Title: The Best Hotels Closest to Looe Key National Marine Sanctuary in - 2026 Updated Prices | Expedia.co.uk [United States of America Travel Guide](https://expedia.co.uk/United-States-Of-America.dx201)[Holiday Rentals in United States of America](https://expedia.co.uk/Destinations-In-United-States-Of-America.d201.Holiday-Rental-Destinations)[Flights to United States of America](https://expedia.co.uk/Destinations-In-United-States-Of-America.d201.Flight-Destinations)[Looe Key National Marine Sanctuary Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Looe-Key-National-Marine-Sanctuary.d553248621533115813.Car-Hire-Guide)[Looe Key National Marine Sanctuary Holidays](https://expedia.co.uk/Looe-Key-National-Marine-Sanctuary-United-States-Of-America.d553248621533115813.Attraction) ![Default HTG hotel image](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://a.travel-assets.com/travel-assets-manager/fallback-images-brand/bex_lodging_v2.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [17 Feb - 18 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248621533115813&startDate=2026-02-17&endDate=2026-02-18&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [18 Feb - 19 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248621533115813&startDate=2026-02-18&endDate=2026-02-19&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [20 Feb - 22 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248621533115813&startDate=2026-02-20&endDate=2026-02-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [27 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=553248621533115813&startDate=2026-02-27&endDate=2026-03-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Recommended Price (low to high) Distance Property class ## Our top choices for Looe Key National Marine Sanctuary hotels ![Flat-screen TV](https://images.trvl-media.com/lodging/91000000/90990000/90989500/90989471/048a25f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/91000000/90990000/90989500/90989471/w6000h3995x0y5-7c6df35f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Flat-screen TV](https://images.trvl-media.com/lodging/91000000/90990000/90989500/90989471/bd29cb67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Treehouse | Terrace/patio](https://images.trvl-media.com/lodging/91000000/90990000/90989500/90989471/ede4faf4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Barnacle Resort [](https://www.expedia.co.uk/Big-Pine-Key-Hotels-Barnacle-Bed-And-Breakfast.h90989471.Hotel-Information) 7 mi from Looe Key National Marine Sanctuary 8.2/10 Very good (43 reviews) "Perfect place for a quiet getaway." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David [](https://www.expedia.co.uk/Big-Pine-Key-Hotels-Barnacle-Bed-And-Breakfast.h90989471.Hotel-Information) ![1 Bedroom Aqualodge # 6 Tarpon | Living area | Flat-screen TV](https://images.trvl-media.com/lodging/18000000/17110000/17102400/17102343/dee083de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/18000000/17110000/17102400/17102343/cbb89b9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 Bedroom Aqua Lodge # 13 Barracuda | Living area | Flat-screen TV](https://images.trvl-media.com/lodging/18000000/17110000/17102400/17102343/92962431.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/18000000/17110000/17102400/17102343/2ece49e6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Old Wooden Bridge Resort and Marina [](https://www.expedia.co.uk/Big-Pine-Key-Hotels-Old-Wooden-Bridge-Marina.h17102343.Hotel-Information) 10.9 mi from Looe Key National Marine Sanctuary 8.6/10 Excellent (302 reviews) "Great stay in Bug Pine Key! Clean and spacious room, excellent staff and Beautiful views!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Peter £282 includes taxes & fees 19 Mar - 20 Mar [](https://www.expedia.co.uk/Big-Pine-Key-Hotels-Old-Wooden-Bridge-Marina.h17102343.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/4000000/3920000/3918200/3918121/8ae32688.