Title: The Best Hotels in Medical Center District, San Antonio - 2026 Updated Prices | Expedia.co.uk [Holiday Rentals in San Antonio](https://expedia.co.uk/San-Antonio-Holiday-Rentals.d178303.Travel-Guide-HolidayRentals)[Flights to San Antonio](https://expedia.co.uk/Cheap-Flights-To-San-Antonio.d178303.Travel-Guide-Flights)[Things to do in San Antonio](https://expedia.co.uk/Things-To-Do-In-San-Antonio.d178303.Travel-Guide-Activities)[Medical Center District Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Medical-Center-District.d553248635978913844.Car-Hire-Guide)[Medical Center District Holidays](https://expedia.co.uk/Medical-Center-District.d553248635978913844.Holidays-City-Breaks) ![Lodging Image](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/bex-affinities/lodging.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [10 Feb - 11 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-02-10&endDate=2026-02-11&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [11 Feb - 12 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-02-11&endDate=2026-02-12&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635978913844&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Medical Center District hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from property](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/243881ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/004315aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast and dinner served, American cuisine](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/053f15e4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Antonio Marriott Northwest Medical Center [](https://www.expedia.co.uk/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information) Medical Center District 8.6/10 Excellent (1,007 reviews) "Courteous staff, clean room, safe location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Danica £88 includes taxes & fees 21 Feb - 22 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/1c416f1a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pool](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/0a8f490a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, desk, laptop workspace, free cots/infant beds](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/0716970b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/52bae0c9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Fairfield Inn & Suites by Marriott San Antonio Medical Center [](https://www.expedia.co.uk/San-Antonio-Hotels-Fairfield-Inn-Suites-By-Marriott-San-Antonio-Medical-Center.h68847371.Hotel-Information) Medical Center District 9.0/10 Wonderful (1,006 reviews) "Very comfortable, everything was clean, great staff and it’s near all the important hospitals. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jesus £77 includes taxes & fees 16 Feb - 17 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Fairfield-Inn-Suites-By-Marriott-San-Antonio-Medical-Center.h68847371.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/1e7b2c4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/2045bf85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV, pay films](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/f47c7eb6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![In-room safe, desk, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/db09d138.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Courtyard by Marriott Medical Center San Antonio [](https://www.expedia.co.uk/San-Antonio-Hotels-Courtyard-By-Marriott-Medical-Center-San-Antonio.h12556.Hotel-Information) Medical Center District 8.8/10 Excellent (1,000 reviews) "Clean rooms @ friendly staff!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) LaTishe £77 includes taxes & fees 18 Feb - 19 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Courtyard-By-Marriott-Medical-Center-San-Antonio.h12556.Hotel-Information) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/3b4d6808.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/ded9f09f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/dd105881.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/8fcc83d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW [](https://www.expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) Medical Center District 8.4/10 Very good (3,193 reviews) "Great stay with nice breakfast and clean rooms " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Leah £77 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Medical-Ctr-NW.h1613977.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/86df295b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Indoor pool](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/8e301658.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/17f1a418.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/0e1dc134.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Drury Inn & Suites San Antonio Northwest Medical Center [](https://www.expedia.co.uk/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Northwest-Medical-Center.h59226.Hotel-Information) Medical Center District 9.2/10 Wonderful (1,284 reviews) "Excellent awesome place we love it Room was super clean staff super nice " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Maria £78 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Drury-Inn-Suites-San-Antonio-Northwest-Medical-Center.h59226.Hotel-Information) ![Desk, laptop workspace, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/cfce1826.