Title: TOP Luxury Hotels in Central San Diego, CA for 2026 - Central San Diego Upscale Hotels | Expedia.co.uk [Central San Diego Travel Guide](https://expedia.co.uk/Central-San-Diego.dx6056570)[Hotels in Central San Diego](https://expedia.co.uk/Central-San-Diego-Hotels.d6056570.Travel-Guide-Hotels)[Holiday Rentals in Central San Diego](https://expedia.co.uk/Central-San-Diego-Holiday-Rentals.d6056570.Travel-Guide-HolidayRentals)[Flights to Central San Diego](https://expedia.co.uk/Cheap-Flights-To-Central-San-Diego.d6056570.Travel-Guide-Flights)[Things to do in Central San Diego](https://expedia.co.uk/Things-To-Do-In-Central-San-Diego.d6056570.Travel-Guide-Activities)[Central San Diego Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Central-San-Diego.d6056570.Car-Hire-Guide)[Central San Diego Holidays](https://expedia.co.uk/Central-San-Diego.d6056570.Holidays-City-Breaks) ![San Diego, California cityscape at the Gaslamp Quarter.; Shutterstock ID 446681584](https://images.trvl-media.com/place/6056570/11e424d0-560b-422b-97ab-cce270c46858.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Find luxury hotels in Central San Diego, CA - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Central San Diego Luxury Hotels Tonight [7 Jan - 8 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-01-07&endDate=2026-01-08&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Tomorrow [8 Jan - 9 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-01-08&endDate=2026-01-09&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) This weekend [9 Jan - 11 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-01-09&endDate=2026-01-11&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) Next weekend [16 Jan - 18 Jan](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-01-16&endDate=2026-01-18&adults=2&propertyStyle=LUXURY&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=luxury_property) ## Our top choices for Central San Diego luxury hotels ![Room, 2 Queen Beds (Trendy, Firepit) | Lobby](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/bf902f64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/62a9579b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior detail](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/e51e5730.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21400/21394/d61b28be.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Town and Country San Diego [](https://www.expedia.co.uk/San-Diego-Hotels-Town-And-Country-San-Diego.h21394.Hotel-Information) Mission Valley 8.6/10 Excellent (1330) "Great Resort, the staff were nice" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Aryana £169 includes taxes & fees 7 Feb - 8 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Town-And-Country-San-Diego.h21394.Hotel-Information) ![3 bars/lounges, lobby lounge, cocktail bar, cocktail bar](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/ce2dc6d1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/abbee14b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, minibar, desk](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/8ea4f9d8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast served](https://images.trvl-media.com/lodging/39000000/38080000/38077800/38077738/fd80224d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Lafayette Hotel & Club [](https://www.expedia.co.uk/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) University Heights 9.4/10 Exceptional (1392) "Amazing hotel, great staff and awesome food!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) michael £194 includes taxes & fees 29 Jan - 30 Jan [](https://www.expedia.co.uk/San-Diego-Hotels-Lafayette-Hotel.h38077738.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/49079311.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/50256145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Suite, 1 King + 1 Queen Murphy Bed | 1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/956312dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/6013e99c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites by Hilton San Diego La Jolla [](https://www.expedia.co.uk/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) University City 8.8/10 Excellent (1824) "Breakfast was great and afternoon happy hours was a plus. The indoor pool was a great value in the rainy days we were visiting SD. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Fernando £164 includes taxes & fees 6 Feb - 7 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/43ef19cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/21efa256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, free pool cabanas, pool umbrellas](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/981f9667.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Room, 1 King Bed (High Floor) | Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/3d7acad3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa [](https://www.expedia.co.uk/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) Mission Valley 9.2/10 Wonderful (2962) "Enjoyed my stay. Clean rooms, nice staff, will come back again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Oscar [](https://www.expedia.co.uk/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Outdoor pool, open 6:00 AM to 10:00 PM, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/acfdb883.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Bar (on property)](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/d6460a60.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/8680bd7b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/8400/8332/272f3969.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Marriott Mission Valley [](https://www.expedia.co.uk/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information) Mission Valley 8.8/10 Excellent (1011) "Staff was polite , room service amazing " ![Canada](https://a.travel-assets.com/egds/marks/flags/ca.svg) Francois £127 includes taxes & fees 11 Jan - 12 Jan [](https://www.expedia.co.uk/San-Diego-Hotels-San-Diego-Marriott-Mission-Valley.h8332.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/717df324.