Title: The 10 Best 5 Star Hotels in Central West End - 2025 Updated Prices | Expedia.co.uk [Central West End Travel Guide](https://expedia.co.uk/St-Louis-Central-West-End.dx6175135)[Holiday Rentals in St. Louis](https://expedia.co.uk/St-Louis-Holiday-Rentals.d178309.Travel-Guide-HolidayRentals)[Flights to St. Louis](https://expedia.co.uk/Cheap-Flights-To-St-Louis.d178309.Travel-Guide-Flights)[Things to do in St. Louis](https://expedia.co.uk/Things-To-Do-In-St-Louis.d178309.Travel-Guide-Activities)[Central West End Car Hire](https://expedia.co.uk/Compare-Cheap-Car-Hire-In-Central-West-End.d6175135.Car-Hire-Guide)[Central West End Holidays](https://expedia.co.uk/Central-West-End.d6175135.Holidays-City-Breaks) ![Central West End](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/199000/199931-Central-West-End.jpg?impolicy=fcrop&w=1200&h=500&q=medium) # Compare and book 5 Star hotels in Central West End, St. Louis ![price find illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__price_find.svg) ### Change your mind Book hotels with free cancellation ![deals illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__deals.svg) ### Treat yourself Save instantly and earn perks with One Key [Learn about One Key](https://www.expedia.co.uk/welcome-one-key) ![bed illustration](https://a.travel-assets.com/travel-assets-manager/pictogram-bex/light__bed.svg) ### Be picky Search almost a million properties worldwide ## Check availability on Central West End 5 Star Hotels Tonight [20 Sept - 21 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6175135&startDate=2025-09-20&endDate=2025-09-21&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Tomorrow [21 Sept - 22 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6175135&startDate=2025-09-21&endDate=2025-09-22&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) Next weekend [26 Sept - 28 Sept](https://www.expedia.co.uk/Hotel-Search?regionId=6175135&startDate=2025-09-26&endDate=2025-09-28&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) In two weeks [3 Oct - 5 Oct](https://www.expedia.co.uk/Hotel-Search?regionId=6175135&startDate=2025-10-03&endDate=2025-10-05&adults=2&star=50&rfrr=TG.LP.CheckPrices.Hotel&openPlayBack=true) ## Top Central West End 5 Star Hotels ## Our top choices for Central West End 5-star hotels ![Rooftop bar](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/89e020ab.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Outdoor pool](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/641d7f21.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Lobby](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/5b370fff.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![View from room](https://images.trvl-media.com/lodging/3000000/2860000/2851500/2851438/e177092f.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### Four Seasons Hotel St Louis Downtown St. Louis 9.4/10 Exceptional (1001) "Beautiful stay at the four seasons! " £367 includes taxes & fees 14 Oct - 15 Oct [](https://www.expedia.co.uk/St-Louis-Hotels-Four-Seasons-Hotel-St-Louis.h2851438.Hotel-Information) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/9a597e77.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![1 bedroom, premium bedding, minibar, in-room safe](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/dbe99670.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Meeting facility](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/a54897ef.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ![Banquet hall](https://images.trvl-media.com/lodging/1000000/10000/6200/6132/8fec4778.jpg?impolicy=fcrop&w=357&h=201&p=1&q=medium) ### The Ritz-Carlton, St. Louis Clayton 9.2/10 Wonderful (548) "Service is exceptional!!!" £449 includes taxes & fees 21 Sept - 22 Sept [](https://www.expedia.co.uk/St-Louis-Hotels-The-Ritz-Carlton.h6132.Hotel-Information) ![](https://a.travel-assets.com/pricing-claim/sparkle_dark.svg) Save an average of 15% on thousands of hotels when you're signed in [Sign in](https://expedia.co.uk/user/signin?ckoflag=0&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Central-West-End-St-Louis-Hotels.s50-n6175135-0.Travel-Guide-Filter-Hotels)[Sign up, it's free](https://expedia.co.uk/signup?enable_registration=true&+=&uurl=e3id%3Dredr%26rurl%3D%2F5Star-Central-West-End-St-Louis-Hotels.s50-n6175135-0.Travel-Guide-Filter-Hotels) ## Explore