Title: TOP Luxury Hotels in Central San Diego, CA for 2026 - Central San Diego Upscale Hotels | Expedia.co.uk [Central San Diego Travel Guide](https://expedia.co.uk/Central-San-Diego.dx6056570)[Hotels in Central San Diego](https://expedia.co.uk/Central-San-Diego-Hotels.d6056570.Travel-Guide-Hotels)[Holiday Rentals in Central San Diego](https://expedia.co.uk/Central-San-Diego-Holiday-Rentals.d6056570.Travel-Guide-HolidayRentals)[Flights to Central San Diego](https://expedia.co.uk/Cheap-Flights-To-Central-San-Diego.d6056570.Travel-Guide-Flights)[Things to do in Central San Diego](https://expedia.co.uk/Things-To-Do-In-Central-San-Diego.d6056570.Travel-Guide-Activities)[Central San Diego Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Central-San-Diego.d6056570.Car-Hire-Guide)[Central San Diego Holidays](https://expedia.co.uk/Central-San-Diego.d6056570.Holidays-City-Breaks) ![San Diego, California cityscape at the Gaslamp Quarter.; Shutterstock ID 446681584](https://images.trvl-media.com/place/6056570/11e424d0-560b-422b-97ab-cce270c46858.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6056570/11e424d0-560b-422b-97ab-cce270c46858.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Central San Diego Luxury Hotels Tonight [22 Feb - 23 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-02-22&endDate=2026-02-23&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [23 Feb - 24 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-02-23&endDate=2026-02-24&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [27 Feb - 1 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-02-27&endDate=2026-03-01&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) In two weeks [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-03-06&endDate=2026-03-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Central San Diego luxury hotels ![3 bars/lounges, lobby lounge, cocktail bar, cocktail bar](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/ce2dc6d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 9:00 PM, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/83e1bd28.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/fd80224d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, minibar, desk](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/8ea4f9d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lafayette Hotel & Club [](https://www.expedia.co.uk/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) University Heights 9.2/10 Wonderful (1,487 reviews) "Stunning hotel, I could have stayed there all day looking at every little design detail. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Holly £195 includes taxes & fees 23 Feb - 24 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Room, 2 Queen Beds (Trendy, Firepit) | Lobby](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/bf902f64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/e51e5730.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/62a9579b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/d61b28be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town and Country San Diego [](https://www.expedia.co.uk/San-Diego-Hotels-Town-And-Country-San-Diego.h21394.Hotel-Information) Mission Valley 8.6/10 Excellent (1,366 reviews) "Staff were pleasant and helpful. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Jacquelin £206 includes taxes & fees 25 Feb - 26 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Town-And-Country-San-Diego.h21394.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/43ef19cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/21efa256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed (High Floor) | Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/3d7acad3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa [](https://www.expedia.co.uk/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) Mission Valley 9.2/10 Wonderful (2,960 reviews) "Excellent facilities and location " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Felix £153 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/3aab4b53.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/8d355501.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Hypo-allergenic bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/bb5c7ad4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/9549ed03.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency La Jolla [](https://www.expedia.co.uk/San-Diego-Hotels-Hyatt-Regency-La-Jolla.h21891.Hotel-Information) University City 8.8/10 Excellent (1,004 reviews) "Really clean room, comfortable towels, would definitely come back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samuel £168 includes taxes & fees 15 Mar - 16 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-Hyatt-Regency-La-Jolla.h21891.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/a9b9662f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Free daily on-the-go breakfast ](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/fcf9ccd4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Suite, 1 King + 1 Queen Murphy Bed | 1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/956312dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/6013e99c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites by Hilton San Diego La Jolla [](https://www.expedia.co.uk/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) University City 8.8/10 Excellent (1,871 reviews) "Great included breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gina £158 includes taxes & fees 27 Feb - 28 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) ![Outdoor pool, open 6:00 AM to 10:00 PM, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/acfdb883.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/d6460a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/272f3969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/31ee5101.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Marriott Mission Valley [](https://www.expedia.co.uk/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information) Mission Valley 8.8/10 Excellent (1,006 reviews) "The staff was very accommodating " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Paolo £140 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information) ![Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/6ef835b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/1b9a69bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![BBQ/picnic Area](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/333bf268.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/aa1995cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City24 Hotel Little Italy Mission Hills [](https://www.expedia.co.uk/San-Diego-Hotels-City24-Hotel-Little-Italy-Mission-Hill.h104140458.Hotel-Information) Middletown 9.6/10 Exceptional (124 reviews) "Very clean, quiet, walking distance to great food" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Amanda [](https://www.expedia.co.uk/San-Diego-Hotels-City24-Hotel-Little-Italy-Mission-Hill.h104140458.