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Check prices for these dates

This weekend
29 May - 31 May
Next weekend
5 Jun - 7 Jun

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Our top choices for East Prairie hotels

Indoor pool, outdoor pool

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,001 reviews)
"Breakfast was good,pool hot tub excellent "
United States
Janica
The price is £95
includes taxes & fees
14 Jun - 15 Jun
Drury Inn & Suites Sikeston, MO
Exterior

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (568 reviews)
"Very clean hotel with comfortable bedding. Front desk staff was very nice and accommodating as we were traveling with a small dog."
United States
Connie
The price is £86
includes taxes & fees
28 Jun - 29 Jun
Hampton Inn Sikeston
Lobby sitting area

The Riverstone Hotel Charleston-Sikeston

The Riverstone Hotel Charleston-Sikeston
2.5 star property
Charleston
6.8 out of 10, (412 reviews)
"All very just okay "
United States
Sherry
The price is £62
includes taxes & fees
30 May - 31 May
The Riverstone Hotel Charleston-Sikeston
Lobby

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (393 reviews)
"Great stay. "
United States
Paul
The price is £77
includes taxes & fees
22 Jun - 23 Jun
Sleep Inn at Discovery Park of America
Individually decorated, individually furnished, desk, blackout curtains

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very good, (783 reviews)
"We were very satisfied with our stay. We will make this a regular stay when traveling to or from Iowa."
United States
Carolyn
The price is £50
includes taxes & fees
9 Jun - 10 Jun
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
Free buffet breakfast

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very good, (515 reviews)
"Breakfast was filling and fresh. Short overnight stay which completely met our needs First level room with convenient vehicle parking right outside the door which made moving luggage painless. "
United States
Lisa
The price is £55
includes taxes & fees
24 Jun - 25 Jun
Quality Inn Union City US 51
Laptop workspace, blackout curtains, free cots/infant beds, free WiFi

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (636 reviews)
"Affordable for a quick one night stay. Restaurant and gas station next to hotel."
United States
Annette
The price is £51
includes taxes & fees
8 Jun - 9 Jun
Super 8 by Wyndham Charleston/Sikeston East MO
Property amenity

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (83 reviews)
"The breakfast was good, the service was good, and the staff was very friendly"
United States
Angela
The price is £93
includes taxes & fees
11 Jun - 12 Jun
Fairfield Inn & Suites by Marriott Sikeston
Free daily full breakfast

Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,000 reviews)
"Breakfast was fresh and the room was clean. It's a good place to stay. Friendly staff. "
United States
Tabitha
The price is £84
includes taxes & fees
14 Jun - 15 Jun
Best Western Plus Sikeston I-55
Room, 1 Queen Bed, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
8.0 out of 10, Very good, (64 reviews)
"Great hotel for the price!!! Remodel very nice and modern. "
United States
Amy
The price is £65
includes taxes & fees
31 May - 1 Jun
Super 8 By Wyndham Marston
Exterior

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (466 reviews)
"Clean rooms, friendly staff and convenient location."
United States
Mark
The price is £88
includes taxes & fees
21 Jun - 22 Jun
Holiday Inn Express & Suites Sikeston Southwest by IHG
1 bedroom, desk, laptop workspace, blackout curtains

Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.2 out of 10, Good, (1,000 reviews)
"When I stay at hotels I like to find hotels like this one for the $$$ value . This hotel was clean and the bed was very comfortable. Room 237 . I didn’t hear any interstate noise . I didn’t eat the breakfast but the coffee was very good . I would stay here again ."
United States
Kurt
The price is £58
includes taxes & fees
2 Jun - 3 Jun
Days Inn and Suites by Wyndham Sikeston
Lobby

Hospitality House Union City I 69 / US 51

Hospitality House Union City I 69 / US 51
2.5 star property
Union City
6.8 out of 10, (391 reviews)
"Yes"
United States
Lashae
The price is £50
includes taxes & fees
31 May - 1 Jun
Hospitality House Union City I 69 / US 51
Lobby

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (571 reviews)
"Very clean nice staff and well run "
United States
zach
The price is £53
includes taxes & fees
7 Jun - 8 Jun
Country Hearth Inn & Suites Union City
Exterior

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (293 reviews)
"nice room, clean. breakfast was great and lady keeping it full, hot, and clean!"
United States
Fred
The price is £86
includes taxes & fees
22 Jun - 23 Jun
Comfort Inn & Suites Sikeston I-55
Terrace/patio

