Title: Hotels in East Prairie, MO - Best East Prairie Hotels from £45 - Fully Refundable Options - Expedia.co.uk

 

[Holiday Rentals in East Prairie](https://expedia.co.uk/East-Prairie-Holiday-Rentals.d3000349349.Travel-Guide-HolidayRentals)[East Prairie Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-East-Prairie.d3000349349.Car-Hire-Guide)[East Prairie Holidays](https://expedia.co.uk/East-Prairie.d3000349349.Holidays-City-Breaks)

![Bridge over Mississippi River, New Orleans in background](https://images.trvl-media.com/place/6209928/57ec11c5-0aa9-4b04-9ae1-c121ec0bef56.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

# Find hotels in East Prairie, MO from £45

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## Go beyond your typical stay in East Prairie

Pool

[](https://www.expedia.co.uk/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2025-12-12&d1=2025-12-12&endDate=2025-12-14&d2=2025-12-14&amenities=POOL)

Family friendly

[](https://www.expedia.co.uk/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2025-12-12&d1=2025-12-12&endDate=2025-12-14&d2=2025-12-14&travelerType=family_friendly)

Pet friendly

[](https://www.expedia.co.uk/Hotel-Search?destination=East+Prairie%2C+Missouri%2C+United+States+of+America&regionId=3000349349&latLong=36.779778%2C-89.38563&adults=2&startDate=2025-12-12&d1=2025-12-12&endDate=2025-12-14&d2=2025-12-14&amenities=PETS)

## Check prices for these dates

Tonight

[28 Nov - 29 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=3000349349&startDate=2025-11-28&endDate=2025-11-29&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[29 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=3000349349&startDate=2025-11-29&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[28 Nov - 30 Nov](https://www.expedia.co.uk/Hotel-Search?regionId=3000349349&startDate=2025-11-28&endDate=2025-11-30&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[5 Dec - 7 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=3000349349&startDate=2025-12-05&endDate=2025-12-07&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Top 10 East Prairie hotels and places to stay

![1 bedroom, desk, laptop workspace, blackout curtains](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/5e8a3e29.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/f00e1c0c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/8fe9a2cc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Days Inn and Suites by Wyndham Sikeston

Sikeston

7.2/10

Good

(1006)

"A great stay in every aspect. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Gertrude

£54

includes taxes & fees

7 Dec - 8 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/4abadc7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/686f0126.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/a8b491ae.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Sikeston

Sikeston

9.0/10

Wonderful

(436)

"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Doncheial

£81

includes taxes & fees

7 Dec - 8 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/3aa729da.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, open 8 AM to 11 PM, pool loungers](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/65f9cbe7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![1 bedroom, hypo-allergenic bedding, down duvets, desk](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/7dc8a5d6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Reception](https://images.trvl-media.com/lodging/9000000/8150000/8144200/8144106/58cb82c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Sikeston Southwest by IHG

Sikeston

8.6/10

Excellent

(440)

"Clean and nice facilities. All the staff we met were friendly and helpful. Breakfast was great."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Kristen

£81

includes taxes & fees

7 Dec - 8 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Holiday-Inn-Express-Suites-Sikeston-Southwest.h8144106.Hotel-Information)

![Free daily full breakfast ](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/13d95c8d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Laptop workspace, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/ed042ada.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/8874e729.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Best Western Plus Sikeston

Sikeston

8.4/10

Very good

(1005)

"Very convenient and great breakfast "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Duwaine

£64

includes taxes & fees

30 Nov - 1 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Hallway](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/c7be0f94.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily continental breakfast ](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/d5d0cfa0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![TV](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/e7b8b662.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Sikeston

8.4/10

Very good

(714)

"Stayed one night. Good rate for the Hotel "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Paul

£54

includes taxes & fees

7 Dec - 8 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/1ca277a1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/a5038447.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/bbf96e9f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Charleston/Sikeston East MO

Charleston

6.6/10

(610)

"Staff was great! Room was nice. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Lana

£45

includes taxes & fees

30 Nov - 1 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/57e73ffd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, iron/ironing board](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/bbc3b8f1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/6532f5b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Sleep Inn at Discovery Park of America

Union City

9.2/10

Wonderful

(306)

