Title: The 10 Best 5 Star Hotels in Santa Cruz - 2025 Updated Prices | Expedia.co.uk [Santa Cruz Travel Guide](https://expedia.co.uk/Seville-Santa-Cruz.dx6005056)[Holiday Rentals in Seville](https://expedia.co.uk/Seville-Holiday-Rentals.d3312.Travel-Guide-HolidayRentals)[Flights to Seville](https://expedia.co.uk/Cheap-Flights-To-Seville.d3312.Travel-Guide-Flights)[Things to do in Seville](https://expedia.co.uk/Things-To-Do-In-Seville.d3312.Travel-Guide-Activities)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6005056.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6005056.Holidays-City-Breaks) ![](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/346000/346159-Santa-Cruz.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Santa Cruz, Seville ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz 5 Star Hotels Tonight [12 Oct - 13 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-10-12&endDate=2025-10-13&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [13 Oct - 14 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-10-13&endDate=2025-10-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [17 Oct - 19 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-10-17&endDate=2025-10-19&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [24 Oct - 26 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2025-10-24&endDate=2025-10-26&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Santa Cruz 5 Star Hotels ![Lobby](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/e6036d75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Deluxe Classic Room | Restaurant | 2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/c6240a75.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/9eff12c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/b5af0c33.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Alfonso XIII, a Luxury Collection Hotel, Seville Historical Center 9.4/10 Exceptional (1007) "A fabulous hotel with fabulous service in the most amazing building " £523 includes taxes & fees 5 Nov - 6 Nov [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) ![City view from property](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/8b75801c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Courtyard](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/a9be631e.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, down duvets, minibar](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/1fb9b2c8.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/d06593f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EME Catedral Mercer Hotel Historical Center 8.8/10 Excellent (1008) "A beautiful hotel in an exceptional location. Very friendly staff, especially Emma Martin. Lovely rooftop bar, modern rooms and on the whole a lovely stay. Will be our first choice for our next trip to Seville " £174 includes taxes & fees 2 Nov - 3 Nov [](https://www.expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Cruz-Seville-Hotels.s50-n6005056-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Cruz-Seville-Hotels.s50-n6005056-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santa Cruz. ![Hotel Rey Alfonso X](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/927628c0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Rey Alfonso X Calle Ximenez De Enciso, 35, Seville, Seville £184 20 Oct - 21 Oct includes taxes & fees 9.4/10 Exceptional! (1,065 reviews) [](https://expedia.co.uk/Seville-Hotels-Hotel-Rey-Alfonso-X.h917067.Hotel-Information) ![Hotel Fernando III](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/d02c6946_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Fernando III San Jose 21, Seville, Seville £130 11 Nov - 12 Nov includes taxes & fees 9.6/10 Exceptional! (1,515 reviews) [](https://expedia.co.uk/Seville-Hotels-Hotel-Fernando-III.h75297.Hotel-Information) ![Las Casas de la Juderia](https://images.trvl-media.com/lodging/1000000/10000/9900/9805/42f0cb8c_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Las Casas de la Juderia Calle Santa Maria La Blanca 5, Seville, Seville £147 2 Nov - 3 Nov includes taxes & fees 9.2/10 Wonderful! (1,004 reviews) [](https://expedia.co.uk/Seville-Hotels-Las-Casas-De-La-Juderia.h9805.Hotel-Information) Still don't see what you're looking for? [See all properties in Santa Cruz.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F10%2F2025&endDate=14%2F10%2F2025®ionId=6005056&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F10%2F2025&endDate=14%2F10%2F2025®ionId=6005056&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F10%2F2025&endDate=14%2F10%2F2025®ionId=6005056&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F10%2F2025&endDate=14%2F10%2F2025®ionId=6005056&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F10%2F2025&endDate=14%2F10%2F2025®ionId=6005056&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F10%2F2025&endDate=14%2F10%2F2025®ionId=6005056&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Santa Cruz Hotel Reviews ![Hotel Alfonso XIII, a Luxury Collection Hotel, Seville](//images.trvl-media.com/lodging/1000000/10000/5700/5692/e6036d75_y.jpg) ### Hotel Alfonso XIII, a Luxury Collection Hotel, Seville 10/10 Excellent "A fabulous hotel with fabulous service in the most amazing building " [](https://expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) ![EME Catedral Mercer Hotel](//images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/8b75801c_y.jpg) ### EME Catedral Mercer Hotel 10/10 Excellent "A beautiful hotel in an exceptional location. Very friendly staff, especially Emma Martin. Lovely rooftop bar, modern rooms and on the whole a lovely stay. Will be our first choice for our next trip to Seville " [](https://expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [1 Star Hotels in Seville](https://www.expedia.co.uk/1Star-Seville-Hotels.s10-0-d3312.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Historical Center](https://www.expedia.co.uk/2Star-Historical-Center-Seville-Hotels.s20-n6158990-0.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Seville](https://www.expedia.co.uk/2Star-Seville-Hotels.s20-0-d3312.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Carmona](https://www.expedia.co.uk/3Star-Carmona-Hotels.s30-0-d182304.Travel-Guide-Filter-Hotels) - [3 Star Hotels in El Rocio](https://www.expedia.co.uk/3Star-El-Rocio-Hotels.s30-0-d6050527.Travel-Guide-Filter-Hotels) - [3 Star Hotels in Gerena](https://www.expedia.co.uk/3Star-Gerena-Hotels.s30-0-d6049118.Travel-Guide-Filter-Hotels) - 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