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (183 reviews)
"The room was clean and comfortable. The staff was courteous during my entire stay."
United States
Alvin
The price is £94
includes taxes & fees
7 Jun - 8 Jun
Hampton Inn Union City
Room, 1 King Bed, Accessible, Non Smoking | Desk, laptop workspace, blackout curtains, free WiFi

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (632 reviews)
"Staff, A/C, adequate breakfast"
United States
David
The price is £53
includes taxes & fees
31 May - 1 Jun
Super 8 by Wyndham Sikeston/Miner Area
Property amenity

TownePlace Suites by Marriott Sikeston

TownePlace Suites by Marriott Sikeston
3.0 star property
Sikeston
9.2 out of 10, Wonderful, (18 reviews)
"Room was very nice and in very clean condition and hotel staff was very helpful and polite. The breakfast was very delicious and coffee served all day. The hotel smelled very nice and had a very welcoming feeling. Will definitely book with them again"
United States
Joseph
The price is £107
includes taxes & fees
11 Jun - 12 Jun
TownePlace Suites by Marriott Sikeston
Standard Room, 2 Double Beds, Non Smoking | Blackout curtains, iron/ironing board, free WiFi, bed sheets

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (492 reviews)
"The lake view was beautiful and staff was amazing"
United States
Richard
The price is £56
includes taxes & fees
31 May - 1 Jun
Reelfoot Lake Inn
Premier Room, 1 Bedroom, Non Smoking | Desk, free WiFi, bed sheets

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very good, (766 reviews)
"Parking was right outside my window so as safe as can be. The staff on the other hand are extremely helpful and wonderful to talk to. Very friendly and professional. "
United States
Honorio
The price is £42
includes taxes & fees
31 May - 1 Jun
New Orleans Inn Portageville
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Big Oak Tree State Park

4.0/5 (20 reviews)
You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks.
See properties

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artefacts tell the storey of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

See all hotels in East Prairie
The Mississippi River near Hannibal, Missouri, USA

Top East Prairie Hotel Reviews

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO

2/10 Terrible
"It was not clean and didn't have a breakfast the coffee was terrible"
vincent 1-night trip
Posted 3 hours ago
Super 8 by Wyndham Charleston/Sikeston East MO

More cheap stays in East Prairie

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

100 Matthews Lane Sikeston MO
The price is £50 per night from 9 Jun to 10 Jun
£50
9 Jun - 10 Jun
includes taxes & fees
8.4/10 Very Good! (783 reviews)

Frequently asked questions

What is the best area to stay in East Prairie?
The best area to stay in East Prairie is near Main Street, particularly around the intersection with Washington Street.

This central part of East Prairie offers the most convenience for visitors. It's where you'll find the majority of local businesses, including eateries and shops. The area is quite walkable, allowing you to easily explore the town's core.

For travellers looking for a straightforward and practical base, staying near Main Street is ideal.
When is the best time to go to East Prairie?
The best time to visit East Prairie, Missouri, is typically during the spring (April to May) and autumn (September to October) months.

These seasons offer the most pleasant weather, with mild temperatures and less humidity, making it ideal for exploring the town and its surrounding natural areas. Spring brings blooming flowers and lush greenery, while autumn showcases beautiful fall foliage, particularly along the nearby Mississippi River.

For those interested in local festivities, visiting in September allows you to experience the annual Sweet Corn Festival, a significant event for the town.
Can I cancel my hotel reservation on Expedia?
You can cancel your hotel reservation on Expedia, though it depends on the cancellation policy of your booking. Most bookings are refundable if canceled within 24-48 hours of the scheduled arrival. Be sure to check your booking confirmation for the exact cancellation policy. If free cancellation is available, you can cancel directly through your Expedia account by logging in, going to "My Trips", and selecting your reservation. To find flexible deals, filter your search by "Fully refundable property" for hotels in East Prairie.
How can I save on a East Prairie hotel booking with Expedia?
Members always get our best prices. Find our best East Prairie hotel deals by joining Expedia's free travel rewards program today. As a member, you can unlock instant savings and member perks when you're logged in to your account. Another tip is to book your hotel and flights together on Expedia, where bundling can result in significant savings.
How much is the nightly rate at a East Prairie hotel?
Prices for hotels in East Prairie often vary, but you can find a great deal from £42 on Expedia. All sorts of factors affect price, such as the time of year or the days of the week you choose for your stay. Find the best deals by being flexible with your dates, and sort search results by "Price: low to high" for the cheapest rate.

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