A tree-lined landscape with a river and fields.

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Check prices for these dates

Tonight
30 Aug - 31 Aug
Tomorrow
31 Aug - 1 Sept
Next weekend
4 Sept - 6 Sept
In two weeks
11 Sept - 13 Sept

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Our top choices for East Prairie hotels

Indoor pool, outdoor pool
Restaurant
Lobby
Property amenity

1. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
United States
Sally
£80
includes taxes & fees
14 Sept - 15 Sept
Drury Inn & Suites Sikeston, MO
Exterior
Lobby sitting area
Free daily buffet breakfast
Desk, laptop workspace, blackout curtains

2. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
Bobby
£55
includes taxes & fees
7 Sept - 8 Sept
The Riverstone Hotel Charleston-Sikeston
Desk, blackout curtains, iron/ironing board (on request), free WiFi
Exterior
TV
Free daily continental breakfast

3. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Sikeston
United States
Sharika West
£52
includes taxes & fees
10 Sept - 11 Sept
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi
Lobby
Front of property – evening/night
Lobby

4. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
France
£49
includes taxes & fees
8 Sept - 9 Sept
Super 8 by Wyndham Charleston/Sikeston East MO
Free daily full breakfast
Exterior
Indoor pool
Lobby

5. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
Sikeston
United States
Kevin
£74
includes taxes & fees
3 Sept - 4 Sept
Best Western Plus Sikeston I-55
Property amenity
Indoor pool
Lobby
Bar (on property)

6. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
£84
includes taxes & fees
13 Sept - 14 Sept
Fairfield Inn & Suites by Marriott Sikeston
1 bedroom, desk, laptop workspace, blackout curtains
Lobby
Restaurant
Exterior

7. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
Sikeston
£56
includes taxes & fees
1 Sept - 2 Sept
Days Inn and Suites by Wyndham Sikeston
Hypo-allergenic bedding, down duvets, desk, iron/ironing board
Exterior
Indoor pool, open 8 AM to 11 PM, pool loungers
Exterior

8. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
Sikeston
United States
Melissa
£83
includes taxes & fees
27 Sept - 28 Sept
Holiday Inn Express & Suites Sikeston Southwest by IHG
Exterior
Lobby
Free daily continental breakfast
Exterior

9. Hampton Inn Sikeston

Hampton Inn Sikeston
Sikeston
United States
Jeffrey
£85
includes taxes & fees
13 Sept - 14 Sept
Hampton Inn Sikeston
Iron/ironing board (on request), free WiFi, bed sheets
Exterior
Iron/ironing board (on request), free WiFi, bed sheets
Lobby

10. Country Yard Inn and Suite

Country Yard Inn and Suite
Sikeston
United States
William
£50
includes taxes & fees
30 Sept - 1 Oct
Country Yard Inn and Suite
Property amenity
Lobby
Exterior
Studio, 1 King Bed with Sofa bed | Hypo-allergenic bedding, in-room safe, desk, laptop workspace

11. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
Sikeston
United States
Lauren
£95
includes taxes & fees
6 Sept - 7 Sept
TownePlace Suites by Marriott Sikeston
Exterior
Desk, free WiFi, alarm clocks, bed sheets
Indoor pool
Breakfast area

12. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
Sikeston
United States
Lakeysha
£76
includes taxes & fees
20 Sept - 21 Sept
Comfort Inn & Suites Sikeston I-55
Room, 1 King Bed, Non Smoking | View from room
Coffee service
Property entrance
Desk, iron/ironing board, free WiFi, alarm clocks

13. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
£63
includes taxes & fees
31 Aug - 1 Sept
Eagle Inn Charleston
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Exterior
Suite, 2 Queen Beds, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Desk, laptop workspace, blackout curtains, free WiFi

14. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
Sikeston
United States
Kevin
£48
includes taxes & fees
7 Sept - 8 Sept
Super 8 by Wyndham Sikeston/Miner Area
Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Suite, 1 King Bed, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi
Lobby
Exterior

15. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
Marston
United States
Rachel
£78
includes taxes & fees
31 Aug - 1 Sept
Super 8 By Wyndham Marston
Lobby
Standard Room, 1 King Bed, Non Smoking | Iron/ironing board, free cots/infant beds, free WiFi, alarm clocks
Lobby
Exterior

16. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
United States
Susan
£56
includes taxes & fees
11 Sept - 12 Sept
Quality Inn Cairo I-57
Free WiFi, bed sheets
Free WiFi, bed sheets
View from room
Reception

17. Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
Marston
United States
Frank
£39
includes taxes & fees
29 Sept - 30 Sept
Travel Inn Marston I-55 by Hotel O
Lobby
Lobby lounge
Reception
Standard Room, 1 King Bed, Accessible, Non Smoking | Iron/ironing board, free WiFi, bed sheets

18. Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
Union City
United States
Jade
£52
includes taxes & fees
26 Sept - 27 Sept
Country Hearth Inn & Suites Union City
Lobby
Seasonal outdoor pool
Free daily buffet breakfast
Combined shower/bathtub, free toiletries, towels

19. Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
Union City
United States
Richard
£49
includes taxes & fees
2 Sept - 3 Sept
Hospitality House Union City I 69 / US 51
Lobby
Property amenity
Indoor pool
Indoor pool

20. Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
Union City
United States
Ben
£69
includes taxes & fees
20 Sept - 21 Sept
Sleep Inn at Discovery Park of America
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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

Reelfoot Lake Inn

Reelfoot Lake Inn

10/10 Excellent
"clean room, nice lake view, very quiet area. Just a good decent place to stay. Not a fancy 5 star hotel, but well worth it to me. Great place....Thanks!"
Larry 4-night trip
Posted 11 hours ago
Reelfoot Lake Inn
Quality Inn Union City US 51

Quality Inn Union City US 51

8/10 Good
"Pros: Excellent staff,Room was very spacious with a comfy bed and very quiet atmosphere Cons:Around edges of room floor was dirty.Wifi is awful and needs to be updated to better Internet service."
Candace 1-night trip
Posted 16 hours ago
Quality Inn Union City US 51
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

10/10 Excellent
"The room was clean and had plenty of room for two adults. Breakfast was fine and kitchen staff very helpful. Same with the desk staff at check-in and check-out. We had some questions about the television, which were quickly resolved. Plenty of parking, pretty scenery, and lots of nearby activities that we unfortunately didn't have time to enjoy. Will stay again when we're in the area."
Dale 1-night trip
Posted 2 days ago
Sleep Inn at Discovery Park of America
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

10/10 Excellent
"This place was very clean. We were given a 2nd floor room. I asked if there was an elevator. Yes. When we brought our things in to go to our room, we found the elevator was temporarily out of order. My friend cannot climb stairs. We were immediately given a 1st floor room close to an entrance near handicap parking. The room was clean. Comfortable beds. Good shower and tub. Excellent breakfast. I've never been to Sikeston before, but if I go again, I'll stay here."
Frances 1-night trip
Posted 4 days ago
Best Western Plus Sikeston I-55
Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"Staff were friendly, room was nice and clean, the breakfast was delicious. Of the three hotels on this trip this was the best one."
David 1-night trip
Posted 5 days ago
Super 8 by Wyndham Sikeston/Miner Area
Hampton Inn Sikeston

Hampton Inn Sikeston

10/10 Excellent
"👍"
Gregory S 1-night trip
Posted 6 days ago
Hampton Inn Sikeston
For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

10/10 Excellent
"Lake view clean room"
Rob G. 4-night trip
Posted 2 months ago
For Larger Groups Up To 24, Right on Reelfoot Lake--Private Dock And Pier.

More cheap stays in East Prairie

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
£56
1 Sept - 2 Sept
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN
£69
20 Sept - 21 Sept
includes taxes & fees
9.2/10 Wonderful! (428 reviews)
Sleep Inn at Discovery Park of America
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO
£74
3 Sept - 4 Sept
includes taxes & fees
8.4/10 Very good! (1,000 reviews)
Best Western Plus Sikeston I-55
Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG

115 Hospitality Dr Sikeston MO
£83
27 Sept - 28 Sept
includes taxes & fees
Holiday Inn Express & Suites Sikeston Southwest by IHG
Hampton Inn Sikeston

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO
£85
13 Sept - 14 Sept
includes taxes & fees
Hampton Inn Sikeston
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

810 BREAM BOULEVARD Union City TN
£90
27 Sept - 28 Sept
includes taxes & fees
Holiday Inn Express & Suites Union City by IHG

Frequently asked questions

What is the best area to stay in East Prairie?
The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.For travellers looking for a straightforward and practical base, staying near Main Street is ideal.
When is the best time to go to East Prairie?
The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from £39 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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