similar 4-star hotels Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Central West End. ![Renaissance St. Louis Airport Hotel](https://images.trvl-media.com/lodging/1000000/10000/4700/4672/879431a1_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Renaissance St. Louis Airport Hotel 9801 Natural Bridge Road, St. Louis, MO £107 3 Oct - 4 Oct includes taxes & fees 8.4/10 Very Good! (1,007 reviews) [](https://expedia.co.uk/St-Louis-Hotels-Renaissance-St-Louis-Airport-Hotel.h4672.Hotel-Information) ![Hyatt Regency St. Louis at The Arch](https://images.trvl-media.com/lodging/1000000/20000/14900/14877/335a172e_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### Hyatt Regency St. Louis at The Arch 315 Chestnut St, St. Louis, MO £109 2 Oct - 3 Oct includes taxes & fees 8.4/10 Very Good! (3,981 reviews) [](https://expedia.co.uk/St-Louis-Hotels-Hyatt-Regency-St-Louis-At-The-Arch.h14877.Hotel-Information) ![21C Museum Hotel St Louis ](https://images.trvl-media.com/lodging/90000000/89170000/89164600/89164592/bb460692_y.jpg?impolicy=resizecrop&rw=402&ra=fit) ### 21C Museum Hotel St Louis 1528 Locust street, St. Louis, MO £121 28 Sept - 29 Sept includes taxes & fees 9/10 Wonderful! (1,376 reviews) [](https://expedia.co.uk/St-Louis-Hotels-21C-Museum-Hotel-St-Louis.h89164592.Hotel-Information) Still don't see what you're looking for? [See all properties in Central West End.](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6175135&star=50) You can also use these popular filters to refine your search. [Pool](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6175135&star=50&star=50&amenities=POOL)[Spa](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6175135&star=50&star=50&amenities=SPA_ON_SITE)[Hot tub](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6175135&star=50&star=50&amenities=HOT_TUB)[Breakfast included](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6175135&star=50&star=50&amenities=FREE_BREAKFAST)[Waterpark](https://expedia.co.uk/Hotel-Search?rfrrid=TG.LP.Hotels.Hotel&startDate=21%2F09%2F2025&endDate=22%2F09%2F2025®ionId=6175135&star=50&star=50&amenities=WATER_PARK) Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply. ## Learn more about Central West End Enjoy this relaxed area, the ultimate destination for a lazy afternoon. Browse unique stores, admire artworks and sip coffee at sidewalk tables shaded by trees. [See all hotels in Central West End](https://www.expedia.co.uk/Hotel-Search?startDate=2025-10-04&endDate=2025-10-05&adults=2®ionId=6175135) ![Central West End](https://a.travel-assets.com/findyours-php/viewfinder/images/res70/199000/199931-Central-West-End.jpg?impolicy=fcrop&w=900&h=506&p=1&q=high) ## Top Central West End Hotel Reviews ## Frequently asked questions ### How much does it cost to stay in a 5-star hotel in Central West End? > The amount you pay for a 5-star hotel in Central West End can vary depending on what time of year you travel and how long you plan to be away, among a range of factors. Use our price per night filter and other search tools to find the best rate on a luxurious stay. > > > > - Search for the lowest price per night from £107 ### What makes a hotel 5 stars in Central West End? > Outstanding guest service is at the heart of every 5-star hotel in Central West End. From the moment you arrive, staff attend to your every whim, whether recommending activities and tours or providing a nightly turn-down service. In addition, hotels must feature superior conveniences to be entitled to a 5-star rating. These can include luxury toiletries, spa facilities, pools, gastronomic kitchens and knowledgeable concierge. ### Are there any 5-star all-inclusive resorts in Central West End? > Find a luxurious stay that includes your room, meals, activities and entertainment in Central West End with our filter tool. Search for hotels with a 5-star rating and click on the "All inclusive" filter. Make sure you check what's included in the purchase price. 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[Things to do in St. Louis](https://www.expedia.co.uk/Things-To-Do-In-St-Louis.d178309.Travel-Guide-Activities) - [Book Hotels in Central West End on Expedia.com](https://www.expedia.com/5Star-Central-West-End-St-Louis-Hotels.s50-n6175135-0.Travel-Guide-Filter-Hotels)