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property grounds](https://images.trvl-media.com/lodging/4000000/3920000/3918200/3918121/125c52d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/4000000/3920000/3918200/3918121/95d2903e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/4000000/3920000/3918200/3918121/fe329a14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sugar Loaf Lodge [](https://www.expedia.co.uk/Sugarloaf-Key-Hotels-Sugar-Loaf-Lodge.h3918121.Hotel-Information) 12.1 mi from Looe Key National Marine Sanctuary 8.2/10 Very good (1,006 reviews) "Clean, convenient location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Michael £246 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/Sugarloaf-Key-Hotels-Sugar-Loaf-Lodge.h3918121.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-03&endDate=2026-03-04®ionId=553248621533115813&adults=2&sort=RECOMMENDED&openPlayBack=true) ## Top Looe Key National Marine Sanctuary Hotel Reviews ![Parmer's Resort](https://images.trvl-media.com/lodging/6000000/5570000/5561500/5561465/6492712a_y.jpg) ### Parmer's Resort 10/10 Excellent "Super nice staff and the property is cute, clean and within walking distances." [](https://expedia.co.uk/Little-Torch-Key-Hotels-Parmers-Resort.h5561465.Hotel-Information) ![Looe Key Reef Resort](https://images.trvl-media.com/lodging/5000000/4760000/4759500/4759500/63d12f01_y.jpg) ### Looe Key Reef Resort 10/10 Excellent "Great place ! Friendly staff " [](https://expedia.co.uk/Ramrod-Key-Hotels-Looe-Key-Reef-Resort.h4759500.Hotel-Information) ![Deep/Wide/Flow-Though Canal, 1st Canal From Open Water, No Hwy 1 Road Noise](https://images.trvl-media.com/lodging/30000000/29940000/29935200/29935101/f156629a_y.jpg) ### Deep/Wide/Flow-Though Canal, 1st Canal From Open Water, No Hwy 1 Road Noise 10/10 Excellent "The host was very accommodating. There’s one small glitch with the blender and it was replaced immediately. For the price we paid is a great value." [](https://expedia.co.uk/Summerland-Key-Hotels-DeepWideFlow-Though-Canal.h29935101.Hotel-Information) ![Barnacle Resort](https://images.trvl-media.com/lodging/91000000/90990000/90989500/90989471/048a25f3_y.jpg) ### Barnacle Resort 10/10 Excellent "The room was beautiful; very clean and spacious. The property was in an excellent location, tucked away on a private beach and the key deer were adorable. It was an easy drive to both Marathon and Key West. Would definitely stay here again. " [](https://expedia.co.uk/Big-Pine-Key-Hotels-Barnacle-Bed-And-Breakfast.h90989471.Hotel-Information) ![Star Room Barnacle Resort](https://images.trvl-media.com/lodging/112000000/111160000/111152500/111152457/9bf80e17_y.jpg) ### Star Room Barnacle Resort 10/10 Excellent "This is a very special place. You pay for the tranquility and the peace. You have a private beach all to yourself. And the deer are super friendly (yes). A great plus is you can BBQ on the beach yourself. Please fix the big fridge and make more kitchen utensils and plates and glasses available. That would make it even more positive. I would come back. " [](https://expedia.co.uk/Big-Pine-Key-Hotels-Star-Room-Barnacle-Bnb.h111152457.Hotel-Information) ![Gorgeous Beachfront Home with a pool. Water views from every direction.](https://images.trvl-media.com/lodging/37000000/36320000/36314300/36314286/d96b30e5_y.jpg) ### Gorgeous Beachfront Home with a pool. Water views from every direction. 10/10 Excellent "Our family really enjoyed our stay at this beautiful home. Amazing views from every room. The deck sitting areas were screen in and very comfortable. We all enjoyed sitting on the deck looking at the ocean and seeing the Key Deer pass by. The deer brought so much joy to our grandchildren! John and the property managerwere very accommodating during our stay. Thank you for a wonderful vacation!" [](https://expedia.co.uk/Big-Pine-Key-Hotels-As-Seen-On-BEACH-HUNTERS-Sn7-Ep5-Feel-Like-You-Are-On-Your-Own-Private-Island.h36314286.Hotel-Information) ![One of the very few beach houses with a daily, rental license in the