Find hotels in East Prairie, MO from £42

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Save instantly and earn perks with One Key
    Learn about One Key

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Tonight
13 Apr - 14 Apr
Tomorrow
14 Apr - 15 Apr
This weekend
17 Apr - 19 Apr
Next weekend
24 Apr - 26 Apr

Filter by

Guest rating
Guest rating
Star rating

Our top choices for East Prairie hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1,004 reviews)
"Very nice for overnight stay"
United States
Scott
The price is £95
includes taxes & fees
19 Apr - 20 Apr
Drury Inn & Suites Sikeston, MO
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (534 reviews)
"Great stay"
United States
grant
The price is £86
includes taxes & fees
3 May - 4 May
Hampton Inn Sikeston
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (375 reviews)
"Great stay. "
United States
Paul
The price is £80
includes taxes & fees
3 May - 4 May
Sleep Inn at Discovery Park of America
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (71 reviews)
"Nice quiet hotel "
United States
Steven
The price is £93
includes taxes & fees
14 May - 15 May
Fairfield Inn & Suites by Marriott Sikeston
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,002 reviews)
"Very nice folks who manage the hotel!!"
United States
Jane
The price is £76
includes taxes & fees
19 Apr - 20 Apr
Best Western Plus Sikeston I-55
Exterior

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (457 reviews)
"Clean rooms, friendly staff and convenient location."
United States
Mark
The price is £88
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express & Suites Sikeston Southwest by IHG
Individually decorated, individually furnished, desk, blackout curtains

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (763 reviews)
"Very nice place, very nice stay! They were out of cream cheese for the bagels at breakfast though.:-)"
United States
Mark
The price is £53
includes taxes & fees
16 Apr - 17 Apr
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.2 out of 10, Very good, (60 reviews)
"The property is beautiful! The rooms are terrific! Staff is amazing! Totally recommend!! "
United States
Sue
The price is £62
includes taxes & fees
19 Apr - 20 Apr
Super 8 By Wyndham Marston
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (411 reviews)
"Clean "
United States
Chris
The price is £68
includes taxes & fees
16 Apr - 17 Apr
The Riverstone Hotel Charleston-Sikeston
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (502 reviews)
"Overall, a decent stay. No fancy bells or whistles, exactly what was advertised and delivered. Only issue of note was that the room smelled of body odder when we stayed. "
United States
John
The price is £70
includes taxes & fees
19 Apr - 20 Apr
Quality Inn Union City US 51
Lobby

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (390 reviews)
"Easy to check in.. Clean Room..Lots of food options near by.. "
United States
Pooran
The price is £50
includes taxes & fees
16 Apr - 17 Apr
Hospitality House Union City I 69 / US 51
1 bedroom, desk, laptop workspace, blackout curtains

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,003 reviews)
"Business friendly, clean room staff very friendly, accommodating."
United States
Janice
The price is £58
includes taxes & fees
13 May - 14 May
Days Inn and Suites by Wyndham Sikeston
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (284 reviews)
"Amenities, microwave, refrigerator,iron and iron board,Shower soap options "
United States
Maurice
The price is £62
includes taxes & fees
26 Apr - 27 Apr
Quality Inn Cairo I-57
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (561 reviews)
"Very clean nice staff and well run "
United States
zach
The price is £56
includes taxes & fees
15 Apr - 16 Apr
Country Hearth Inn & Suites Union City
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.8 out of 10, (629 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is £54
includes taxes & fees
19 Apr - 20 Apr
Super 8 by Wyndham Charleston/Sikeston East MO
Exterior

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (318 reviews)
"The room was spacious & clean. The complimentary breakfast was nice. Very quiet place and next to a unique tourist attraction."
United States
Angela
The price is £115
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express & Suites Union City by IHG
Exterior

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (293 reviews)
"nice room, clean. breakfast was great and lady keeping it full, hot, and clean!"
United States
Fred
The price is £80
includes taxes & fees
5 May - 6 May
Comfort Inn & Suites Sikeston I-55
Property amenity

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (16 reviews)
"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."
United States
Jason
The price is £113
includes taxes & fees
7 May - 8 May
TownePlace Suites by Marriott Sikeston
Suite, 2 Queen Beds, Non Smoking | Individually furnished, desk, laptop workspace, blackout curtains

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (45 reviews)
"Very clean room, friendly staff! I would highly recommend this place! "
United States
Lydia
The price is £89
includes taxes & fees
10 May - 11 May
MainStay Suites Union City, TN
Terrace/patio

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (178 reviews)
"Spotless , friendly staff."
United States
Gail
The price is £116
includes taxes & fees
7 May - 8 May
Hampton Inn Union City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Stay near popular East Prairie attractions

Big Oak Tree State Park

4.0/5 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

8/10 Good
"It had a clean room. Better than most hotels like this. The bathroom smelled like mold or mildew. And the lobby smelled of moth balls. Some of the sheets had black stuff on them. Not sure what it was. Air conditioning was cold. "
Maddison 2-night trip
Posted 20 hours ago
Days Inn and Suites by Wyndham Sikeston

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is £53 per night from 16 Apr to 17 Apr
£53
16 Apr - 17 Apr
includes taxes & fees
8.4/10 Very Good! (763 reviews)

Frequently asked questions

What is the best area to stay in East Prairie?
The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.

This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.

For travellers looking for a straightforward and practical base, staying near Main Street is ideal.
When is the best time to go to East Prairie?
The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.

These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.

For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How can I save on a East Prairie hotel booking with Expedia?
Members always get our best prices. Find our best East Prairie hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from £42 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

Explore a world of travel with Expedia