Title: Top Hotels in Mississippi County - Compare Mississippi County Hotels | Expedia.co.uk

[Holiday Rentals in Mississippi County](https://expedia.co.uk/Destinations-In-Mississippi-County.d553248635976432410.Holiday-Rental-Destinations)[Mississippi County Car Hire](https://expedia.co.uk/Destinations-In-Mississippi-County.d553248635976432410.Car-Hire-Destinations)[Mississippi County Holidays](https://expedia.co.uk/Mississippi-County.d553248635976432410.Holidays-City-Breaks)

![MAY 17 2019, HERMANN MISSOURI USA - The Hermann Bridge was a cantilevered truss bridge over the Missouri River at Hermann, Missouri between Gasconade and Montgomery County](https://images.trvl-media.com/place/553248635976432410/2a0290c4-0f21-4601-a6ec-0bb9d391debf.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find the best Mississippi County Hotels

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## Go beyond your typical stay in Mississippi County

Pool

[](https://www.expedia.co.uk/Hotel-Search?destination=Mississippi+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976432410&latLong=36.828087%2C-89.291149&adults=2&startDate=2025-12-20&d1=2025-12-20&endDate=2025-12-22&d2=2025-12-22&amenities=POOL)

Family friendly

[](https://www.expedia.co.uk/Hotel-Search?destination=Mississippi+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976432410&latLong=36.828087%2C-89.291149&adults=2&startDate=2025-12-20&d1=2025-12-20&endDate=2025-12-22&d2=2025-12-22&travelerType=family_friendly)

Pet friendly

[](https://www.expedia.co.uk/Hotel-Search?destination=Mississippi+County%2C+Missouri%2C+United+States+of+America&regionId=553248635976432410&latLong=36.828087%2C-89.291149&adults=2&startDate=2025-12-20&d1=2025-12-20&endDate=2025-12-22&d2=2025-12-22&amenities=PETS)

## Check prices for these dates

Tonight

[6 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976432410&startDate=2025-12-06&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[7 Dec - 8 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976432410&startDate=2025-12-07&endDate=2025-12-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[12 Dec - 14 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976432410&startDate=2025-12-12&endDate=2025-12-14&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

In two weeks

[19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976432410&startDate=2025-12-19&endDate=2025-12-21&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top Hotels Mississippi County

![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/1ca277a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

6.6/10

(611)

"Staff was great! Room was nice. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lana

£57

includes taxes & fees

7 Dec - 8 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/d2862bfb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/94d9e92f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/fa992d12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/20600/20594/cde4423c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Charleston - Sikeston

Charleston

6.8/10

(406)

"The staff was very friendly and accommodating "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Arturo

£53

includes taxes & fees

13 Dec - 14 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Quality-Inn-Charleston-I-57.h20594.Hotel-Information)

![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hair dryer, towels](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/2b61a8ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property entrance](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/ec6ce079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Coffee service](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/e769dedb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Eagle Inn Charleston

Charleston

6.8/10

(103)

"Middle of nowhere hotel was ok"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

David

£50

includes taxes & fees

10 Dec - 11 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Double Beds, Accessible, Non Smoking | Iron/ironing board, free cots/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/0feda7c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/c71a6d1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking | Iron/ironing board, free cots/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Cairo I-57

Cairo

6.6/10

(272)

"Break fast was excellent "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Uma

£58

includes taxes & fees

27 Dec - 28 Dec

[](https://www.expedia.co.uk/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/8a1aff87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/6520deeb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/a250fc1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/88161c16.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Charming 3-bedroom house near ball park in quiet neighborhood

Bardwell

10/10

Exceptional

(11)

"Quaint stay to see Grand and kids. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Sheila C.

£123

includes taxes & fees

17 Dec - 18 Dec

[](https://www.expedia.co.uk/Bardwell-Hotels-Charming-3-Bedroom-House-Near-Ball-Park-In-Quiet-Neighborhood.h106623184.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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## Top Mississippi County Hotel Reviews

![Cozy cabins on beautiful Horseshoe Lake](https://images.trvl-media.com/lodging/91000000/90340000/90331200/90331191/53db6388_y.jpg)

### Cozy cabins on beautiful Horseshoe Lake

10/10 Excellent

"The cabin was great"

[](https://expedia.co.uk/Cozy-Cabins-On-Beautiful-Horseshoe-Lake.h90331191.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg)

### Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"Very nice room with a separate room for relaxing and watching TV. Generous breakfast bar and very nice staff. I plan on staying again next month."