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/cc477a8e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/15001725.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Laundry room](https://images.trvl-media.com/lodging/84000000/83410000/83406000/83405963/0d622081.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 San Antonio, Tx - Northwest Medical Center [](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h83405963.Hotel-Information) Medical Center District 7.4/10 Good (244 reviews) "Good stay and safe area" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Mario £43 includes taxes & fees 12 Feb - 13 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h83405963.Hotel-Information) ![Breakfast area](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/9628dbca.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/fea7afce.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/f2ac3195.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/28200/28102/ea511f30.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Park Inn by Radisson [](https://www.expedia.co.uk/San-Antonio-Hotels-Welcome-Inn-San-Antonio-Medical-Center.h28102.Hotel-Information) Medical Center District 7.2/10 Good (1,004 reviews) "Room was spotless and bed was great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Pamela £54 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Welcome-Inn-San-Antonio-Medical-Center.h28102.Hotel-Information) ![Basic Room, 1 King Bed, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/53fea236.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/00bf65b4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Basic Room, Multiple Beds, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/42431698.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/76000000/75220000/75211700/75211602/52d716c1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Flex Studios [](https://www.expedia.co.uk/San-Antonio-Hotels-Flex-Studios.h75211602.Hotel-Information) Medical Center District 6.0/10 (506 reviews) "Was good, but there is no one overnight, security doesn't answer and the opening person was almost an hour late. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michelle £38 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Flex-Studios.h75211602.Hotel-Information) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/63a40a4f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/39b28cd2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/e79204bf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fitness facility](https://images.trvl-media.com/lodging/12000000/11750000/11744300/11744297/5f7054f8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, San Antonio Medical Center, TX [](https://www.expedia.co.uk/San-Antonio-Hotels-Country-Inn-Suites-By-Radisson.h11744297.Hotel-Information) Medical Center District 6.8/10 (1,000 reviews) "Great place , front desk are helpful and friendly. Safe place to stay ." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Justin £51 includes taxes & fees 3 Mar - 4 Mar [](https://www.expedia.co.uk/San-Antonio-Hotels-Country-Inn-Suites-By-Radisson.h11744297.Hotel-Information) ![Property entrance](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/41551429.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/6d7e3cbb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/a061f3de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds | Television](https://images.trvl-media.com/lodging/1000000/700000/692600/692534/06f7cfb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### OYO Inn & Suites Medical Center San Antonio [](https://www.expedia.co.uk/San-Antonio-Hotels-OYO-Inn-Suites-Medical-Center-San-Antonio.h692534.Hotel-Information) Medical Center District 7.2/10 Good (228 reviews) "Staff was courteous and professional and the room is nice." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Thomas £54 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-OYO-Inn-Suites-Medical-Center-San-Antonio.h692534.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/1b117ba4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 King Deluxe Suite | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/76d52754.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 Queen Deluxe Suites | Bathroom | Combined shower/bathtub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/d7b70ede.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/97000000/96190000/96182100/96182039/82bbe653.