Title: TOP Business Hotels in Central San Diego, CA for 2026 | Expedia.co.uk [Central San Diego Travel Guide](https://expedia.co.uk/Central-San-Diego.dx6056570)[Hotels in Central San Diego](https://expedia.co.uk/Central-San-Diego-Hotels.d6056570.Travel-Guide-Hotels)[Holiday Rentals in Central San Diego](https://expedia.co.uk/Central-San-Diego-Holiday-Rentals.d6056570.Travel-Guide-HolidayRentals)[Flights to Central San Diego](https://expedia.co.uk/Cheap-Flights-To-Central-San-Diego.d6056570.Travel-Guide-Flights)[Things to do in Central San Diego](https://expedia.co.uk/Things-To-Do-In-Central-San-Diego.d6056570.Travel-Guide-Activities)[Central San Diego Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Central-San-Diego.d6056570.Car-Hire-Guide)[Central San Diego Holidays](https://expedia.co.uk/Central-San-Diego.d6056570.Holidays-City-Breaks) ![San Diego, California cityscape at the Gaslamp Quarter.; Shutterstock ID 446681584](https://images.trvl-media.com/place/6056570/11e424d0-560b-422b-97ab-cce270c46858.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6056570/11e424d0-560b-422b-97ab-cce270c46858.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Central San Diego Business Hotels Tonight [3 Feb - 4 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-02-03&endDate=2026-02-04&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Tomorrow [4 Feb - 5 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-02-04&endDate=2026-02-05&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) This weekend [6 Feb - 8 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-02-06&endDate=2026-02-08&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) Next weekend [13 Feb - 15 Feb](https://www.expedia.co.uk/Hotel-Search?regionId=6056570&startDate=2026-02-13&endDate=2026-02-15&adults=2&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true&travelerType=business_friendly) ## Our top choices for Central San Diego business-friendly hotels ![3 restaurants, breakfast, lunch, dinner served; Regional cuisine ](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/a77f85c3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Suite, 1 King Bed, Non Smoking, Bay View (Point Loma) | Premium bedding, in-room safe, desk, blackout curtains](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/5629b8dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![32-inch LCD TV with digital channels, TV](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/563e5d96.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/11200/11177/7f3bc7ed.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Wyndham San Diego Bayside [](https://www.expedia.co.uk/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) Downtown San Diego 8.4/10 Very good (6,009 reviews) "Great place to stay" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) David £154 includes taxes & fees 6 Feb - 7 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Wyndham-San-Diego-Bayside.h11177.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/aa48478b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, open 7:00 AM to 10 PM, pool cabanas (surcharge)](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/3e5abcfe.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/ad83f8b2.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Breakfast, lunch, dinner served; American cuisine, pool views ](https://images.trvl-media.com/lodging/1000000/20000/15300/15236/9862c417.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### DoubleTree by Hilton San Diego - Del Mar [](https://www.expedia.co.uk/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) Carmel Valley 8.4/10 Very good (2,028 reviews) "Nice hotel, staff is great." ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Felipe Ramirez £109 includes taxes & fees 1 Mar - 2 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-DoubleTree-By-Hilton-San-Diego-Del-Mar.h15236.Hotel-Information) ![Standard Room, 1 King Bed, Non Smoking, Bay View | Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/6fe441dd.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool umbrellas, pool loungers](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/1a09735e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/1e0934c7.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, in-room safe, desk](https://images.trvl-media.com/lodging/1000000/180000/170400/170338/66a8936b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The DEXTRO Little Italy, BW Premier Collection [](https://www.expedia.co.uk/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) Downtown San Diego 9.0/10 Wonderful (1,012 reviews) "Clean rooms and friendly staff" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Topeka £98 includes taxes & fees 22 Feb - 23 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Four-Points-By-Sheraton-San-Diego-Downtown-Little-Italy.h170338.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/43ef19cb.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/21efa256.