A tree-lined landscape with a river and fields.

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Check prices for these dates

Tonight
14 Oct - 15 Oct
Tomorrow
15 Oct - 16 Oct
This weekend
16 Oct - 18 Oct
Next weekend
23 Oct - 25 Oct

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Our top choices for East Prairie hotels

A building with a fountain and flower beds in front.
A modern kitchen with dark wooden cabinets, a central island, and a ceiling fan.
A hotel room with a beige sofa, two patterned armchairs, a ceiling fan, a flat-screen TV, and a window with curtains.
A hotel room with a large bed, two bedside tables with lamps, a chair, a small table, and a picture on the wall.

1. The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
Charleston
United States
Kathleen
£56
includes taxes & fees
16 Oct - 17 Oct
The Riverstone Hotel Charleston-Sikeston
A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.
An indoor swimming pool with clear water, surrounded by lounge chairs and tables, and large windows providing natural light.
A reception area with a wooden reception desk, a large painting on the wall, and a potted plant.
A hotel with a covered entrance, a sign indicating a restaurant, and a well-lit parking area.

2. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
Sikeston
United States
Shelley
£72
includes taxes & fees
15 Oct - 16 Oct
Best Western Plus Sikeston I-55
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.
A spacious dining area with high tables and chairs, a bar counter, and large windows providing natural light.
A hotel room with a patterned sofa, a yellow ottoman, a desk with a TV, and a framed picture on the wall.
A spacious lobby with a polished floor, seating areas, and modern lighting fixtures.

3. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
Sikeston
United States
Tim
£82
includes taxes & fees
29 Oct - 30 Oct
Drury Inn & Suites Sikeston, MO
A hotel room with a large bed, a desk with a computer, a chair, a window with a view, and a wall-mounted TV.
A modern kitchen with stainless steel appliances, wooden cabinets, and a bright yellow accent wall.
A reception area with a sign for 'Travel Inn and Suites' and a counter with a computer and a phone.
A Travel Inn and Suites with a brick facade, a flat roof, and a welcoming entrance.

4. Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Sikeston
United States
Craig
£53
includes taxes & fees
21 Oct - 22 Oct
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.
A Hampton Inn hotel with a modern facade, a stone entrance, and a well-lit entrance area.
An indoor swimming pool with lounge chairs, a lifeguard stand, and large windows offering a view of the outside.
A hotel lobby with a bar area, seating arrangements, and a large window providing natural light.

5. Hampton Inn Sikeston

Hampton Inn Sikeston
Sikeston
United States
Lori
£90
includes taxes & fees
18 Oct - 19 Oct
Hampton Inn Sikeston
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.
A hotel room with two beds, a sofa, a coffee table, and artwork on the walls.
A hotel room with a flat-screen TV, a microwave, a coffee maker, a dining table, and two sofas.
A motel with a covered entrance, multiple rooms, and a parking lot.

6. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
Sikeston
United States
Laura
£49
includes taxes & fees
20 Oct - 21 Oct
Super 8 by Wyndham Sikeston/Miner Area
A hotel room with two beds, a desk with a chair, a TV, and a window with curtains.
A buffet with various food items, including omelets and baked goods, served in metal containers.
A reception area with a reception desk, a large wall-mounted sign, and a potted plant.
A Holiday Inn Express & Suites building with a covered entrance, multiple windows, and a parking lot.

7. Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
Sikeston
United States
Melissa
£80
includes taxes & fees
18 Oct - 19 Oct
Holiday Inn Express & Suites Sikeston Southwest by IHG
A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.
A Days Inn hotel with a brick facade, large windows, and a sign above the entrance.
A spacious lobby with a central atrium, a piano, and a reception desk.
A spacious room with a large dining table and chairs, a kitchenette area, and a television mounted on the wall.

8. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
Sikeston
United States
David
£57
includes taxes & fees
1 Nov - 2 Nov
Days Inn and Suites by Wyndham Sikeston
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.
A modern indoor swimming pool with clear glass walls, a tiled deck, and multiple lounge chairs.
A modern hotel building with a sign reading "TOWNPLACE SUITES BY MARRIOTT" and "Fairfield BY MARRIOTT".
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

9. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
Sikeston
United States
Allen
£87
includes taxes & fees
25 Oct - 26 Oct
Fairfield Inn & Suites by Marriott Sikeston
Property amenity
A modern hotel with a sign reading "Towneplace Suites by Marriott Fairfield." It features a flat roof, large windows, and a well-lit entrance.
A modern hotel room with a large window, a gray sofa, a small round table, a white chair, and a bed.
A modern lobby with a green sofa, two armchairs, a wooden coffee table, and a patterned rug.

10. TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
Sikeston
United States
Rubin
£94
includes taxes & fees
22 Oct - 23 Oct
TownePlace Suites by Marriott Sikeston
A hotel room with two beds, a desk, a chair, a TV, and a mirror.
A bathroom with a bathtub, toilet, and shower curtain.
A motel with a blue awning and a green 7-Eleven. It has a covered parking area and a two-story structure with a balcony.
A reception area with a sofa, a small table, a trash bin, a microwave, and a book display.

11. Country Yard Inn and Suite

Country Yard Inn and Suite
Sikeston
United States
William
£48
includes taxes & fees
18 Oct - 19 Oct
Country Yard Inn and Suite
A modern hotel room with a large bed, bedside tables, a nightstand, a wall-mounted lamp, a window with a view of a road, and a wall-mounted air conditioner.
A hotel with a central entrance, multiple parking spaces, and a well-lit facade.
A modern kitchen with a stone backsplash, a dining area with red chairs, and a red accent wall with a framed picture.
A modern kitchen with a built-in microwave, a black refrigerator, and a wooden countertop.

12. Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
Marston
United States
Brenda
£48
includes taxes & fees
21 Oct - 22 Oct
Super 8 By Wyndham Marston
A hotel room with a large bed, a desk, a television, and a bathroom visible through an open door.
A hotel room with two beds, a nightstand, a lamp, and a window with curtains.
A bathroom with a sink, mirror, towel rack, shower, and toilet.
A kitchen with wooden cabinets, a granite countertop, a built-in microwave, and a window with a view.

13. Eagle Inn Charleston

Eagle Inn Charleston
Charleston
United States
Jackson
£56
includes taxes & fees
15 Oct - 16 Oct
Eagle Inn Charleston
A Comfort Inn & Suites hotel with a clear entrance, a covered parking area, and a sign indicating a 12' clearance.
A hotel lobby with a reception desk, seating area, and large windows offering a view of the outdoors.
A hotel room with a bed, a desk with a TV, a chair, a bathroom with a bathtub, and a window with curtains.
A living room with two sofas, a coffee table, a TV, and a cabinet.

14. Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
Sikeston
United States
Kathryn
£68
includes taxes & fees
8 Nov - 9 Nov
Comfort Inn & Suites Sikeston I-55
A reception area with a reception desk, two blue armchairs, a round table, and a glass door leading outside.
An outdoor patio area with a blue sectional sofa, an orange ottoman, and black metal chairs.
A large indoor swimming pool with a tiled floor, surrounded by seating areas and tables.
A corridor with a vending machine displaying various beverages and a wall with hanging products.

15. Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
Union City
United States
Ben
£65
includes taxes & fees
8 Nov - 9 Nov
Sleep Inn at Discovery Park of America
A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.
A reception area with a counter, a flat-screen TV, and a window with blinds.
A restaurant with wooden cabinets, a refrigerator, and a counter with various items. There are tables and chairs for dining.
A reception area with a sofa, a coffee table, a potted plant, and a framed picture on the wall.

16. Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
Charleston
United States
William
£50
includes taxes & fees
15 Oct - 16 Oct
Super 8 by Wyndham Charleston/Sikeston East MO
A fireplace with a framed painting above it, flanked by two vases of flowers.
A restaurant with yellow walls, a red carpet, a chandelier, a ceiling fan, and Christmas decorations.
A reception desk with a wooden counter, a chandelier, and a plant on the right.
A Country Hearth Inn with a red brick facade, a covered front porch, and a well-maintained lawn.

17. Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
Union City
United States
Jade
£61
includes taxes & fees
16 Oct - 17 Oct
Country Hearth Inn & Suites Union City
A hotel lobby with a reception desk, seating area, and a large window.
A hotel room with a desk, chair, television, and a lamp.
A Quality Inn hotel with a green sign, a covered outdoor area, and a parking lot.
A hotel lobby with a reception desk, two armchairs, a coffee table, and large windows with potted plants.

18. Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo
United States
Santiago
£58
includes taxes & fees
2 Nov - 3 Nov
Quality Inn Cairo I-57
A living room with a sofa, chairs, a glass coffee table, and a TV.
A modern bathroom with a large sink, towel rack, and a mirror reflecting a dining area.
Room
A kitchen area with a coffee machine, microwave, and various appliances.

19. Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
Union City
United States
Joan
£50
includes taxes & fees
15 Oct - 16 Oct
Hospitality House Union City I 69 / US 51
A hotel room with two beds, a television, a desk, and a mirror.
A bathroom with a sink, mirror, and chair.
A hotel room with a bed, a desk, a television, and a seating area with a small table.
A Travel Inn with a sign indicating affordable rooms, a parking lot, and a clear sky.

20. Travel Inn Marston I-55 by Hotel O

Travel Inn Marston I-55 by Hotel O
Marston
United States
Frank
£38
includes taxes & fees
25 Oct - 26 Oct
Travel Inn Marston I-55 by Hotel O
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Stay near popular East Prairie attractions

Big Oak Tree State Park

8.0/10 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
A tree-lined landscape with a river and fields.

Top East Prairie Hotel Reviews

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

10/10 Excellent
"good, clean, affordable :)"
Nicholas 1-night trip
Posted 16 hours ago
Super 8 by Wyndham Sikeston/Miner Area
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

8/10 Good
"Everything was nice. Bed very comfortable."
ROBERT 6-night trip
Posted 23 hours ago
Sleep Inn at Discovery Park of America
Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

10/10 Excellent
"Everything perfect. Drury Inns sweat the details."
Richard 1-night trip
Posted 2 days ago
Drury Inn & Suites Sikeston, MO
Reelfoot Lake Inn

Reelfoot Lake Inn

8/10 Good
"Dated but descent."
Lisa 1-night trip
Posted 4 days ago
Reelfoot Lake Inn
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

8/10 Good
"Easy parking, our bathroom sink was leaning forward and we had to place our soap in the sink so it didn't slide on the floor."
Ronda 1-night trip
Posted 4 days ago
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG

10/10 Excellent
"It was the perfect stay."
Kevin 2-night trip
Posted 4 days ago
Holiday Inn Express & Suites Union City by IHG
Hampton Inn Union City

Hampton Inn Union City

10/10 Excellent
"The room was pretty spacious and very clean with updated furniture. Breakfast was great!"
Debra 2-night trip
Posted 5 days ago
Hampton Inn Union City
The Dragonfly - Sleeps up to 8, Lake views.

The Dragonfly - Sleeps up to 8, Lake views.

10/10 Excellent
"This was the perfect place for us to stay when we were in town for the real foot art and craft show the house was clean. Nice size. We loved the views we had. A a fire that we sat around with and did some mores. It was just wonderful Kristi the host was awesome, very responsive and helpful. Hope to stay there again in the future!"
Andena F. 4-night trip
Posted 6 days ago
The Dragonfly - Sleeps up to 8, Lake views.
Quality Inn Union City US 51

Quality Inn Union City US 51

8/10 Good
"No comments"
Dan 1-night trip
Posted 10 days ago
Quality Inn Union City US 51

More cheap stays in East Prairie

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area

2609 E Malone Ave Sikeston MO
£49
20 Oct - 21 Oct
includes taxes & fees
7/10 Good! (687 reviews)
Super 8 by Wyndham Sikeston/Miner Area
Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

310 S Story St Charleston MO
£50
15 Oct - 16 Oct
includes taxes & fees
Super 8 by Wyndham Charleston/Sikeston East MO
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

220 S Interstate Dr Sikeston MO
£57
1 Nov - 2 Nov
includes taxes & fees
Days Inn and Suites by Wyndham Sikeston
Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America

1111 BLue Heron Lane Union City TN
£65
8 Nov - 9 Nov
includes taxes & fees
9.2/10 Wonderful! (438 reviews)
Sleep Inn at Discovery Park of America
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

120 S Interstate Drive Sikeston MO
£72
15 Oct - 16 Oct
includes taxes & fees
8.4/10 Very good! (1,000 reviews)
Best Western Plus Sikeston I-55
Hampton Inn Sikeston

Hampton Inn Sikeston

1240 Commerce Drive Sikeston MO
£90
18 Oct - 19 Oct
includes taxes & fees
Hampton Inn Sikeston

Frequently asked questions

What is the best area to stay in East Prairie?
The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.For travellers looking for a straightforward and practical base, staying near Main Street is ideal.
When is the best time to go to East Prairie?
The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from £48 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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