Title: East Prairie Travel Guide: Best of East Prairie, Missouri Travel 2026 | Expedia.co.uk [Hotels in East Prairie](https://expedia.co.uk/East-Prairie-Hotels.d3000349349.Travel-Guide-Hotels)[Holiday Rentals in East Prairie](https://expedia.co.uk/East-Prairie-Holiday-Rentals.d3000349349.Travel-Guide-HolidayRentals)[East Prairie Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-East-Prairie.d3000349349.Car-Hire-Guide)[East Prairie Holidays](https://expedia.co.uk/East-Prairie.d3000349349.Holidays-City-Breaks) # East Prairie Travel Guide ## Tourist Guide ![Bridge over Mississippi River, New Orleans in background](https://images.trvl-media.com/place/6209928/57ec11c5-0aa9-4b04-9ae1-c121ec0bef56.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![Bridge over Mississippi River, New Orleans in background](https://images.trvl-media.com/place/6209928/57ec11c5-0aa9-4b04-9ae1-c121ec0bef56.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![0_16158](https://images.trvl-media.com/place/6209928/e540f256-d3e0-4f4d-8f10-2501e789aacc.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ![The Mississippi River near Hannibal, Missouri, USA](https://images.trvl-media.com/place/6209928/2afb9a4b-494b-462a-af23-159cb6a96bb2.jpg?impolicy=fcrop&w=1040&h=580&q=mediumHigh) ## Visit East Prairie Things to do ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=DX_SPRING_PROMO_3000349349) - Top hotels in East Prairie - Top Holiday Rentals in East Prairie ![Drury Inn & Suites Sikeston, MO](https://images.trvl-media.com/lodging/1000000/30000/24300/24210/8e55cf67_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Drury Inn & Suites Sikeston, MO 2608 East Malone Ave, Miner Sikeston MO £79 22 Feb - 23 Feb includes taxes & fees Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the breakfast and the helpful staff in ... 9.4/10 Exceptional! (1,000 reviews) Room was very nice, housekeeping forgot room service on my second night stay. Breakfast Buffet was very nice especially the evening Kickback buffet .Will stay again soon!!!! Reviewed on 10 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=22%2F02%2F2026&endDate=23%2F02%2F2026&selected=24210&PinnedHotelID=24210&HadPinnedHotel=true®ionId=3000349349) ![Hampton Inn Sikeston](https://images.trvl-media.com/lodging/26000000/25180000/25178200/25178175/d0739759_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Hampton Inn Sikeston 1240 Commerce Drive Sikeston MO £79 28 Feb - 1 Mar includes taxes & fees Stay at this hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff in their reviews. Popular attractions ... 8.8/10 Excellent! (478 reviews) Very Clean room, friendly staff, breakfast in the morning. Will be staying again! Reviewed on 10 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=28%2F02%2F2026&endDate=01%2F03%2F2026&selected=25178175&PinnedHotelID=25178175&HadPinnedHotel=true®ionId=3000349349) ![Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)](https://images.trvl-media.com/lodging/1000000/40000/34800/34745/f91b29ea_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67) 100 Matthews Lane Sikeston MO £50 16 Feb - 17 Feb includes taxes & fees Stay at this business-friendly hotel in Sikeston. Enjoy free breakfast, free Wi-Fi and free parking. Our guests praise the helpful staff and the clean rooms ... 8.4/10 Very Good! (735 reviews) Room was clean ! Ice and snow made parking lot rough!! Enjoyed my days for work ! Reviewed on 5 Feb 2026 [](https://expedia.co.uk/Hotel-Search?startDate=16%2F02%2F2026&endDate=17%2F02%2F2026&selected=34745&PinnedHotelID=34745&HadPinnedHotel=true®ionId=3000349349) [See all 85 properties in East Prairie](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience&startDate=16%2F02%2F2026&endDate=17%2F02%2F2026®ionId=3000349349) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ![Duck Hunting, Fishing or Relaxing Family Vacation](https://images.trvl-media.com/lodging/37000000/36090000/36089000/36088974/09116238_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Duck Hunting, Fishing or Relaxing Family Vacation Hornbeak TN Stay at this holiday home in Hornbeak. Enjoy a garden, laundry facilities and patios. Popular attractions Willow Towhead and Rat Island are located nearby. 