Keys.](https://images.trvl-media.com/lodging/39000000/38420000/38413600/38413504/ccc6991c_y.jpg) ### One of the very few beach houses with a daily, rental license in the Keys. 10/10 Excellent "If you are looking to see spectacular sunrises in the Keys, this location is great. Kitchen is well stocked with everything you need. " [](https://expedia.co.uk/Summerland-Key-Hotels-Acreage-Beach-House-W-Pool-Billiards.h38413504.Hotel-Information) ![Florida keys Waterfront,Forever Summer](https://images.trvl-media.com/lodging/61000000/60280000/60277700/60277645/0ac065ce_y.jpg) ### Florida keys Waterfront,Forever Summer 10/10 Excellent "We had a great time. Everything was what we were told. Michael was a great host." [](https://expedia.co.uk/Summerland-Key-Hotels-Forever-Summer.h60277645.Hotel-Information) ![Keys On Jamaica: 3BR Waterfront Home, Large Corner Lot on Ramrod Key, Convenient to Atlantic & Gulf!](https://images.trvl-media.com/lodging/106000000/105440000/105435500/105435445/c1d1798c_y.jpg) ### Keys On Jamaica: 3BR Waterfront Home, Large Corner Lot on Ramrod Key, Convenient to Atlantic & Gulf! 8/10 Good "The house was nice and comfortable. The spiral staircase to the beds upstairs is very narrow, designed for young children or very petite adults. Parking was also very tight in the fenced in area and your boat trailer has to be backed in for the length of Jamaica Lane. " [](https://expedia.co.uk/Summerland-Key-Hotels-Keys-On-Jamaica-3BR-Waterfront-Home.h105435445.Hotel-Information) ## Hotels near other Looe Key National Marine Sanctuary attractions ### Munson Island Commune with nature and explore the great outdoors at Munson Island during your travels in Big Pine Key. While you're in the area, stroll along the beaches. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=874556621345521664) ### Big Munson Island Commune with nature and explore the great outdoors at Big Munson Island during your travels in Big Pine Key. While you're in the area, stroll along the beaches. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=874555262665744384) ### Newfound Harbor Keys Commune with nature and explore the great outdoors at Newfound Harbor Keys during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=874556615670603776) ### Hopkins Island Commune with nature and explore the great outdoors at Hopkins Island during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=874555017892454400) ### Cook Island Commune with nature and explore the great outdoors at Cook Island during your travels in Big Pine Key. While you're in the area, wander around the natural setting. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=553248635976197877) ### Pye Key Commune with nature and explore the great outdoors at Pye Key during your travels in Summerland Key. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=874555935142699008) ### Coupon Bight Aquatic Preserve Commune with nature and explore the great outdoors at Coupon Bight Aquatic Preserve during your travels in Big Pine Key. While in this relaxing area, you can enjoy the restaurants. [See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests®ionId=6177699) ## Frequently asked questions ### What's the area like around Looe Key National Marine Sanctuary? ### What's the best hotel to stay close to Looe Key National Marine Sanctuary? ### If I need to cancel the hotel reservation for my stay near Looe Key National Marine Sanctuary, will I receive a refund? ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - [Bahia Honda Key Hotels ](https://www.expedia.co.uk/Bahia-Honda-Key-Hotels.d553248635083902001.Travel-Guide-Hotels) - [Bay Point Hotels ](https://www.expedia.co.uk/Bay-Point-Hotels.d553248635976383913.Travel-Guide-Hotels) - [Big Coppitt Key Hotels ](https://www.expedia.co.uk/Big-Coppitt-Key-Hotels.d553248635975850102.Travel-Guide-Hotels) - [Cheap Hotels in Big Pine Key ](https://www.expedia.co.uk/Big-Pine-Key-Hotels-Budget-Hotels.0-0-d7195-tBudgetHotels.Travel-Guide-Filter-Hotels) - 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