"Awesome room wonderful breakfast great staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Thomas

£72

includes taxes & fees

28 Dec - 29 Dec

[](https://www.expedia.co.uk/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/e3fbcab1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily breakfast ](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/8df39481.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/3c8c0a82.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Pear Tree Inn Sikeston

Sikeston

9.4/10

Exceptional

(1005)

"Everything was clean, staff was friendly "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Matthew

£67

includes taxes & fees

2 Dec - 3 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

![Seasonal outdoor pool](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/w1290h938x0y0-9734f59a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite, 1 King Bed, Non Smoking, Microwave | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/73298be5.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Banquet hall](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/3817bb3f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Junior Suite, 1 King Bed, Non Smoking, Microwave | Desk, iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/22000000/21830000/21826900/21826840/c064d51d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hospitality House Union City I 69 / US 51

Union City

6.8/10

(362)

"Easy to check in.. Clean Room..Lots of food options near by.. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Pooran

£49

includes taxes & fees

29 Dec - 30 Dec

[](https://www.expedia.co.uk/Union-City-Hotels-Hospitality-House.h21826840.Hotel-Information)

![Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/d9ee28fe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/715f35ea.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/dda7050d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/860000/855500/855478/cc9ac69a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Super 8 by Wyndham Sikeston/Miner Area

Sikeston

6.6/10

(561)

"The room was good a/c kept it cold "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mary

£50

includes taxes & fees

8 Dec - 9 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Super-8-By-Wyndham-SikestonMiner-Area.h855478.Hotel-Information)

![Property amenity](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool, outdoor pool](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/f737107e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/ea01e15a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Deluxe Room, 2 Queen Beds, Accessible, Refrigerator & Microwave (Tub) | Desk, blackout curtains, iron/ironing board, free cots/infant beds](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/0941dc05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Drury Inn & Suites Sikeston, MO

Sikeston

9.4/10

Exceptional

(1005)

"Clean room, great location and friendly staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Mark

£78

includes taxes & fees

2 Dec - 3 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/7736e60a.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free buffet breakfast ](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/aedf0c05.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Business centre](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/00c11afc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/1000000/20000/14600/14571/0cb56003.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Union City US 51

Union City

8.4/10

Very good

(482)

"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Walter

£63

includes taxes & fees

28 Dec - 29 Dec

[](https://www.expedia.co.uk/Union-City-Hotels-Quality-Inn-Union-City-US-51.h14571.Hotel-Information)

![Exterior](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/6afdbde2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Meeting facility](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/d534aac0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/5be64f6d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible, Non Smoking | Desk, free WiFi, bed sheets, alarm clocks](https://images.trvl-media.com/lodging/2000000/1810000/1804500/1804447/664c9838.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Comfort Inn & Suites Sikeston I-55

Sikeston

8.4/10

Very good

(280)

"Room was clean, breakfast was very good. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Connie

£72

includes taxes & fees

24 Dec - 25 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Comfort-Inn-Suites-Sikeston-I-55.h1804447.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/cffe72cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![View from property](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/7d2010d2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/27c728aa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/f2cf9c54.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Fairfield Inn & Suites by Marriott Sikeston

Sikeston

9.2/10

Wonderful

(37)

"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

AHMAD

£86

includes taxes & fees

4 Dec - 5 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Reception](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/d5184d02.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Iron/ironing board, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/e1bf04ad.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/7bc13d14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby lounge](https://images.trvl-media.com/lodging/1000000/970000/969900/969839/3fa32ded.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Country Hearth Inn & Suites Union City

Union City

8.6/10

Excellent

(547)

"Clean rooms, helpful and polite staff"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Jennifer

£65

includes taxes & fees

4 Dec - 5 Dec

[](https://www.expedia.co.uk/Union-City-Hotels-Country-Hearth-Inn-Suites-Union-City.h969839.Hotel-Information)

![Terrace/patio](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/f7d6d20c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/2c1de1a2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/6c3de37b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Room, 2 Queen Beds, Accessible, Bathtub (Mobility & Hearing) | Iron/ironing board, bed sheets](https://images.trvl-media.com/lodging/71000000/70820000/70814800/70814746/78e85b4b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Hampton Inn Union City

Union City

9.6/10

Exceptional

(161)

