Title: The Best Hotels in Medical Center District, San Antonio - 2026 Updated Prices | Expedia.co.uk

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## Check prices for these dates

Tonight

[8 Mar - 9 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-03-08&endDate=2026-03-09&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[9 Mar - 10 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-03-09&endDate=2026-03-10&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-03-13&endDate=2026-03-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[20 Mar - 22 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-03-20&endDate=2026-03-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Recommended

Price (low to high)

Distance

Property class

## Our top choices for Medical Center District hotels

![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/053f15e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/004315aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/e0b99e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### San Antonio Marriott Northwest Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information)

Medical Center District

8.6/10

Excellent

(1,008 reviews)

"Courteous staff, clean room, safe location "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Danica

£90

includes taxes & fees

27 Mar - 28 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/1c416f1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Pool](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/0a8f490a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/fdfc11cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/52bae0c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott San Antonio Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-Fairfield-Inn-Suites-By-Marriott-San-Antonio-Medical-Center.h68847371.Hotel-Information)

Medical Center District

9.0/10

Wonderful

(1,011 reviews)

"Very comfortable, everything was clean, great staff and it’s near all the important hospitals. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jesus

£77

includes taxes & fees

15 Mar - 16 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Fairfield-Inn-Suites-By-Marriott-San-Antonio-Medical-Center.h68847371.Hotel-Information)

![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/3b4d6808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/ded9f09f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/w9000h6173x0y15-23603cae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/667d95b8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

[](https://www.expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information)

Medical Center District

8.4/10

Very good

(3,224 reviews)

"Great stay with nice breakfast and clean rooms "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Leah

£78

includes taxes & fees

9 Mar - 10 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information)

![Property entrance](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/41551429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds | Television](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/06f7cfb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/e974d0cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/a061f3de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### OYO Inn & Suites Medical Center San Antonio

[](https://www.expedia.co.uk/San-Antonio-Hotels-OYO-Inn-Suites-Medical-Center-San-Antonio.h692534.Hotel-Information)

Medical Center District

7.2/10

Good

(229 reviews)

"Staff was courteous and professional and the room is nice."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Thomas

£61

includes taxes & fees

9 Mar - 10 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-OYO-Inn-Suites-Medical-Center-San-Antonio.h692534.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/86df295b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/8e301658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/0e1dc134.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/17f1a418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites San Antonio Northwest Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Northwest-Medical-Center.h59226.Hotel-Information)

Medical Center District

9.2/10

Wonderful

(1,281 reviews)

"Excellent awesome place we love it Room was super clean staff super nice "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Maria

£79

includes taxes & fees

23 Mar - 24 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Northwest-Medical-Center.h59226.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/1e7b2c4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Flat-screen TV, pay films](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/f47c7eb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/2045bf85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/1cc9e707.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Courtyard by Marriott Medical Center San Antonio

[](https://www.expedia.co.uk/San-Antonio-Hotels-Courtyard-By-Marriott-Medical-Center-San-Antonio.h12556.Hotel-Information)

Medical Center District

8.8/10

Excellent

(1,004 reviews)

"Clean rooms @ friendly staff!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

LaTishe

£78

includes taxes & fees

22 Mar - 23 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Courtyard-By-Marriott-Medical-Center-San-Antonio.h12556.Hotel-Information)

![Breakfast area](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/9628dbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/fea7afce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/4918a4df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/ea511f30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Park Inn by Radisson

[](https://www.expedia.co.uk/San-Antonio-Hotels-Welcome-Inn-San-Antonio-Medical-Center.h28102.Hotel-Information)

Medical Center District

7.2/10

Good

(1,006 reviews)

"Room was spotless and bed was great."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pamela

£55

includes taxes & fees

22 Mar - 23 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Welcome-Inn-San-Antonio-Medical-Center.h28102.Hotel-Information)

![Desk, laptop workspace, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/cfce1826.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/15001725.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/cc477a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Full-sized fridge, microwave, coffee/tea maker, cookware/dishes/utensils](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/e2843e2f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Studio 6 San Antonio, Tx - Northwest Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h83405963.Hotel-Information)

