Title: The 10 Best 5 Star Hotels in Santa Cruz - 2026 Updated Prices | Expedia.co.uk [Santa Cruz Travel Guide](https://expedia.co.uk/Seville-Santa-Cruz.dx6005056)[Holiday Rentals in Seville](https://expedia.co.uk/Seville-Holiday-Rentals.d3312.Travel-Guide-HolidayRentals)[Flights to Seville](https://expedia.co.uk/Cheap-Flights-To-Seville.d3312.Travel-Guide-Flights)[Things to do in Seville](https://expedia.co.uk/Things-To-Do-In-Seville.d3312.Travel-Guide-Activities)[Santa Cruz Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Santa-Cruz.d6005056.Car-Hire-Guide)[Santa Cruz Holidays](https://expedia.co.uk/Santa-Cruz.d6005056.Holidays-City-Breaks) ![Santa Cruz](https://images.trvl-media.com/place/6005056/76322155-c0b9-4bf9-8b7b-37408ab9b072.jpg?impolicy=fcrop&w=1200&h=500&q=medium) ![](https://images.trvl-media.com/place/6005056/76322155-c0b9-4bf9-8b7b-37408ab9b072.jpg?impolicy=fcrop&w=1200&h=500&q=medium) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) - ![](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Santa Cruz 5 Star Hotels Tonight [2 Mar - 3 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2026-03-02&endDate=2026-03-03&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [3 Mar - 4 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2026-03-03&endDate=2026-03-04&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) This weekend [6 Mar - 8 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2026-03-06&endDate=2026-03-08&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [13 Mar - 15 Mar](https://www.expedia.co.uk/Hotel-Search?regionId=6005056&startDate=2026-03-13&endDate=2026-03-15&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Our top choices for Santa Cruz 5-star hotels ![Exterior](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/388658c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![2 restaurants, breakfast, lunch, dinner served; international cuisine ](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/9eff12c0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/01fb742c.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Property amenity](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/e2911775.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Hotel Alfonso XIII, a Luxury Collection Hotel, Seville [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) Historical Center 9.4/10 Exceptional (1,002 reviews) "Stunning hotel with incredible food in the heart of Sevilla! " ![United States](https://a.travel-assets.com/egds/marks/flags/us.svg) Rebecca £558 includes taxes & fees 13 Mar - 14 Mar [](https://www.expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) ![Outdoor pool, pool loungers](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/d06593f0.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Porch](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/6b5e554b.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Junior Suite Views | City view](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/82daf4e3.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Rooftop bar, al fresco dining, open daily](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/b88f4a64.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### EME Catedral Mercer Hotel [](https://www.expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) Historical Center 8.8/10 Excellent (1,002 reviews) "Great location, and thank you to all the staff for making our stay so enjoyable. " ![United Kingdom](https://a.travel-assets.com/egds/marks/flags/uk.svg) Samir £166 includes taxes & fees 8 Mar - 9 Mar [](https://www.expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in ](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Cruz-Seville-Hotels.s50-n6005056-0.Travel-Guide-Filter-Hotels)[ Sign up, it's free ](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Santa-Cruz-Seville-Hotels.s50-n6005056-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santa Cruz. ![Hotel Fernando III](https://images.trvl-media.com/lodging/1000000/80000/75300/75297/d02c6946_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Fernando III San Jose 21 Seville Seville £150 10 Mar - 11 Mar includes taxes & fees 9.6/10 Exceptional! (1,501 reviews) [](https://expedia.co.uk/Seville-Hotels-Hotel-Fernando-III.h75297.Hotel-Information) ![Hotel Rey Alfonso X](https://images.trvl-media.com/lodging/1000000/920000/917100/917067/927628c0_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Rey Alfonso X Calle Ximenez De Enciso, 35 Seville Seville £145 5 Mar - 6 Mar includes taxes & fees 9.6/10 Exceptional! (1,135 reviews) [](https://expedia.co.uk/Seville-Hotels-Hotel-Rey-Alfonso-X.h917067.Hotel-Information) ![Hotel Doña Maria](https://images.trvl-media.com/lodging/2000000/1180000/1177700/1177678/90293ccc_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hotel Doña Maria Don Remondo 19 Seville Seville £140 8 Mar - 9 Mar includes taxes & fees 9/10 Wonderful! (1,004 reviews) [](https://expedia.co.uk/Seville-Hotels-Hotel-Dona-Maria.h1177678.Hotel-Information) Still don't see what you're looking for? [See all properties in Santa Cruz.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=03%2F03%2F2026&endDate=04%2F03%2F2026®ionId=6005056&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=03%2F03%2F2026&endDate=04%2F03%2F2026®ionId=6005056&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=03%2F03%2F2026&endDate=04%2F03%2F2026®ionId=6005056&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=03%2F03%2F2026&endDate=04%2F03%2F2026®ionId=6005056&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=03%2F03%2F2026&endDate=04%2F03%2F2026®ionId=6005056&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=03%2F03%2F2026&endDate=04%2F03%2F2026®ionId=6005056&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Top Santa Cruz Hotel Reviews ![EME Catedral Mercer Hotel](https://images.trvl-media.com/lodging/2000000/1910000/1901800/1901701/8b75801c_y.jpg) ### EME Catedral Mercer Hotel 10/10 Excellent "Localizado excelente " [](https://expedia.co.uk/Seville-Hotels-EME-Catedral-Hotel.h1901701.Hotel-Information) ![Hotel Alfonso XIII, a Luxury Collection Hotel, Seville](https://images.trvl-media.com/lodging/1000000/10000/5700/5692/388658c0_y.jpg) ### Hotel Alfonso XIII, a Luxury Collection Hotel, Seville 10/10 Excellent "Great property" [](https://expedia.co.uk/Seville-Hotels-Hotel-Alfonso-XIII.h5692.Hotel-Information) ## Explore a world of travel with Expedia - Accommodation - Flights - Packages - Cars - Holiday Homes - Other - More ways to book - [1 Star Hotels in Seville ](https://www.expedia.co.uk/1Star-Seville-Hotels.s10-0-d3312.Travel-Guide-Filter-Hotels) - [2 Star Hotels in Historical Center ](https://www.expedia.co.uk/2Star-Historical-Center-Seville-Hotels.s20-n6158990-0.Travel-Guide-Filter-Hotels) - 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