"Staff was very friendly, room was quiet, easy to get to. Room was clean and comfortable❤️"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Diana

£78

includes taxes & fees

26 Dec - 27 Dec

[](https://www.expedia.co.uk/Union-City-Hotels-Hampton-Inn-Union-City.h70814746.Hotel-Information)

![Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/2d9e6936.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Combined shower/bathtub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/1d8642af.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/06367e7f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Premier Room, 1 Bedroom, Non Smoking | Bathroom | Combined shower/bathtub, free toiletries, towels, soap](https://images.trvl-media.com/lodging/39000000/38980000/38979800/38979739/5fa7b845.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### New Orleans Inn Portageville

Portageville

8.0/10

Very good

(723)

"Quiet area and helpful staff. Glad we took a chance on this local hotel while traveling."

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Roger

[](https://www.expedia.co.uk/Hayti-Hotels-New-Orleans-Inn.h38979739.Hotel-Information)

![Free daily buffet breakfast ](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/c9703c12.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/2feca880.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/6140f4df.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/40000000/39580000/39579100/39579081/c970f53d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Holiday Inn Express & Suites Union City by IHG

Union City

9.2/10

Wonderful

(306)

"It was a great hotel! No complaints. Loved the front staff!"

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Felicia

£85

includes taxes & fees

19 Dec - 20 Dec

[](https://www.expedia.co.uk/Union-City-Hotels-Holiday-Inn-Express-Suites-Union-City.h39579081.Hotel-Information)

![Bar (on property)](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/0e9a77e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Exterior](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w4000h2662x0y0-82d0e62d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Property amenity](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/w3995h2667x0y0-6f8601de.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Indoor pool](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247452/fcfb42b9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### TownePlace Suites by Marriott Sikeston

Sikeston

9.0/10

Wonderful

(7)

"Great hotel! Very clean, quiet, plenty of amenities, pool was clean, breakfast in the morning was good with lots of options. I would definitely stay here again. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Scott

£97

includes taxes & fees

14 Dec - 15 Dec

[](https://www.expedia.co.uk/Sikeston-Hotels-Towneplace-Suites-By-Marriott-Sikeston.h111247452.Hotel-Information)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/9d3e181d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Standard Room, 1 King Bed, Non Smoking | Iron/ironing board, free cots/infant beds, free WiFi, bed sheets](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/e2b2c624.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Front of property – evening/night](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/c71a6d1d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21600/21513/f1c41457.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### Quality Inn Cairo I-57

Cairo

6.6/10

(272)

"Break fast was excellent "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Uma

£61

includes taxes & fees

5 Dec - 6 Dec

[](https://www.expedia.co.uk/Cairo-Hotels-Quality-Inn-Cairo-I-57.h21513.Hotel-Information)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

[View all properties](https://expedia.co.uk/Hotel-Search?startDate=2025-12-12&endDate=2025-12-13&regionId=3000349349&adults=2&sort=RECOMMENDED&openPlayBack=true)

![](https://forever.travel-assets.com/flex/flexmanager/images/2025/11/05/BEX-BF-25_FR-DE-MX-UK_1_Desktop.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh)

## 

Black Friday Sale

Save up to 40% on select hotels.

[Book now](https://expedia.co.uk/cheap-deals?rfrr=HTG_BF_PROMO_3000349349)

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Save an average of 15% on thousands of hotels when you're signed in

[Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2FEast-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)

## Stay near popular East Prairie attractions

[](https://www.expedia.co.uk/Big-Oak-Tree-State-Park-Hotels.0-l553248621532655754-0.Travel-Guide-Filter-Hotels)

### Big Oak Tree State Park

3.8/5 (8 reviews)

You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.

