A red train on tracks, palm trees, and modern buildings.

Search Business Hotels in Central San Diego

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Save instantly and earn perks with One Key
  • Be picky

    Search almost a million properties worldwide

Check availability on Central San Diego Business Hotels

Next weekend
In two weeks

Our top choices for Central San Diego business-friendly hotels

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
University Heights
9.4 out of 10, Exceptional, (1,779 reviews)
"Beautiful hotel"
United States
Cuauhtemoc
The price is £223
includes taxes & fees
7 Jul - 8 Jul
Lafayette Hotel & Club

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
Mission Valley
8.4 out of 10, Very good, (1,031 reviews)
"great stay"
United States
David
The price is £105
includes taxes & fees
27 Jul - 28 Jul
Crowne Plaza San Diego - Mission Valley by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
Mission Hills
9.2 out of 10, Wonderful, (1,076 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is £138
includes taxes & fees
6 Jul - 7 Jul
Holiday Inn Express San Diego Airport - Old Town by IHG

Old Town Western Inn & Suites

Old Town Western Inn & Suites
2.5 star property
Old Town San Diego
8.0 out of 10, Very good, (1,001 reviews)
"Very good area for visiting the area"
United States
Carla
The price is £94
includes taxes & fees
6 Jul - 7 Jul
Old Town Western Inn & Suites

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld
2.5 star property
Mission Valley
8.0 out of 10, Very good, (331 reviews)
"Staff was great and rooms were nice."
United States
Brittney
The price is £91
includes taxes & fees
6 Jul - 7 Jul
The Alcala Hotel Mission Valley/Seaworld

Best Western San Diego/Miramar Hotel

Best Western San Diego/Miramar Hotel
2.5 star property
Miramar
8.0 out of 10, Very good, (1,437 reviews)
"Great stay Really close to the cut water brewery!"
United States
Jessica
The price is £122
includes taxes & fees
6 Jul - 7 Jul
Best Western San Diego/Miramar Hotel

Courtyard by Marriott Old Town

Courtyard by Marriott Old Town
3.0 star property
Old Town San Diego
8.8 out of 10, Excellent, (1,006 reviews)
"Great location with great amenities!"
United States
Christie
The price is £139
includes taxes & fees
9 Jul - 10 Jul
Courtyard by Marriott Old Town

Hampton Inn San Diego-Kearny Mesa

Hampton Inn San Diego-Kearny Mesa
2.5 star property
Kearny Mesa
9.2 out of 10, Wonderful, (1,002 reviews)
"Great place for kids and adults."
United States
Susana
The price is £109
includes taxes & fees
2 Aug - 3 Aug
Hampton Inn San Diego-Kearny Mesa

California Suites Hotel

California Suites Hotel
2.0 star property
Clairemont
7.8 out of 10, Good, (2,684 reviews)
"Had a wonderful stay. Would stay here again"
United States
Ariana
The price is £89
includes taxes & fees
2 Aug - 3 Aug
California Suites Hotel

Best Western Plus Hacienda Hotel Old Town

Best Western Plus Hacienda Hotel Old Town
3.0 star property
Old Town San Diego
8.4 out of 10, Very good, (2,069 reviews)
"Excellent stay! Beautiful grounds and friendly staff."
United States
Rebecca
The price is £144
includes taxes & fees
6 Jul - 7 Jul
Best Western Plus Hacienda Hotel Old Town
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Central San Diego Hotel Reviews

Frequently asked questions

Why book your business hotel in Central San Diego with Expedia?
Here at Expedia, we make it our job to help you land an ideal stay at the right price. From 5-star corporate-friendly properties to affordable hotels filled with conveniences, you'll have your next work trip organised in a few quick clicks.
How can I find cheap business hotels in Central San Diego?
When you're travelling for work in Central San Diego, our "business friendly" filter will help you find a suitable hotel. From free WiFi and included breakfast to conference spaces and in-room desks, they come with the amenities you need for a comfortable and productive stay. Another tip? Narrow your search by your preferred star rating and budget to see the most affordable stays.

Explore a world of travel with Expedia