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, free pool cabanas, pool umbrellas](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/981f9667.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Garden](https://images.trvl-media.com/lodging/42000000/41510000/41504800/41504735/0bbd67f4.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Legacy Resort Hotel & Spa [](https://www.expedia.co.uk/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) Mission Valley 9.2/10 Wonderful (2,945 reviews) "Great relaxing hotel" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Christopher [](https://www.expedia.co.uk/San-Diego-Hotels-Legacy-Resort-Hotel-Spa.h41504735.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/2d829d4d.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lounge](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/6e469c5b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/9101297c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hilton San Diego Mission Valley [](https://www.expedia.co.uk/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) Mission Valley 8.0/10 Very good (2,320 reviews) "The cleanest room and nicest staff honestly would stay here again" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Kevin £108 includes taxes & fees 6 Feb - 7 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/76b95bec.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/036e1947.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/7c98a26c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Reception](https://images.trvl-media.com/lodging/1000000/10000/4500/4415/96d645ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hampton Inn San Diego/Mission Valley [](https://www.expedia.co.uk/San-Diego-Hotels-Hampton-Inn-San-Diego-Mission-Valley.h4415.Hotel-Information) Mission Valley 8.6/10 Excellent (1,406 reviews) "Great breakfast-comfortable rooms-helpful staff-great location for events" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) bill £107 includes taxes & fees 2 Mar - 3 Mar [](https://www.expedia.co.uk/San-Diego-Hotels-Hampton-Inn-San-Diego-Mission-Valley.h4415.Hotel-Information) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16600/16546/b9bb0320.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Room, 2 Queen Beds, Non Smoking | Premium bedding, in-room safe, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/20000/16600/16546/7f899010.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/1000000/20000/16600/16546/64e3d597.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Exterior](https://images.trvl-media.com/lodging/1000000/20000/16600/16546/4be6a85e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Country Inn & Suites by Radisson, San Diego North, CA [](https://www.expedia.co.uk/San-Diego-Hotels-Country-Inn-Suites-By-Radisson.h16546.Hotel-Information) Sorrento Valley 9.0/10 Wonderful (1,417 reviews) "staff, clean room, good breakfast, plenty of tables and seats for breakfast, tables and fire pit outside would be nice for team gathering. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Nit £114 includes taxes & fees 20 Feb - 21 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Country-Inn-Suites-By-Radisson.h16546.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/717df324.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/f15931a3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Restaurant](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/b197cd41.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/239995d9.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hyatt Regency La Jolla [](https://www.expedia.co.uk/San-Diego-Hotels-Hyatt-Regency-La-Jolla.h21891.Hotel-Information) University City 8.8/10 Excellent (1,007 reviews) "Really clean room, comfortable towels, would definitely come back!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Samuel £165 includes taxes & fees 8 Feb - 9 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Hyatt-Regency-La-Jolla.h21891.Hotel-Information) ![Terrace/patio](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/49079311.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium Suite, 1 King + 1 Queen Murphy Bed | 1 bedroom, in-room safe, desk, iron/ironing board](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/956312dc.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor spa tub](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/6013e99c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Point of interest](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/50256145.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Embassy Suites by Hilton San Diego La Jolla [](https://www.expedia.co.uk/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) University City 8.8/10 Excellent (1,848 reviews) "Great included breakfast!" ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Gina £149 includes taxes & fees 7 Feb - 8 Feb [](https://www.expedia.co.uk/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) ![Restaurant](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/w3996h2667x0y0-24fa7374.