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Atria Inn & Suites [](https://www.expedia.co.uk/San-Antonio-Hotels-9727-Fredericksburg-Rd.h96182039.Hotel-Information) Medical Center District 7.4/10 Good (281 reviews) "Room was good standings, staff was friendly " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Luis [](https://www.expedia.co.uk/San-Antonio-Hotels-9727-Fredericksburg-Rd.h96182039.Hotel-Information) ![Desk, laptop workspace, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/c7a8846b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/60308f28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, coffee/tea maker, dining tables](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/4c605dff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Vending machine](https://images.trvl-media.com/lodging/1000000/60000/51000/50914/45eebc93.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Studio 6 San Antonio, TX - Medical Center [](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h50914.Hotel-Information) Medical Center District 6.8/10 (821 reviews) "Staff was great, very clean rooom" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Laura £46 includes taxes & fees 11 Feb - 12 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Studio-6-San-Antonio.h50914.Hotel-Information) ![Free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/c1974da9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/155e0f25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/a69289e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/60000/50600/50555/a8e3513c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Motel 6 San Antonio, TX - Northwest Medical Center [](https://www.expedia.co.uk/San-Antonio-Hotels-Motel-6-San-Antonio.h50555.Hotel-Information) Medical Center District 6.0/10 (999 reviews) "Great experience " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) John £40 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/San-Antonio-Hotels-Motel-6-San-Antonio.h50555.Hotel-Information) ![Fireplace](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4657a7fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/4f4dbae3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Waterslide](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/f77355b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/2000000/1120000/1113200/1113168/72554b53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Vacation Club at Wild Oak Ranch, San Antonio [](https://www.expedia.co.uk/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information) Far West Side, 7 mi from Medical Center District 9.0/10 Wonderful (1,444 reviews) "Great room and amenities, gorgeous property " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) jason £90 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/San-Antonio-Hotels-Hyatt-Vacation-Club-At-Wild-Oak-Ranch.h1113168.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/ae1a8ff6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 9:00 AM to 10:00 PM, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/dad59fda.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/578a3dd5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/0a592140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Menger Hotel [](https://www.expedia.co.uk/San-Antonio-Hotels-Menger-Hotel.h5877.Hotel-Information) Downtown San Antonio, 7.9 mi from Medical Center District 9.0/10 Wonderful (3,794 reviews) "Loved the stay here. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David £73 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Menger-Hotel.h5877.Hotel-Information) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/9feb5dde.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Suite, 2 Double Beds, Non Smoking (Deluxe Family Suite) | Pillow-top beds, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/eccadf60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/544ec14c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/25700/25689/732bf58e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### La Quinta Inn & Suites by Wyndham San Antonio Riverwalk [](https://www.expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information) Downtown San Antonio, 8.1 mi from Medical Center District 7.8/10 Good (3,873 reviews) "very nice and clean rooms close to all the good attractions " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) nancy £76 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-La-Quinta-Inn-Suites-By-Wyndham-San-Antonio-Riverwalk.h25689.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/4db1357c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/7c5ba6dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/3ded3c64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/50000000/49150000/49148700/49148640/9bb2dd09.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Canopy by Hilton San Antonio Riverwalk [](https://www.expedia.co.uk/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information) Downtown San Antonio, 7.6 mi from Medical Center District 9.4/10 Exceptional (1,625 reviews) "The place was very clean, friendly staff and the location is perfect for anything you want to do. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kyisha £139 includes taxes & fees 20 Feb - 21 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Canopy-By-Hilton-San-Antonio-Riverwalk.h49148640.Hotel-Information) ![Front of property](https://images.trvl-media.com/lodging/3000000/2240000/2239900/2239843/64227c46.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/3000000/2240000/2239900/2239843/0b912981.