Medical Center District Holidays from £385

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Your Medical Centre District Holiday

Experience everything this neighbourhood has to offer with a customized Medical Centre District holiday package. However you imagine spending your time here, you'll find endless opportunities for fun, relaxation and adventure. Eager to get out and see the sights during your trip to Medical Centre District? Be sure to stop by nearby attractions like San Antonio Aquarium, University of Texas Health and Science Centre at San Antonio and Huebner Oaks. Expedia will help turn your ideal Medical Centre District holiday into reality, no matter your travel plans or budget.

Price found within the past 48 hours. Click for updated prices.
Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG

Holiday Inn Express & Suites San Antonio Medical-Six Flags by IHG

2.5 out of 5
Northwest Side
Price was £473, price is now £385 per person
£385
per person
31 Jul - 4 Aug
found 15 hours ago
Return flight included
Detroit (DTT) to San Antonio (SAT)
7.8/10 Good! (1,111 reviews)
Shower curtain was missing. Remote control for tv nonfunctional. Sound insulation is not ideal, proximity to the highway was noticeable

Reviewed on 10 May 2026

Hilton Palacio Del Rio

Hilton Palacio Del Rio

4 out of 5
Downtown San Antonio
Price was £817, price is now £640 per person
£640
per person
31 Jul - 4 Aug
found 15 hours ago
Return flight included
Detroit (DTT) to San Antonio (SAT)
9/10 Wonderful! (1,171 reviews)
Recommend adding breakfast to your stay. You can eat the buffet or order off the menu. From the moment we arrive to the moment we left the staff friendly helpful and professional. We stayed in room 1002 beautiful scenery of the Riverwalk. We take binoculars so that we could people watchoff the balcony. I've seen a lot of reviews stating that there was a terrible odor from sewer gas but we did not experience that at all. This was a wonderful hotel with highly highly recommend staying here

Reviewed on 12 May 2026

Plaza San Antonio Hotel & Spa, Autograph Collection

Plaza San Antonio Hotel & Spa, Autograph Collection

4 out of 5
Downtown San Antonio
Price was £675, price is now £534 per person
£534
per person
31 Jul - 4 Aug
found 15 hours ago
Return flight included
Detroit (DTT) to San Antonio (SAT)
9.4/10 Exceptional! (792 reviews)
How clean and beautiful it was

Reviewed on 10 May 2026

InterContinental San Antonio Riverwalk by IHG

InterContinental San Antonio Riverwalk by IHG

4.5 out of 5
Downtown San Antonio
Price was £641, price is now £508 per person
£508
per person
31 Jul - 4 Aug
found 15 hours ago
Return flight included
Detroit (DTT) to San Antonio (SAT)
9.2/10 Wonderful! (678 reviews)
Everything is as I envision it to be.

Reviewed on 6 May 2026

Hotel Contessa

Hotel Contessa

4 out of 5
Downtown San Antonio
Price was £604, price is now £483 per person
£483
per person
31 Jul - 4 Aug
found 15 hours ago
Return flight included
Detroit (DTT) to San Antonio (SAT)
9/10 Wonderful! (3,548 reviews)
Everything about this hotel is amazing !!!

Reviewed on 10 May 2026

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most. Learn more about Medical Center District
Downtown San Antonio

Downtown San Antonio

4 out of top 10 points of interest in this area
4.5/5(42 area reviews)

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

Find hotels in Downtown San Antonio

Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is £77 per night from 13 May to 14 May
£77
13 May - 14 May
includes taxes & fees
8.4/10 Very Good! (3,350 reviews)
Great stay in a great location

Reviewed on 11 May 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is £88 per night from 30 May to 31 May
£88
30 May - 31 May
includes taxes & fees
8.6/10 Excellent! (1,063 reviews)
The hotel’s location is great. The reception staff was welcoming and friendly, and the rooms are always clean.

Reviewed on 11 May 2026

San Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
Fully refundableReserve now, pay when you stay
The price is £85 per night from 1 Jun to 2 Jun
£85
1 Jun - 2 Jun
includes taxes & fees
8.8/10 Excellent! (1,000 reviews)
When I checked for a week and payed CASH IN TOWN FOR A MILITARY EVENT AT LACKLAND AFB DRIVE 25 hours, NO ONE INFORMED ME IF I HAD TO LEAVE EARLY I NEED TO GIVE A NOTICE OR THE HOTEL WOULD RETAIN A FEE OF 129.00. It just not a way to handle playing customers of over 25 years!

