Title: Medical Center District Travel Guide: Best of Medical Center District, San Antonio Travel 2026 | Expedia.co.uk [Hotels in Medical Center District](https://expedia.co.uk/Medical-Center-District-Hotels.d553248635978913844.Travel-Guide-Hotels)[Flights to San Antonio](https://expedia.co.uk/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.co.uk/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Medical-Center-District.d553248635978913844.Car-Hire-Guide)[Medical Center District Holidays](https://expedia.co.uk/Medical-Center-District.d553248635978913844.Holidays-City-Breaks) # Medical Center District Travel Guide ## San Antonio ![River walk in San Antonio](https://images.trvl-media.com/place/553248635978913844/ef5a7faf-f6d9-4f7e-b325-ac477c5ad14d.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![River walk in San Antonio](https://images.trvl-media.com/place/553248635978913844/ef5a7faf-f6d9-4f7e-b325-ac477c5ad14d.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![SanAntonio_SouthTexasMedicalCenter_6193120_01](https://images.trvl-media.com/place/6193120/6208bc73-d0ab-4fda-b1af-d2c1bae086ed.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit Medical Center District Things to do Hotels Where to stay [San Antonio travel guide](https://expedia.co.uk/San-Antonio.dx178303) --- ### Popular places to visit ![SanAntonio_SouthTexasMedicalCenter_6193120_01](https://images.trvl-media.com/place/6193120/6208bc73-d0ab-4fda-b1af-d2c1bae086ed.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### South Texas Medical Center If South Texas Medical Center is what brings you to town, hopefully you'll have a chance to explore more of San Antonio. [](https://expedia.co.uk/South-Texas-Medical-Center-Medical-Center-District.d6193120.Attraction) #### USAA Corporate Office Headquarters USAA Corporate Office Headquarters is just one of the places to see in San Antonio, so why not enjoy the other things to explore during your travels? Stroll along the riverfront or attend a sporting event in this family-friendly area. [](https://expedia.co.uk/USAA-Corporate-Office-Headquarters-Medical-Center-District.d553248621593511346.Attraction) #### University of Texas Health and Science Center at San Antonio If University of Texas Health and Science Center at San Antonio is what brings you to town, hopefully you'll have a chance to explore more of San Antonio. [](https://expedia.co.uk/University-Of-Texas-Health-And-Science-Center-At-San-Antonio-Medical-Center-District.d6191585.Attraction) #### CHRISTUS Santa Rosa Hospital - Medical Center If CHRISTUS Santa Rosa Hospital - Medical Center is what brings you to town, hopefully you'll have a chance to explore more of San Antonio. [](https://expedia.co.uk/CHRISTUS-Santa-Rosa-Hospital-Medical-Center-Medical-Center-District.d553248621593511347.Attraction) #### Methodist Healthcare If Methodist Healthcare is what brings you to town, hopefully you'll have a chance to explore more of San Antonio. [](https://expedia.co.uk/Methodist-Healthcare-Medical-Center-District.d624557431461228544.Attraction) #### University Hospital - University Health System If University Hospital - University Health System is what brings you to town, hopefully you'll have a chance to explore more of San Antonio. [](https://expedia.co.uk/University-Hospital-University-Health-System-Medical-Center-District.d624549029572980736.Attraction) ### Things to do ![San Antonio Zoo Any Day Ticket including ZooLights](https://mediaim.expedia.com/localexpert/45080165/434c10f8-837c-410b-b9dc-b8fa99016dbc.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Antonio Zoo Any Day Ticket including ZooLights £22 per adult **96%** of travellers recommend [](https://expedia.co.uk/things-to-do/san-antonio-zoo-any-day-ticket-including-zoolights.a45080165.activity-details) ![San Antonio: Tower of the Americas Entry Ticket](https://mediaim.expedia.com/localexpert/47884193/1a9b90cf-4155-41db-8db5-31c88c9f9d49.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### San Antonio: Tower of the Americas Entry Ticket £16 per adult [](https://expedia.co.uk/things-to-do/san-antonio-tower-of-the-americas-entry-ticket.a47884193.activity-details) ![The Undead: Zombie Apocalypse Escape Room at Extreme Escape](https://mediaim.expedia.com/localexpert/45274098/3aaba3fb-2e9a-469b-8b57-77d9bdf88cae.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### The Undead: Zombie Apocalypse Escape Room at Extreme Escape £24 per adult [](https://expedia.co.uk/things-to-do/the-undead-zombie-apocalypse-escape-room-at-extreme-escape.a45274098.activity-details) ![Entrance to the Hard Rock Cafe in San Antonio](https://mediaim.expedia.com/localexpert/438559/4ca23546-e642-4c4a-8213-1f1f72cbb943.