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite | View from room](https://images.trvl-media.com/lodging/3000000/2240000/2239900/2239843/45e033bd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Executive Room, 2 Queen Beds | Frette Italian sheets, premium bedding, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/3000000/2240000/2239900/2239843/9ee51d9e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Gibbs Downtown Riverwalk [](https://www.expedia.co.uk/San-Antonio-Hotels-Hotel-Gibbs-Downtown-Riverwalk.h2239843.Hotel-Information) Downtown San Antonio, 7.7 mi from Medical Center District 9.0/10 Wonderful (1,840 reviews) "This was an excellent stay." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James £80 includes taxes & fees 17 Feb - 18 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Hotel-Gibbs-Downtown-Riverwalk.h2239843.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/800000/798100/798052/6da910ee.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pillow-top beds, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/800000/798100/798052/3e5782a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/800000/798100/798052/75c21402.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Balcony (Walk-in Shower;with Sofabed) | Pillow-top beds, desk, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/1000000/800000/798100/798052/d169f6b3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Aiden San Antonio Riverwalk [](https://www.expedia.co.uk/San-Antonio-Hotels-Aiden-By-Best-Western-San-Antonio-Riverwalk.h798052.Hotel-Information) 8.2 mi from Medical Center District 9.2/10 Wonderful (1,132 reviews) "Excellent staff, great location, really cool place! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Brandelyn £68 includes taxes & fees 15 Feb - 16 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Aiden-By-Best-Western-San-Antonio-Riverwalk.h798052.Hotel-Information) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/2e90fb1e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/a296bfd9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/6841f291.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Shopping centre](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/63a37f35.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Crockett Hotel [](https://www.expedia.co.uk/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) Downtown San Antonio, 7.9 mi from Medical Center District 8.8/10 Excellent (2,547 reviews) "Clearn room, excellent staff, superb location, walkable to all the major sites." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Ronald £77 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-24&endDate=2026-02-25®ionId=553248635978913844&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Compare popular hotels in Medical Center District | Property | Property class | Guest rating | Breakfast included | Pool | Spa | Pet-friendly | WiFi included | | | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ----------------- | ------------------------- | ------------------ | ---- | --- | ------------ | ------------- | | | ![Lobby](https://images.trvl-media.com/lodging/1000000/60000/59300/59226/86df295b.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Drury Inn & Suites San Antonio Northwest Medical Center | 3.0 star property | 9.2Wonderful1,284 reviews | View | | | | | | | ![Lobby](https://images.trvl-media.com/lodging/69000000/68850000/68847400/68847371/1c416f1a.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Fairfield Inn & Suites by Marriott San Antonio Medical Center | 2.5 star property | 9.0Wonderful1,006 reviews | View | | | | | | | ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/20000/12600/12556/1e7b2c4d.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)Courtyard by Marriott Medical Center San Antonio | 3.0 star property | 8.8Excellent1,000 reviews | View | | | | | | | ![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/2000000/1620000/1614000/1613977/3b4d6808.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW | 3.0 star property | 8.4Very good3,193 reviews | View | | | | | | | ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de.jpg?impolicy=fcrop&w=900&h=675&p=1&q=medium)San Antonio Marriott Northwest Medical Center | 3.5 star property | 8.6Excellent1,007 reviews | View | | | | | | ## Where to stay in Medical Center District Find the best Medical Center District areas for the activities you enjoy most. - Downtown San Antonio - Uptown - Far West Side - Fort Sam Houston - Near East Side ![Downtown - Riverwalk showing a river or creek, a bridge and boating](https://images.trvl-media.com/place/800120/c427a760-8f08-4152-8ff2-5ee8720d9068.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Downtown San Antonio which includes cafe lifestyle, night scenes and boating](https://images.trvl-media.com/place/800120/4b544474-7c50-4664-b4ab-ad70250a41a0.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Downtown - Riverwalk which includes signage](https://images.trvl-media.com/place/800120/135587e2-2707-47b4-9d5d-cb8857baf764.