[See properties](https://www.expedia.co.uk/Hotel-Search?rfrrid=TG.LP..PointOfInterests&regionId=553248621532655754)

## Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

[See all hotels in East Prairie](https://www.expedia.co.uk/Hotel-Search?startDate=2025-12-12&endDate=2025-12-13&adults=2&regionId=3000349349)

![Bridge over Mississippi River, New Orleans in background](https://images.trvl-media.com/place/6209928/57ec11c5-0aa9-4b04-9ae1-c121ec0bef56.jpg?impolicy=fcrop&w=900&h=292&p=1&q=high)

## Top East Prairie Hotel Reviews

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

10/10 Excellent

"Everything was clean and comfortable. "

[](https://expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Super 8 By Wyndham Marston](https://images.trvl-media.com/lodging/109000000/108420000/108416700/108416635/7d663210_y.jpg)

### Super 8 By Wyndham Marston

10/10 Excellent

"Great staff "

[](https://expedia.co.uk/Marston-Hotels-Super-8-By-Wyndham-Marston.h108416635.Hotel-Information)

![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg)

### Drury Inn & Suites Sikeston, MO

10/10 Excellent

"Friendly staff, clean room, comfortable beds and great breakfast"

[](https://expedia.co.uk/Sikeston-Hotels-Drury-Inn-Suites-Sikeston.h24210.Hotel-Information)

![Pear Tree Inn Sikeston](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg)

### Pear Tree Inn Sikeston

10/10 Excellent

"Check-in took only a few minutes and staff was courteous and efficient. All was explained clearly and efficiently. Room was clean and well maintained. I did not take part in the 5:30 pm event or attend breakfact, so I cannot comment on these amenities. Everything else was wonderful."

[](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg)

### Hampton Inn Sikeston

10/10 Excellent

"Modern up to date facilities "

[](https://expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg)

### Days Inn and Suites by Wyndham Sikeston

10/10 Excellent

"Great staff. Great prices. Beautiful specious rooms. Great all round loved it"

[](https://expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Fairfield Inn & Suites by Marriott Sikeston](https://images.trvl-media.com/lodging/112000000/111250000/111247500/111247451/cffe72cf_y.jpg)

### Fairfield Inn & Suites by Marriott Sikeston

10/10 Excellent

"Extremely clean, and it looks to be updated in the more recent years. Large workout room that looks into the pool. Hot and tasty breakfast. "

[](https://expedia.co.uk/Sikeston-Hotels-Fairfield-By-Marriott-Inn-Suites-Sikeston.h111247451.Hotel-Information)

![Super 8 by Wyndham Charleston/Sikeston East MO](https://images.trvl-media.com/lodging/1000000/990000/988800/988758/55ffcc39_y.jpg)

### Super 8 by Wyndham Charleston/Sikeston East MO

10/10 Excellent

"Thank you "

[](https://expedia.co.uk/Sikeston-Hotels-Super-8-By-Wyndham-Charleston-MO.h988758.Hotel-Information)

![ For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.](https://images.trvl-media.com/lodging/35000000/34330000/34322400/34322352/537131b5_y.jpg)

### For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

10/10 Excellent

"Cypress Knee Lodge was a great gathering place for our hiking group. After nearly 20 years we don't hike much anymore, we are more of a card playing group now! We enjoyed the space, the views, the location, and the accommodations in general. All of this prove to be important because it rained every day we were at Reelfoot Lake. Watching hundreds of pelicans, cormorants, coots, and various other ducks was an added bonus! We would definitely stay here again. Thanks, Jim!"

[](https://expedia.co.uk/Hornbeak-Hotels-For-Larger-Groups-Right-On-Reelfoot-Lake-Private-Dock-And-Pier.h34322352.Hotel-Information)

## More cheap stays in East Prairie

![Days Inn and Suites by Wyndham Sikeston](https://images.trvl-media.com/lodging/1000000/30000/22100/22041/e12b74a2_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO

£54

7 Dec - 8 Dec

includes taxes & fees

7.2/10 Good! (1,003 reviews)

[](https://expedia.co.uk/Sikeston-Hotels-Days-Inn-And-Suites-By-Wyndham-Sikeston.h22041.Hotel-Information)

![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO

£81

7 Dec - 8 Dec

includes taxes & fees

8.8/10 Excellent! (429 reviews)

[](https://expedia.co.uk/Sikeston-Hotels-Hampton-Inn-Sikeston.h25178175.Hotel-Information)

![Sleep Inn at Discovery Park of America](https://images.trvl-media.com/lodging/39000000/38310000/38309600/38309567/2a51d3d0_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN

£72

28 Dec - 29 Dec

includes taxes & fees

9/10 Wonderful! (305 reviews)