Medical Center District

7.4/10

Good

(254 reviews)

"Good stay and safe area"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mario

£41

includes taxes & fees

11 Mar - 12 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h83405963.Hotel-Information)

![Basic Room, 1 King Bed, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/53fea236.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/52d716c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Basic Room, Multiple Beds, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/42431698.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/00bf65b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Flex Studios

[](https://www.expedia.co.uk/San-Antonio-Hotels-Flex-Studios.h75211602.Hotel-Information)

Medical Center District

6.0/10

(511 reviews)

"Was good, but there is no one overnight, security doesn't answer and the opening person was almost an hour late. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Michelle

£35

includes taxes & fees

15 Mar - 16 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Flex-Studios.h75211602.Hotel-Information)

![Front of property](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/1b117ba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/82bbe653.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 King Deluxe Suite | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/3d551d47.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![2 Queen Deluxe Suites | Bathroom | Combined shower/bathtub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/d7b70ede.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Atria Inn & Suites

[](https://www.expedia.co.uk/San-Antonio-Hotels-9727-Fredericksburg-Rd.h96182039.Hotel-Information)

Medical Center District

7.6/10

Good

(284 reviews)

"Room was good standings, staff was friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Luis

[](https://www.expedia.co.uk/San-Antonio-Hotels-9727-Fredericksburg-Rd.h96182039.Hotel-Information)

![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/c7a8846b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/10b53b97.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Vending machine](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/45eebc93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/60308f28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Studio 6 San Antonio, TX - Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h50914.Hotel-Information)

Medical Center District

6.8/10

(836 reviews)

"Staff was great, very clean rooom"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Laura

£43

includes taxes & fees

9 Mar - 10 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h50914.Hotel-Information)

![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/c1974da9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/a69289e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/155e0f25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/a8e3513c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Motel 6 San Antonio, TX - Northwest Medical Center

[](https://www.expedia.co.uk/San-Antonio-Hotels-Motel-6-San-Antonio.h50555.Hotel-Information)

Medical Center District

6.0/10

(1,000 reviews)

"Room was clean, beds comfortable, staff extremely friendly and helpful "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kathleen

£42

includes taxes & fees

9 Mar - 10 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Motel-6-San-Antonio.h50555.Hotel-Information)

![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/63a40a4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/ca8040db.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/e79204bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/5f7054f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Inn & Suites by Radisson, San Antonio Medical Center, TX

[](https://www.expedia.co.uk/San-Antonio-Hotels-Country-Inn-Suites-By-Radisson.h11744297.Hotel-Information)

Medical Center District

6.8/10

(1,007 reviews)

"Great place , front desk are helpful and friendly. Safe place to stay ."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Justin

£51

includes taxes & fees

29 Mar - 30 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Country-Inn-Suites-By-Radisson.h11744297.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/16200/16129/c4a6b786.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/1000000/20000/16200/16129/78b57ad8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Outdoor pool, open 9:00 AM to 11:00 PM, pool loungers](https://images.trvl-media.com/lodging/1000000/20000/16200/16129/5f6bebbc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/1000000/20000/16200/16129/ce079052.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Garden Inn

[](https://www.expedia.co.uk/San-Antonio-Hotels-Best-Western-Garden-Inn.h16129.Hotel-Information)

Uptown, 13.2 mi from Medical Center District

8.2/10

Very good

(1,005 reviews)

"Clean room, friendly and helpful staff."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Robyn

£56

includes taxes & fees

9 Mar - 10 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Best-Western-Garden-Inn.h16129.Hotel-Information)

![Fireplace](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4657a7fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Check-in/check-out kiosk](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/afa62b6a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4f4dbae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Waterslide](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/f77355b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hyatt Vacation Club at Wild Oak Ranch, San Antonio

[](https://www.expedia.co.uk/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information)

Far West Side, 7 mi from Medical Center District

9.0/10

Wonderful

(1,499 reviews)

