Title: Cheap Car Hire in Medical Center District, USA - Expedia.co.uk [Medical Center District Travel Guide](https://expedia.co.uk/San-Antonio-Medical-Center-District.dx553248635978913844)[Hotels in Medical Center District](https://expedia.co.uk/Medical-Center-District-San-Antonio-Hotels.0-n553248635978913844-0.Travel-Guide-Filter-Hotels)[Flights to San Antonio](https://expedia.co.uk/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.co.uk/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Holidays](https://expedia.co.uk/Medical-Center-District.d553248635978913844.Holidays-City-Breaks) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=300&q=medium) # Car Rentals in Medical Center District, USA ## Search and Compare from Car Companies in Medical Center District ## Featured car rental suppliers Compare from agencies ![car supplier logos](https://forever.travel-assets.com/flex/flexmanager/images/2022/05/16/BEXUK-car-suppliers-logo-desktop.jpg) - ![protection illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__protection.svg) ### Change your mind Penalty-free cancellation on many/select car hire - ![trophy illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__trophy.svg) ### Treat yourself One Key members save 10% or more on over 1 million car hire [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![package illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__package.svg) ### Shop smart Compare car suppliers and package your flight, hotel, and car to save ## Top Rental Car Deals in Medical Center District \* Price found within the past 6 days. Click for updated prices. ### Economy Chevrolet Spark or similar - 4 people San Antonio, Texas, USA ![Chevrolet Spark](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_EC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Medical%20Center%20District,%20San%20Antonio,%20Texas,%20United%20States%20of%20America&dpln=553248635978913844&date1=17/02/2026&date2=19/02/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22economy%22]) ### Compact Ford Focus or similar - 4 people San Antonio, Texas, USA ![Ford Focus](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_CC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Medical%20Center%20District,%20San%20Antonio,%20Texas,%20United%20States%20of%20America&dpln=553248635978913844&date1=17/02/2026&date2=19/02/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22compact%22]) ### Midsize Toyota Corolla or similar - 5 people San Antonio, Texas, USA ![Toyota Corolla](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_IC.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Medical%20Center%20District,%20San%20Antonio,%20Texas,%20United%20States%20of%20America&dpln=553248635978913844&date1=17/02/2026&date2=19/02/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22midsize%22]) ### SUV Jeep Compass or similar - 5 people San Antonio, Texas, USA ![Jeep Compass](//images.trvl-media.com/media/content/shared/images/car/Common_90X50/US_SF.png) [](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Medical%20Center%20District,%20San%20Antonio,%20Texas,%20United%20States%20of%20America&dpln=553248635978913844&date1=17/02/2026&date2=19/02/2026&crfrr=defaultFlex&SearchType=Place&selCC=[%22suv%22]) ### Don't see what you're looking for? See all car hire in Medical Center District [View all cars](https://expedia.co.uk/carsearch?paandi=true&fdrp=1&styp=2&dagv=1&subm=1&locn=Medical%20Center%20District,%20San%20Antonio,%20Texas,%20United%20States%20of%20America&dpln=553248635978913844&date1=17/02/2026&date2=19/02/2026&crfrr=defaultFlex&SearchType=Place) ## Frequently asked questions ### How much is a rental car per day in Medical Centre District? ### What happens if I need to cancel my Medical Centre District car reservation? ### What types of cars can I rent in Medical Centre District? ### Where can I go on a road trip from Medical Centre District? > - You'll find University of Texas at Austin and lots more amazing attractions in Austin. From Medical Centre District, it's about 75 miles away. > - Next stop? It has to be San Marcos, which is around 45 miles away. San Marcos Premium Outlets is one local hot spot you shouldn't miss. > - Make your way to Port Aransas Beach to feel grounded in nature. Pack a picnic to enjoy or just sit and unwind. From Medical Centre District, it's around 150 miles away. ### How do I find the best car hire deals in Medical Centre District with Expedia? ### How old do you have to be to rent a car in Medical Centre District? ### What do you need to hire a car in Medical Centre District? ### What is the cheapest car hire in Medical Centre District? ### Can I hire a car for a month or longer in Medical Centre District? ### Where can I find a Medical Centre District hire car if I am younger than 25? ### Can I drive in Medical Centre District with my current driver's license? > - Age restrictions: You must be at least 25 in many states to hire a car, although in some places, the minimum age is 21 years. We recommend checking local regulations, as well as with the company you're hiring from before you book to understand all the terms and conditions. > - Driving limitations: Don't forget to read the fine print before you drive off the lot so you can avoid unnecessary fees. When hiring a car in the United States, you usually can't cross country borders into Canada or Mexico, drive onto ferries or traverse off-road areas with your hire vehicle. Please read all the rules and regulations before booking! ### Why should I rent a Medical Centre District car with Expedia? ## Car Hire Information | Popular car types: | [SUV](https://www.expedia.co.uk/lp/b/car-rental/suv?rfrr=car.table.SUV), [Full Size](https://www.expedia.co.uk/lp/b/car-rental/fullsize?rfrr=car.table.FullSize), [Economy](https://www.expedia.co.uk/lp/b/car-rental/economy?rfrr=car.table.Economy) | | -------------------------------- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | | Car suppliers available: | | | Our best deal of the day: | | | Our second best deal of the day: | | | Our third best deal of the day: | | | From the airport to your hotel: | [Airport Transportation](https://www.expedia.co.uk/ground-transfers?rfrr=car.table.AirportTransportation) |