Photo by rikki cornett
Compare and book 5 Star hotels in Central United States, United States of America
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Central United States 5 Star Hotels
Our top choices for Central United States 5-star hotels
The Roosevelt New Orleans, A Waldorf Astoria Hotel
The Roosevelt New Orleans, A Waldorf Astoria HotelNew Orleans Central Business District
9.4 out of 10, Exceptional, (1,000 reviews)
"Amazing hotel, great roof top pool/bar/spa!"
Jacob
The price is £155
includes taxes & fees
19 Jul - 20 Jul
9.6 out of 10, Exceptional, (1,896 reviews)
"Great stay and location."
Tammy Lynn
The price is £419
includes taxes & fees
19 Jul - 20 Jul
9.4 out of 10, Exceptional, (1,000 reviews)
"Loved our suite- gorgeous views! Great service and excellent location "
lora
The price is £474
includes taxes & fees
5 Jul - 6 Jul
Thompson San Antonio - Riverwalk, by Hyatt
Thompson San Antonio - Riverwalk, by HyattDowntown San Antonio
9.0 out of 10, Wonderful, (1,000 reviews)
"Great hotel on a nice spot on the Riverwalk."
Brett
The price is £184
includes taxes & fees
5 Jul - 6 Jul
8.6 out of 10, Excellent, (1,878 reviews)
"Enjoyed our stay, staff was wonderful, breakfast buffet was delicious and the water park/ pool, was a big hit with the kids"
shari
The price is £217
includes taxes & fees
21 Jun - 22 Jun
9.8 out of 10, Exceptional, (1,001 reviews)
"Very good hotel"
Sanjay
The price is £525
includes taxes & fees
9 Jul - 10 Jul
The Joseph, a Luxury Collection Hotel, Nashville
The Joseph, a Luxury Collection Hotel, NashvilleDowntown Nashville
9.4 out of 10, Exceptional, (505 reviews)
"The hotel is beautiful! And a great location to Broadway. Easy access to get around to other places too."
Jody
The price is £222
includes taxes & fees
5 Jul - 6 Jul
9.0 out of 10, Wonderful, (521 reviews)
"Beautiful room, views and amenities. And lots of dining options available right at the hotel."
Trisha
The price is £342
includes taxes & fees
9 Jul - 10 Jul
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 4-star hotels
Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Central United States.
Hilton Cincinnati Netherland Plaza
35 W 5th St Cincinnati OH
The price is £115 per night from 5 Jul to 6 Jul
£115
5 Jul - 6 Jul
includes taxes & fees
8/10 Very Good! (1,547 reviews)
Still don't see what you're looking for?
See all properties in Central United States.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Central United States
Enjoy access to sights and activities in the surrounding area during your stay in Central United States.
Photo by Michael Schuier
Open Photo by Michael Schuier
Top Central United States Hotel Reviews
Find out more about Central United States
Frequently asked questions
Explore a world of travel with Expedia
- 4 Star Hotels in Ozarks
- Hotels near Mississippi River
- Serviced Apartments in Ozarks
- B&B in Ozarks
- Guest Houses in Ozarks
- Resorts in Ozarks
- Adults Only Resorts & in Ozarks
- All-Inclusive Hotels in Ozarks
- Boutique Hotels in Ozarks
- Golf Hotels in Ozarks
- Hotels Suites in Ozarks
- Hotels with Restaurant in Ozarks
- Hotels with Balcony in Ozarks
- Hotels with Hot Tubs in Ozarks
- Hotels with Indoor Pools in Ozarks
- Hotels with Pool in Ozarks
- Lakeside Hotels in Ozarks
- Luxury Hotels in Ozarks
- Marina Hotels in Ozarks
- Mountain Hotels in Ozarks
- Spa Hotels in Ozarks
- Ozarks Hotels
- Lodges in Ozarks
- Holiday Homes in Ozarks
- B&B in Southeast Iowa
- Hotels with Hot Tubs in Southeast Iowa
- Spa Hotels in Southeast Iowa
- Hotels with Waterpark in Southeast Iowa
- Southeast Iowa Hotels