"Great Stay"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Melissa

£99

includes taxes & fees

22 Mar - 23 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information)

![Room amenity](https://images.trvl-media.com/lodging/88000000/87820000/87818100/87818058/6c1b3082.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/88000000/87820000/87818100/87818058/34ebc80f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free WiFi](https://images.trvl-media.com/lodging/88000000/87820000/87818100/87818058/e7d0b28b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/88000000/87820000/87818100/87818058/6e566597.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Staybridge Suites San Antonio Lackland AFB Area by IHG

[](https://www.expedia.co.uk/San-Antonio-Hotels-Staybridge-Suites-San-Antonio-Richland-Hills.h87818058.Hotel-Information)

Far West Side, 6 mi from Medical Center District

9.6/10

Exceptional

(423 reviews)

"Breakfast, evening social, kitchenettes, friendly staff, good location to visit downtown and Lackland Airforce base."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kelly

£89

includes taxes & fees

29 Mar - 30 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Staybridge-Suites-San-Antonio-Richland-Hills.h87818058.Hotel-Information)

![Outdoor pool, open 9:00 AM to 10:00 PM, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/f40a8bb2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Poolside views, open daily](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/9b05a270.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/d2818479.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Poolside views, open daily](https://images.trvl-media.com/lodging/1000000/30000/27900/27848/74fd26e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Plaza San Antonio Hotel & Spa, Autograph Collection

[](https://www.expedia.co.uk/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information)

Downtown San Antonio, 8 mi from Medical Center District

9.4/10

Exceptional

(738 reviews)

"The room was great and staff was very helpful and kind. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Corina

£172

includes taxes & fees

5 Apr - 6 Apr

[](https://www.expedia.co.uk/San-Antonio-Hotels-The-Otis-Hotel-San-Antonio.h27848.Hotel-Information)

![Standard Studio, 1 King Bed, Refrigerator & Microwave | Premium bedding, laptop workspace, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/c658d6d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fitness facility](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/dffc90af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Full-sized fridge, microwave, stovetop](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/51ed1ba2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/111000000/110170000/110167700/110167699/9293cc9d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Extended Stay America Premier Suites - San Antonio - Schertz

[](https://www.expedia.co.uk/San-Antonio-Hotels-Extended-Stay-America-Premier-Suites-San-Antonio-Schertz.h110167699.Hotel-Information)

18.2 mi from Medical Center District

9.2/10

Wonderful

(216 reviews)

"Room was excellent and staff were friendly and helpful. Will stay here again"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sharon

£73

includes taxes & fees

22 Mar - 23 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Extended-Stay-America-Premier-Suites-San-Antonio-Schertz.h110167699.Hotel-Information)

![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/4db1357c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/3ded3c64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/9bb2dd09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Bar (on property)](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/15176e54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Canopy by Hilton San Antonio Riverwalk

[](https://www.expedia.co.uk/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information)

Downtown San Antonio, 7.6 mi from Medical Center District

9.4/10

Exceptional

(1,634 reviews)

"Great hospitality and location. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Shannon

£152

includes taxes & fees

5 Apr - 6 Apr

[](https://www.expedia.co.uk/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/17000000/16220000/16219100/16219094/df4bd134.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/17000000/16220000/16219100/16219094/5e9a8e3e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily full breakfast ](https://images.trvl-media.com/lodging/17000000/16220000/16219100/16219094/826c8b04.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![BBQ/picnic Area](https://images.trvl-media.com/lodging/17000000/16220000/16219100/16219094/a325e39f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Downtown North

[](https://www.expedia.co.uk/San-Antonio-Hotels-Best-Western-Plus-Downtown-North.h16219094.Hotel-Information)

8.3 mi from Medical Center District

8.6/10

Excellent

(1,010 reviews)

"Great stay. Everything was pretty much close riverwalk etc. clean rooms and courteous staff. Breakfast was good too. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Miguel Garrido

£77

includes taxes & fees

29 Mar - 30 Mar

[](https://www.expedia.co.uk/San-Antonio-Hotels-Best-Western-Plus-Downtown-North.h16219094.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-22&endDate=2026-03-23&regionId=553248635978913844&adults=2&sort=RECOMMENDED&openPlayBack=true)

## Where to stay in Medical Center District

Find the best Medical Center District areas for the activities you enjoy most. 

