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Check prices for these dates

Tonight
27 Feb - 28 Feb
Tomorrow
28 Feb - 1 Mar
This weekend
27 Feb - 1 Mar
Next weekend
6 Mar - 8 Mar

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Our top choices for East Prairie hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,001 reviews)
"As always it was a perfect visit"
United States
John
The price is £80
includes taxes & fees
8 Mar - 9 Mar
Drury Inn & Suites Sikeston, MO
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (485 reviews)
"Very Clean room, friendly staff, breakfast in the morning. Will be staying again! "
United States
Affinity
The price is £80
includes taxes & fees
7 Mar - 8 Mar
Hampton Inn Sikeston
Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.2 out of 10, Very good, (50 reviews)
"Room clean bed comfortable, breakfast simple but good."
United States
James
The price is £56
includes taxes & fees
2 Mar - 3 Mar
Super 8 By Wyndham Marston
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (60 reviews)
"Clean rooms great staff"
United States
IRA
The price is £84
includes taxes & fees
5 Mar - 6 Mar
Fairfield Inn & Suites by Marriott Sikeston
Free daily continental breakfast

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (447 reviews)
"Stay was excellent "
United States
Kourtney
The price is £73
includes taxes & fees
1 Mar - 2 Mar
Holiday Inn Express & Suites Sikeston Southwest by IHG
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (746 reviews)
"Parking was good, staff was great "
United States
Corey
New Orleans Inn Portageville
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (554 reviews)
"Very clean nice staff and well run "
United States
zach
The price is £63
includes taxes & fees
1 Mar - 2 Mar
Country Hearth Inn & Suites Union City
Exterior

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (408 reviews)
"The staff was very friendly and accommodating "
United States
Arturo
The price is £57
includes taxes & fees
28 Feb - 1 Mar
The Riverstone Hotel Charleston-Sikeston
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (625 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is £51
includes taxes & fees
5 Mar - 6 Mar
Super 8 by Wyndham Charleston/Sikeston East MO
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (353 reviews)
"The rooms are big and the property is spotless!"
United States
debbie
The price is £63
includes taxes & fees
29 Mar - 30 Mar
Sleep Inn at Discovery Park of America
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (282 reviews)
"The quality was not what I expected for a "Quality Inn". It felt more light a Motel 6. I was not satisfied at all."
United States
ReShena
The price is £56
includes taxes & fees
6 Mar - 7 Mar
Quality Inn Cairo I-57
Terrace/patio

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (172 reviews)
"Spotless , friendly staff."
United States
Gail
The price is £108
includes taxes & fees
7 Mar - 8 Mar
Hampton Inn Union City
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,006 reviews)
"Great stay, everything was clean and comfortable. "
United States
Charles
The price is £69
includes taxes & fees
26 Mar - 27 Mar
Best Western Plus Sikeston I-55
Individually decorated, individually furnished, desk, blackout curtains

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (742 reviews)
"Room was clean. Fairly quiet room. Front desk was kind. Would stay here again. ."
United States
Becky
The price is £55
includes taxes & fees
20 Mar - 21 Mar
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Exterior

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (313 reviews)
"The room was spacious & clean. The complimentary breakfast was nice. Very quiet place and next to a unique tourist attraction."
United States
Angela
The price is £90
includes taxes & fees
1 Mar - 2 Mar
Holiday Inn Express & Suites Union City by IHG
Desk, free WiFi, bed sheets, alarm clocks

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (287 reviews)
"The hotel was very clean, beds were comfortable, and staff was friendly and helpful."
United States
aileen
The price is £73
includes taxes & fees
5 Mar - 6 Mar
Comfort Inn & Suites Sikeston I-55
1 bedroom, desk, laptop workspace, blackout curtains

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,001 reviews)
"Everything was excellent"
United States
James
The price is £59
includes taxes & fees
2 Mar - 3 Mar
Days Inn and Suites by Wyndham Sikeston
Lobby

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (381 reviews)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is £48
includes taxes & fees
29 Mar - 30 Mar
Hospitality House Union City I 69 / US 51
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (597 reviews)
"Great place"
United States
Misty
The price is £52
includes taxes & fees
1 Mar - 2 Mar
Super 8 by Wyndham Sikeston/Miner Area
Property amenity

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (12 reviews)
"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."
United States
Jason
The price is £95
includes taxes & fees
8 Mar - 9 Mar
TownePlace Suites by Marriott Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

3.8/5 (8 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Yes"
Jacqueline 1-night trip
Posted 2 days ago
Drury Inn & Suites Sikeston, MO

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is £55 per night from 20 Mar to 21 Mar
£55
20 Mar - 21 Mar
includes taxes & fees
8.4/10 Very Good! (742 reviews)

Frequently asked questions

What is the best area to stay in East Prairie?
The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.

This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.

For travellers looking for a straightforward and practical base, staying near Main Street is ideal.
When is the best time to go to East Prairie?
The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.

These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.

For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How can I save on a East Prairie hotel booking with Expedia?
Members always get our best prices. Find our best East Prairie hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from £48 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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