Medical Center District Travel Guide

San Antonio

River walk in San Antonio
Riverboat on the San Antonio River Walk, San Antonio, Texas, United States of America.
River walk in San Antonio
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Popular places to visit

Things to do


Top hotels in Medical Center District

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
The price is £79 per night from 20 Apr to 21 Apr
£79
20 Apr - 21 Apr
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ...
8.4/10 Very Good! (3,237 reviews)
We've stayed here several times over the past 10 years and it's a very good hotel for the price. Clean rooms, well kept bathroom, adequate breakfast. It's in a good location close to the medical center. We will keep it as our primary choice in the area

Reviewed on 27 Mar 2026

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
The price is £90 per night from 18 Apr to 19 Apr
£90
18 Apr - 19 Apr
includes taxes & fees
Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ...
8.6/10 Excellent! (1,001 reviews)
Room was great, also great lobby

Reviewed on 23 Mar 2026

San Antonio Marriott Northwest Medical Center
Park Inn by Radisson

Park Inn by Radisson

2 out of 5
7500 Louis Pasteur Drive San Antonio TX
The price is £56 per night from 12 Apr to 13 Apr
£56
12 Apr - 13 Apr
includes taxes & fees
Stay at this motel in San Antonio. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff in their reviews. Popular attractions ...
7.2/10 Good! (1,000 reviews)
Close to my destination, clean, quiet.

Reviewed on 23 Mar 2026

Park Inn by Radisson
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
The price is £79 per night from 5 Apr to 6 Apr
£79
5 Apr - 6 Apr
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, room service and a 24-hour fitness centre. Our guests praise the restaurant and the helpful ...
8/10 Very Good! (6,405 reviews)
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Reviewed on 27 Mar 2026

Riverwalk Plaza
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
The price is £143 per night from 26 Apr to 27 Apr
£143
26 Apr - 27 Apr
includes taxes & fees
Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms ...
9.4/10 Exceptional! (2,580 reviews)
Lovely rooms, attentive staff, great location. Thoroughly enjoyed our three night stay!

Reviewed on 26 Mar 2026

Hotel Valencia Riverwalk
Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
The price is £107 per night from 27 Apr to 28 Apr
£107
27 Apr - 28 Apr
includes taxes & fees
Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and 2 hot tubs. Our guests praise the pool and the helpful staff in their reviews. ...
9/10 Wonderful! (1,525 reviews)
great pools perfect place for families

Reviewed on 25 Mar 2026

Hyatt Vacation Club at Wild Oak Ranch, San Antonio
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Other neighbourhoods around Medical Center District

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Northwest Side

If you're spending some time in Northwest Side, Huebner Oaks and Dub Farris Athletic Complex are top sights worth seeing.

Northwest Side
River Walk in San Antonio, Texas

Midtown

Unique features of Midtown include the river views and bars. Make a stop by San Antonio Zoo and Aquarium or The DoSeum while you're exploring the area.

Midtown
Historic architecture Spanish San Antonio Texas Mission San Jose on a cloudy day

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

La Cantera District
Tobin Hill

Tobin Hill

Tobin Hill might not have many top sights, but San Antonio Zoo and Aquarium and San Antonio Museum of Art are two attractions nearby that you can check out.

Tobin Hill
Colorful LED Christmas lights at the restaurants at the  San Antonio Riverwalk on a December Texas evening

Uptown

If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing.

Uptown
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Alamo Heights

You'll enjoy the museums and coffee shops in Alamo Heights. You might want to make time for a stop at San Antonio River or Toilet Seat Museum.

Alamo Heights


Medical Center District Travel Guide

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