The Best Hotels Closest to Looe Key National Marine Sanctuary in - 2026 Updated Prices

Our top choices for Looe Key National Marine Sanctuary hotels

Parmer's Resort

8.7 mi from Looe Key National Marine Sanctuary

Dean

includes taxes & fees

2 Aug - 3 Aug

Looe Key Reef Resort

7.8 mi from Looe Key National Marine Sanctuary

Dwain

includes taxes & fees

19 Jul - 20 Jul

1 Bedroom Aqualodge # 6 Tarpon | Living area | Flat-screen TV

Old Wooden Bridge Resort and Marina

10.9 mi from Looe Key National Marine Sanctuary

Sofia

includes taxes & fees

14 Jul - 15 Jul

Sugar Loaf Lodge

12.1 mi from Looe Key National Marine Sanctuary

Oyuntseren

includes taxes & fees

5 Jul - 6 Jul

View all properties

Top Looe Key National Marine Sanctuary Hotel Reviews

Parmer's Resort

10/10 Excellent

"We love Palmer’s resort!"

Looe Key Reef Resort

8/10 Good

"Very "Florida Keys" type of place to stay. The good: Very convenient, super friendly staff, big pool, the overall "Keys" vibe. Rooms were decent and clean. Dive and snorkeling trips daily and a very convenient Shell station next door. The not so great: Rooms a bit dated and in need of some minor repairs here and there. The Tiki Hut ran out of food for a couple of days so we had to search out other places to eat in the evenings. Nothing was bad enough for us to not want to go back! Outstanding staff!"

Deep/Wide/Flow-Though Canal, 1st Canal From Open Water, No Hwy 1 Road Noise

10/10 Excellent

"I gotta say our host exceeded my expectations in every way, the property was immaculate. I wanted to buy it. I hope to be contacted if they have any sales aspirations and if so, I hope by chance their motivated."

Beautiful 2/2 Waterfront Designer Home for your family vacation

10/10 Excellent

" Nice house, beautifully decorated and clean. Great location for boating. We brought our 24’ boat, total length is 27.5’ with windlass, anchor and motor up. The neighbor is so kind and didn’t mind that our boat was encroaching on his seawall."

Beachfront 3B/3B Fishing Oasis

10/10 Excellent

"This house was exactly how we like to vacation. The property is cozy with a laid-back easy-living vibe. Perfect place to launch your kayaks, then lounge in the pool afterwards. Great water views with no mangroves to interrupt it.The kitchen was fully stocked with all the dishes, pots/pans, and appliances you could need. Gas grill downstairs. I did try out the pizza oven, but it was just too windy for it to be effective.There are many very good Cuban restaurants nearby. 8 minutes to Big Pine where you’ll find more restaurants, shops, and Winn-Dixie for groceries. 30 miles into Key West if you feel the need to be a tourist.Definitely want to return for another stay if the property (which is for sale) remains on the vacation rental market.We stayed for a month in April and the temperatures were perfect."

Treehouse Private Village Barnacle Resort

10/10 Excellent

"Barnacle Resort Stayed 3 nights at the “Treehouse Private Village” in the Barnacle Resort on Big Pine Key. I really enjoyed my stay, the property is quite nice, and very private. One of the attractions on Big Pine Key is seeing Key deer, which astonishingly wandered around the resort property several times a day. Don’t touch or feed them, very illegal, but you can get quite close, as they are fairly tame.It wasn’t clear when I made my reservation just where the room was on the property, since the pictures mainly showed the larger building. As it turns out, my reservation was for the separate, smaller building next to the main house. The “Treehouse” was completely private, and has its own kitchen and full bath, which I really appreciated. There are three or four available rooms in the main building, along with the common areas for dining, etc. So be sure you have the correct room information when you book your stay.There were a couple of things I had to deal with, like the TV wasn’t plugged in, no power outlets in the kitchen for the coffee machine (ran it off the floor in the main room), but really nothing major. And the host responded quickly to any questions, plus I think there’s folks onsite for anything that might be needed.All in all, I was quite pleased with my experience there. If natural beauty, privacy, and location close to Bahia Honda State Park and Key West are at the top of your list, check this place out."

