Title: TOP Adults Only Resorts & Hotels in Mission Valley, CA for 2025 | Expedia.co.uk [Holiday Rentals in San Diego](https://expedia.co.uk/San-Diego-Holiday-Rentals.d3073.Travel-Guide-HolidayRentals)[Flights to San Diego](https://expedia.co.uk/Cheap-Flights-To-San-Diego.d3073.Travel-Guide-Flights)[Things to do in San Diego](https://expedia.co.uk/Things-To-Do-In-San-Diego.d3073.Travel-Guide-Activities)[Mission Valley Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mission-Valley.d800124.Car-Hire-Guide)[Mission Valley Holidays](https://expedia.co.uk/Mission-Valley.d800124.Holidays-City-Breaks) ![](https://mediaim.expedia.com/destination/1/c9e921ee48ed278ba029d508e2d24762.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Search Adults Only Resorts & Hotels in Mission Valley ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Mission Valley Adults Only Resorts & Hotels Tonight [25 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=800124&startDate=2025-10-25&endDate=2025-10-26&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) Tomorrow [26 Oct - 27 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=800124&startDate=2025-10-26&endDate=2025-10-27&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) Next weekend [31 Oct - 2 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=800124&startDate=2025-10-31&endDate=2025-11-02&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) In two weeks [7 Nov - 9 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=800124&startDate=2025-11-07&endDate=2025-11-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=adults_only) ## Top Mission Valley Adults Only Resorts & Hotels ![3 outdoor pools, pool cabanas (surcharge), pool umbrellas](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/1f4c359a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, hypo-allergenic bedding, down duvets, pillow-top beds](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/8995625e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/91cdc1c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![7 restaurants, breakfast served](https://images.trvl-media.com/lodging/34000000/33670000/33661500/33661441/7910f1d4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sycuan Casino Resort El Cajon 9.2/10 Wonderful (1587) "Great resort!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Vicky £83 includes taxes & fees 19 Nov - 20 Nov [](https://www.expedia.co.uk/El-Cajon-Hotels-Sycuan-Casino-Resort.h33661441.Hotel-Information) ![Memory-foam beds, blackout curtains, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/55000000/54920000/54911400/54911318/dc9bc184.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/55000000/54920000/54911400/54911318/2180fd33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/55000000/54920000/54911400/54911318/04f95010.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Books](https://images.trvl-media.com/lodging/55000000/54920000/54911400/54911318/99376419.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Stay Classy Hostel Downtown San Diego 9.4/10 Exceptional (744) "Good place to stay " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) sai [](https://www.expedia.co.uk/San-Diego-Hotels-Stay-Classy.h54911318.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-11-08&endDate=2025-11-09®ionId=800124&adults=2&travelerType=adults_only&sort=RECOMMENDED&openPlayBack=true) ## Top Mission Valley Hotel Reviews ![Hotel del Coronado, Curio Collection by Hilton](//images.trvl-media.com/lodging/1000000/10000/7500/7496/20fe4d95_y.jpg) ### Hotel del Coronado, Curio Collection by Hilton 10/10 Excellent "Perfect room overlooking beach. Veranda dining experience was top notch, outstanding service and excellent food " [](https://expedia.co.uk/Coronado-Hotels-Hotel-Del-Coronado.h7496.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - More ways to book - [Sports Hotels in Anaheim](https://www.expedia.co.uk/Anaheim-Hotels-Adventure-Sport-Hotel.0-0-d5921-tAdventureSportHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Anaheim](https://www.expedia.co.uk/Anaheim-Hotels-Business-Hotel.0-0-d5921-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Anaheim](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-Bar.0-0-d5921-thotelwithabar.Travel-Guide-Filter-Hotels) - [Hotels with a View in Anaheim](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-View.0-0-d5921-thotelwithaview.Travel-Guide-Filter-Hotels) - [Hotels with Air Conditioning in Anaheim](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-Air-Conditioning.0-0-d5921-thotelwithairconditioning.Travel-Guide-Filter-Hotels) - 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