[](https://expedia.co.uk/Union-City-Hotels-Sleep-Inn.h38309567.Hotel-Information)

![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO

£54

10 Dec - 11 Dec

includes taxes & fees

8.4/10 Very Good! (713 reviews)

[](https://expedia.co.uk/Sikeston-Hotels-Travel-Inn-Suites.h34745.Hotel-Information)

![Best Western Plus Sikeston](https://images.trvl-media.com/lodging/9000000/8430000/8420600/8420572/29a4ab37_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Best Western Plus Sikeston

120 S Interstate Drive Sikeston MO

£64

30 Nov - 1 Dec

includes taxes & fees

8.2/10 Very Good! (1,003 reviews)

[](https://expedia.co.uk/Sikeston-Hotels-Best-Western-Plus-Sikeston.h8420572.Hotel-Information)

![Pear Tree Inn Sikeston](https://images.trvl-media.com/lodging/1000000/20000/19300/19205/ff050f85_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Pear Tree Inn Sikeston

2602 E Malone Avenue Sikeston MO

£67

2 Dec - 3 Dec

includes taxes & fees

9.2/10 Wonderful! (1,004 reviews)

[](https://expedia.co.uk/Sikeston-Hotels-Pear-Tree-Inn-Sikeston.h19205.Hotel-Information)

## Frequently asked questions

### When is the best time to go to East Prairie?

> The most popular time to visit East Prairie is June. As the summer begins, the weather is typically warm, with temperatures ranging from 22 to 28 Celsius, superb for enjoying the great outdoors and taking part in local events.
> 
>   
> 
> From June through August, East Prairie experiences its peak season, drawing in visitors eager to explore the area's natural beauty and vibrant community. This is an ideal time for those who love outdoor activities, as the lush landscapes and scenic parks offer ample opportunities for hiking, biking, and picnicking. The comfortable warmth encourages leisurely strolls through the town and along the lakes, making it a delightful time for sightseeing.
> 
>   
> 
> If you're considering a trip with family or friends, June is particularly lively, with various festivals and events taking place, allowing you to immerse yourself in the local culture and traditions. The friendly atmosphere and the chance to connect with residents can enhance your experience, making your adventure even more memorable.
> 
>   
> 
> For travellers seeking a more budget-friendly option, November presents a great opportunity to explore East Prairie at slightly lower prices. While the weather may be cooler, you can still enjoy the charm of the town and its surroundings, perhaps even embracing the quieter pace of life during this season.

### Can I cancel my hotel reservation on Expedia?

> Many Expedia hotel reservations are refundable, provided that you cancel before the hotel's cancellation deadline – this is often within 24-48 hours of your scheduled arrival. If you have a non-refundable booking, it might still be possible to receive a refund if you cancel it within 24 hours of booking. Be sure to check your booking confirmation for the exact cancellation policy. For maximum flexibility, use our "Fully refundable property" filter during your search to find the right East Prairie hotel for you.

### How can I save on a East Prairie hotel booking with Expedia?

> With Expedia, you'll unlock our lowest prices by becoming a member. It's free and easy to join, and you can even access member perks too. Just remember to sign in to get our best prices on East Prairie hotels. Another way to save is by booking your hotel and flights together on Expedia, where bundling can lead to significant savings.

