Title: The 10 Best 5 Star Hotels in Mayo River - 2026 Updated Prices | Expedia.co.uk

[Mayo River Travel Guide](https://expedia.co.uk/Mayo-River.dx553248635976006279)[Hotels in Mayo River](https://expedia.co.uk/Mayo-River-Hotels.d553248635976006279.Travel-Guide-Hotels)[Holiday Rentals in Mayo River](https://expedia.co.uk/Mayo-River-Holiday-Rentals.d553248635976006279.Travel-Guide-HolidayRentals)[Flights to Mayo River](https://expedia.co.uk/Cheap-Flights-To-Mayo-River.d553248635976006279.Travel-Guide-Flights)[Mayo River Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Mayo-River.d553248635976006279.Car-Hire-Guide)[Mayo River Holidays](https://expedia.co.uk/Mayo-River.d553248635976006279.Holidays-City-Breaks)

![The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.](https://images.trvl-media.com/place/553248621561864249/54558157-d5bc-4ba5-a77d-f9a917492c5a.jpg?impolicy=fcrop&w=1200&h=500&q=medium)

Photo by Ed Mayfield

# Compare and book 5 Star hotels in Mayo River, Virginia

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## Check availability on Mayo River 5 Star Hotels

Tonight

[12 Dec - 13 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976006279&startDate=2025-12-12&endDate=2025-12-13&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Tomorrow

[13 Dec - 14 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976006279&startDate=2025-12-13&endDate=2025-12-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

This weekend

[12 Dec - 14 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976006279&startDate=2025-12-12&endDate=2025-12-14&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

Next weekend

[19 Dec - 21 Dec](https://www.expedia.co.uk/Hotel-Search?regionId=553248635976006279&startDate=2025-12-19&endDate=2025-12-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true)

## Our top choices for Mayo River 5-star hotels

![Exterior](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/d7ce6da6.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Suite, 2 Queen Beds (Fairway) | Premium bedding, in-room safe, blackout curtains, free cots/infant beds](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/347c008f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Lobby sitting area](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/84ebd106.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

![Tree House, 1 King Bed (Cooper's Hawk, Adults Only) | Premium bedding, in-room safe, blackout curtains, free cots/infant beds](https://images.trvl-media.com/lodging/4000000/3640000/3633200/3633184/0892b487.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium)

### The Lodge at Primland, Auberge Collection

[](https://www.expedia.co.uk/Meadows-Of-Dan-Hotels-The-Lodge-At-Primland.h3633184.Hotel-Information)

Meadows Of Dan

9.0/10

Wonderful

(25)

"The resort is an experience. The staff were helpful and genuine. "

![United States](https://a.travel-assets.com/egds/marks/flags/us.svg)

Melinda

£330

includes taxes & fees

8 Jan - 9 Jan 2026

[](https://www.expedia.co.uk/Meadows-Of-Dan-Hotels-The-Lodge-At-Primland.h3633184.Hotel-Information)

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## Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Mayo River.

![Tuggle's Gap Roadside Inn - Blue Ridge Parkway](https://images.trvl-media.com/lodging/90000000/89180000/89174900/89174849/f1861bf5_y.jpg?impolicy=resizecrop&rw=402&ra=fit)

### Tuggle's Gap Roadside Inn - Blue Ridge Parkway

3351 Parkway Ln S Floyd VA

[Get rates](https://expedia.co.uk/Hotel-Search?startDate=26%2F12%2F2025&endDate=27%2F12%2F2025&selected=89174849&PinnedHotelID=89174849&HadPinnedHotel=true&regionId=553248635976006279)

9.2/10 Wonderful! (157 reviews)

[](https://expedia.co.uk/Floyd-Hotels-Tuggles-Gap-Roadside-Inn.h89174849.Hotel-Information)

Still don't see what you're looking for?

[See all properties in Mayo River.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=553248635976006279&star=50)

You can also use these popular filters to refine your search.

[Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=553248635976006279&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=553248635976006279&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=553248635976006279&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=553248635976006279&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=13%2F12%2F2025&endDate=14%2F12%2F2025&regionId=553248635976006279&star=50&star=50&amenities=WATER_PARK)

Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

## Learn more about Mayo River

Head to sights like Reynolds Homestead as you discover the local area in Mayo River. 

[See all hotels in Mayo River](https://www.expedia.co.uk/Hotel-Search?startDate=2025-12-26&endDate=2025-12-27&adults=2&regionId=553248635976006279)

![The Reynolds Homestead, built in 1943 is in a beautiful foothill setting. Hardin Reynolds and his wife produced 16 children here, the most famous being RJ Reynolds who migrated to Winston Salem, NC to start the tobacco empire of the same name. The catalpa tree in the foreground still remains from the earliest days of the homestead.](https://images.trvl-media.com/place/553248621561864249/54558157-d5bc-4ba5-a77d-f9a917492c5a.jpg?impolicy=fcrop&w=899&h=675&p=1&q=high)

Photo by Ed Mayfield

## Top Mayo River Hotel Reviews

## Find out more about Mayo River

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