- Downtown San Antonio
- Uptown
- Far West Side
- Stone Oak
- Arena District

![Downtown - Riverwalk showing a river or creek, a bridge and boating](https://images.trvl-media.com/place/800120/c427a760-8f08-4152-8ff2-5ee8720d9068.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Downtown San Antonio which includes cafe lifestyle, night scenes and boating](https://images.trvl-media.com/place/800120/4b544474-7c50-4664-b4ab-ad70250a41a0.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Downtown - Riverwalk which includes signage](https://images.trvl-media.com/place/800120/135587e2-2707-47b4-9d5d-cb8857baf764.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Downtown - Riverwalk which includes street scenes, outdoor eating and a city](https://images.trvl-media.com/place/800120/d5fb17cd-5ebd-4eba-ae25-0c264111a700.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![Downtown - Riverwalk featuring boating and a river or creek](https://images.trvl-media.com/place/800120/4342dae3-9acc-4423-bc98-26f47e6b055f.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map&regionId=800120)

![Downtown San Antonio map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7BrmrDhqgxQ%7Bu%40iUe%60%40ia%40y%7EAmMkRgUqO_d%40wPi%5CT%7DPdJmc%40xQElH%60CrZlR%7EIgDjNP%3FuPbh%40Lph%40a%40pQtLzb%40bFvIXdg%40mPxE%60R%7BK%60%7CAaAd%7EAoc%40dA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=RuyIpZHEnQcp_rXJYAlWPqPpku0=)

### Downtown San Antonio

Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums.

[See properties](https://www.expedia.co.uk/Hotel-Search?regionId=800120)

![It's Texas, of course everything is bigger! #guinessworldrecord #visittexas #hdr #fisheye](https://images.trvl-media.com/place/3077/4cdbcd9a-ec5a-47a7-8436-9b378ab6bf93.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Sarah C. 

![Marion Koogler McNay Art Museum which includes art and interior views as well as an individual male](https://images.trvl-media.com/place/502610/f2b1df08-6a69-4feb-8248-be1130a68fb3.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![SanAntonio_NorthStarMall_502628_05](https://images.trvl-media.com/place/502628/fc86b101-dc2f-4e75-a1bf-b214a3fa4dc2.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map&regionId=553248635974902947)

![Uptown map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ydesDviexQgd%40qGeaDglA%7BiAuZssAq%5Cof%40aLcgCoh%40wHeEx%5C_fB%60YwpB%7BMooG%7B%40%7D_DlF%7BZhHuIbgCm%7DAdJvIjUpGzM%7EMhHha%40nFrG%60YePfWmEbYcPlF%3FhHxKdJvg%40%7CZ%7Cx%40%7Cv%40p_BzKhXfLrPlb%40xXzi%40tIn%60%40dn%40rDhRz%40%7C%7DDlFfAfW%7BK%7EpA%3FxOuVjUnEzMqGjU%3FdoAzi%40hHtIpDvXhH%7EMz%40dhB%7CM%7EMz%40ha%40%3Fj_AmF%60Nx%40bhBqDlEs%7BIbA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=j0bUoKNjCSIIV8aMqbcD3ISkFXM=)

### Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing. 

[See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635974902947)

![SanAntonio_SanAntonioSeaWorld_502636_04](https://images.trvl-media.com/place/502636/21ddbcf6-e0f6-4e89-a158-96c7800472ba.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![SeaWorld San Antonio is one of the world's largest marine life parks and spans 416 acres. SeaWorldoffers an exciting and educational blend of extraordinary marine-life shows, rides, and attractions, as well as up-close animal encounters and behind-the-scenes tours.

