-Guide-Flights)[Things to do in Ortygia](https://expedia.co.uk/Things-To-Do-In-Ortygia.d6182482.Travel-Guide-Activities)[Ortygia Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Ortygia.d6182482.Car-Hire-Guide)[Ortygia Holidays](https://expedia.co.uk/Ortygia.d6182482.Holidays-City-Breaks) ![Ortygia featuring street scenes and markets as well as a small group of people](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/87000/87652-Ortygia.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Boutique Hotels in Ortygia ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Ortygia Boutique Hotels Tonight [11 Oct - 12 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6182482&startDate=2025-10-11&endDate=2025-10-12&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [12 Oct - 13 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6182482&startDate=2025-10-12&endDate=2025-10-13&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6182482&startDate=2025-10-17&endDate=2025-10-19&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6182482&startDate=2025-10-24&endDate=2025-10-26&adults=2&propertyStyle=BOUTIQUE&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Ortygia Boutique Hotels ![Classic Double Room, Partial Sea View | View from room](https://images.trvl-media.com/lodging/8000000/7800000/7797300/7797247/f02c4712.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Double Room, Sea View | 1 bedroom, premium bedding, down duvets, memory-foam beds](https://images.trvl-media.com/lodging/8000000/7800000/7797300/7797247/4e88f169.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily continental breakfast ](https://images.trvl-media.com/lodging/8000000/7800000/7797300/7797247/4e4f954f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Panoramic Double Room, Sea View | View from room](https://images.trvl-media.com/lodging/8000000/7800000/7797300/7797247/f43052d5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charme Hotel Henry's House Ortigia 9.6/10 Exceptional (316) "Wonderful place to stay!" £226 includes taxes & fees 4 Nov - 5 Nov [](https://www.expedia.co.uk/Syracuse-Hotels-Charme-Hotel-Henrys-House.h7797247.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-10-25&endDate=2025-10-26®ionId=6182482&adults=2&specialized_stays_group_explore=boutique_property&sort=RECOMMENDED&openPlayBack=true) ## Top Ortygia Hotel Reviews ![L'Approdo delle Sirene](//images.trvl-media.com/lodging/3000000/2530000/2527300/2527263/fe44f2b7_y.jpg) ### L'Approdo delle Sirene 10/10 Excellent "This hotel has a family atmosphere starting from breakfast on wonderful terrace with a sea port view, very tasty fresh food and personal, that care you very personal. And all together match the historical locations around. Just to recommend for visiting." [](https://expedia.co.uk/Syracuse-Hotels-LApprodo-Delle-Sirene.h2527263.Hotel-Information) ![Charme Hotel Henry's House](//images.trvl-media.com/lodging/8000000/7800000/7797300/7797247/f02c4712_y.jpg) ### Charme Hotel Henry's House 10/10 Excellent "Beautiful property. Perfect location. Outstanding service. Comfortable bed. " [](https://expedia.co.uk/Syracuse-Hotels-Charme-Hotel-Henrys-House.h7797247.Hotel-Information) ![Alla Giudecca](//images.trvl-media.com/lodging/2000000/1760000/1759000/1758948/02859755_y.jpg) ### Alla Giudecca 10/10 Excellent "We loved the history of the building, it was beautiful. Spacious rooms with outside sitting area. Walkable to all areas of interest in Ortigia and cafes and restaurants. Staff were helpful. " [](https://expedia.co.uk/Syracuse-Hotels-Alla-Giudecca.h1758948.Hotel-Information) ![Palazzo Artemide - VRetreats](//images.trvl-media.com/lodging/1000000/980000/974100/974007/5db9500b_y.jpg) ### Palazzo Artemide - VRetreats 10/10 Excellent "This hotel is really a gem. It is close to all attraction, the staff is so welcoming, helpful and friendly. Our room was big and comfortable. The only thing that bothered us is an automatic light that was turning on at night from the mini bar station in the room on your way to the bathroom. The staff was really helpful and deactivated that light when ask. To access the hotel with a car it is tricky because you have to drive in a narrow pedestrian type of street. That being said it is very well explained by the staff and easy after you didn't once. I would recommend that hotel. We liked it so much that we decided to stay one more night. " [](https://expedia.co.uk/Syracuse-Hotels-Palazzo-Artemide-VRetreats.h974007.Hotel-Information) ![Algila' Ortigia Charme Hotel](//images.trvl-media.com/lodging/2000000/1890000/1883500/1883438/d402c8e9_y.jpg) ### Algila' Ortigia Charme Hotel 10/10 Excellent "Wonderful hotel in the best spot in Sicily! Superb service, great location! 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