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/05285107.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Premium bedding, pillow-top beds, desk, laptop workspace](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/d7035e73.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property entrance](https://images.trvl-media.com/lodging/1000000/10000/2100/2097/ca374c23.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### San Diego Marriott La Jolla [](https://www.expedia.co.uk/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information) University City 8.6/10 Excellent (2,252 reviews) "Friendly staff and great location. " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Allison £151 includes taxes & fees 27 Feb - 28 Feb [](https://www.expedia.co.uk/La-Jolla-Hotels-San-Diego-Marriott-La-Jolla.h2097.Hotel-Information) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. [View all properties](https://expedia.co.uk/Hotel-Search?startDate=2026-02-17&endDate=2026-02-18®ionId=6056570&adults=2&travelerType=business_friendly&sort=RECOMMENDED&openPlayBack=true) ## Top Central San Diego Hotel Reviews ![Hyatt Regency La Jolla](https://images.trvl-media.com/lodging/1000000/30000/21900/21891/0a66ad12_y.jpg) ### Hyatt Regency La Jolla 10/10 Excellent "Clean" [](https://expedia.co.uk/San-Diego-Hotels-Hyatt-Regency-La-Jolla.h21891.Hotel-Information) ![Courtyard by Marriott San Diego Mission Valley/Hotel Circle](https://images.trvl-media.com/lodging/2000000/1990000/1987700/1987617/43ae1d02_y.jpg) ### Courtyard by Marriott San Diego Mission Valley/Hotel Circle 10/10 Excellent "Staff Ricky i believe his name was, was amazing even chatted with my son bout his baseball tournament. Room was what we payed for clean, and quiet " [](https://expedia.co.uk/San-Diego-Hotels-Courtyard-By-Marriott-San-Diego-Mission-ValleyHotel-Circle.h1987617.Hotel-Information) ![Hilton Garden Inn San Diego Old Town/SeaWorld Area](https://images.trvl-media.com/lodging/1000000/920000/919100/919096/ed62594a_y.jpg) ### Hilton Garden Inn San Diego Old Town/SeaWorld Area 10/10 Excellent "Great location, great price, nice hotel " [](https://expedia.co.uk/San-Diego-Hotels-Hilton-Garden-Inn-San-Diego-Old-TownSeaWorld-Area.h919096.Hotel-Information) ![Embassy Suites by Hilton San Diego La Jolla](https://images.trvl-media.com/lodging/1000000/10000/8500/8434/49079311_y.jpg) ### Embassy Suites by Hilton San Diego La Jolla 10/10 Excellent "Great included breakfast!" [](https://expedia.co.uk/San-Diego-Hotels-Embassy-Suites-By-Hilton-San-Diego-La-Jolla.h8434.Hotel-Information) ![California Suites Hotel](https://images.trvl-media.com/lodging/1000000/50000/40600/40531/4d1b251a_y.jpg) ### California Suites Hotel 10/10 Excellent "nice., quiet, clean and good rates" [](https://expedia.co.uk/San-Diego-Hotels-California-Suites-Hotel.h40531.Hotel-Information) ![Days Inn by Wyndham San Diego Hotel Circle](https://images.trvl-media.com/lodging/1000000/20000/19300/19220/3334d773_y.jpg) ### Days Inn by Wyndham San Diego Hotel Circle 10/10 Excellent "Great" [](https://expedia.co.uk/San-Diego-Hotels-Days-Inn-By-Wyndham-San-Diego-Hotel-Circle.h19220.Hotel-Information) ![Kings Inn San Diego](https://images.trvl-media.com/lodging/1000000/20000/17000/16910/a5f26080_y.jpg) ### Kings Inn San Diego 10/10 Excellent "Clean rooms, nice gym, my only complaint is that there is no" [](https://expedia.co.uk/San-Diego-Hotels-Kings-Inn-San-Diego-Seaworld-Zoo.h16910.Hotel-Information) ![DoubleTree by Hilton Hotel San Diego - Mission Valley](https://images.trvl-media.com/lodging/1000000/10000/400/332/8e34f752_y.jpg) ### DoubleTree by Hilton Hotel San Diego - Mission Valley 10/10 Excellent "Very nice room. Clean and well appointed amenities. The staff was very friendly upon check-in and even the next say when i asked for directions to the restaurant for breakfast. " [](https://expedia.co.uk/San-Diego-Hotels-DoubleTree-By-Hilton-Hotel-San-Diego-Mission-Valley.h332.Hotel-Information) ![Hilton San Diego Mission Valley](https://images.trvl-media.com/lodging/1000000/20000/16100/16019/w5586h3835x5y5-2b129a15_y.jpg) ### Hilton San Diego Mission Valley 10/10 Excellent "The cleanest room and nicest staff honestly would stay here again" [](https://expedia.co.uk/San-Diego-Hotels-Hilton-San-Diego-Mission-Valley.h16019.Hotel-Information) ## Frequently asked questions ### Why book your business hotel in Central San Diego with Expedia? ### How can I find cheap business hotels in Central San Diego? ## Explore a world of travel with Expedia - Accommodation - Flights - Cars - More ways to book - [Sports Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Adventure-Sport-Hotel.0-0-d5921-tAdventureSportHotel.Travel-Guide-Filter-Hotels) - [Business Hotels in Anaheim ](https://www.expedia.co.uk/Anaheim-Hotels-Business-Hotel.0-0-d5921-tBusinessHotel.Travel-Guide-Filter-Hotels) - 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