](https://images.trvl-media.com/place/3077/08b2cbda-5618-42d5-95f6-c67aaf059c26.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Dean Moore

![](https://images.trvl-media.com/place/3077/f575c4b1-bcb1-4812-8208-54a3a54b6ebf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://images.trvl-media.com/place/3077/55bed7d9-3745-4494-865f-1356c1ad509c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![](https://images.trvl-media.com/place/3077/648ee6fc-247e-4471-88bf-89e6ed95d234.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map&regionId=553248635975749416)

![Far West Side map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:afyrDb%7EwyQkpLsbDyqCo%7B%40d%7BAi%7EDbJih%40ukAsa%40mp%40yr%40raBofBxZaj%40xfAeu%40bn%40uRtf%40y%5DpqAwr%40%7ChAg%60B%7CKqLlOyd%40xKhZp%7DAbzArdEheDrUxOfQpDjzDl%40%60XfbAn%5DblAph%40bnD%7EX%7EgBjPviDmpJzf%40gkDbr%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=VMxJSqyr4lT0QcBLFKtAFNJkV0g=)

### Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club. 

[See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749416)

![Famous American landmark - Alamo mission in downtown San Antonio, Texas, USA](https://images.trvl-media.com/place/6343068/f511f264-1622-41ec-949e-c6074dc12bcb.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![SanAntonio_StoneOak_6343068_01](https://images.trvl-media.com/place/6343068/7278ad15-e098-4e46-b18d-52e713033ba5.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

[](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map&regionId=6343068)

![Stone Oak map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:qg_tDfmixQqXq_Mx%60I%7EuBmHzl%40vObfEmiB%60eAcdEnM&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=S1oBhJpmo5OYXFc5vi-iyXqubu4=)

### Stone Oak

Stone Oak is known for its abundant dining options, and you can plan a trip to Shops at Hardy Oak and Alta Vista while you're in town. 

[See properties](https://www.expedia.co.uk/Hotel-Search?regionId=6343068)

![The Alamo, San Antonio, USA © Arena Photo UK](https://images.trvl-media.com/place/553248635976384171/5c700a4e-c87b-4025-8a9d-148e2d7ae617.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![SanAntonio_FreemanColiseum_502631_04](https://images.trvl-media.com/place/502631/69fc7a4e-59cf-4406-a292-faad74e0526a.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

![The San Antonio Spurs](https://images.trvl-media.com/place/3077/65ec6a9c-1221-429d-8b58-b82ce63c93ac.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by George Zimzores

![Street art in San Antonio](https://images.trvl-media.com/place/3077/acd4e1c9-a686-4032-9510-f2238e3391a2.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Sara Crotts

![Street art in San Antonio](https://images.trvl-media.com/place/3077/8ebae03a-8d34-471f-9235-727bb2daca12.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium)

Photo by Sara Crotts

[](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map&regionId=553248635976384171)

![Arena District map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ksmrDtqaxQ%7Bl%40gH_N%7CBoKFxIeQrKeOuIEHci%40cn%40%3F%3FaXcZf%40AyCeGJ%3FgLeFAUi%40um%40ASzhB_CiAeKuAL%7BfBxB_k%40r%40c%40rBui%40HqIq%40qM_Ps%40%7DPeB%7D%7C%40cg%40%7DIuNoNoL%7DHcQPgqA%7CIwDjDyOdLuTtUuXtNi%5D%7CLcRrScSjKaGpMeE%60mAmCkCrRWlrAoCne%40Rvx%40%7CGtGhe%40b%5BxiAttAxHzKdCjGmGjLpG%7EJvG%3FIriB%60%40hZ%60GjOpKpM%60I%7CF%7EIhLwd%40%7EOmHv%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=6hrpI9VtJejTYy1e3i9k2g_nnRA=)

### Arena District

If you're spending some time in Arena District, Frost Bank Center and Freeman Coliseum are top sights worth seeing. 