### How much is the nightly rate at a East Prairie hotel?

> Prices for hotels in East Prairie often vary, but you can find a great deal from £45 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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-   [Flights from Wyatt](https://www.expedia.co.uk/lp/flights/553248634983534991/flights-from-wyatt)
-   [Flights from Scott City](https://www.expedia.co.uk/lp/flights/553248634983544376/flights-from-scott-city)
-   [Flights from Homestown](https://www.expedia.co.uk/lp/flights/553248634983587633/flights-from-homestown)
-   [Flights from Dunklin County](https://www.expedia.co.uk/lp/flights/553248635976432466/flights-from-dunklin-county)
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-   [Flights from Cape Girardeau](https://www.expedia.co.uk/lp/flights/820/flights-from-cape-girardeau)
-   [Flights from Poplar Bluff](https://www.expedia.co.uk/lp/flights/9449/flights-from-poplar-bluff)
-   [Flights from Atlanta (ATL) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/atl/cgi/atlanta-to-cape-girardeau)
-   [Flights from Birmingham (BHM) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/bhm/cgi/birmingham-to-cape-girardeau)
-   [Flights from Mumbai (BOM) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/bom/cgi/mumbai-to-cape-girardeau)
-   [Flights from Sedalia (DMO) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/dmo/cgi/sedalia-to-cape-girardeau)
-   [Flights from Dublin (DUB) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/dub/cgi/dublin-to-cape-girardeau)
-   [Flights from New York (JFK) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/jfk/cgi/new-york-to-cape-girardeau)
-   [Flights from Los Angeles (LAX) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/lax/pof/los-angeles-to-poplar-bluff)
-   [Flights from London (LHR) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/lhr/cgi/london-to-cape-girardeau)
-   [Flights from Lewiston (LWS) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/lws/cgi/lewiston-to-cape-girardeau)
-   [Flights from Carbondale (MDH) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/mdh/pof/carbondale-to-poplar-bluff)
-   [Flights from Chicago (MDW) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/mdw/cgi/chicago-to-cape-girardeau)
-   [Flights from Stow (MMN) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/mmn/cgi/stow-to-cape-girardeau)
-   [Flights from Pittsburgh (PIT) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/pit/pof/pittsburgh-to-poplar-bluff)
-   [Flights from Pasco (PSC) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/psc/cgi/pasco-to-cape-girardeau)
-   [Flights from San Antonio (SAT) to Poplar Bluff (POF)](https://www.expedia.co.uk/lp/flights/sat/pof/san-antonio-to-poplar-bluff)
-   [Flights from St. Louis (STL) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/stl/cgi/st-louis-to-cape-girardeau)
-   [Flights from Tijuana (TIJ) to Cape Girardeau (CGI)](https://www.expedia.co.uk/lp/flights/tij/cgi/tijuana-to-cape-girardeau)

-   [Bernie Holidays](https://www.expedia.co.uk/Bernie.d3000349284.Holidays-City-Breaks)
-   [Braggadocio Holidays](https://www.expedia.co.uk/Braggadocio.d3000349297.Holidays-City-Breaks)
-   [Dexter Holidays](https://www.expedia.co.uk/Dexter.d55097.Holidays-City-Breaks)
-   [Kennett Holidays](https://www.expedia.co.uk/Kennett.d55774.Holidays-City-Breaks)
-   [Marston Holidays](https://www.expedia.co.uk/Marston.d55824.Holidays-City-Breaks)
-   [Visit New Madrid](https://www.expedia.co.uk/New-Madrid.dx3000445315)
-   [Visit Poplar Bluff](https://www.expedia.co.uk/Poplar-Bluff.dx9449)
-   [Visit Qulin](https://www.expedia.co.uk/Qulin.dx3000349508)
-   [Senath Holidays](https://www.expedia.co.uk/Senath.d3000349538.Holidays-City-Breaks)
-   [Sikeston Holidays](https://www.expedia.co.uk/Sikeston.d6058766.Holidays-City-Breaks)
-   [Visit Sikeston](https://www.expedia.co.uk/Sikeston.dx6058766)

-   [Rental cars Cape Girardeau Municipal airport](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Cape-Girardeau-Municipal.d6026978.Car-Hire-Guide)
-   [Car hire Cape Girardeau](https://www.expedia.co.uk/Compare-Cheap-Car-Hire-In-Cape-Girardeau.d820.Car-Hire-Guide)
-   [Car hire in Hertz 1 Pottery Road, Southern Cross, South Leeds Industrial Estate](https://www.expedia.co.uk/Hertz-at-1-Pottery-Road.v55080.Car-Rental-Guide-Location)
-   [Redspot Rental Cars in Oran](https://www.expedia.co.uk/Redspot-Car-Rentals-In-Oran.d3000445386-c1078.Car-Rental-Guide-Suppliers)

-   [Charleston Holiday Rentals](https://www.expedia.co.uk/Charleston-Holiday-Rentals.d7182.Travel-Guide-HolidayRentals)
-   [Kennett Holiday Rentals](https://www.expedia.co.uk/Kennett-Holiday-Rentals.d55774.Travel-Guide-HolidayRentals)

-   [Book Hotels in East Prairie on Expedia.com](https://www.expedia.com/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)

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