Title: Top Hotels in Mississippi County - Compare Mississippi County Hotels | Expedia.co.uk [Holiday Rentals in Mississippi County](https://expedia.co.uk/Destinations-In-Mississippi-County.d553248635976432410.Holiday-Rental-Destinations)[Mississippi County Car Hire](https://expedia.co.uk/Destinations-In-Mississippi-County.d553248635976432410.Car-Hire-Destinations)[Mississippi County Holidays](https://expedia.co.uk/Mississippi-County.d553248635976432410.Holidays-City-Breaks) ![MAY 17 2019, HERMANN MISSOURI USA - The Hermann Bridge was a cantilevered truss bridge over the Missouri River at Hermann, Missouri between Gasconade and Montgomery County](https://images.trvl-media.com/place/553248635976432410/2a0290c4-0f21-4601-a6ec-0bb9d391debf.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/553248635976432410/2a0290c4-0f21-4601-a6ec-0bb9d391debf.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check prices for these dates Tonight [21 Jan - 22 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976432410&startDate=2026-01-21&endDate=2026-01-22&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [22 Jan - 23 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976432410&startDate=2026-01-22&endDate=2026-01-23&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [23 Jan - 25 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976432410&startDate=2026-01-23&endDate=2026-01-25&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [30 Jan - 1 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976432410&startDate=2026-01-30&endDate=2026-02-01&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Mississippi County hotels ![Laptop workspace, blackout curtains, free cots/infant beds, free WiFi](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/679acee6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Super 8 by Wyndham Charleston/Sikeston East MO [](https://www.expedia.co.uk/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) Charleston 6.8/10 (622 reviews) "Affordable for a quick one night stay. Restaurant and gas station next to hotel." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Annette £51 includes taxes & fees 24 Jan - 25 Jan [](https://www.expedia.co.uk/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ![Room, 1 King Bed, Non Smoking | View from room](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/183a17d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/ec6ce079.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Desk, iron/ironing board, free WiFi, alarm clocks](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/228b486a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Coffee service](https://images.trvl-media.com/lodging/5000000/4490000/4480300/4480270/8720ff7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Eagle Inn Charleston [](https://www.expedia.co.uk/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) Charleston 6.6/10 (105 reviews) "Middle of nowhere hotel was ok" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David £50 includes taxes & fees 26 Jan - 27 Jan [](https://www.expedia.co.uk/Sikeston-Hotels-Eagle-Inn-Charleston.h4480270.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/74187a0b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Standard Room, 1 King Bed, Non Smoking | Iron/ironing board, free cots/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Quality Inn Cairo I-57 [](https://www.expedia.co.uk/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) Cairo 6.6/10 (275 reviews) "The quality was not what I expected for a "Quality Inn". It felt more light a Motel 6\. I was not satisfied at all." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) ReShena £59 includes taxes & fees 31 Jan - 1 Feb [](https://www.expedia.co.uk/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information) ![TV, DVD player](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/88c653dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Fridge, microwave, oven, stovetop](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/8a1aff87.