[See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976384171)

## Top Medical Center District Hotel Reviews

![Drury Plaza Hotel San Antonio Riverwalk](https://images.trvl-media.com/lodging/2000000/1540000/1534300/1534252/40c220b5_y.jpg)

### Drury Plaza Hotel San Antonio Riverwalk

10/10 Excellent

"Clean, great location, awesome staff!"

[](https://expedia.co.uk/San-Antonio-Hotels-Drury-Plaza-Hotel-San-Antonio-Riverwalk.h1534252.Hotel-Information)

![San Antonio Marriott Northwest Medical Center](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de_y.jpg)

### San Antonio Marriott Northwest Medical Center

10/10 Excellent

"Desayuno desastroso "

[](https://expedia.co.uk/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information)

![Spark By Hilton San Antonio Northwest near Six Flags](https://images.trvl-media.com/lodging/1000000/50000/41300/41271/8db3c38d_y.jpg)

### Spark By Hilton San Antonio Northwest near Six Flags

10/10 Excellent

"Clean room, quiet surroundings, nearby restaurants "

[](https://expedia.co.uk/San-Antonio-Hotels-Quality-Inn-San-Antonio-Fiesta-At-Six-Flags.h41271.Hotel-Information)

![Wyndham Garden San Antonio Airport](https://images.trvl-media.com/lodging/1000000/20000/15800/15751/51291603_y.jpg)

### Wyndham Garden San Antonio Airport

4/10 Poor

"As I arrived everything was good check in and then I got to the room and everything looked good but it was the bathroom that really bothered me and well to be honest I’ve been a housekeeper for several hotels here in SA and one thing I noticed was hair long black hair i have blonde hair so it wasn’t mine there was hair stuck to the to toilet and hair in the shower on the rail and little hairs little black hairs all around the bathtub on the floor. That’s just one thing. I just don’t like to see when I check in a room. And then breakfast was okay the fountain drinks well there could of been a sign to say out of order but there wasn’t but other than that, I stay there was all right thank you "

[](https://expedia.co.uk/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Airport.h15751.Hotel-Information)

![La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/3b4d6808_y.jpg)

### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

10/10 Excellent

"We've stayed at several hotels in the past week as we were traveling, our bed here was the best out of all of them"

[](https://expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information)

![Hyatt Regency San Antonio Riverwalk](https://images.trvl-media.com/lodging/1000000/20000/10700/10636/b322b66a_y.jpg)

### Hyatt Regency San Antonio Riverwalk

8/10 Good

"Perfect place to stay. "

[](https://expedia.co.uk/San-Antonio-Hotels-Hyatt-Regency-San-Antonio-Riverwalk.h10636.Hotel-Information)

![Riverwalk Plaza](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg)

### Riverwalk Plaza

4/10 Poor

"Elevator was so dirty like walls have never been clean floor dirty and stain. Walking to our room carpet was dirty. Room needed to be cleaned better there was hair in the bathroom dust under tv stand. Room smelled misty Not happy with condition. I will not recommend "

[](https://expedia.co.uk/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information)

![Omni La Mansion del Rio](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/a20972d6_y.jpg)

### Omni La Mansion del Rio

10/10 Excellent

"The whole experience of the hotel was amazing. I left the location. all the stuff was great. valet was amazing too. housekeeping did awesome. even at the bar we had an overall amazing time"

[](https://expedia.co.uk/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information)

![La Quinta Inn & Suites by Wyndham San Antonio Riverwalk](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/9feb5dde_y.jpg)

### La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

10/10 Excellent

"Love the location "

[](https://expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information)

## Frequently asked questions

### What is Medical Center District like?

### What's a favourite hotel to stay in Medical Center District?

### How many hotels will I be able to find in Medical Center District?

### If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?

### What can I see and do in this San Antonio neighbourhood?

## Explore a world of travel with Expedia

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- [Book Hotels in Medical Center District on Expedia.com ](https://www.expedia.com/Medical-Center-District-San-Antonio-Hotels.0-n553248635978913844-0.Travel-Guide-Filter-Hotels)