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/8399b5a6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/b197cd41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/f15931a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency La Jolla [](https://www.expedia.co.uk/San-Diego-Hotels-Hyatt-Regency-La-Jolla.h21891.Hotel-Information) University City 8.8/10 Excellent (1003) "Really clean room, comfortable towels, would definitely come back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samuel £142 includes taxes & fees 9 Jan - 10 Jan [](https://www.expedia.co.uk/San-Diego-Hotels-Hyatt-Regency-La-Jolla.h21891.Hotel-Information) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/f387ad25.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/88b059dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![42-inch flat-screen TV with satellite channels, TV](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/d4a1ddb8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/11800/11725/ad966b3d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Sheraton Mission Valley San Diego Hotel [](https://www.expedia.co.uk/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) Mission Valley 8.6/10 Excellent (1709) "Clean room , good breakfast and staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kaustubh £100 includes taxes & fees 11 Jan - 12 Jan [](https://www.expedia.co.uk/San-Diego-Hotels-Sheraton-Mission-Valley-San-Diego-Hotel.h11725.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/400/332/027b3bfa.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/400/332/9fc85073.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/400/332/e4705932.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/400/332/6ddceb14.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton Hotel San Diego - Mission Valley [](https://www.expedia.co.uk/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) Mission Valley 8.4/10 Very good (1460) "Staff, rooms, pools, and price..very good! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) James £101 includes taxes & fees 11 Jan - 12 Jan [](https://www.expedia.co.uk/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Breakfast, lunch and dinner served](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/18794ebf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/9101297c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/df29ea56.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Mission Valley [](https://www.expedia.co.uk/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) Mission Valley 8.0/10 Very good (2275) "Amazing stay with effortless check in!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Sofia £104 includes taxes & fees 31 Jan - 1 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Deluxe 2 King Bedrooms, Multiple Beds, Sleeps 11ppl | Terrace/patio](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/6ef835b1.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/1b9a69bb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Front of property](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/6c7bbd52.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, in-room safe, iron/ironing board, free WiFi](https://images.trvl-media.com/lodging/105000000/104150000/104140500/104140458/aa1995cf.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### City24 Hotel Little Italy Mission Hills [](https://www.expedia.co.uk/San-Diego-Hotels-City24-Hotel-Little-Italy-Mission-Hill.h104140458.Hotel-Information) Middletown 9.6/10 Exceptional (108) "would definitely go back and stay there again " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kounwick [](https://www.expedia.co.uk/San-Diego-Hotels-City24-Hotel-Little-Italy-Mission-Hill.h104140458.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-01-21&endDate=2026-01-22®ionId=6056570&adults=2&sort=LUXURY&star=40,50&openPlayBack=true) ## Find out more about Central San Diego ### Central San Diegoand its attractions for luxury travelers Central San Diego offers a wealth of luxurious experiences perfect for discerning travellers. Begin your adventure at Balboa Park, where you can explore stunning gardens and world-class museums, such as the San Diego Museum of Art, all set within a picturesque landscape that invites leisurely strolls and refined picnics. The Gaslamp Quarter, known for its vibrant nightlife and historic architecture, is a hub of upscale dining and chic boutiques, making it the ideal spot for a gourmet meal or an afternoon of shopping. For those who enjoy the outdoors, the stunning views from the cliffs at La Jolla Cove are not to be missed; here, you can indulge in kayaking or simply relax on the beach, soaking in the sun. A visit to the iconic San Diego Zoo, famous for its conservation efforts and diverse animal exhibits, is a must for families seeking both adventure and education. After a day of exploration, retreat to the luxurious accommodations in the Hillcrest neighbourhood, where boutique hotels offer a blend of modern elegance and personalised service, ensuring you feel pampered throughout your stay. With its vibrant culture, stunning scenery, and exceptional hospitality, Central San Diego is an exquisite choice for luxury travellers seeking both comfort and adventure. ## Top Central San Diego Hotel Reviews ## Explore a world of travel with Expedia - Accommodation - Flights - Cars - More ways to book - [Sports Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Adventure-Sport-Hotel.0-0-d5921-tAdventureSportHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Business-Hotel.0-0-d5921-tBusinessHotel.Travel-Guide-Filter-Hotels) - [Hotels with a Bar in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-Bar.0-0-d5921-thotelwithabar.Travel-Guide-Filter-Hotels) - [Hotels with a View in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-A-View.0-0-d5921-thotelwithaview.Travel-Guide-Filter-Hotels) - [Hotels with Air Conditioning in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Hotel-With-Air-Conditioning.0-0-d5921-thotelwithairconditioning.Travel-Guide-Filter-Hotels) - 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