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Downtown - Riverwalk which includes street scenes, outdoor eating and a city](https://images.trvl-media.com/place/800120/d5fb17cd-5ebd-4eba-ae25-0c264111a700.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Downtown - Riverwalk featuring boating and a river or creek](https://images.trvl-media.com/place/800120/4342dae3-9acc-4423-bc98-26f47e6b055f.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=800120) ![Downtown San Antonio map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:%7BrmrDhqgxQ%7Bu%40iUe%60%40ia%40y%7EAmMkRgUqO_d%40wPi%5CT%7DPdJmc%40xQElH%60CrZlR%7EIgDjNP%3FuPbh%40Lph%40a%40pQtLzb%40bFvIXdg%40mPxE%60R%7BK%60%7CAaAd%7EAoc%40dA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=RuyIpZHEnQcp_rXJYAlWPqPpku0=) ### Downtown San Antonio Explore the network of pedestrian paths that follows the beautiful San Antonio River to discover restaurants and bars, gift shops, galleries and museums. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=800120) ![It's Texas, of course everything is bigger! #guinessworldrecord #visittexas #hdr #fisheye](https://images.trvl-media.com/place/3077/4cdbcd9a-ec5a-47a7-8436-9b378ab6bf93.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Sarah C. ![Marion Koogler McNay Art Museum which includes art and interior views as well as an individual male](https://images.trvl-media.com/place/502610/f2b1df08-6a69-4feb-8248-be1130a68fb3.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![SanAntonio_NorthStarMall_502628_05](https://images.trvl-media.com/place/502628/fc86b101-dc2f-4e75-a1bf-b214a3fa4dc2.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248635974902947) ![Uptown map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ydesDviexQgd%40qGeaDglA%7BiAuZssAq%5Cof%40aLcgCoh%40wHeEx%5C_fB%60YwpB%7BMooG%7B%40%7D_DlF%7BZhHuIbgCm%7DAdJvIjUpGzM%7EMhHha%40nFrG%60YePfWmEbYcPlF%3FhHxKdJvg%40%7CZ%7Cx%40%7Cv%40p_BzKhXfLrPlb%40xXzi%40tIn%60%40dn%40rDhRz%40%7C%7DDlFfAfW%7BK%7EpA%3FxOuVjUnEzMqGjU%3FdoAzi%40hHtIpDvXhH%7EMz%40dhB%7CM%7EMz%40ha%40%3Fj_AmF%60Nx%40bhBqDlEs%7BIbA&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=j0bUoKNjCSIIV8aMqbcD3ISkFXM=) ### Uptown If you're spending some time in Uptown, San Antonio Zoo and Aquarium and Marion Koogler McNay Art Museum are top sights worth seeing. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635974902947) ![SanAntonio_SanAntonioSeaWorld_502636_04](https://images.trvl-media.com/place/502636/21ddbcf6-e0f6-4e89-a158-96c7800472ba.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![SeaWorld San Antonio is one of the world's largest marine life parks and spans 416 acres. SeaWorldoffers an exciting and educational blend of extraordinary marine-life shows, rides, and attractions, as well as up-close animal encounters and behind-the-scenes tours. ](https://images.trvl-media.com/place/3077/08b2cbda-5618-42d5-95f6-c67aaf059c26.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Dean Moore ![](https://images.trvl-media.com/place/3077/f575c4b1-bcb1-4812-8208-54a3a54b6ebf.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://images.trvl-media.com/place/3077/55bed7d9-3745-4494-865f-1356c1ad509c.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![](https://images.trvl-media.com/place/3077/648ee6fc-247e-4471-88bf-89e6ed95d234.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248635975749416) ![Far West Side map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:afyrDb%7EwyQkpLsbDyqCo%7B%40d%7BAi%7EDbJih%40ukAsa%40mp%40yr%40raBofBxZaj%40xfAeu%40bn%40uRtf%40y%5DpqAwr%40%7ChAg%60B%7CKqLlOyd%40xKhZp%7DAbzArdEheDrUxOfQpDjzDl%40%60XfbAn%5DblAph%40bnD%7EX%7EgBjPviDmpJzf%40gkDbr%40&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=VMxJSqyr4lT0QcBLFKtAFNJkV0g=) ### Far West Side While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635975749416) ![River Walk in San Antonio, Texas](https://images.trvl-media.com/place/5521747/f1120902-a2c1-40fb-9523-dc22cbec2f63.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=6127453) ![Fort Sam Houston map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:e%7DurDrd%60xQiBEa%40g%40kAiGmAs%40oAtBx%40vAgCf%40EyVcMNQrCgH%3FClN%7BBwABue%40iR%3FDm%5Df%40o%40Og%5B_a%40gG%7DBcBo%40gDoK_ByI_%40%7DApB%7B%40ZoPLCsXsA_G%3F%7DGjU%3F%5CXt%40%5D%7EI%40Mc%40v%40u%40g%40q%40%7DBcMyIySmI_FgtAim%40W_A%7D%40EoRyIsC%7BCEc%7B%40pS%3F%40wMnQEDg%5Cdj%40DfFdGb%40rAnAPJyAbAb%40%7ERH%60%40x%40Ji%5Ed%40aBvA%5Bbl%40bVvEnDzA%60DJhsAtAvDtFvJ%7CJzIzJzMz_Alk%40xAvF%60AvH%7BBd%40qFvDwBmEqN%7CGCtP%5BA%3FfDW%3FVl_%40zSG%40lX%3FhI_IJBby%40_IJ%40tU&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=Y3gB_-MzVMF3Dq4DB-Bw3uDigNk=) ### Fort Sam Houston You'll love the stunning river views in Fort Sam Houston, and you might want to stick around to check out United States Army Medical Department Museum, a top place to visit. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=6127453) ![SanAntonio_Alamodome_502630_05](https://images.trvl-media.com/place/502630/6e7f09eb-333f-40ac-9f49-fbc6079528dd.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![The Alamodome](https://images.trvl-media.com/place/502630/6012209d-9f54-4f86-a4be-2e18cdfa1cd9.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![The Alamo in San Antonio, Texas](https://images.trvl-media.com/place/502630/0e25bbb0-c16e-4b4e-abd5-97a31135a87a.