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![3 bedrooms, iron/ironing board, WiFi, bed sheets](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/a250fc1c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor dining](https://images.trvl-media.com/lodging/107000000/106630000/106623200/106623184/e22587fb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Charming 3-bedroom house near ball park in quiet neighborhood [](https://www.expedia.co.uk/Bardwell-Hotels-Charming-3-Bedroom-House-Near-Ball-Park-In-Quiet-Neighborhood.h106623184.Hotel-Information) Bardwell 10/10 Exceptional (14 reviews) "Quaint stay to see Grand and kids. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sheila C. [](https://www.expedia.co.uk/Bardwell-Hotels-Charming-3-Bedroom-House-Near-Ball-Park-In-Quiet-Neighborhood.h106623184.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-04&endDate=2026-02-05®ionId=553248635976432410&adults=2&sort=RECOMMENDED&openPlayBack=true) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FDestinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations) ## Top Mississippi County Hotel Reviews ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg) ### Drury Inn & Suites Sikeston, MO 10/10 Excellent "As always it was a perfect visit" [](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) ![Pear Tree Inn Sikeston](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg) ### Pear Tree Inn Sikeston 10/10 Excellent "Very welcoming staff. Nice room for the money plus 3 free drinks per guest and breakfast!" [](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg) ### Hampton Inn Sikeston 10/10 Excellent "The room was very clean and nicely appointed. The continental breakfast was good with hot food items and hard boiled eggs, oatmeal, fruit, etc. Price was reasonable. " [](https://expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) ![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg) ### Days Inn and Suites by Wyndham Sikeston 10/10 Excellent "It was nice a hotel have to come back sometime " [](https://expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) ![Great location just across the street from Reelfoot Lake close to boat ramps](https://images.trvl-media.com/lodging/90000000/89880000/89872800/89872735/96df576d_y.jpg) ### Great location just across the street from Reelfoot Lake close to boat ramps 10/10 Excellent "We had a wonderful time! The house is very comfortable, and we loved the proximity to the lake. We saw so many bald eagles! " [](https://expedia.co.uk/Hornbeak-Hotels-Great-Location-Just-Across-The-Street-From-Reelfoot-Lake-Close-To-Boat-Ramps.h89872735.Hotel-Information) ![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/cffe72cf_y.jpg) ### Fairfield Inn & Suites by Marriott Sikeston 10/10 Excellent "Staff promptly fixed a problem, room smelled very clean." [](https://expedia.co.uk/Sikeston-Hotels-Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 10/10 Excellent "Nice man and good hotel" [](https://expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) ![Reelfoot Lake Inn](https://images.trvl-media.com/lodging/17000000/16770000/16770000/16769945/755237c5_y.jpg) ### Reelfoot Lake Inn 10/10 Excellent "Homegate Inn is an older property and there is some noticeable wear and tear on the exterior. My room appears to have been updated recently with new bedding and furniture. Had a nice tv with tons of channels. Heat and air worked very well. Plenty of hot water. Room was very clean and comfortable. Nice desk and chair, tv, large fridge with freezer, coffee maker, dresser, large closet. Bath was clean and nice. Check-in was fast and easy. Owner and staff were friendly and attentive. Reelfoot Lake is directly across the street and is a beautiful area. Dining, gas, shopping is closeby, though it is a small town. This was my second stay and I will stay again, I'm sure. " [](https://expedia.co.uk/Union-City-Hotels-Reelfoot-Lake-Inn.h16769945.Hotel-Information) ![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39_y.jpg) ### Super 8 by Wyndham Charleston/Sikeston East MO 10/10 Excellent "Thank you " [](https://expedia.co.uk/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) ## Explore a world of travel with Expedia - Explore a world of travel with Expedia ### Top cities in Mississippi County - [Charleston Hotels ](https://expedia.co.uk/Charleston-Hotels.d7182.Travel-Guide-Hotels) - [East Prairie Hotels ](https://expedia.co.uk/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels) - [Bertrand Hotels ](https://expedia.co.uk/Bertrand-Hotels.d3000349285.Travel-Guide-Hotels) - [Wyatt