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Dining at Hard Rock Cafe San Antonio £29 per traveller **74%** of travellers recommend [](https://expedia.co.uk/things-to-do/dining-at-hard-rock-cafe-san-antonio.a438559.activity-details) ![The Buckhorn Museum and the Texas Ranger Museum are located under one roof.](https://mediaim.expedia.com/localexpert/641554/8b50fabe-78dc-4271-a0a7-3ffc11ed3fee.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### The Buckhorn Saloon & Museum and Texas Ranger Museum Admission £17 per adult **92%** of travellers recommend [](https://expedia.co.uk/things-to-do/the-buckhorn-saloon-museum-and-texas-ranger-museum-admission.a641554.activity-details) ![Master Of Illusions Magic & Paranormal Escape Room at Extreme Escape San Antonio](https://mediaim.expedia.com/localexpert/45272613/7ddc8090-245c-4090-91cc-ecb4c940e01b.jpg?impolicy=fcrop&w=900&h=506&q=mediumHigh) #### Master Of Illusions Magic & Paranormal Escape Room at Extreme Escape San Antonio £24 per adult [](https://expedia.co.uk/things-to-do/master-of-illusions-magic-paranormal-escape-room-at-extreme-escape-san-antonio.a45272613.activity-details) [See all activities in San Antonio](https://expedia.co.uk/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities) --- ## Top hotels in Medical Center District ![La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/w9000h6173x0y15-23603cae_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW 4431 Horizon Hill Blvd San Antonio TX £77 10 Feb - 11 Feb includes taxes & fees Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ... 8.4/10 Very Good! (3,192 reviews) Very courteous and helpful staff at front desk. Reviewed on 2 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=10%2F02%2F2026&endDate=11%2F02%2F2026&selected=1613977&PinnedHotelID=1613977&HadPinnedHotel=true®ionId=553248635978913844) ![San Antonio Marriott Northwest Medical Center](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### San Antonio Marriott Northwest Medical Center 3233 NW Loop 410 San Antonio TX £88 20 Feb - 21 Feb includes taxes & fees Stay at this business-friendly hotel in San Antonio. Enjoy a free local area shuttle, room service and a 24-hour fitness centre. Our guests praise the helpful ... 8.4/10 Very Good! (1,003 reviews) clean room; courteous staff at front desk & dining room Reviewed on 2 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=20%2F02%2F2026&endDate=21%2F02%2F2026&selected=4192&PinnedHotelID=4192&HadPinnedHotel=true®ionId=553248635978913844) ![Park Inn by Radisson](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/034bcb0d_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Park Inn by Radisson 7500 Louis Pasteur Drive San Antonio TX £54 22 Feb - 23 Feb includes taxes & fees Stay at this motel in San Antonio. Enjoy free Wi-Fi, free parking and a 24-hour front desk. Our guests praise the helpful staff in their reviews. Popular attractions ... 7.2/10 Good! (1,003 reviews) Room was clean and I enjoyed it. Reviewed on 4 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=28102&PinnedHotelID=28102&HadPinnedHotel=true®ionId=553248635978913844) ![Hotel Valencia Riverwalk](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hotel Valencia Riverwalk 150 E Houston St San Antonio TX £117 15 Feb - 16 Feb includes taxes & fees Stay at this luxury hotel in San Antonio. Enjoy free Wi-Fi, a full-service spa and breakfast (surcharge). Our guests praise the helpful staff and the clean rooms ... 9.2/10 Wonderful! (2,449 reviews) Great stay! Loved the hotel. Reviewed on 8 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=15%2F02%2F2026&endDate=16%2F02%2F2026&selected=897388&PinnedHotelID=897388&HadPinnedHotel=true®ionId=553248635978913844) ![La Quinta Inn & Suites by Wyndham San Antonio Riverwalk](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/544ec14c_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### La Quinta Inn & Suites by Wyndham San Antonio Riverwalk 303 Blum Street San Antonio TX £76 15 Feb - 16 Feb includes taxes & fees Stay at this business-friendly hotel in San Antonio. Enjoy free breakfast, free Wi-Fi and a fitness centre. Our guests praise the breakfast and the helpful staff ... 