A tree-lined landscape with a river and fields.

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Check prices for these dates

This weekend
17 Jul - 19 Jul
Next weekend
24 Jul - 26 Jul

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Our top choices for East Prairie hotels

East Prairie
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (785 reviews)
"Great stay with Great people, very clean and welcoming"
United States
Mircea
The price is Ā£44
includes taxes & fees
26 Jul - 27 Jul
New Orleans Inn Portageville
Exterior

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (420 reviews)
"Staff was excellent. It was fine for what it was ā€” a cheap place near the highway"
United States
Emily
The price is Ā£59
includes taxes & fees
19 Jul - 20 Jul
The Riverstone Hotel Charleston-Sikeston
Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,017 reviews)
"Great place!"
United States
Jennifer
The price is Ā£96
includes taxes & fees
27 Jul - 28 Jul
Drury Inn & Suites Sikeston, MO
Desk, blackout curtains, iron/ironing board (on request), free WiFi

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (799 reviews)
"I love it there."
United States
Sharika West
The price is Ā£56
includes taxes & fees
15 Jul - 16 Jul
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.2 out of 10, Very good, (532 reviews)
"Breakfast was filling and fresh. Short overnight stay which completely met our needs First level room with convenient vehicle parking right outside the door which made moving luggage painless. "
United States
Lisa
The price is Ā£63
includes taxes & fees
28 Jul - 29 Jul
Quality Inn Union City US 51
Exterior

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (479 reviews)
"Nice!"
United States
theresa
The price is Ā£80
includes taxes & fees
26 Jul - 27 Jul
Holiday Inn Express & Suites Sikeston Southwest by IHG
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (99 reviews)
"Great stay, kind staff, very clean property."
United States
Joni
The price is Ā£93
includes taxes & fees
13 Aug - 14 Aug
Fairfield Inn & Suites by Marriott Sikeston
Iron/ironing board, free WiFi, bed sheets

Country Yard Inn and Suite

Country Yard Inn and Suite
2.0 star property
Sikeston
6.8 out of 10, (143 reviews)
"Enjoyed our stay. All the appliances worked and our air conditioner kept us cool! Will definitely stay here again!"
United States
Sheryl
The price is Ā£49
includes taxes & fees
16 Jul - 17 Jul
Country Yard Inn and Suite
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,006 reviews)
"Very friendly and helpful staff. Everything I saw was that Mgmt is on point and I would highly recommend staying !!"
United States
Gregory
The price is Ā£74
includes taxes & fees
12 Aug - 13 Aug
Best Western Plus Sikeston I-55
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (648 reviews)
"Clean rooms,"
United States
Karl
The price is Ā£49
includes taxes & fees
9 Aug - 10 Aug
Super 8 by Wyndham Charleston/Sikeston East MO
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (590 reviews)
"Staff were great at Check in, room was clean, breakfast was good."
United States
Brandi
The price is Ā£93
includes taxes & fees
13 Aug - 14 Aug
Hampton Inn Sikeston
Lobby

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.4 out of 10, (291 reviews)
"Breakfast was sparse. This motel needs a complete overhaul. "
United States
Susan
The price is Ā£56
includes taxes & fees
25 Jul - 26 Jul
Quality Inn Cairo I-57
Standard Room, 2 Double Beds, Non Smoking | Blackout curtains, iron/ironing board (on request), free WiFi

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (500 reviews)
"The lake view was beautiful and staff was amazing"
United States
Richard
The price is Ā£52
includes taxes & fees
31 Jul - 1 Aug
Reelfoot Lake Inn
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (413 reviews)
"The room was clean, the breakfast was good. We enjoyed our stay."
United States
David
The price is Ā£75
includes taxes & fees
5 Aug - 6 Aug
Sleep Inn at Discovery Park of America
1 bedroom, desk, laptop workspace, blackout curtains

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,005 reviews)
"Business friendly, clean room staff very friendly, accommodating."
United States
Janice
The price is Ā£58
includes taxes & fees
10 Aug - 11 Aug
Days Inn and Suites by Wyndham Sikeston
Terrace/patio

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (189 reviews)
"Quick over night stay. Room was clean, complementary breakfast was good"
United States
Sarah
The price is Ā£91
includes taxes & fees
6 Aug - 7 Aug
Hampton Inn Union City
Property amenity

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (18 reviews)
"This hotel was great. Good location. Awesome staff. Hopefully I get the opportunity to stay here again."
United States
Jason
The price is Ā£108
includes taxes & fees
2 Aug - 3 Aug
TownePlace Suites by Marriott Sikeston
Free WiFi, bed sheets

Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
2.5 star property
Marston
6.0 out of 10, (125 reviews)
"Quiet safe area."
United States
Frank
The price is Ā£47
includes taxes & fees
15 Jul - 16 Jul
Travel Inn Marston I-55 by Hotel O
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (657 reviews)
"Staff is great rooms clean no bugs and bed was comfortable "
United States
James
The price is Ā£54
includes taxes & fees
9 Aug - 10 Aug
Super 8 by Wyndham Sikeston/Miner Area
Exterior

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (298 reviews)
"Hotel was nice an clean. Friendly staff. Clean hotel rooms and free breakfast every morning."
United States
Starlette
The price is Ā£78
includes taxes & fees
4 Aug - 5 Aug
Comfort Inn & Suites Sikeston I-55
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

Duck Hunting, Fishing or Relaxing Family Vacation

Duck Hunting, Fishing or Relaxing Family Vacation

10/10 Excellent
"As described. Place is nice great for the family we had thereBack deck is beautiful, fishing wasnā€™t too successful, but we had a nice time there. Very responsive and no surprises"
Christi C. 3-night trip
Posted 1 day ago
Duck Hunting, Fishing or Relaxing Family Vacation

More cheap stays in East Prairie

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
The price is Ā£58 per night from 10 Aug to 11 Aug
Ā£58
10 Aug - 11 Aug
includes taxes & fees
7.2/10 Good! (1,005 reviews)

Frequently asked questions

What is the best area to stay in East Prairie?
The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.

This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.

For travellers looking for a straightforward and practical base, staying near Main Street is ideal.
When is the best time to go to East Prairie?
The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.

These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.

For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How can I save on a East Prairie hotel booking with Expedia?
Members always get our best prices. Find our best East Prairie hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from Ā£44 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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