9.8/10 Exceptional! (219 reviews) Great host, went above and beyond to get us taken care of. Beautiful sunsets on the dock! Reviewed on 12 Feb 2026 [](https://expedia.co.uk/Hornbeak-Hotels-Duck-Hunting.h36088974.Hotel-Information) ![Buddy's Reel' Em Inn 2 Bd 1 Bath home on Reelfoot Lake. Sleeps 6.](https://images.trvl-media.com/lodging/91000000/90850000/90841600/90841539/957cbbdf_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Buddy's Reel' Em Inn 2 Bd 1 Bath home on Reelfoot Lake. Sleeps 6. Hornbeak TN Stay at this holiday home in Hornbeak. Enjoy free Wi-Fi, a garden and laundry facilities. Popular attractions Willow Towhead and Rat Island are located ... 9.8/10 Exceptional! (23 reviews) Everything wa as advertised Reviewed on 16 Nov 2025 [](https://expedia.co.uk/Hornbeak-Hotels-Buddys-Reel-Em-Inn-2-Bd-1-Bath-Home-On-Reelfoot-Lake-Sleeps-6.h90841539.Hotel-Information) ![Come and relax at the Refuge at beautiful Reelfoot Lake!](https://images.trvl-media.com/lodging/84000000/83580000/83572000/83571978/a7c0fe31_y.jpg?impolicy=resizecrop&rw=340&ch=150) ### Come and relax at the Refuge at beautiful Reelfoot Lake! Hornbeak TN Enjoy free Wi-Fi, laundry facilities and patios. Popular attractions Willow Towhead and Rat Island are located nearby. 9.2/10 Wonderful! (23 reviews) Great place Reviewed on 19 Jan 2026 [](https://expedia.co.uk/Hornbeak-Hotels-Enjoy-Beautiful-Sunsets-At-The-HUT-2-At-Beautiful-Reelfoot-Lake.h83571978.Hotel-Information) [See all properties in East Prairie](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.DestinationExperience®ionId=3000349349&sort=VACATION_RENTAL) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Check East Prairie hotel availability [Tonight ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-02-15&endDate=2026-02-16)[15 Feb - 16 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-02-15&endDate=2026-02-16) [Tomorrow night ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-02-16&endDate=2026-02-17)[16 Feb - 17 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=2026-02-16&endDate=2026-02-17) [Next weekend ](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=20%2F02%2F2026&endDate=22%2F02%2F2026)[20 Feb - 22 Feb](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.CheckPrices.DestinationExperience&adults=2&openPlayBack=true®ionId=3000349349&startDate=20%2F02%2F2026&endDate=22%2F02%2F2026) ### Popular places to visit #### Big Oak Tree State Park You can take time to visit Big Oak Tree State Park during your travels to East Prairie. While you're in the area, wander around the parks. [](https://expedia.co.uk/Big-Oak-Tree-State-Park-Missouri.d553248621532655754.Attraction) ## Cities near East Prairie ![Pre-teen girl walking through corn maze during fall](https://images.trvl-media.com/place/6058766/0353751e-5978-48d0-a913-84533caba2b0.jpg?impolicy=fcrop&w=512&h=288&q=medium) ### Sikeston - Cities near East Prairie - Places of interest [Sikeston](https://expedia.co.uk/Sikeston.dx6058766) - [Ohio River Valley ](https://expedia.co.uk/Ohio-River-Valley-United-States-of-America.d6233674.Attraction) ![](https://a.travel-assets.com/mad-service/footer/bnaBanners/BEX_Footer.jpg) ## Go further with the Expedia app Save on select hotels when you book in the app. Our app deals help you to save on trips so you can travel more and manage it all on the go. Scan the QR code with your device camera and download our app