A bridge over a muddy river with green trees and hills in the background.

Find the best Mississippi County Hotels

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Mississippi County Accommodation: Most Popular Cities to Stay

A sunset over a calm lake with tall trees reflected in the water.
HotelsHotels

Charleston

Charleston
A tree-lined landscape with a river and fields.
HotelsHotels

East Prairie

East Prairie

Check prices for these dates

Next weekend
18 Sept - 20 Sept
In two weeks
25 Sept - 27 Sept

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Our top choices for Mississippi County hotels

Room

1. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (667 reviews)
"Canceled"
United States
Crystal
The price is £49
includes taxes & fees
14 Sept - 15 Sept
Super 8 by Wyndham Charleston/Sikeston East MO
Exterior

2. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (432 reviews)
"Everything was fine for a one night stay."
United States
Jay
The price is £55
includes taxes & fees
15 Sept - 16 Sept
The Riverstone Hotel Charleston-Sikeston
Room, 1 King Bed, Non Smoking | View from room

3. Eagle Inn Charleston

Eagle Inn Charleston
2.0 star property
Charleston
6.6 out of 10, (107 reviews)
"Great"
United States
Jackson
The price is £63
includes taxes & fees
14 Sept - 15 Sept
Eagle Inn Charleston
Lobby

4. Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (295 reviews)
"Good service,nice stuff and no complaints"
United States
Santiago
The price is £57
includes taxes & fees
2 Oct - 3 Oct
Quality Inn Cairo I-57
Room

5. The Roost | Hot Tub, Ponds & Farm Views

The Roost | Hot Tub, Ponds & Farm Views
Carlisle County
The price is £157
includes taxes & fees
14 Sept - 15 Sept
The Roost | Hot Tub, Ponds & Farm Views
Property grounds

6. Perfect Couples Retreat - firepit

Perfect Couples Retreat - firepit
Carlisle County
The price is £141
includes taxes & fees
14 Sept - 15 Sept
Perfect Couples Retreat - firepit
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Mississippi County Hotel Reviews

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good
"Clean room. The front desk was very kind and helpful."
Mercedes 3-night trip
Posted 2 days ago
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

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