7.8/10 Good! (3,861 reviews) All the people at front counter are really nice!! and caring. And that Eddie is great person! Reviewed on 4 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=15%2F02%2F2026&endDate=16%2F02%2F2026&selected=25689&PinnedHotelID=25689&HadPinnedHotel=true®ionId=553248635978913844) ![Hyatt Vacation Club at Wild Oak Ranch, San Antonio](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/5058d5ba_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hyatt Vacation Club at Wild Oak Ranch, San Antonio 9700 West Military Drive San Antonio TX £88 1 Mar - 2 Mar includes taxes & fees Stay at this family-friendly hotel in San Antonio. Enjoy free Wi-Fi, free parking and 2 hot tubs. Our guests praise the pool and the helpful staff in their reviews. ... 8.8/10 Excellent! (1,432 reviews) The best!! Reviewed on 6 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=01%2F03%2F2026&endDate=02%2F03%2F2026&selected=1113168&PinnedHotelID=1113168&HadPinnedHotel=true®ionId=553248635978913844) [See all 4,815 properties in Medical Center District](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=10%2F02%2F2026&endDate=11%2F02%2F2026®ionId=553248635978913844) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check Medical Center District hotel availability [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635978913844&startDate=2026-02-09&endDate=2026-02-10)[9 Feb - 10 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635978913844&startDate=2026-02-09&endDate=2026-02-10) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635978913844&startDate=2026-02-10&endDate=2026-02-11)[10 Feb - 11 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635978913844&startDate=2026-02-10&endDate=2026-02-11) [This weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635978913844&startDate=13%2F02%2F2026&endDate=15%2F02%2F2026)[13 Feb - 15 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635978913844&startDate=13%2F02%2F2026&endDate=15%2F02%2F2026) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635978913844&startDate=20%2F02%2F2026&endDate=22%2F02%2F2026)[20 Feb - 22 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=553248635978913844&startDate=20%2F02%2F2026&endDate=22%2F02%2F2026) --- ### Other neighbourhoods around Medical Center District ![SanAntonio_UniversityofTexasSanAntonio_502634_03](https://images.trvl-media.com/place/502634/945a8dab-33e9-4021-b3e8-69459429f49c.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Northwest Side If you're spending some time in Northwest Side, Huebner Oaks and Convocation Center are top sights worth seeing. [](https://expedia.co.uk/San-Antonio-Northwest-Side.dx887264728595001344) ![Sam's Burger Joint](https://images.trvl-media.com/place/3077/091a70ef-d0f6-48e0-aed3-a87ca4f8d8ac.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Midtown Unique features of Midtown include the river views and bars. Make a stop by San Antonio Zoo and Aquarium or The DoSeum while you're exploring the area. [](https://expedia.co.uk/San-Antonio-Midtown.dx553248633938969302) ![Historic architecture Spanish San Antonio Texas Mission San Jose on a cloudy day](https://images.trvl-media.com/place/887254682616180736/28a6177d-3849-42e4-9cbd-06791c063489.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### La Cantera District If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing. [](https://expedia.co.uk/San-Antonio-La-Cantera-District.dx887254682616180736) ![One of the coolest bars in San Antonio. Definitely check it out.](https://images.trvl-media.com/place/3077/3c0c5f8a-19d7-42d6-9757-86d993027c3b.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Tobin Hill Tobin Hill might not have many top sights, but San Antonio Zoo and Aquarium and San Antonio Museum of Art are two attractions nearby that you can check out. [](https://expedia.co.uk/San-Antonio-Tobin-Hill.dx553248635976386526) ![Marion Koogler McNay Art Museum which includes art and interior views as well as an individual male](https://images.trvl-media.com/place/502610/f2b1df08-6a69-4feb-8248-be1130a68fb3.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Uptown If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing. [](https://expedia.co.uk/San-Antonio-Uptown.dx553248635974902947) ![SanAntonio_AlamoHeights_553248633938969296_04](https://images.trvl-media.com/place/553248633938969296/05ce3c51-220d-42e3-ace0-f5ff49980ee1.jpg?impolicy=fcrop&w=350&h=192&q=medium) ### Alamo Heights You'll enjoy the museums and coffee shops in Alamo Heights. You might want to make time for a stop at San Antonio River or Toilet Seat Museum. [](https://expedia.co.uk/San-Antonio-Alamo-Heights.dx553248633938969296) --- --- - [Stays](?pwaLob=wizard-hotel-pwa-v2) - [Packages](?pwaLob=wizard-package-pwa) - [Flights](?pwaLob=wizard-flight-pwa) - [Things to do](?pwaLob=wizard-lx-pwa) - [Cruises](?pwaLob=wizard-cruise-pwa) - [Cars](?pwaLob=wizard-car-pwa) # Medical Center District Travel Guide ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app