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/400/332/027b3bfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/400/332/771038f3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/400/332/9fc85073.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/400/332/e4705932.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel San Diego - Mission Valley [](https://www.expedia.co.uk/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) Mission Valley 8.4/10 Very good (1,541 reviews) "Clean and great staff " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Peter £115 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/f387ad25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![42-inch flat-screen TV with satellite channels, TV](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/d4a1ddb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/88b059dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Pure, Room, 1 King Bed | Premium bedding, down duvets, pillow-top beds, in-room safe](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/3bae0140.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Mission Valley San Diego Hotel [](https://www.expedia.co.uk/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) Mission Valley 8.6/10 Excellent (1,731 reviews) "Great stay!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Linda £115 includes taxes & fees 27 Feb - 28 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/2d829d4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/9101297c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/6e469c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Mission Valley [](https://www.expedia.co.uk/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) Mission Valley 8.0/10 Very good (2,331 reviews) "The cleanest room and nicest staff honestly would stay here again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin £104 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-03-08&endDate=2026-03-09®ionId=6056570&adults=2&sort=LUXURY&star=40,50&openPlayBack=true) ![](https://forever.travel-assets.com/flex/flexmanager/images/2026/02/06/expedia-sale-2026-desktop-uk-fr-de.jpg?impolicy=fcrop&w=1400&h=600&q=mediumHigh) ## The Annual Holiday Sale Members save up to 40% on hotels and holiday homes. Plan this year’s big trip and save. [Book now](https://expedia.co.uk/cheap-deals?rfrr=AFFINITY_SPRING_PROMO_6056570) ## Find out more about Central San Diego ### Central San Diegoand its attractions for luxury travelers Central San Diego offers a wealth of luxurious experiences perfect for discerning travellers. Begin your adventure at Balboa Park, where you can explore stunning gardens and world-class museums, such as the San Diego Museum of Art, all set within a picturesque landscape that invites leisurely strolls and refined picnics. The Gaslamp Quarter, known for its vibrant nightlife and historic architecture, is a hub of upscale dining and chic boutiques, making it the ideal spot for a gourmet meal or an afternoon of shopping. For those who enjoy the outdoors, the stunning views from the cliffs at La Jolla Cove are not to be missed; here, you can indulge in kayaking or simply relax on the beach, soaking in the sun. A visit to the iconic San Diego Zoo, famous for its conservation efforts and diverse animal exhibits, is a must for families seeking both adventure and education. After a day of exploration, retreat to the luxurious accommodations in the Hillcrest neighbourhood, where boutique hotels offer a blend of modern elegance and personalised service, ensuring you feel pampered throughout your stay. With its vibrant culture, stunning scenery, and exceptional hospitality, Central San Diego is an exquisite choice for luxury travellers seeking both comfort and adventure. ## Top Central San Diego Hotel Reviews ![Town and Country San Diego](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/bbee5f13_y.jpg) ### Town and Country San Diego 10/10 Excellent "Staff was awesome, there was a reptile show, and we had a great time at the valentines dinner. " [](https://expedia.co.uk/San-Diego-Hotels-Town-And-Country-San-Diego.h21394.Hotel-Information) ![Kings Inn San Diego](https://images.trvl-media.com/lodging/1000000/20000/17000/16910/a5f26080_y.jpg) ### Kings Inn San Diego 10/10 Excellent "Staff very courteous and professional Cleaning was very good " [](https://expedia.co.uk/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) ![Best Western Inn & Suites San Diego – Zoo/SeaWorld Area ](https://images.trvl-media.com/lodging/1000000/50000/40800/40745/a5f33771_y.jpg) ### Best Western Inn & Suites San Diego – Zoo/SeaWorld Area 10/10 Excellent "Staff was nice " [](https://expedia.co.uk/San-Diego-Hotels-Comfort-Inn-Suites-San-Diego-Zoo-SeaWorld-Area.h40745.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Great stay, staff was friendly " [](https://expedia.co.uk/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Crowne Plaza San Diego - Mission Valley by IHG](https://images.trvl-media.com/lodging/1000000/580000/571600/571545/f294be65_y.jpg) ### Crowne Plaza San Diego - Mission Valley by IHG 10/10 Excellent "Beautiful courtyards." [](https://expedia.co.uk/San-Diego-Hotels-Crowne-Plaza-San-Diego-Mission-Valley.h571545.Hotel-Information) ![Best Western Seven Seas](https://images.trvl-media.com/lodging/1000000/10000/1800/1734/w3837h2556x3y3-8b148daf_y.jpg) ### Best Western Seven Seas 10/10 Excellent "Always a good experience " [](https://expedia.co.uk/San-Diego-Hotels-Best-Western-Seven-Seas.h1734.Hotel-Information) ![Hampton Inn San Diego/Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/036e1947_y.jpg) ### Hampton Inn San Diego/Mission Valley 10/10 Excellent "The staff members were consistently positive and exuded hospitality. I observed many interactions many with several guests over my four day stay. They were consistent in warm and professional interactions. Well done!" [](https://expedia.co.uk/San-Diego-Hotels-Hampton-Inn-San-Diego-Mission-Valley.h4415.Hotel-Information) ![San Diego Marriott La Jolla](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/05285107_y.jpg) ### San Diego Marriott La Jolla 10/10 Excellent "Very good, " [](https://expedia.co.uk/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information) ![Handlery Hotel](https://images.trvl-media.com/lodging/1000000/10000/8400/8374/ab6ccd55_y.jpg) ### Handlery Hotel 10/10 Excellent "Friendly staff" [](https://expedia.co.uk/San-Diego-Hotels-Handlery-Hotel.h8374.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Cars - More ways to book - [Sports Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Adventure-Sport-Hotel.0-0-d5921-tAdventureSportHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Business-Hotel.0-0-d5921-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-Bar.0-0-d5921-thotelwithabar.Travel-Guide-Filter-Hotels) - 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