Keys To The Kingdom! Private Oceanfront Retreat with Beach and Pool

10/10 Excellent

"We just spent 31 nights in Jan/Feb 2026 celebrating our 48th wedding anniversary. The location was perfect for exploring all the keys. We even drove up to Miami Beach one day and was easy to get back before sunset. The location was great for day trips to Key West, getting there in less than 45 minutes. The house is on a very quiet dead-end road. There is a convenience store within 2 miles and a Winn-Dixie within 5 miles. The bird life and key deer on the beach were amazing. The heated pool was so nice and well maintained. The large washer and dryer were very nice. The Kitchen had everything we needed. The place was relaxing. Greg was very helpful and attentive. We would give this place more than 5 stars if we could."

Star Room Barnacle Resort

10/10 Excellent

"This is a very special place. You pay for the tranquility and the peace. You have a private beach all to yourself. And the deer are super friendly (yes). A great plus is you can BBQ on the beach yourself. Please fix the big fridge and make more kitchen utensils and plates and glasses available. That would make it even more positive. I would come back. "

Gorgeous Beachfront Home with a pool. Water views from every direction.

10/10 Excellent

"Our family really enjoyed our stay at this beautiful home. Amazing views from every room. The deck sitting areas were screen in and very comfortable. We all enjoyed sitting on the deck looking at the ocean and seeing the Key Deer pass by. The deer brought so much joy to our grandchildren! John and the property managerwere very accommodating during our stay. Thank you for a wonderful vacation!"

Hotels near other Looe Key National Marine Sanctuary attractions

Munson Island

Commune with nature and explore the great outdoors at Munson Island during your travels in Big Pine Key. While you're in the area, stroll along the beaches.

See properties

Frequently asked questions

What's the area like around Looe Key National Marine Sanctuary?

Looe Key National Marine Sanctuary is located in an area that travellers like for its local tours. When you want to settle in and find a place to stay, take a look at some of the hotels and other accommodation options that Expedia offers in the area.

What's the best hotel to stay close to Looe Key National Marine Sanctuary?

Barnacle Resort is one of the top choices for your stay based on our traveller data, and this B&B offers free parking and a rooftop terrace. You'll find it 7 mi (11.3 km) from Looe Key National Marine Sanctuary. Another good choice is Parmer's Resort, located 8.2 mi (13.2 km) away.

If I need to cancel the hotel reservation for my stay near Looe Key National Marine Sanctuary, will I receive a refund?

Yes! Most hotel reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which is usually within 24-48 hours of your check-in date. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best options available near Looe Key National Marine Sanctuary.

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Looe Key National Marine Sanctuary hotels

Parmer's Resort

Looe Key Reef Resort

Old Wooden Bridge Resort and Marina

Sugar Loaf Lodge

Top Looe Key National Marine Sanctuary Hotel Reviews

Parmer's Resort

Looe Key Reef Resort

Deep/Wide/Flow-Though Canal, 1st Canal From Open Water, No Hwy 1 Road Noise

Beautiful 2/2 Waterfront Designer Home for your family vacation

Beachfront 3B/3B Fishing Oasis

Treehouse Private Village Barnacle Resort

Keys To The Kingdom! Private Oceanfront Retreat with Beach and Pool

Star Room Barnacle Resort

Gorgeous Beachfront Home with a pool. Water views from every direction.

Hotels near other Looe Key National Marine Sanctuary attractions

Munson Island

Big Munson Island

Newfound Harbor Keys

Hopkins Island

Cook Island

Pye Key

Coupon Bight Aquatic Preserve

Frequently asked questions

Explore a world of travel with Expedia

Search Hotels Near Looe Key National Marine Sanctuary,

Change your mind

Treat yourself

Be picky

Check prices for these dates

Filter by

Our top choices for Looe Key National Marine Sanctuary hotels

Parmer's Resort

Looe Key Reef Resort

Old Wooden Bridge Resort and Marina

Sugar Loaf Lodge

Top Looe Key National Marine Sanctuary Hotel Reviews

Parmer's Resort

Hotels near other Looe Key National Marine Sanctuary attractions

Munson Island

Frequently asked questions

Explore a world of travel with Expedia