[](https://expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Clean big room, great staff"

[](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Nice quiet night"

[](https://expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent

"The room was extremely clean, it was quiet, front desk was friendly. Would definitely stay here again! Very good experience!"

[](https://expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Pear Tree Inn Sikeston](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg)

### Pear Tree Inn Sikeston

10/10 Excellent

"Check-in took only a few minutes and staff was courteous and efficient. All was explained clearly and efficiently. Room was clean and well maintained. I did not take part in the 5:30 pm event or attend breakfact, so I cannot comment on these amenities. Everything else was wonderful."

[](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/cffe72cf_y.jpg)

### Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent

"Extremely clean, and it looks to be updated in the more recent years. Large workout room that looks into the pool. Hot and tasty breakfast. "

[](https://expedia.co.uk/Sikeston-Hotels-Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39_y.jpg)

### Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent

"Thank you "

[](https://expedia.co.uk/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![ For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.](https://images.trvl-media.com/lodging/35000000/34330000/34322400/34322352/537131b5_y.jpg)

###  For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

10/10 Excellent

"Cypress Knee Lodge was a great gathering place for our hiking group. After nearly 20 years we don't hike much anymore, we are more of a card playing group now! We enjoyed the space, the views, the location, and the accommodations in general. All of this prove to be important because it rained every day we were at Reelfoot Lake. Watching hundreds of pelicans, cormorants, coots, and various other ducks was an added bonus! We would definitely stay here again. Thanks, Jim!"

[](https://expedia.co.uk/Hornbeak-Hotels-For-Larger-Groups-Right-On-Reelfoot-Lake-Private-Dock-And-Pier.h34322352.Hotel-Information)

## Explore a world of travel with Expedia

- Explore a world of travel with Expedia

### Top cities in Mississippi County

- [Charleston Hotels ](https://expedia.co.uk/Charleston-Hotels.d7182.Travel-Guide-Hotels)
- [East Prairie Hotels ](https://expedia.co.uk/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)
- [Bertrand Hotels ](https://expedia.co.uk/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels)
- [Wyatt Hotels ](https://expedia.co.uk/Wyatt-Hotels.d553248634983534991.Travel-Guide-Hotels)
- [Anniston Hotels ](https://expedia.co.uk/Anniston-Hotels.d553248634983588922.Travel-Guide-Hotels)

### Hotels near popular Attractions

- [Hotels near Mississippi River ](https://expedia.co.uk/Mississippi-River-Hotels.0-l6209928-0.Travel-Guide-Filter-Hotels)
- [Hotels near Shawnee National Forest ](https://expedia.co.uk/Shawnee-National-Forest-Hotels.0-l553248635944113522-0.Travel-Guide-Filter-Hotels)
- [Hotels near Ohio River Valley ](https://expedia.co.uk/Ohio-River-Valley-Hotels.0-l6233674-0.Travel-Guide-Filter-Hotels)

### Explore more hotels

- [Super 8 by Wyndham Charleston/Sikeston East MO ](https://expedia.co.uk/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)
- [Drury Inn & Suites Sikeston, MO ](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)
- [Hampton Inn Sikeston ](https://expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)
- [Days Inn and Suites by Wyndham Sikeston ](https://expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)
- [Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) ](https://expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)
- [Pear Tree Inn Sikeston ](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

[See a list of all hotels in Mississippi County](https://expedia.co.uk/All-Mississippi-County-Hotels.d553248635976432410.Travel-Guide-City-All-Hotels)

### More ways to book

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General

- [Visit North Slope Borough](https://expedia.co.uk/North-Slope-Borough.dx6228899)
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- [Visit Cumbria](https://expedia.co.uk/Cumbria.dx6046194)

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