Hotels ](https://expedia.co.uk/Wyatt-Hotels.d553248634983534991.Travel-Guide-Hotels) - [Anniston Hotels ](https://expedia.co.uk/Anniston-Hotels.d553248634983588922.Travel-Guide-Hotels) ### Hotels near popular Attractions - [Hotels near Mississippi River ](https://expedia.co.uk/Mississippi-River-Hotels.0-l6209928-0.Travel-Guide-Filter-Hotels) - [Hotels near Shawnee National Forest ](https://expedia.co.uk/Shawnee-National-Forest-Hotels.0-l553248635944113522-0.Travel-Guide-Filter-Hotels) - [Hotels near Ohio River Valley ](https://expedia.co.uk/Ohio-River-Valley-Hotels.0-l6233674-0.Travel-Guide-Filter-Hotels) ### Explore more hotels - [Super 8 by Wyndham Charleston/Sikeston East MO ](https://expedia.co.uk/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information) - [Drury Inn & Suites Sikeston, MO ](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information) - [Hampton Inn Sikeston ](https://expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information) - [Days Inn and Suites by Wyndham Sikeston ](https://expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information) - [Pear Tree Inn Sikeston ](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information) - [Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) ](https://expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information) [See a list of all hotels in Mississippi County](https://expedia.co.uk/All-Mississippi-County-Hotels.d553248635976432410.Travel-Guide-City-All-Hotels) ### More ways to book - [Book Hotels in Mississippi County on Expedia.com ](https://www.expedia.com/Destinations-In-Mississippi-County.d553248635976432410.Hotel-Destinations) ### Expedia's Latest Trends Hotels - [Hotels near Hollywood Casino Amphitheatre](https://expedia.co.uk/Hollywood-Casino-Amphitheatre-Hotels.0-l6174066-0.Travel-Guide-Filter-Hotels) - [Hotels in Orange County](https://expedia.co.uk/Destinations-In-Orange-County.d603224.Hotel-Destinations) - [All-Inclusive Hotels in San Diego County](https://expedia.co.uk/Destinations-In-San-Diego-County-All-Inclusive-Hotel.0-0-d178304-tAllInclusiveHotel.Hotel-Filter-Destinations) - [Hotels in Lakeview](https://expedia.co.uk/Lakeview-Hotels.d183478.Travel-Guide-Hotels) - 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[Flights to Orange County](https://expedia.co.uk/Destinations-In-Orange-County.d603224.Flight-Destinations) - [Flights to Norfolk County](https://expedia.co.uk/Destinations-In-Norfolk-County.d553248635976433043.Flight-Destinations) Cars - [convertible Car Hire near Route 66 State Park](https://expedia.co.uk/Convertible-Car-Rentals-In-Route-66-State-Park.d6292976-tConvertible.Car-Rental-Guide-Class) - [Car hire in Kansas City](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Kansas-City-Intl.d4801357.Car-Hire-Guide) - [convertible Car Hire in San Diego County](https://expedia.co.uk/Convertible-Car-Rentals-In-San-Diego-County.d178304-tConvertible.Car-Rental-Destination-Class) Activities - [Things to do in San Diego County](https://expedia.co.uk/Things-To-Do-In-San-Diego-County.d178304.Travel-Guide-Activities) - [Things to do in Orange County](https://expedia.co.uk/Things-To-Do-In-Orange-County.d603224.Travel-Guide-Activities) Packages - [Orange County Holidays](https://expedia.co.uk/Orange-County.d603224.Holidays-City-Breaks) - [Magic House - St. Louis Children's Museum](https://expedia.co.uk/Magic-House-St-Louis-Childrens-Museum-St-Louis.d6191631.Attraction) - [St. Charles Holidays](https://expedia.co.uk/St-Charles.d9786.Holidays-City-Breaks) - [Silver Dollar City](https://expedia.co.uk/Silver-Dollar-City-Branson-West.d6064111.Attraction) - [Vaile Mansion](https://expedia.co.uk/Vaile-Mansion-Kansas-City.d6323538.Attraction) - [San Diego County Holidays](https://expedia.co.uk/San-Diego-County.d178304.Holidays-City-Breaks) General - [Visit North Slope Borough](https://expedia.co.uk/North-Slope-Borough.dx6228899) - [Visit Downtown Kansas City](https://expedia.co.uk/Kansas-City-Downtown-Kansas-City.dx6058828) - [Visit Suffolk County](https://expedia.co.uk/Suffolk-County.dx553248635083916458) - [Visit Los Angeles County](https://expedia.co.uk/Los-Angeles-County.dx6056560) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. 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