Reviewed on 8 May 2026

Courtyard by Marriott Medical Center San Antonio
See all 4,897 properties in Medical Center District
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Frequently asked questions

How much does a Medical Centre District travel package cost?
Go from looking to booking with our Medical Centre District travel packages, which start from only £385. Choose the hotels and flights that suit your travel style. Then, add on a few sightseeing tours to round off your unique adventure.
If I'm not able to travel, can I cancel my Medical Centre District travel package?
Yes, you can. We totally understand that things don't always go to plan, so we're happy to help if you need to make changes to your Medical Centre District travel package. It may be possible to change or cancel your itinerary at no cost if you've booked within 24 hours. Your airline, hotel or car rental company may impose a fee if you booked more than 24 hours ago. Head to our Customer Service Portal for further information. Also, check your itinerary for the nitty-gritty on change fees.
How do I get a cheap travel package to Medical Centre District?
Our Medical Centre District travel packages promise plenty of savings for the savvy globetrotter. For the best deals, simply combine your flights, hotels and tours into a handy package. But impressive bargains are just the beginning of your next memorable adventure. Book with Expedia and you'll have more than 550 air carriers and 1,000,000 hotels all over the world to choose from. Whatever your style, there's a travel package with your name on it.
Does Expedia offer Book Now, Pay Later Medical Centre District holidays?
We do. Expedia has teamed up with online lender Klarna to help you conveniently pay for your holiday in manageable instalments. Simply pick the payment plan that works for you during checkout and take the stress out of budgeting for your next trip. Be sure to bundle your flights, accommodation and car hire with Expedia to get the biggest bang for your holiday buck. Browse our flexible payment options below:

  • Pay monthly holidays: Klarna offers manageable monthly payment plans that fit all budgets, so you can jet away on that well-earned holiday sooner.
  • Pay in instalments holidays: If you want to pay off your getaway across multiple transactions, holidays paid in instalments might be the best option for your Book Now, Pay Later holiday through Klarna.
  • Low deposit holidays: When you want to grab an amazing deal but your budget doesn't quite go that far, Klarna's low deposit holiday plan will help you get what you want.

Where should I stay in Medical Centre District?
A trip to Medical Centre District isn't over until you've seen River Walk and Alamo. Book a room nearby and easily access these impressive sights.
What are the top hotels in Medical Centre District?
Hyatt Regency San Antonio Riverwalk and La Cantera Resort And Spa are a couple of the most sought-after properties in Medical Centre District. Why not have a look at the amenities and facilities at each and then make a decision?
How far in advance should I book my Medical Centre District holiday?
To score discount prices, book early. Airlines generally advertise flights, along with some of the lowest fares, nearly 12 months ahead of time. Hotels, car rental and experiences should also be booked early so you can have the pick of the bunch. If you were hoping for a last-minute getaway to Medical Centre District, there are always plenty of great deals to be had on Expedia. Check them out now!
What does an Expedia Medical Centre District travel package include?
From hotels and airfares to car rentals, Expedia can help you shape a Medical Centre District package that's ideal for you. Heading off for a while? Consider a rental car, hotel and flight bundle. If you're taking a short break, an airfare and hotel deal could be more your style. Activities can also be added once you've made your booking. Our packages make it simple to save and plan.
What should I know before booking a Medical Centre District travel package?
When you book your flights, hotels and car rentals together, you'll land great discounts. Whether you're planning an island getaway in a villa or want to stay in a convenient hotel in the city, Expedia will help make it happen.
Can I choose my airline with a Medical Centre District Expedia travel package?
Yes — and it's easy too. Expedia has access to more than 550 partner airlines around the world. Our travel packages give you the flexibility to pick from available flights, hotels and activities that suit you.

Things to do

San Antonio Zoo Any Day Ticket including ZooLights

San Antonio Zoo Any Day Ticket

£22
per adult
96% of travellers recommend
San Antonio Zoo Any Day Ticket
San Antonio: Botanical Garden Admission Ticket

San Antonio: Botanical Garden Admission Ticket

£13
per adult
San Antonio: Botanical Garden Admission Ticket
San Antonio: Fredericksburg Wineries Day Trip with Tastings

San Antonio: Fredericksburg Wineries Day Trip with Tastings

£132
per adult
100% of travellers recommend
San Antonio: Fredericksburg Wineries Day Trip with Tastings
See all activities in San Antonio

* Savings based on package bookings compared to the price of the same components booked separately. Savings not available on all packages. Flight-inclusive packages are ATOL protected.