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) ![Located East of Downtown, the Hays Street Bridge has developed into the center point of a budding neighborhood. With bars and restaurants popping up nearby, the bridge offers terrific views of the city and an urban feel.](https://images.trvl-media.com/place/3077/173ba817-4b39-444f-acbe-903e20dc9d65.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) Photo by Andrew Smith ![SanAntonio_HistoricSunsetStation_553248634333457641_03](https://images.trvl-media.com/place/553248634333457641/a2e54cff-ef47-4747-9082-84e98a453c5b.jpg?impolicy=fcrop&w=960&h=540&p=1&q=medium) [](https://www.expedia.co.uk/Hotel-Search?pwaOverlay=map®ionId=553248635976482249) ![Near East Side map](https://maps.googleapis.com/maps/api/staticmap?&size=289x340&map_id=c017d89749dc74ad&markers=icon:%7C&path=enc:ekrrDfwaxQkd%40gQwPwJqSfC%5CkkBzdFlExAtt%40he%40hp%40%7Bk%40nTum%40%7BKai%40lFeYeBmc%40xJ&key=AIzaSyAoVHdVOa5-BDRxGhFoAHYIHPst1T09Jo0&signature=mVERdgl0dS_fnRKGl4hCazVtg6M=) ### Near East Side If you're spending some time in Near East Side, Alamodome and Historic Sunset Station are top sights worth seeing. [See properties](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976482249) ## Top Medical Center District Hotel Reviews ![Menger Hotel](https://images.trvl-media.com/lodging/1000000/10000/5900/5877/ae1a8ff6_y.jpg) ### Menger Hotel 10/10 Excellent "Yes" [](https://expedia.co.uk/San-Antonio-Hotels-Menger-Hotel.h5877.Hotel-Information) ![San Antonio Marriott Northwest Medical Center](https://images.trvl-media.com/lodging/1000000/10000/4200/4192/aa83e7de_y.jpg) ### San Antonio Marriott Northwest Medical Center 10/10 Excellent "The room was fantastic, and the hotel staff was incredibly friendly. " [](https://expedia.co.uk/San-Antonio-Hotels-San-Antonio-Marriott-Northwest.h4192.Hotel-Information) ![Sonesta ES Suites San Antonio Downtown Alamo Plaza](https://images.trvl-media.com/lodging/1000000/50000/41200/41122/11513eda_y.jpg) ### Sonesta ES Suites San Antonio Downtown Alamo Plaza 10/10 Excellent "Clean room and the location is very accessible. Limited parking space. It says there’s ‘self parking available’ but there’s none. " [](https://expedia.co.uk/San-Antonio-Hotels-Sonesta-ES-Suites-San-Antonio-Downtown.h41122.Hotel-Information) ![Hotel Valencia Riverwalk](https://images.trvl-media.com/lodging/1000000/900000/897400/897388/2b6d39b3_y.jpg) ### Hotel Valencia Riverwalk 10/10 Excellent "Great stay! Loved the hotel. " [](https://expedia.co.uk/San-Antonio-Hotels-Hotel-Valencia-Riverwalk.h897388.Hotel-Information) ![Riverwalk Plaza](https://images.trvl-media.com/lodging/1000000/290000/288400/288321/ef3ca433_y.jpg) ### Riverwalk Plaza 10/10 Excellent "Super clean! Very nice staff! Thank you for the stay!" [](https://expedia.co.uk/San-Antonio-Hotels-Riverwalk-Plaza.h288321.Hotel-Information) ![Crockett Hotel](https://images.trvl-media.com/lodging/1000000/10000/1600/1534/a3dd07e6_y.jpg) ### Crockett Hotel 10/10 Excellent "Clean, quiet, excellent location right across from the Alamo and river walk " [](https://expedia.co.uk/San-Antonio-Hotels-Crockett-Hotel.h1534.Hotel-Information) ![Hotel Contessa](https://images.trvl-media.com/lodging/2000000/1240000/1234400/1234369/a6fac7f7_y.jpg) ### Hotel Contessa 10/10 Excellent "The overall experience was just great" [](https://expedia.co.uk/San-Antonio-Hotels-Hotel-Contessa-Suites-On-The-Riverwalk.h1234369.Hotel-Information) ![Omni La Mansion del Rio](https://images.trvl-media.com/lodging/1000000/20000/17400/17329/1aaa0955_y.jpg) ### Omni La Mansion del Rio 10/10 Excellent "I was staying on the 6th floor, 610 to be exact. The elevator from the lobby wasnt working due to construction. The lovely lady at the counter, started with a J, really pretty, told me where to go. But as everyone knows you listen and sayhsjs uh hu, but your not listening. " [](https://expedia.co.uk/San-Antonio-Hotels-Omni-La-Mansion-Del-Rio.h17329.Hotel-Information) ![Holiday Inn San Antonio - Riverwalk by IHG](https://images.trvl-media.com/lodging/1000000/20000/12700/12642/5f5ef28b_y.jpg) ### Holiday Inn San Antonio - Riverwalk by IHG 10/10 Excellent "It’s a great place to stay, clean rooms, the food was great and the customer service was excellent. The only thing we didn’t like it’s that you have to pay for parking. But this hotel would be the best option to stay if the parking was included. " [](https://expedia.co.uk/San-Antonio-Hotels-Holiday-Inn-San-Antonio-Riverwalk.h12642.Hotel-Information) ## Frequently asked questions ### What is Medical Center District like? ### What's a favourite hotel to stay in Medical Center District? ### How many hotels will I be able to find in Medical Center District? ### If I need to cancel my hotel reservation in Medical Center District, will I receive a refund? ### What can I see and do in this San Antonio neighbourhood? ## Explore a world of travel with Expedia - More ways to book - [Book Hotels in Medical Center District on Expedia.com ](https://www.expedia.com/Medical-Center-District-San-Antonio-Hotels.0-n553248635978913844-0.Travel-Guide-Filter-Hotels)